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Characterization of Arroyo Verde Epithermal deposit:Paragenesis,Mineral Geochemistry,Geochronology and Fluid Inclusions in Lower Chon Aike Volcanism,Argentina

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Journal of Earth Science 2024年第1期35卷 62-84页

作者： Cecilia Pavón Pivetta Leonardo Benedini Paulo marcos ma.Agustina Cócola Mercedes virginia Barros Daniel Gregori Leonardo Strazzere Anderson costa dos Santos mauro C.Geraldes Instituto Geologico del Sur(INGEOSUR) Universidad Nacional del Sur(UNS)-Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET)Bahia Blanca 8000Argentina Dpto.de Geologia Universidad Nacional del Sur(UNS)Bahia Blanca 8000Argentina Universidad Nacional de Rio Negro Instituto de Investigacion en Paleobiologia y GeologiaGeneral Roca 8332Argentina Universidade do Estado do Rio de Janeiro Faculdade de GeologiaDepartamento de Mineralogia e Petrologia igneaRiodeJaneiro20559-900Brazil Geobiotec Departamento de GeocienciasUniversidade de AveiroAveiro 3800-002Portuga

Arroyo Verde epithermal deposit,in the North Patagonia region of Argentina,is located within the Lower Chon Aike volcanism and is developed between 192.6±2.5 ma(mineralization host rock)and 189.5±2.6 ma(overlying lava).marifil volcanic complex is the host rock for these veins,veinlets and *** particular small deposit has developed low to intermediate sulphidation characteristics,with gangue mineral textures associated with several ore *** probe microanalysis determines electrum,silver minerals such as acanthite,and tetrahedrite,related Ag-Cu minerals like jalpaite,mckinstryite,stromeyerite,and base metals like chalcopyrite,sphalerite,galena and *** inclusions in quartz of two out of five events indicate that these Low Jurassic veins were formed due to subtle boiling and dilution mechanisms and by low-salinity(3.4 wt.%to 6.7 wt.%NaCl Eq)magmatic-hydrothermal fluid at 225 to 310℃.The fluid inclusion measurements that indicate boiling(Event 3)were plotted,and based on this data,we interpret that the Arroyo Verde deposit has been eroded between 550 and 700 *** particular character has not been previously recorded for other sectors of the eastern north Patagonian region.

关键词： epithermal deposit Ag minerals mineral geochemistry fluid inclusions Chon Aike geochronology

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Psychiatric comorbidities in children with conduct disorder:a descriptive analysis of real-world data

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General Psychiatry 2024年第2期37卷 301-305页

作者： Tashalee R Brown Anita S Kablinger Robert Trestman Eraka Bath cynthia Rogers Binx Yezhe Lin Kevin Young Xu University of california Los Angeles David Geffen School of Medicine Los AngelesCaliforniaUSA department of Psychiatry and Behavioral Medicine Virginia Tech Carilion School of MedicineRoanokeVirginiaUSA Washington University in St Louis School of Medicine St LouisMissouriUSA Clinical Research Center for Mental Disorders Chinese-German Institute of Mental HealthShanghai Pudong New Area Mental Health CenterSchool of MedicineTongji UniversityShanghaiChina department of Psychosomatic Medicine Shanghai East HospitalTongji University School of MedicineShanghaiChina department of Psychiatry Washington University School of Medicine in Saint LouisSt LouisMissouriUSA

To the editor:Two recent advisories from the US surgeon general have underscored the unprecedented public health crisis in youth mental health and emphasised the need for“timely data collection and research to identify and respond to youth mental health needs more rapidly”.1 Increased rates of suicidal behaviour,depression and anxiety symptoms and substance use.

关键词： morbid Psychiat editor

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Endophytic Fungi from Sorghum bicolor(L.)Moench:Influence of Genotypes and Crop Systems and Evaluation of Antimicrobial Activity

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Journal of Agricultural Science and Technology(B) 2018年第5期8卷 267-277页

作者： Ruth Terezinha Rodrigues Márcia marília de Souza Silva Douglas Moreira de Oliveira Josimar Bento Simplício cynthia.ma.ia.ca.neiro costa.virginia.medeiros de siqueira Federal Rural University of Pernambuco Academic Unit of Serra Talhada56909-535Serra TalhadaPernambucoBrazil

Endophytic fungi(EF)colonize plant tissues without causing damage;this relationship brings benefits to both,including a greater resistance to environmental stresses,but the influence of genotypes and culture system in endophytic community is still ***,this work aimed to study EF from Sorghum bicolor and correlate to its genotypes submitted to different culture systems;their potential to produce antimicrobial compounds was also *** optimize the production of metabolites,four isolates were submitted to liquid medium and the crude extracts of different culture times were *** of leaves of Qualimax and SF15 genotypes were isolated after superficial *** identification was made using classical *** results,the traditional system presented the lowest number EF isolates,while the minimum system showed the *** genera Aspergillus,Fusarium,Penicillium,Cladosporium,Curvularia and Syncephalastrum were found;Aspergillus *** pointed out as a predominant endophyte of genotype *** the 25 endophytes submitted antimicrobial activity assay in solid medium,21 presented antibacterial activity against at least one bacterium with the highest inhibition zone of 29.3 mm of diameter against Staphylococcus *** EF submitted to liquid medium kept the capacity to produce antibacterial *** conclusion,regardless of genotype and culture system,sorghum is colonized by different EF,mainly Aspergillus *** from leaves of *** produce antibacterial compounds and their biotechnological applications can be explored in future.

关键词： Plant microbiome genotypes sorghum semi-arid antimicrobial compounds

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Roots and rhizomes of wild Asparagus:Nutritional composition,bioactivity and nanoencapsulation of the most potent extract

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Food Bioscience 2022年第1期45卷 349-360页

作者： Khaoula Adouni Ana Júlio Celestino Santos-Buelga Ana M.Gonzalez-Paramas Patrícia Filipe Patricia Rijo Sofia A.costa Lima Salette Reis Angela Fernandes Isabel C.F.R.Ferreira virginia Fernandez-Ruiz Patricia Morales Guido Flamini Lotfi Achour Pedro Fonte Laboratoire de Recherche“Bioressources:Biologie Integrative&Valorisation” Institut Superieur de Biotechnologie de MonastirAvenue Tahar HaddedBP 74Universite de Monastir5000MonastirTunisia CBIOS-Research Center for Biosciences&Health Technologies Universidade Lusofona de Humanidades e TecnologiasCampo Grande 3761749-024LisbonPortugal department of Biomedical Sciences University of Alcal´aCtra.Madrid-Barcelona Km.33.60028871Alcala de HenaresMadridSpain Grupo de Investigacion en Polifenoles(GIP-USAL) Facultad de FarmaciaUniversidad de SalamancaCampus Miguel de UnamunoE-37007SalamancaSpain Research Institute for Medicines(iMed.ULisboa) Faculty of PharmacyUniversidade de LisboaAv.Professor Gama Pinto1649-003LisboaPortugal LAQV REQUIMTEDepartment of Chemical Sciences–Applied Chemistry LabFaculty of Pharmacy10 University of PortoRua Jorge de Viterbo Ferreira 2284050-313PortoPortugal Centro de Investigacao de Montanha(CIMO) Instituto Politecnico de BragancaCampus de Santa Apolonia5300-253BragancaPortugal department of Nutrition and Food Science Faculty of PharmacyComplutense University of Madrid(UCM)Plaza Ramon y Cajal s/n28040MadridSpain Dipartimento di Farmacia University of Pisavia Bonanno 656126PisaItaly Centro Interdipartimentale di Ricerca“Nutraceutica e Alimentazione per la Salute”University of Pisa Via del Borghetto 8056124PisaItaly Center for marine Sciences(CCmar) University of AlgarveGambelas Campus8005-139FaroPortugal department of Chemistry and Pharmacy Faculty of Sciences and TechnologyUniversity of AlgarveGambelas Campus8005-139FaroPortugal iBB-Institute for Bioengineering and Biosciences Department of BioengineeringInstituto Superior TecnicoUniversidade de Lisboa1049-001LisboaPortugal Associate Laboratory i4HB—Institute for Health and Bioeconomy at Instituto Superior Tecnico Universidade de LisboaAv.Rovisco Pais1049-001LisboaPortugal

The nutritional composition and bioactive properties of roots and rhizomes of Asparagus stipularis were *** activity of extracts obtained by infusion was evaluated using free radicals scavenging and reducing power *** liver primary cell was used to check the hepatotoxicity of *** revealed that Asparagus samples are likely a source of nutrients,such as dietary fibre and essential fatty ***-DAD-ESI/MS characterization of infusions allowed the identification and quantitation of 7 phenolic compounds,all hydroxycinnamoyl derivatives,with caffeic acid as the most *** infusion contained the highest amounts of these *** also exhibited the highest antioxidant activity in all assays,with EC_(50) values of 0.44±0.01,0.98±0.03 and 0.64±0.01 mg/mL for DPPH,ABTS and FRAP assays,respectively,with no toxicity towards PLP2 primary cell cultures(GI_(50)>400μg/mL).PLGA nanoparticles loaded with root extract were prepared using solvent-evaporation double emulsion *** size was about 260 nm and a polydispersity index around 0.1,with a zeta potential of about-36 mV,as well as a good encapsulation efficiency of approximately 83%.Their morphology was analysed by SEM and spherical polymeric nanoparticles with a smooth surface were *** and DSC were also performed,which allowed corroborating the efficacy of the encapsulation and to confirm the production of a stable and robust system to load Asparagus *** developed nanoparticles are expected to be used as delivery systems for bioactive compounds of *** and they could be used as an innovative dietary supplement.

关键词： Asparagus stipularis Nutritional composition Antioxidant activity Nanoparticles PLGA

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Continuous-Flow Removal of Arsenic in Drinking Water by Filtering down through Fe₃O₄@SiO₂ magnetic Composite

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Journal of Water Resource and Protection 2016年第5期8卷 619-630页

作者： virginia Montero-campos Allen Puente-Urbina Centro de Investigación y de Servicios Químicos y Microbiológicos (CEQiaTEC) Escuela de Química Tecnológico de Costa Rica Cartago Costa Rica

Natural contamination of world groundwater supplies with arsenic of volcanic origin has become a complicated and growing problem given current shortage of water. maintenance cost of treatments that are based on ion exchange and reverse osmosis is considered high, in addition to the high production of sludge with such methods. On the other hand, efficiency of treatments employing coagulation/filtration is usually relative, depending on the method of application. Currently, emerging treatments that use nanotechnology are gaining relevance, due to their high efficiency and low cost. These methods are highly selective, with minimum generation of toxic wastes, as long as particle release into the environment is kept under control to avoid health risks. The present study developed filters with magnetic nanoparticles of Fe3O4 (magnetite) supported on porous silica (Fe3O4@SiO2) at a mass ratio of 2:1. The nanoparticles were synthetized by co-precipitation of Fe(II) and Fe(III) using NH4OH(ac) under inert atmosphere. Average sizes of 15 nm were obtained, measured by means of Transmission Electronic Microscopy (TEM) and characterized by X-ray Powder Diffraction (XRD);the magnetic power was qualitatively determined. The efficiency of the composite material (Fe3O4@SiO2) was determined in a prototype laboratory with a height of 60 cm and a diameter of 5 cm, assembled with five filters of the composite material, with 1 g each filter. The filters were wrapped in resistant water-porous fabric to favor continuous flow at a ratio of 0.015 L/min. The test was performed with arsenic solutions at (43.7 ± 2.1 μg/L), similar to the amount present in water supplies currently treated in costa Rica. The removal was completed in 7 minutes with 0 N.T.U and less than 10 μg/L arsenic concentration (maximum limit allowed in costa Rica), quantified by Atomic Absorption Spectrometry with Hy

关键词： magnetite Drinking Water Arsenic Nanotoxicology

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Culture and Molecular Identification of <i>Helicobacter pylori</i>in Drinking Water from Areas of High and Low Incidence of Gastric cancer in costa Rica

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Open Journal of Medical Microbiology 2014年第4期4卷 261-269页

作者： virginia Montero campos Alejandro Hernández Soto Jorge camacho Sandoval Instituto Tecnológico de costa Rica Research & Chemical and Microbiology Services Center-CEQIATEC Cartago Costa Rica Instituto Tecnológico de costa Rica Biotechnology Research Center Cartago Costa Rica Doctorate in Natural Sciences for development DOCINADE Cartago Costa Rica

Background: Most patients infected with Helicobacter pylori show no clinical symptoms. Nonetheless, approximately 10% to 20% of these patients will develop peptic ulcers and 1% will develop gastric cancer. The International Agency for cancer Research has classified Helicobacter pylori as a Group 1 carcinogen. materials and Methods: Drinking water samples from 20 cantons situated in areas of low and high incidence of gastric cancer in costa Rica were analyzed. Water samples were concentrated and the nitrocellulose filter was cultivated for later molecular identification of Helicobacter pylori using the glmM marker. The tumor necrosis factor-alpha inducing protein (Tipalpha TNF-α) was used as a pathogenicity marker of the strains found followed by the sequencing of two products. Information on water management by aqueduct operators was collected in order to establish statistical relationships. Results: A total of 112 water samples were analyzed. Successful cultivation and molecular identification using the glmM marker was achieved in 39% of samples from areas of high incidence and in 7.5% of samples from areas of low incidence. Two glmM gene PCR products were sequenced and confirmed as true positives. Conclusions: The highest prevalence rate of Helicobacter pylori was found in water from areas with a high incidence of gastric cancer. Additionally, significant statistical correlations were established among environmental conditions, drinking water management and incidence of gastric cancer.

关键词： Helicobacter pylori cancer Gastric Drinking Water glmM marker

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Molecular detection of vector-borne bacteria and protozoa in healthy hunting dogs from Central Italy

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Asian Pacific Journal of Tropical Biomedicine 2015年第2期5卷 108-112页

作者： Valentina virginia Ebani Simona Nardoni Giulia Fognani Linda Mugnaini Fabrizio Bertelloni Guido Rocchigiani Roberto Amerigo Papini Francesco Stefani Francesca mancianti department of Veterinary Science University of Pisa Veterinary Clinic "costa d'Argento" Orbetello(Grosseto)Italy

Objective:To determine the pi'evalence of vector-bome bacteria and protozoa in hunting dogs living in Central ***:Molecular testing was executed on DNA which was extracted from blood specimens collected from 117 asymptomatic dogs to detect Anaplasma phagocytophilum,Babesia canis(***),Bartonella spp..Coxiella burnetii(***).Ehrlichia *** *** Leislnnania ***:A total of 48 dogs(41.0%) were infested by Ixodes ricinus and Rhipicephalus sanguineus ***-borne infections were observed in 64(54.7%) *** in detail.38 dogs(32.5%) screened positive for Hepatozoon canis,24(20.5%) for Bartonella rinsonii ***.20(17.1%) for Leishmania infantum,6(5.1%) for ***,5(4.3%) for ***(3 *** vogeli and 2 *** canis),3(2.5%) for Anaplasma phagocytophilum,and 2(1.7%) for Ehrlichia *** infection by 2 agents occurred in 17(14.5%) subjects,by 3 agents in 7(6.0%) dogs,and by 4 agents in 1(0.9%) ***:The results demonstrated that several vector-borne pathogens were circulating in this region and dogs infected by these agents were usually asymptomatic.A relevant finding was the presence of DNA of ***,a severe zoonotic agent,in the 5.1% of tested dogs,which can be source of infection for their owners not only through tick bites,but also directly with urine,feces and birth products.

关键词： Arthropod-bornc infection Bacteria Dog PCR Protozoa

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Quantitative detection of <i>Helicobacter pylori</i>by Real Time PCR in Drinking Water—Environmental and Public Health Risk Significance

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Open Journal of Medical Microbiology 2015年第3期5卷 118-127页

作者： virginia Montero-campos Shirley Arias-Cordero Benedicto Valdés-Rodríguez Monserrat Jarquín-Cordero Research & Chemical and Microbiology Services Center—CEQiaTEC School of Chemistry Instituto Tecnológico de Costa Rica Cartago Costa Rica Biotechnology Research Center School of Biology Instituto Tecnológico de Costa Rica Cartago Costa Rica Water Laboratory Services Physicochemical University of Chiriqui Chiriqui City Panama

Helicobacter pylori (H. pylori) is bacteria considered to be present in half of the population and it is a public health problem worldwide. Most patients infected with H. pylori show no clinical symptoms;nonetheless, approximately 10% to 20% of these patients will develop peptic ulcers and 1% will develop gastric cancer. The International Agency for Research on cancer has classified H. pylori as a Group 1 carcinogen, recognized as the only bacteria capable of producing cancer. Samples of drinking water (n = 44) from aqueducts with chlorination treatment in selected areas with high prevalence of gastric cancer were analyzed in costa Rica. Samples of drinking water from Panamá (n = 44) from aqueducts supplying untreated water for human consumption in the province of Chiriquí were also analyzed. The molecular marker of H. pylori, glmM, was used, and to optimize the Real Time PCR (qPCR) technique, annealing temperature, concentration of primers and probe were standardized;also, by analyzing different standard curves, the best reaction conditions that allowed detecting and quantifying the gene were determined. The LightCycler® 480 II (LC480II) equipment from Roche Diagnostics GmbH was used, as well as the Absolute Quantification Analysis by means of the Second derivative maximum Method. In the case of the samples from costa Rica, it was determined that 79.5% were positive for H. pylori;removing outlier high average, quantification of bacteria was determined in 3.6 × 103 copies/100 mL. For Panamá it was determined that 86% of the samples were found positive for the presence of H. pylori;removing outlier high average quantification of bacteria was determined at 3.3 × 102 copies/100 mL. The difference in values between the aqueducts in both countries revealed an environmental distribution of the bacteria of epidemiological interest in each case.

关键词： Helicobacter pylori Drinking Water Real Time PCR (qPCR) Chlorination Treatment

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CEPC Technical design Report

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Radiation detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili deng Binglin denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert maarten Boonekamp marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya masroor Bukhari Vladimir Bytev Giacomo cacciapaglia Hua cai Wenyong cai Wujun cai Yijian cai Yizhou cai Yuchen cai Haiying cai Huacheng cai Lorenzo calibbi Junsong cang Guofu cao Jianshe cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio de maria Nicola de Filippis Christophe de La Taille Francesca de Mori Chiara de Sio Elisa del Core Shuangxue deng Wei-Tian deng Zhi deng Ziyan deng Bhupal dev Tang dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian deutsches Elektronen-Synchrotron deSY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical design Report(TDR)follows the Preliminary Conceptual design Report(Pre-CDR,2015)and the Conceptual design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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Impact of Insurance Status on the Prognosis of Acute Lower Limb Ischemia

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World Journal of cardiovascular Diseases 2016年第7期6卷 218-223页

作者： Shyamal Premaratne J. David Neel cynthia X. Zhao Linda D. Doucet Tze-Woei Tan Wayne W. Zhang Hunter Holmes McGuire Veterans Administration Medical Center Richmond Virginia USA department of Surgery Louisiana State University Health Sciences Center Shreveport Louisiana USA department of Pathology Louisiana State University Health Sciences Center Shreveport Louisiana USA

The objective of this study was to investigate if the insurance status of patients impacted the treatment options and prognosis in acute limb ischemia (ALI). A retrospective chart review was performed at a single university tertiary care center using ICD-9 codes for the diagnosis and procedure for ALI from January 2000 to January 2011. A total of 96 patients were diagnosed with ALI, comprising of 66 males and 30 females with a mean age of 56 years (range was 19 - 80 years). Time to presentation and prognosis (rate and level of amputation) were analyzed using insurance status as the independent variable. Patients covered under commercial insurance were compared to patients with Medicare and Medicaid and to patients without any insurance coverage. Statistical analysis was performed using the proportion z test to evaluate differences among the groups investigated. A “p” value of ≤0.05 was considered significant. In this study, ALI occurred more commonly in African Americans (p = 0.0029) and in patients without insurance coverage regardless of race (p = 0.0034). Chronic obstructive pulmonary disease (COPD), hypertension (HTN), and acute renal failure (ARF) were significantly higher in the uninsured group, compared to the insured group (p = 0.0005, 0.0055, and 0.0034, respectively). The time to hospital admission was significantly longer in uninsured patients compared to the insured group (p = 0.0449). The rates of major amputation above the ankle were 46% in patients with commercial insurance, 62% in the government insurance (Medicare and Medicaid) group, and 51% in the uninsured group. There was no significant difference in major versus minor amputation in patients with commercial insurances. However, the rates of major amputation were significantly higher than the rates of minor amputation in both Medicare and Medicaid and uninsured patients (p = 0.005, and ia, African Americans presented more frequently a

关键词： Ischemia Lower Extremity Amputation Insurance

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