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结直肠癌肝转移的流行病学及处理

医学信息（手术学分册） 2007年第9期20卷 853-853页

作者： Manfredi, Sylvain Lepage, Come Hatem, cyril Coatmeur, Olivier Faivre, Jean Bouvier, Anne - Marie

目的／背景：基于人群水平对结直肠癌肝转移的流行病学及处理的认识还很少。这项基于人群的研究目的是报告同期或后期结直肠癌肝转移的发病率、治疗及预后。方法：本项研究的所有数据来自法国勃艮第人群癌症注册系统。结果：同期肝转移... 详细信息

目的／背景：基于人群水平对结直肠癌肝转移的流行病学及处理的认识还很少。这项基于人群的研究目的是报告同期或后期结直肠癌肝转移的发病率、治疗及预后。方法：本项研究的所有数据来自法国勃艮第人群癌症注册系统。结果：同期肝转移的发病率为14．5％，年龄标准化发病率为：男性7．6／100000、女性3．7／100000。5年累计肝转移率为14．5％，TNM分期Ⅰ期患者为3．7％，Ⅱ期为13．3％，Ⅲ期为30．4％（P〈0．001）。

关键词：结直肠癌肝转移流行病学标准化发病率同期肝转移 TNM分期人群转移率

Identification of new genetic risk factors for prostate cancer

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Asian Journal of Andrology 2009年第1期11卷 49-55页

作者： Michelle Guy Zsofia Kote-Jarai Graham G. Giles Ali Amin Al Olama Sarah K. Jugurnauth Shani Mulholland Daniel A. Leongamomlert Stephen M. Edwards Jonathan Morrison Helen I. Field Melissa C. Southey Gianluca Severi Jenny L. Donovan Freddie C. Hamdy David R Dearnaley Kenneth R. Muir Charmaine Smith Melisa Bagnato Audrey T. Ardern-Jones Amanda L. Hall Lynne T. O＇Brien Beatrice N. Gehr-Swain Rosemary A. Wilkinson Angela Cox Sarah Lewis Paul M. Brown Sameer G. Jhavar Malgorzata Tymrakiewicz Artitaya Lophatananon Sarah L. Bryant The UK Genetic Prostate Cancer Study Collaborators British Association of Urological Surgeons＇ Section of Oncology and The UK ProtecT Study Collaborators Alan Horwich Robert A. Huddart Vincent S. Khoo Christopher C. Parker Christopher J. Woodhouse Alan Thompson Tim Christmas Chris Ogden cyril Fisher Charles Jameson Colin S. Cooper Dallas R. English John L. Hopper David E. Neal Douglas E Easton Rosalind A. Eeles Section of Cancer Genetics The Institute of Cancer Research Sutton Surrey SM2 5NG UK Cancer Epidemiology Centre The Cancer Council Victoria Carlton VIC 3053 Australia Centre for Molecular Environmental Genetic and Analytic Epidemiology The University of Melbourne Carlton VIC 3053 Australia Cancer Research UK Genetic Epidemiology Unit University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Department of Oncology University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Genetic Epidemiology Laboratory Department of Pathology The University of Melbourne Parkville VIC 3052 Australia Department of Social Medicine University of Bristol Bristol BS8 2PR UK Academic Urology Unit University of Sheffield Sheffield SIO 2JF UK The Royal Marsden NHS Foundation trust Sutton Surrey SM2 5PT and London SW3 6JJ UK University of Nottingham Medical School Queens Medical Centre Nottingham NG7 2UH UK Institute for Cancer Studies University of Sheffield Sheffield SIO 2RX UK Surgical Oncology （Uro-Oncology S4） Departments of Oncology and Surgery University of Cambridge Addenbrooke＇s Hospital Cambridge CB2 2QQ UK A full list of authors is provided in the Supplementary Note online Ka Shing Centre Cambridge CB2 ORE UK Cancer Research UK Cambridge Research Institute Li Ka Shing Centre Cambridge CB2 ORE UK.

There is evidence that a substantial part of genetic predisposition to prostate cancer （PCa） may be due to lower penetrance genes which are found by genome-wide association studies. We have recently conducted such a study and seven new regions of the genome linked to PCa risk have been identified. Three of these loci contain candidate susceptibility genes： MSMB, LMTK2 and KLK2/3. The MSMB and KLK2/3 genes may be useful for PCa screening, and the LMTK2 gene might provide a potential therapeutic target. Together with results from other groups, there are now 23 germline genetic variants which have been reported. These results have the potential to be developed into a genetic test. However, we consider that marketing of tests to the public is premature, as PCa risk can not be evaluated fully at this stage and the appropriate screening protocols need to be developed. Follow-up validation studies, as well as studies to explore the psychological implications of genetic profile testing, will be vital prior to roll out into healthcare.

关键词： prostate cancer genetics susceptibility loci SNPs relative risks

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澳门摩珀斯酒店

建筑实践 2020年第9期3卷 90-109页

作者： Zaha Hadid Patrik Schumacher Viviana Muscettola Michele Pasca di Magliano Michele Salvi Bianca Cheung Maria Loreto Flores Clara Martins Miron Mutyaba Milind Khade Pierandrea Angius Massimo Napoleoni Stefa no lacopini Davide Del Giudice Luciano Letteriello Luis Migue Samanez cyril Manyara Alvin triestanto Muhammed Shameel Goswin Rothenthal Santiago Fernandez-Achury Vahid Eshraghi Melika Aljukic Virgile Simon Bertrand(摄) Ivan Dupont(摄) 无不详哈迪德建筑事务所

澳门新濠天地旗舰酒店摩珀斯酒店于2018年6月15日开业。澳门作为亚洲最受欢迎的娱乐目的地,2017年接待了超过3,200万名游客,并且游客数量连年增加。新濠天地位于澳门路氹城,是一个集赌场、戏院、购物区、餐厅及酒店于一体的综合度假胜... 详细信息

澳门新濠天地旗舰酒店摩珀斯酒店于2018年6月15日开业。澳门作为亚洲最受欢迎的娱乐目的地,2017年接待了超过3,200万名游客,并且游客数量连年增加。新濠天地位于澳门路氹城,是一个集赌场、戏院、购物区、餐厅及酒店于一体的综合度假胜地。扎哈·哈迪德建筑事务所于2012年接受委托建造该酒店,当时项目场地上有一座已经打好地基但没有后续进展的塔楼。建筑师以中国传统玉雕丰富而流畅的造型为灵感,用创新的工程技术和流动性的方式将建筑的公共空间和私密空间融合在一起。建筑形体被构想为一个垂直挤压的矩形体量,建筑中部的一系列虚空间仿佛城市的窗口,将酒店内部的公共空间与城市连接起来,形成具有雕塑感的独特空间形式。

关键词：建筑事务所公共空间扎哈·哈迪德私密空间建筑形体度假胜地工程技术酒店

The Giant Radio Array for Neutrino Detection(GRAND):Science and design

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Science China(Physics,Mechanics & Astronomy) 2020年第1期Mechanics & Astronomy) .卷 5-47页

作者： Jaime álvarez-Mu?iz Rafael Alves Batista Aswathi Balagopal V. Julien Bolmont Mauricio Bustamante Washington Carvalho Jr. Didier Charrier Isma?l Cognard Valentin Decoene Peter B.Denton Sijbrand De Jong Krijn D.De Vries Ralph Engel Ke Fang Chad Finley Stefano Gabici Quan Bu Gou Jun Hua Gu Claire Guépin Hong Bo Hu Yan Huang Kumiko Kotera Sandra Le Coz Jean-Philippe Lenain Guo Liang Léü Olivier Martineau-Huynh Miguel Mostafá Fabrice Mottez Kohta Murase Valentin Niess Foteini Oikonomou Tanguy Pierog Xiang Li Qian Bo Qin Duan Ran Nicolas Renault-Tinacci Markus Roth Frank G.Schr ?der Fabian Schüssler cyril Tasse Charles Timmerman Matías Tueros Xiang Ping Wu Philippe Zarka Andreas Zech B.Theodore Zhang Jian Li Zhang Yi Zhang Qian Zheng Anne Zilles Departamento de Física de Partículas & Instituto Galego de Física de Altas Enerxías Universidad de Santiago de Compostela Instituto de Astronomia Geofísica e Ciências Atmosféricas Universidade de S?o Paulo Department of Physics—Astrophysics University of Oxford DWB Institute of Experimental Particle Physics (ETP) Karlsruhe Institute of Technology (KIT) Laboratoire de Physique Nucléeaire et de Hautes Energies (LPNHE) Sorbonne Université Université Paris Diderot Sorbonne Paris Cité Niels Bohr International Academy and DARK Niels Bohr Institute Discovery Center Niels Bohr Institute Center for Cosmology and Astro Particle Physics (CCAPP) & Department of Physics Ohio State University Universidade de Santiago de Compostela SUBATECH Institut Mines-Telecom Atlantique – CNRS/IN2P3 – Université de Nantes Laboratoire de Physique et Chimie de l’Environnement et de l’Espace LPC2E CNRS-Université d’Orléans Station de Radioastronomie de Nan?cay Observatoire de Paris Sorbonne Université UMR 7095 Institut d’Astrophysique de Paris Institute for Mathematics Astrophysics and Particle Physics (IMAPP) Radboud Universiteit Nationaal Instituut voor Kernfysica en Hoge Energie Fysica (NIKHEF) IIHE/ELEM Vrije Universiteit Brussel Institute for Nuclear Physics (IKP) Karlsruhe Institute of Technology (KIT) Einstein Fellow Stanford University Department of Astronomy University of Maryland Joint Space-Science Institute Oskar Klein Centre Stockholm University Department of Physics Stockholm University Astro Particule et Cosmologie (APC) Université Paris Diderot CNRS/IN2P3 CEA/Irfu Observatoire de Paris Institute of High Energy Physics Chinese Academy of Sciences National Astronomical Observatories Chinese Academy of Sciences School of Physical Science and Technology Xinjiang University Center for Particle and Gravitational Astrophysics Pennsylvania State University Department of Physics Pennsylvania State University Department of Astronomy & Astrophysics Pennsylvania State University LUTH Observatoire de Paris

The Giant Radio Array for Neutrino Detection（GRAND） is a planned large-scale observatory of ultra-high-energy（UHE） cosmic particles, with energies exceeding 10～8 Ge V. Its goal is to solve the long-standing mystery of the origin of UHE cosmic rays. To do this, GRAND will detect an unprecedented number of UHE cosmic rays and search for the undiscovered UHE neutrinos and gamma rays associated to them with unmatched sensitivity. GRAND will use large arrays of antennas to detect the radio emission coming from extensive air showers initiated by UHE particles in the atmosphere. Its design is modular: 20 separate, independent sub-arrays, each of 10000 radio antennas deployed over 10000 km2. A staged construction plan will validate key detection techniques while achieving important science goals early. Here we present the science goals, detection strategy, preliminary design, performance goals, and construction plans for GRAND.

关键词： radio telescopes neutrinos in astronomical observations cosmic rays in astronomical observations radiowave radiation: sources galactic and extragalactic cosmic rays

大型动物的种群恢复:大象种群增长的生态学效应

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AMBIO－人类环境杂志 2004年第6期33卷 254-260页

作者： Christina Skarpe Per Arild Aarrestad Harry P.Andreassen Shivcharn S.Dhillion Thatayaone Dimakatso Johan T.duToit Duncan J.Halley Hkan Hytteborn Shimane Makhabu Moses Mari Wilson Marokane Gaseitsiwe Masunga Ditshoswane Modise(+) Stein R.Moe Rapelang Mojaphoko David Mosugelo Sekgowa Motsumi Gosiame Neo-Mahupeleng Mpho Ramotadima Lucas Rutina Lettie Sechele Thato B.Sejoe Sigbjφrn Stokke Jon E.Swenson cyril Taolo Mark Vandewalle Per Wegge 周立志 Norwegian Institute for Nature Research Tungasletta 2N-7485 TrondheimNorway

博茨瓦纳北部及其毗邻地区分布着世界上最大的非洲象种群(Loxodonta africana),而在100年前,由于过度捕猎,大象的种群数量极为稀少。与此同时,有蹄类由于疾病,种群数量严重下降。大型草食性动物种群数量降低的生态学效应一定是显著的,... 详细信息

博茨瓦纳北部及其毗邻地区分布着世界上最大的非洲象种群(Loxodonta africana),而在100年前,由于过度捕猎,大象的种群数量极为稀少。与此同时,有蹄类由于疾病,种群数量严重下降。大型草食性动物种群数量降低的生态学效应一定是显著的,但我们却知之甚少,不过,目前博茨瓦纳大象种群数量上升之后产生的生态系统变化却引起人们相当大的关注。调查大象种群和其它生态系统组分及过程相互作用的项目"BONIC"就是的基于这种背景。调查结果表明,生态系统随着大象和其它有蹄类的种群数量的增长而发生变化,并且可能向着原先大型草食性动物数量减少之前的方向变化。我们认为人为地改变大象的种群数量没有生态学理由,但控制大象数量有经济和社会道理,而且博茨瓦纳北部大象的分布区可能必须要受到人为限制。

关键词：大象种群数量草食性动物生态系统有蹄类博茨瓦纳贝专纳种群恢复黑斑羚取食压力生态学效应种群增长

肌萎缩性侧索硬化蛋白激活小胶质细胞NLRP3炎性小体

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神经损伤与功能重建 2020年第9期15卷 F0003-F0003页

作者： Vandana Deora John D Lee Eduardo AAlbornoz Luke McAlary cyril J Jagaraj Avril A B Robertson Julie D Atkin Matthew A Cooper Kate Schroder Justin J Yerbury Richard Gordon trent MWoodruff 杜一星(编译) School of Biomedical Sciences Faculty of MedicineThe University of QueenslandSt.LuciaQueenslandAustralia University of Queensland Centre for Clinical Research Faculty of MedicineThe University of QueenslandHerstonQueenslandAustralia Institute for Molecular Bioscience and Centre for Inflammation and Disease ResearchThe University of QueenslandSt.LuciaQueenslandAustralia School of Chemistry and Molecular Biosciences Faculty of ScienceMedicine and HealthUniversity of WollongongWollongongNew SouthWalesAustralia Illawarra Health and Medical Institute University ofWollongongWollongongNew SouthWalesAustralia Faculty of Medicine and Health Sciences Department of Biomedical SciencesCentre for MND ResearchMacquarie UniversityNew SouthWalesAustralia School of Chemistry and Molecular Biosciences The University of QueenslandSt.LuciaQueenslandAustralia 不详

小胶质细胞NLRP3炎性小体激活正在成为神经退行性变过程中神经炎症的关键因素。诸如β-淀粉样蛋白和α-突触核蛋白之类的致病性蛋白质聚集体触发小胶质NLRP3激活,从而导致半胱天冬酶-1激活和IL-1β的分泌。在小鼠肌萎缩性侧索硬化症(ALS... 详细信息

小胶质细胞NLRP3炎性小体激活正在成为神经退行性变过程中神经炎症的关键因素。诸如β-淀粉样蛋白和α-突触核蛋白之类的致病性蛋白质聚集体触发小胶质NLRP3激活,从而导致半胱天冬酶-1激活和IL-1β的分泌。在小鼠肌萎缩性侧索硬化症(ALS)的SOD1G93A模型中,半胱天冬酶-1和IL-1β均促进疾病进展,提示小胶质NLRP3在该进程中发挥作用。然而先前的研究表明,SOD1G93A小鼠小胶质细胞不表达NLRP3,SOD1G93A蛋白在小胶质细胞中产生独立于NLRP3的IL-1β。本研究论证了使用Nlrp3-GFP基因敲入小鼠,在SOD1G93A小鼠中小胶质细胞表达NLRP3。本研究显示聚集和可溶性SOD1G93A均可激活小鼠原代小胶质细胞中的炎性小体,导致半胱天冬酶-1和IL-1β裂解,ASC斑点形成以及呈剂量和时间依赖性的IL-1β分泌。重要的是,SOD1G93A无法从缺乏Nlrp3的小胶质细胞或者用特异性NLRP3抑制剂MCC950预处理的小胶质细胞中诱导IL-1β分泌,从而证实NLRP3是介导SOD1诱导的小胶质细胞IL-1β分泌的关键炎症小体复合物。在TDP-43Q331K ALS小鼠模型中也观察到小胶质NLRP3上调,TDP-43野生型和突变蛋白亦可以NLRP3依赖性的方式激活小胶质炎性小体。从机制上讲,本研究确定了活性氧簇和ATP的生成是SOD1G93A介导的NLRP3激活所需的关键事件。总之,本研究的数据表明ALS小胶质细胞表达NLRP3,而病理ALS蛋白激活小胶质NLRP3炎性小体。因此,NLRP3抑制可能是阻止小胶质细胞神经炎症和ALS疾病进展的潜在治疗方法。

关键词：白介素-1β 胶质细胞先天免疫运动神经元病

Nature:研究利用单细胞分析阐明癌症干细胞在脑癌中的关键角色

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现代生物医学进展 2017年第6期17卷 I0003-I0003页

作者： Itay Tirosh, Andrew S. Venteicher, Christine Hebert, Leah E. Escalante, Keren Yizhak, Jonathan M. Fisher, Christopher Rodman, Mariella G. Filbin, cyril Neftel, Jackson Nyman, Benjamin Izar, Joshua M. Francis, Kenneth J. Livak, Dave Gennert, Rahul Satija, Todd R. Golub, Miguel N. Rivera, Gad Getz, Orit Rozenblatt-Rosen, Bradley E. Bernstein, Aviv Regev Mario L. Suv agrave Andrew S. Venteicher, Christine Hebert, Leah E. Escalante, Keren Yizhak, Mariella G. Filbin, cyril Neftel, Niyati Desai, Christina C. Luo, Aanand A. Patel, Maristela L. Onozato, Nicolo Riggi, Ravindra Mylvaganam, A. John Iafrate, Matthew P. Frosch, Miguel N. Rivera, Gad Getz, Bradley E. Bernstein, David N. Louis Mario L. Suv agrave Andrew S. Venteicher, Anoop P. Patel, Brian V. Nahed, William T. Curry, Robert L. Martuza Daniel P. Cahill Christopher Mount Michelle Monje Mariella G. Filbin Todd R. Golub Joshua M. Francis Todd R. Golub Aviv Regev Broad Institute of Harvard and MIT Cambridge Massachusetts 02142 USA Department of Pathology and Center for Cancer Research Massachusetts General Hospital and Harvard Medical School Boston Massachusetts 02114 USA Department of Neurosurgery Massachusetts General Hospital and Harvard Medical School Boston Massachusetts 02114 USA Departments of Neurology Neurosurgery Pediatrics and Pathology Stanford University School of Medicine Stanford California 94305 USA Department of Pediatric Oncology Dana-Farber Cancer Institute and Children’s Hospital Cancer Center Boston Massachusetts 02215 USA Department of Medical Oncology Dana-Farber Cancer Institute Boston Massachusetts 02215 USA Howard Hughes Medical Institute Koch Institute Department of Biology MIT Cambridge Massachusetts 02139 USA

近日。来自麻省总医院、博德研究所及哈佛大学的研究人员通过联合研究，在单细胞水平上对脑瘤基因组进行了分析。他们发现。癌症干细胞或许能够诱发少突神经胶质瘤的发生，少突神经胶质瘤是一种缓慢发展但却非常难以治愈的脑癌，相关研... 详细信息

近日。来自麻省总医院、博德研究所及哈佛大学的研究人员通过联合研究，在单细胞水平上对脑瘤基因组进行了分析。他们发现。癌症干细胞或许能够诱发少突神经胶质瘤的发生，少突神经胶质瘤是一种缓慢发展但却非常难以治愈的脑癌，相关研究刊登于Nature杂志上。同时研究者还首次在人类脑瘤样本中鉴别出了癌症干细胞及其分化的后代细胞。

关键词：干细胞单细胞分析癌症脑瘤神经胶质瘤键角利用研究人员