检索结果-南通市图书馆

Functions of NKG2D in CD8^(+) T cells: an opportunity for immunotherapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2018年第5期15卷 470-479页

作者： Kushal Prajapati cynthia perez Lourdes Beatriz Plaza Rojas Brianna Burke Jose A Guevara-Patino Loyola University Chicago Oncology InstituteMaywoodIL 60153USA

Natural killer group 2 member D(NKG2D)is a type II transmembrane ***2D is present on NK cells in both mice and humans,whereas it is constitutively expressed on CD8+T cells in humans but only expressed upon T-cell activation in ***2D is a promiscuous receptor that recognizes stress-induced surface *** NK cells,NKG2D signaling is sufficient to unleash the killing response;in CD8+T cells,this requires concurrent activation of the T-cell receptor(TCR).In this case,the function of NKG2D is to authenticate the recognition of a stressed target and enhance TCR ***28 has been established as an archetype provider of costimulation during T-cell *** has become apparent,however,that signals from other costimulatory receptors,such as NKG2D,are required for optimal T-cell function outside the priming *** review will focus on the similarities and differences between NKG2D and CD28;less well-described characteristics of NKG2D,such as the potential role of NKG2D in CD8+T-cell memory formation,cancer immunity and autoimmunity;and the opportunities for targeting NKG2D in immunotherapy.

关键词： NKG2D CD28 CD8+T Cell Cancer Immunity Auto-immunity Memory Immunotherapy

Histone deacetylases,microRNA and leptin crosstalk in pancreatic cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2017年第3期8卷 178-189页

作者： cynthia I Tchio Mantho Adriana Harbuzariu Ruben R Gonzalez-perez Department of Microbiology Biochemistry and ImmunologyMorehouse School of Medicine

Because pancreatic cancer(PC) historically has had poor prognosis and five year survival rates,it has been intensely *** of PC incidence and biology has shown a link between different risk factors such as smoking,alcoholism,and obesity and disease *** factors affecting PC include the epigenomic changes driven by DNA methylation and histone acetylation,and actions of microRNA inducing oncogenic or tumor suppressor *** have identified markers whose dysregulation seem to play important roles in PC *** markers involve classical histone deacetylases(HDAC),PC stem cell(PCSC),and *** this review,we discuss the role of several PC biomarkers,and the potential crosstalk between HDAC,microRNA,and leptin in PC *** expression of these molecules can increase proliferation,survival,PCSC,resistance to chemotherapy and tumor *** potential relationships between these molecules are further analyzed using data from The Cancer Genome Atlas and crosstalk pathways generated by the Pathway Studio Platform(Ariadne Genomics,Inc.).Oncogenic miRNA21 and tumor suppressor miRNA200 have been previously linked to leptin *** analysis of PC biopsies and signaling crosstalk suggests that the main adipokine leptin could affect the expression of microRNA and HDAC in *** analysis suggests that HDAC-microRNA-leptin signaling crosstalk may be a new target for PC therapy.

关键词： Pancreatic Cancer MicroRNA Histone deacetylases Pancreatic cancer stem cell markers Leptin Obesity

Bile acids and their effects on diabetes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Medicine 2018年第6期12卷 608-623页

作者： cynthia Rajani Wei Jia University of Hawaii Cancer Center HonoluluHI 96813USA Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China

Diabetes is a widespread, rapidly increasing metabolic disease that is driven by hyperglycemia. Early glycemic control is of primary importance to avoid vascular complications including development of retinal disorders leading to blindness, end-stage renal disease, and accelerated atherosclerosis with a higher risk of myocardial infarction, stroke and limb amputations. Even after hyperglycemia has been brought under control, "metabolic memory," a cluster of irreversible metabolic changes that allow diabetes to progress, may persist depending on the duration of hyperglycemia. Manipulation of bile acid (BA) receptors and the BA pool have been shown to be useful in establishing glycemic control in diabetes due to their ability to regulate energy metabolism by binding and activating nuclear transcription factors such as farnesoid X receptor (FXR) in liver and intestine as well as the G-protein coupled receptor, TGR5, in enteroendocrine cells and pancreatic β-cells. The downstream targets of BA activated FXR, FGF15/21, are also important for glucose/insulin homeostasis. In this review we will discuss the effect of BAs on glucose and lipid metabolism and explore recent research on establishing glycemic control in diabetes through the manipulation of BAs and their receptors in the liver, intestine and pancreas, alteration of the enterohepatic circulation, bariatric surgery and alignment of circadian rhythms.

关键词： bariatric surgery bile acids circadian rhythm diabetes metabolic memory

Using RGB displays to portray colorrealistic imagery to animal eyes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2017年第1期63卷 27-34页

作者： cynthia TEDORE Sonke JOHNSEN Department of Biology Lund University Solvegatan 35 Lund 223 62 Sweden Department of Biology DukeUniversity Durham 125 Science Drive NC 27708 USA

RGB displays effectively simulate millions of colors in the eyes of humans by modulating the rela-tive amount of light emitted by 3 differently colored juxtaposed lights （red, green, and blue）. Therelationship between the ratio of red, green, and blue light and the perceptual experience of thatlight has been well defined by psychophysical experiments in humans, but is unknown in *** perceptual experience of an animal looking at an RGB display of imagery designed for humansis likely to poorly represent an animal＇s experience of the same stimulus in the real world. This isdue, in part, to the fact that many animals have different numbers of photoreceptor classes thanhumans do and that their photoreceptor classes have peak sensitivities centered over differentparts of the ultraviolet and visible spectrum. However, it is sometimes possible to generate videosthat accurately mimic natural stimuli in the eyes of another animal, even if that animal＇s sensitivityextends into the ultraviolet portion of the spectrum. How independently each RGB phosphor stimu-lates each of an animal＇s photoreceptor classes determines the range of colors that can be simu-lated for that animal. What is required to determine optimal color rendering for another animal is adevice capable of measuring absolute or relative quanta of light across the portion of the spectrumvisible to the animal （i.e., a spectrometer）, and data on the spectral sensitivities of the animal＇sphotoreceptor classes. In this article, we outline how to use such equipment and information togenerate video stimuli that mimic, as closely as possible, an animal＇s color perceptual experienceof real-world objects.

关键词： color vision, computer animation, perception, video playback, virtual reality.

Using Domain Ontology in a Semantic Blogging System for Construction Professionals

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tsinghua Science and Technology 2008年第S1期13卷 279-285页

作者： cynthia Changxin Wang School of the Built Environment Faculty of Design Architecture and Building University of Technology Sydney

Smooth communication is essential for the success of construction projects. As an easy-to-use, context-rich, and high-capacity communication tool, blogging is gaining popularity in construction industry. In this paper, the features of blogging technology and how it could benefit construction organizations are presented. To further improve the effectiveness of blogging technology in information and knowledge sharing, an ontology-based semantic blogging system is proposed. Semantic blogging is an extension of conventional blogging and ontology is the key enabling technology for it. Domain-ontology-based semantic blogging site is composed of a network of concepts, which are clearly defined and interlinked according to their context and bound to certain behaviors. This paper reports how the e-Cognos ontology was implemented into a blogging system and how the system functions to process its contents. The paper concludes that using on-tology-based semantic blogging site can greatly enhance information sharing between construction professionals and it is a very promising tool for construction communities to publish and share their experience.

关键词： semantic blogging ontology construction industry information technology

Occurrence and formation of disinfection by-products in the swimming pool environment： A critical review

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2017年第8期29卷 19-50页

作者： Rhys A.A.Carter cynthia A.Joll Curtin Water Quality Research Centre Department of Chemistry Curtin Uniuersity Perth Western Australia 6102 Australia

Disinfection of water for human use is essential to protect against microbial disease;however, disinfection also leads to formation of disinfection by-products（DBPs）, some of which are of health concern. From a chemical perspective, swimming pools are a complex matrix, with continual addition of a wide range of natural and anthropogenic chemicals via filling waters, disinfectant addition, pharmaceuticals and personal care products and human body excretions. Natural organic matter, trace amounts of DBPs and chlorine or chloramines may be introduced by the filling water, which is commonly disinfected distributed drinking water. Chlorine and/or bromine is continually introduced via the addition of chemical disinfectants to the pool. Human body excretions（sweat, urine and saliva） and pharmaceuticals and personal care products（sunscreens, cosmetics, hair products and lotions） are introduced by swimmers. High addition of disinfectant leads to a high formation of DBPs from reaction of some of the chemicals with the *** pool air is also of concern as volatile DBPs partition into the air above the *** presence of bromine leads to the formation of a wide range of bromo-and bromo/chloro-DBPs, and Br-DBPs are more toxic than their chlorinated analogues. This is particularly important for seawater-filled pools or pools using a bromine-based *** review summarises chemical contaminants and DBPs in swimming pool waters, as well as in the air above pools. Factors that have been found to affect DBP formation in pools are discussed. The impact of the swimming pool environment on human health is reviewed.

关键词： Disinfection by-products Disinfection Swimming pool Spa Water quality Health effects

Hepatic macrophages in liver homeostasis and diseasesdiversity,plasticity and therapeutic opportunities

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第1期18卷 45-56页

作者： Yankai Wen Joeri Lambrecht cynthia Ju Frank Tacke Department of Anesthesiology McGovern Medical SchoolUniversity of Texas Health Science Center at HoustonHoustonTXUSA Department of Hepatology and Gastroenterology Charity University Medicine BerlinBerlinGermany

Macrophages,which are key cellular components of the liver,have emerged as essential players in the maintenance of hepatic homeostasis and in injury and repair processes in acute and chronic liver *** liver injury,resident Kupffer cells(KCs)sense disturbances in homeostasis,interact with hepatic cell populations and release chemokines to recruit circulating leukocytes,including monocytes,which subsequently differentiate into monocyte-derived macrophages(MoMφs)in the *** KCs and MoMφs contribute to both the progression and resolution of tissue inflammation and injury in various liver *** diversity of hepatic macrophage subsets and their plasticity explain their different functional responses in distinct liver *** this review,we highlight novel findings regarding the origins and functions of hepatic macrophages and discuss the potential of targeting macrophages as a therapeutic strategy for liver disease.

关键词： Kupffer cells monocyte-derived macrophages liver inflammation liver fibrosis liver cancer

Comparison of intraocular pressure peak and fluctuations among Filipino patients with non-glaucomatous eyes and glaucoma suspects using water drinking test and diurnal intraocular pressure

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2021年第11期14卷 1729-1734页

作者： Anelisa Koh cynthia Verzosa Department of Ophthalmology Jose R.Reyes Memorial Medical CenterManila 1003Philippines

AIM:To compare the intraocular pressure(IOP)peaks and fluctuations using water drinking tests(WDTs)and mean diurnal IOP among Filipino patients with normal eyes and glaucoma suspectsMETHODS:This prospective study included normal and glaucoma suspect *** patient underwent both WDT and mean diurnal examination on separate *** mean diurnal examination,IOP was recorded every 2 h for 8 h while in WDT,IOP was recorded prior to WDT,and postWDT at 5,15,30,45,and 60 *** peak was recorded as the highest IOP for both methods,and IOP fluctuation was recorded as highest IOP minus lowest ***:With the comparison of diagnostic tests,both normal eyes and glaucoma suspect groups,the peak IOP was caught at 15 *** analysis of both groups also showed that the peak IOP measurements were statistically higher for the WDT compared to mean diurnal IOP(P=0.039,P=0.048 under normal group and P=0.032 and P=0.031 under glaucoma suspect group).Similarly,the WDT had a statistically higher mean IOP fluctuation score than the mean diurnal IOP method in both groups(P=0.003,P=0.011 under normal group;P=0.002 and P=0.005 under glaucoma suspect group).CONCLUSION:This study shows that WDT is a comparable diagnostic exam in predicting IOP fluctuations than mean diurnal *** is a promising diagnostic procedure for risk assessment in glaucoma.

关键词： glaucoma waterdrinking test intraocular pressure intraocular pressure peak fluctuation

CT and MRI of the liver for hepatocellular carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatoma Research 2020年第9期6卷 93-106页

作者： cynthia Santillan Department of Radiology University of California San DiegoSan DiegoCA 92103USA.

Computed tomography(CT)and magnetic resonance imaging(MRI)are commonly used modalities for the imaging based diagnosis and staging of hepatocellular carcinoma(HCC).The Liver Imaging Reporting and Data System(LI-RADS)was initially released in 2011 in an effort to standardize the interpretation and reporting of these studies in patients at increased risk for the development of *** the release of LI-RADS v2018,LI-RADS has reached two important milestones-10 years since the formation of the American College of Radiology supported LI-RADS committee and integration of LI-RADS into the 2018 American Association for the Study of Liver Disease practice guidance for *** this article,we will discuss recent changes to LI-RADS with v2018,technical recommendations for the performance of CT and MRI in patients at risk for HCC,and critical imaging features in the LI-RADS algorithm.

关键词： Hepatocellular carcinoma Liver Imaging Reporting and Data System magnetic resonance imaging computed tomography