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Invariant natural killer T cells contribute to chronic-plus-binge ethanol-mediated liver injury by promoting hepatic neutrophil infiltration

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Cellular & Molecular Immunology 2016年第2期13卷 206-216页

作者： Stephanie Mathews Dechun Feng Igor Maricic cynthia Ju Vipin Kumar Bin Gao Laboratory of Liver Diseases National institute on Alcohol Abuse and Alcoholism National Institutes of Health Bethesda MD USA Laboratory of Autoimmunity Torrey Pines Institute for Molecular Studies San Diego CA USA Skaggs School of Pharmacy and Pharmaceutical Sciences and Integrated Immunology University of Colorado Anschutz Medical Campus Aurora CO USA

Neutrophil infiltration is a hallmark of alcoholic steatohepatitis; however, the underlying mechanisms remain unclear. We previously reported that chronic-plus-binge ethanol feeding synergistically induces hepatic recruitment of neutrophils, which contributes to liver injury. In this paper, we investigated the roles of invariant natural killer T （iNKT） cells in chronic-plus-binge ethanol feeding-induced hepatic neutrophil infiltration and liver injury. Wild-type and two strains of iNKT cell-deficient mice （CDld- and Ja18-deficient mice） were subjected to chronic-plus-binge ethanol feeding. Liver injury and inflammation were examined. Chronic-plus-binge ethanol feeding synergistically increased the number of hepatic iNKT cells and induced their activation, compared with chronic feeding or binge alone, iNKT cell-deficient mice were protected from chronic-plus-binge ethanol-induced hepatic neutrophil infiltration and liver injury. Moreover, chronic-plus-binge ethanol feeding markedly upregulated the hepatic expression of several genes associated with inflammation and neutrophil recruitment in wild-type mice, but induction of these genes was abrogated in iNKT cell-deficient mice. Importantly, several cytokines and chemokines （e.g., MIP-2, MIP-1, IL-4, IL-6 and osteopontin） involved in neutrophil infiltration were upregulated in hepatic NKT cells isolated from chronic-plus-binge ethanol-fed mice compared to pair-fed mice. Finally, treatment with CDld blocking antibody, which blocks iNKT cell activation, partially prevented chronic-plus-binge ethanol-induced liver injury and inflammation. Chronic-plus-binge ethanol feeding activates hepatic iNKT cells, which play a critical role in the development of early alcoholic liver injury, in part by releasing mediators that recruit neutrophils to the liver, and thus, iNKT cells represent a potential therapeutic target for the treatment of alcoholic liver disease.

关键词： alcoholic hepatitis CDld inflammation liver

Successful management of hepatic artery pseudoaneurysm complicating chronic pancreatitis by stenting

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World Journal of Gastroenterology 2006年第35期12卷 5733-5734页

作者： cynthia Sudar Singh Kamini Giri Renuka Gupta Mohammed Aladdin Harinder Sawhney Department of Medicine WyckoffHeights Medical Center Brooklyn New York United States

A 41-year old alchoholic male with a history of chronic pancreatitis was admitted for nausea, vomiting and weight loss. Angiogram was performed and demonstrated an aneurysmal sac with a narrow neck originating from the inferior aspect of the distal portion of the proper hepatic artery. The origin of the pseudoaneurysm was covered with a 5 mm × 2.5 cm Viabahn cover stent （Gore）. A repeat angiogram showed some leak and a second stent （6 mm × 2.3 cm） was deployed and overlapped with the first stent by 3 mm. Contrast was injected and a repeat angiogram demonstrated complete exclusion of the aneurysm. A repeat computerized axial tomography （CAT） scan of the abdomen after 24 h showed successful stenting. The patient had an uneventful post-operative course.

关键词： Hepatic artery Aneurysm Stents

Comment on “Using a modern analogue to interpret depositional position in ancient fluvial-tidal channels:Example from the McMurray Formation,Canada” by Andrew *** Croix,Shahin ***,James ***,Geoscience Frontiers,Volume 10,Issue 6,Pages 2

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Geoscience Frontiers 2020年第3期11卷 1081-1086页

作者： Paul R.Durkin Sean C.Horner cynthia A.Hagstrom Department of Geological Sciences University of ManitobaWinnipegMBCanada Department of Geoscience University of CalgaryCalgaryABCanada CNOOC International CalgaryABCanada

*** La Croix et al.(2019)attempt to interpret the depositional position of the Lower Cretaceous McMurray Formation"A Valley"deposits using the tidally-influenced Fraser River in British Columbia as a modern *** of a portion of seven cores from three study areas(South,Central,and North)positioned along a 145-km basinward transect suggests that observed sedimentological and ichnological trends are indicative of a time-equivalent fluvial-tidal transition(FTT)zone within the"A Valley".

关键词： tidal fluvial depositional

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The soul of justice

The soul of justice

Formation and control of nitrogenous DBPs from Western Australian source waters: Investigating the impacts of high nitrogen and bromide concentrations

作者： cynthia Willett.

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Journal of Environmental Sciences 2017年第8期29卷 102-115页

作者： Ina Kristiana Deborah Liew Rita K.Henderson cynthia A.Joll Kathryn L.Linge Curtin Water Quality Research Centre Department of Chemistry Curtin University School of Chemical Engineering University of New South Wales

We studied the formation of four nitrogenous DBPs（N-DBPs） classes（haloacetonitriles,halonitromethanes, haloacetamides, and N-nitrosamines）, as well as trihalomethanes and total organic halogen（TOX）, after chlorination or chloramination of source waters. We also evaluated the relative and additive toxicity of N-DBPs and water treatment options for minimisation of N-DBPs. The formation of halonitromethanes, haloacetamides, and N-nitrosamines was higher after chloramination and positively correlated with dissolved organic nitrogen or total nitrogen. N-DBPs were major contributors to the toxicity of both chlorinated and chloraminated waters. The strong correlation between bromide concentration and the overall calculated DBP additive toxicity for both chlorinated and chloraminated source waters demonstrated that formation of brominated haloacetonitriles was the main contributor to toxicity. Ozone–biological activated carbon treatment was not effective in removing N-DBP precursors. The occurrence and formation of N-DBPs should be investigated on a case-by-case basis, especially where advanced water treatment processes are being considered to minimise their formation in drinking waters, and where chloramination is used for final disinfection.

关键词： Haloacetonitriles Haloacetamides Halonitromethanes N-nitrosamines Chlorination Chloramination

The Center for Creative Leadership Handbook of Leadership Development 2

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Functions of NKG2D in CD8^(+) T cells: an opportunity for immunotherapy

丛书名： J-B CCL (Center for Creative Leadership)

2004年

作者： cynthia D.McCauley

ISBN: (数字)9780787974497

ISBN: (纸本)9780787965297

The Center for Creative Leadership (CCL) is the world's largest institution devoted exclusively to leadership research and education. For more than three decades, CCL has studied and trained hundreds of thousands of executives and worked with them to create practical models, tools, and publications for the development of effective leaders and leadership. This second edition of The Center for Creative Leadership Handbook of Leadership Development brings together the wealth of practical knowledge that CCL has gained from this experience. It explores the essence of leadership development, reveals how individuals can effectively enhance their leadership skills, and demonstrates what organizations can do to help build leaders and leadership capacity. The book also includes a companion CD-ROM that contains a library of classic CCL publications for practicing leaders.

关键词： BA14

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Cellular & Molecular Immunology 2018年第5期15卷 470-479页

作者： Kushal Prajapati cynthia Perez Lourdes Beatriz Plaza Rojas Brianna Burke Jose A Guevara-Patino Loyola University Chicago Oncology InstituteMaywoodIL 60153USA

Natural killer group 2 member D(NKG2D)is a type II transmembrane ***2D is present on NK cells in both mice and humans,whereas it is constitutively expressed on CD8+T cells in humans but only expressed upon T-cell activation in ***2D is a promiscuous receptor that recognizes stress-induced surface *** NK cells,NKG2D signaling is sufficient to unleash the killing response;in CD8+T cells,this requires concurrent activation of the T-cell receptor(TCR).In this case,the function of NKG2D is to authenticate the recognition of a stressed target and enhance TCR ***28 has been established as an archetype provider of costimulation during T-cell *** has become apparent,however,that signals from other costimulatory receptors,such as NKG2D,are required for optimal T-cell function outside the priming *** review will focus on the similarities and differences between NKG2D and CD28;less well-described characteristics of NKG2D,such as the potential role of NKG2D in CD8+T-cell memory formation,cancer immunity and autoimmunity;and the opportunities for targeting NKG2D in immunotherapy.

关键词： NKG2D CD28 CD8+T Cell Cancer Immunity Auto-immunity Memory Immunotherapy

Conquering math anxiety: : A Self-Help Workbook/ 2nd ed.

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Preparation and Characterization of TaN ALD Precursors

2003年

作者： Arem cynthia A.

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半导体技术 2004年第7期29卷 82-85,91页

作者： Tracy Yund cynthia A. Hoover Praxair Inc. 175 E. Park Dr. Tonawanda NY 14150Praxair Inc. 175 E. Park Dr. Tonawanda NY 14150

High purity organic-tantalum precursors forthin film ALD TaN were synthesized andcharacterized. Vapor pressure and thermal stabilityof these precursors were studied. From the vaporpressure analysis, it was found that TBTEMT has ahigher vapor pressure than any other published liq-uid TaN precursor, including TBTDET,TAITMATA,and IPTDET. Thermal stability of the alkyl groupson the precursors was investigated using a 1H NMRtechnique. The results indicated that the tert-butylimino group is the most stable group onTBTDET and TBTEMT as compared to thedialkylamido groups. Thermal stability of TaN pre-cursors decreased in the following order: TBTDET> PDMAT > TBTEMT. In conclusion, precursor va-por pressure and thermal stability were tuned bymaking slight variations in the ligand sphere aroundthe metal center.

关键词：热稳定性汽压分析 TBTDET PDMAT TBTEMT TaN ALD