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Rheumatic manifestations of inflammatory bowel disease

World Journal of Gastroenterology 2009年第44期15卷 5517-5524页

作者： Tatiana Sofía Rodríguez-Reyna cynthia Martínez-Reyes Jesús Kazúo Yamamoto-Furusho Department of Immunology and Rheumatology National Institute of Medical Sciences and Nutrition Salvador ZubiránVasco de Quiroga 15Col Sección XVI. DelTlalpanMexico City 14000Mexico Department of Gastro-enterology National Institute of Medical Sciences and Nutrition Salvador ZubiránVasco de Quiroga 15Col Sección XVI. DelTlalpanMexico City 14000Mexico

This article reviews the literature concerning rheu-matic manifestations of inflammatory bowel disease (IBD),including common immune-mediated pathways,frequency,clinical course and therapy. Musculoskel-etal complications are frequent and well-recognized manifestations in IBD,and affect up to 33% of pa-tients with IBD. The strong link between the bowel and the osteo-articular system is suggested by many clinical and experimental observations,notably in HLA-B27 transgenic rats. The autoimmune pathogenic mechanisms shared by IBD and spondyloarthropathies include genetic susceptibility to abnormal antigen pre-sentation,aberrant recognition of self,the presence of autoantibodies against specific antigens shared by the colon and other extra-colonic tissues,and increased intestinal permeability. The response against microor-ganisms may have an important role through molecular mimicry and other mechanisms. Rheumatic mani-festations of IBD have been divided into peripheral arthritis,and axial involvement,including sacroiliitis,with or without spondylitis,similar to idiopathic anky-losing spondylitis. Other periarticular features can oc-cur,including enthesopathy,tendonitis,clubbing,peri-ostitis,and granulomatous lesions of joints and *** and osteomalacia secondary to IBD and iatrogenic complications can also occur. The manage-ment of the rheumatic manifestations of IBD consists of physical therapy in combination with local injection of corticosteroids and nonsteroidal anti-inflammatory drugs; caution is in order however,because of their possible harmful effects on intestinal integrity,perme-ability,and even on gut inflammation. Sulfasalazine,methotrexate,azathioprine,cyclosporine and lefluno-mide should be used for selected indications. In some cases,tumor necrosis factor-α blocking agents should be considered as first-line therapy.

关键词： Inflammatory bowel disease Spondylitis Rheumatic diseases

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Supplementation of oligosaccharide-based polymer enhanced growth and disease resistance of weaned pigs by modulating intestinal integrity and systemic immunity

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Journal of Animal Science and Biotechnology 2022年第3期13卷 802-815页

作者： Kwangwook Kim Yijie He cynthia Jinno Lauren Kovanda Xunde Li David Bravo Eric Cox Yanhong Liu Department of Animal Science University of CaliforniaDavisCA 95616USA School of Veterinary Medicine University of CaliforniaDavisCA 95616USA Pancosma ADM 1180 RolleSwitzerland Department of Virology Parasitology and ImmunologyGhent University9000 GhentBelgium

Background:There is a great demand for antibiotic alternatives to maintain animal health and *** objective of this experiment was to determine the efficacy of dietary supplementation of a blood group A6 type 1antigen oligosaccharides-based polymer(Coligo)on growth performance,diarrhea severity,intestinal health,and systemic immunity of weaned pigs experimentally infected with an enterotoxigenic Escherichia coli(ETEC),when compared with ***:Pigs in antibiotic carbadox or Coligo treatment groups had greater(P<0.05)body weight on d 5 or d 11post-inoculation(PI)than pigs in the control group,*** of antibiotics or Coligo enhanced(P<0.05)feed efficiency from d 0 to 5 PI and reduced(P<0.05)frequency of diarrhea throughout the experiment,compared with pigs in the control *** of antibiotics reduced(P<0.05)fecalβ-hemolytic coliforms on d 2,5,and 8 *** in antibiotics or Coligo groups had reduced(P<0.05)neutrophil counts and serum haptoglobin concentration compared to pigs in the control group on d 2 and 5 *** in Coligo had reduced(P<0.05)total coliforms in mesenteric lymph nodes on d 5 and 11 PI,whereas pigs in antibiotics or Coligo groups had reduced(P<0.05)total coliforms in spleen on d 11 PI compared with pigs in the control *** d 5 PI,pigs in the Coligo group had greater(P<0.05)gene expression of ZO1 in jejunal mucosa,but less(P<0.05)m RNA expression of IL1B,IL6,and TNF in ileal mucosa,in comparison with pigs in the control *** of antibiotics enhanced(P<0.05)the gene expression of OCLN in jejunal mucosa but decreased(P<0.05)IL1B and IL6 gene expression in ileal mucosa,compared with the *** d 11 PI,supplementation of antibiotics or Coligo up-regulated(P<0.05)gene expression of CLDN1 in jejunal mucosa,but Coligo reduced(P<0.05)IL6 gene expression in ileal mucosa compared to pigs in the control ***:Supplementation of Coligo improved growth performance,al

关键词： Enterotoxigenic E.coli Growth rate Intestinal barrier function Oligosaccharide-based polymer Systemic immunity Weaned pigs

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Dietary Bacillus *** growth and disease resistance of weaned pigs by modulating intestinal microbiota and systemic immunity

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Journal of Animal Science and Biotechnology 2021年第2期12卷 579-597页

作者： Yijie He cynthia Jinno Kwangwook Kim Zhaohai Wu Bie Tan Xunde Li Rose Whelan Yanhong Liu Department of Animal Science University of CaliforniaDavisCA 95616USA Institute of Animal Science Chinese Academy of Agricultural SciencesBeijing 100193China Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China School of Veterinary Medicine University of CaliforniaDavisCA 95616USA Evonik Nutrition&Care GmbH 63457 Hanau-WolfgangGermany

Background:Previous research has shown that dietary supplementation of Bacillus *** exerts beneficial effects on animals’***,limited studies have evaluated the efficacy of Bacillus *** weaned pigs and their effects on host gut health and microbiome,and systemic immunity using a disease challenge *** objective of this experiment was to investigate the effects of two Bacillus ***(Bacillus subtilis DSM 32540 and Bacillus pumilus DSM 32539)on growth performance,diarrhea,intestinal health,microbiome,and systemic immunity of weaned pigs experimentally infected with an enterotoxigenic Escherichia coli(ETEC).Results:Pigs in PRO1(Bacillus subtilis DSM 32540)had greater(P<0.05)body weight on d 7 and 14 PI,greater(P<0.05)ADG from d 0 to 7 and d 7 to 14 PI,compared with pigs in CON(Control).Pigs in PRO1 had milder(P<0.05)diarrhea on d 2 and 3 PI compared with pigs in ***,no differences were observed in growth performance and diarrhea score between PRO2(Bacillus pumilus DSM 32539)and CON *** of PRO1 decreased(P<0.05)lymphocyte counts on d 7 and 14 PI,compared with *** of PRO1 and PRO2 both reduced(P<0.05)total coliforms in mesenteric lymph nodes on d 21 *** in PRO2 had greater(P<0.05)goblet cell number and sulfomucin percentage in duodenal villi and greater(P<0.05)sialomucin percentage in jejunal villi than pigs in *** of PRO1 up-regulated(P<0.05)MUC2 gene expression in jejunal mucosa and reduced(P<0.05)PTGS-2 and IL1B gene expression in ileal mucosa on d 21 PI,compared with *** in PRO1 had reduced(P<0.05)relative abundance of families Lachnospiraceae,Peptostreptococcaceae and Pasteurellaceae in the ***:Supplementation of Bacillus subtilis DSM 32540 improved growth performance,alleviated diarrhea severity,enhanced gut health,and reduced systemic inflammation of weaned pigs infected with ETEC *** Bacillus pumilus DSM 32539 was able to alleviate systemi

关键词： Bacillus spp. Diarrhea Escherichia coli Gut health Weaned pigs

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A pretargeting nanoplatform for imaging and enhancing anti-inflammatory drug delivery

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Bioactive Materials 2020年第4期5卷 1102-1112页

作者： Min Kyung Khang Jun Zhou cynthia M.Co Shuxin Li Liping Tang Department of Chemistry and Biochemistry University of Texas at Arlington700 Planetarium PlaceChemistry Physics Building Room 130ArlingtonTX76019-0065USA Department of Bioengineering University of Texas at ArlingtonEngineering Research BuildingRoom 226Box 19138ArlingtonTX76010USA

This work details a newly developed“sandwich”nanoplatform via neutravidin-biotin system for the detection and treatment of ***,biotinylated-and folate-conjugated optical imaging micelles targeted activated macrophages via folate/folate receptor ***,multivalent neutravidin proteins in an optimal concentration accumulated on the biotinylated ***,biotinylated anti-inflammatory drug-loaded micelles delivered drugs effectively at the inflammatory sites via a highly specific neutravidin-biotin *** in vitro and in vivo studies have shown that the“sandwich”pretargeting platform was able to diagnose inflammation by targeting activated macrophages as well as improve the therapeutic efficacy by amplifying the drug delivery to the inflamed *** overall results support that our new pretargeting platform has the potential for inflammatory disease diagnosis and treatment.

关键词： Polymeric micelles Neutravidin/biotin system Pretargeting Macrophages Dexamethasone Inflammatory responses

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UV-B-induced photomorphogenesis in Arabidopsis

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Protein & Cell 2013年第7期4卷 485-492页

作者： Jigang Li Li Yang Dan Jin cynthia D.Nezames William Terzaghi Xing Wang Deng Peking-Yale Joint Center for Plant Molecular Genetics and Agro-biotechnology State Key Laboratory of Protein and Plant Gene ResearchCollege of Life SciencesPeking UniversityBeijing 100871China Department of Molecular Cellularand Developmental BiologyYale UniversityNew HavenCT 06520USA Key Laboratory of Biotechnology and Crop Quality Improvement of Ministry of Agriculture Biotechnology Research CenterSouthwest UniversityChongqing 400716China Department of Biology Wilkes UniversityWilkes-BarrePA 18766USA

Ultraviolet-B(UV-B)is a relatively minor component of sunlight,but can induce stress-related physiological pro-cesses or UV-B-specifi c photomorphogenic responses in *** the last decade,signifi cant progress has been made in understanding the UV-B photomorphogenic pathway,including identifi cation of the key components in the pathway,molecular characterization of UV-B pho-toreceptor and perception mechanism,and elucidation of the signal transduction mechanisms from the photo-activated UV-B receptor to downstream gene *** review summarizes the key players identifi ed to date in the UV-B photomorphogenic pathway and their roles in mediating UV-B signal transduction.

关键词： UV-B photomorphogenesis signal transduc-tion gene expression

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Abode of Immortals-Mountain Huangshan

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中国周刊 2002年第3期 64-69页

作者： cynthia

Mt. Huangshan, stretching among the four counties of She, Yi, Taiping and Xiuning in southern Anhui Province, covers an area of 250 sqm. Legend has it that Chinese forefather, the Yellow Emperor cultivated moral character and refined pills of immortality in the mountain, hence the name Yellow Mountain (Huangshan). The best part of the spectacular moun-

关键词： Abode of Immortals-Mountain Huangshan down

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Friendship and Co-opera tion between China and Israe-An interview with Israeli Ambassador to China

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中国周刊 2002年第7期 40-45页

作者： cynthia

"I had been to China 5 times before I wasappointed as the ambassador to China. Everytime I came to China I saw the difference." Chinaweek: Would you mind talk-ing a little about your experience in thepast time, such a... 详细信息

关键词： Friendship and Co-opera tion between China and Israe-An interview with Israeli Ambassador to China MFA

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Exosomes: Emerging implementation of nanotechnology for detecting and managing novel corona virus-SARS-CoV-2

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Asian Journal of Pharmaceutical Sciences 2022年第1期17卷 20-34页

作者： Akhilesh Dubey cynthia Lizzie Lobo Ravi GS Amitha Shetty Srinivas Hebbar Sally AEl-Zahaby Department of Pharmaceutics NGSM Institute of Pharmaceutical SciencesNitte(Deemed to be University)Mangaluru 575018India Formulation and Development Viatris R&D CentreBengaluru 560105India Department of Pharmaceutics and Pharmaceutical Technology Faculty of PharmacyPharos University in AlexandriaAlexandria 21311Egypt

The spread of SARS-CoV-2 as an emerging novel coronavirus disease (COVID-19) had progressed as a worldwide pandemic since the end of 2019. COVID-19 affects firstly lungs tissues which are known for their very slow regeneration. Afterwards, enormous cytokine stimulation occurs in the infected cells immediately after a lung infection which necessitates good management to save patients. Exosomes are extracellular vesicles of nanometric size released by reticulocytes on maturation and are known to mediate intercellular communications. The exosomal cargo serves as biomarkers in diagnosing various diseases;moreover, exosomes could be employed as nanocarriers in drug delivery systems. Exosomes look promising to combat the current pandemic since they contribute to the immune response against several viral pathogens. Many studies have proved the potential of using exosomes either as viral elements or host systems that acquire immune-stimulatory effects and could be used as a vaccine or drug delivery tool. It is essential to stop viral replication, prevent and reverse the massive storm of cytokine that worsens the infected patients’ situations for the management of COVID-19. The main benefits of exosomes could be;no cells will be introduced, no chance of mutation, lack of immunogenicity and the damaged genetic material that could negatively affect the recipient is avoided. Additionally, it was found that exosomes are static with no ability for in vivo reproduction. The current review article discusses the possibilities of using exosomes for detecting novel coronavirus and summarizes state of the art concerning the clinical trials initiated for examining the use of COVID-19 specific T cells derived exosomes and mesenchymal stem cells derived exosomes in managing COVID-19.

关键词： Exosomes COVID-19 Specific T cell-derived exosomes Mesenchymal stem cells-derived exosomes Nanotechnology SARS-Co V-2

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Socio-cultural determinants of timely and delayed treatment of Buruli ulcer: implications for disease control

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Infectious Diseases of Poverty 2012年第1期1卷 48-60页

作者： Mercy M Ackumey Margaret Gyapong Matilda Pappoe cynthia Kwakye Maclean Mitchell G Weiss School of Public Health College of Health SciencesUniversity of GhanaAccraGhana Swiss Tropical and Public Health Institute BaselSwitzerland University of Basel BaselSwitzerland Dodowa Health Research Centre Ghana Health ServiceDodowaGhana Amasaman Hospital Ghana Health ServiceAccraGhana

Introduction:Public health programmes recommend timely medical treatment for Buruli ulcer(BU)infection to prevent pre-ulcer conditions from progressing to ulcers,to minimise surgery,disabilities and the socio-economic impact of *** the role of socio-cultural determinants of timely medical treatment may assist in guiding public health programmes to improve treatment *** study clarified the role of socio-cultural determinants and health system factors affecting timely medical treatment for BU in an endemic area in ***:A semi-structured explanatory model interview based on the explanatory model interview catalogue(EMIC)was administered to 178 BU-affected *** on research evidence,respondents were classified as timely treatment(use of medical treatment 3 months from awareness of disease)and delayed treatment(medical treatment 3 months after onset of disease and failure to use medical treatment).The outcome variable,timely treatment was analysed with cultural epidemiological variables for categories of distress,perceived causes of BU,outside-help and reasons for medical treatment in logistic regression *** median time for the onset of symptoms to treatment was computed in *** phenomenological analysis of respondents’narratives clarified the meaning,context and dynamic features of the relationship of explanatory variables with timely medical ***:The median time for initiating treatment was 25 days for pre-ulcers,and 204 days for *** loss and use of herbalists showed significantly negative associations with timely ***’use of herbalists was often motivated by the desire for quick recovery in order to continue with work and because herbalists were relatives and easily ***,drinking unclean water was significantly associated with timely treatment and access to health services encouraged timely treatment(OR 8.5,p=0.012).Findings show that health system factors of

关键词： services lists clarified

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Preventive effect of Peperomia pellucida(L.) Kunth herbs on ovariectomyinduced osteoporotic rats

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Journal of Chinese Pharmaceutical Sciences 2016年第7期25卷 546-551页

作者： cynthia Astiti Putri I Gusti Agung Ayu Kartika I Ketut Adnyana Department of Clinical Pharmacology and Toxicology School of Pharmacy Bandung Institute of Technology

Osteoporosis is a metabolic skeletal disorder leading to bone fracture which adversely impacts the quality of life. In the present, we aimed to investigate the effect of Peperomia pellucida(L.) Kunth herb juice and ethanolic extract on ovariectomy(OVX)-induced osteoporotic rat model. Osteoporosis was induced by OVX with a double dorsolateral approach on female Wistar rats. Female Wistar rats undergoing sham surgeries(sham-control group) served as controls. The ovariectomized rats were divided into six groups based on administered treatments,(i) CMC Na 0.3%(OVX-control group),(ii) standard drug(ethynil estradiol 4.5 μg/kg),(iii) P. pellucida juice at dose of 50 mg/kg, and(iv) 100 mg/kg,(v) P. pellucida ethanolic extract at dose of 50 mg/kg, and(vi) 100 mg/kg. Treatments were started 1 week after the surgeries and lasted for 6 weeks. Rats treated with 100 mg/kg P. pellucida ethanol extract had significantly decreased serum ALP level and reduced excretion of urine calcium compared with the OVX-control group(P<0.05). These levels were not significantly altered when compared with the sham-control group(P<0.05). Furthermore, 100 mg/kg ethanolic extract-treated group showed improvement on three-dimensional image of the trabecular bone compared with the OVX-control group. Trabecular cavity formation in 100 mg/kg ethanolic extract-treated group was minimal. Ethanolic extract of Peperomia pellucida(L.) Kunth herbs at a dose of 100 mg/kg had preventive effect on OVX-induced osteoporotic rats.

关键词： Osteoporosis Ovariectomy Peperomia pellucida(L.)Kunth

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