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Is Hypoxic/Altitude Training an Important Topic in the Field of Hypoxia?

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Journal of Science in Sport and Exercise 2022年第4期4卷 293-305页

作者： grégoire P.Millet Martin Burtscher Johannes Burtscher Institute of Sport Sciences University of LausanneCampus Dorigny1015 LausanneSwitzerland Department of Biomedical Sciences University of Lausanne1015 LausanneSwitzerland Department of Sport Science University of InnsbruckInnsbruckAustria

Hypoxia is an essential topic in medical or biological *** main aims of the present study were to examine the most important medical articles(i.e.,the top 100 most cited)on *** examine how the Nobel-prize awarded hypoxia inducible factor(HIF)-pathway discovery in the early 1990s has changed the thematic composition of this body of literature,with a special emphasis on the studies linking hypoxia and *** searched Pubmed for articles with the terms#Hypox,#Altitude,or#Mountain in the title that have been published in biomedical journals and ranked the articles on their number of citations in Web of Science.A second search was performed in all journals for articles related to hypoxia and ***,only 12 of the top-100 most-cited articles on hypoxia and only 3 articles of the top-100 articles related to cancer were published before ***,only 5 articles from prior 1995 reached 1000 citations,while 27 articles published in 1995 or later were cited more than 1000 times,most of them on the HIF-1 *** percent of the top-100 articles were related to the HIF pathway,while there were no articles on the application of hypoxia either for therapeutic use(i.e.,hypoxic conditioning in patients)or for performance enhancement(i.e.,altitude training in athletes).In conclusion,the early-1990s discovery of the HIF pathway and of its molecular regulation has shifted the focus of hypoxia research towards molecular mechanisms and consequences of tissue hypoxia,most notably in *** importance of studies focusing on clinical and performance applications of systemic hypoxia is relatively lower.

关键词： Altitude training Cancer Hypoxia HIF pathway Mountain

Sparse current source reconstruction in MCG

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Science Bulletin 2015年第14期60卷 1235-1240页

作者： Mengpei Chen Shiqin Jiang Lu Bing Chen Zhao Birgit Hailer Dietrich gr nemeyer Peter Van Leeuwen School of Electronics and Information Engineering Tongji University Department of Internal Medicine Philippusstift University Witten/Herdecke Faculty of Health Gro¨ nemeyer Institute for MicrotherapyUniversity Witten/Herdecke

Cardiac current source reconstruction is investigated by a fast greedy sparse(FGS) method applied to simulated and real magnetocardiography(MCG) data measured using 61-channel superconducting quantum interference device. The approach reduces the size of the lead field matrix based on a priori knowledge of dipolar magnetic field map. Consequently, the computational demands and the accuracy of sparse source reconstruction are improved simultaneously. The simulation results demonstrate that the FGS method is capable of reconstructing sparse equivalent current sources using the magnetic field data generated by a single current source with varying orientation or multiple current sources generated randomly. In addition, we analyze the cardiac current source reconstructed with real MCG data at typical instants and discuss the electrical excitation conduction during the QRS complex based on moving sparse source imaging.

关键词： Magnetocardiography (MCG) Sparsedecomposition Current source reconstruction Cardiac electrical activity Signal processing

Nutraceutical Potentiality of Fruits of Red Variety of Pseudospondias microcarpa (A. Rich) Engl.

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Rationale for the potential use of mesenchymal stromal cells in liver transplantation

Food and Nutrition Sciences（食品与营养科学） 2024年第3期 224页

作者： Babouongolo Sévère-grébel Niang Lahat Nkounkou-Loumpangou Célestine Bonazaba Milandou Longin Justin Clair Ouamba Jean-Maurille

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World Journal of Gastroenterology 2014年第44期20卷 16418-16432页

作者： Morgan Vandermeulen Céline grégoire Alexandra Briquet Chantal Lechanteur Yves Beguin Olivier Detry Department of Abdominal Surgery and Transplantation CHU Liege University of Liege Department of Hematology CHU Liege University of Liege Laboratory of Cell and Gene Therapy CHU Liege University of Liege

Mesenchymal stromal cells (MSCs) are multipotent and self-renewing cells that reside essentially in the bone marrow as a non-hematopoietic cell population, but may also be isolated from the connective tissues of most organs. MSCs represent a heterogeneous population of adult, fibroblast-like cells characterized by their ability to differentiate into tissues of mesodermal lineages including adipocytes, chondrocytes and osteocytes. For several years now, MSCs have been evaluated for their in vivo and in vitro immunomodulatory and ‘tissue reconstruction’ properties, which could make them interesting in various clinical settings, and particularly in organ transplantation. This paper aims to review current knowledge on the properties of MSCs and their use in pre-clinical and clinical studies in solid organ transplantation, and particularly in the field of liver transplantation. The first available clinical data seem to show that MSCs are safe to use, at least in the medium-term, but more time is needed to evaluate the potential adverse effects of long-term use. Many issues must be resolved on the correct use of MSCs. Intensive in vitro and pre-clinical research are the keys to a better understanding of the way that MSCs act, and to eventually lead to clinical success.

关键词： Mesenchymal stem cells Organ transplantation Complication Immunosuppression Tolerance

Double Layer Composite Electrode Strategy for Efficient Perovskite Solar Cells with Excellent Reverse-Bias Stability

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Nano-Micro Letters 2023年第1期15卷 225-235页

作者： Chaofan Jiang Junjie Zhou Hang Li Liguo Tan Minghao Li Wolfgang Tress Liming Ding Michael grätzel Chenyi Yi State Key Laboratory of Power System Department of Electrical EngineeringTsinghua UniversityBeijing 100084People’s Republic of China Institute of Computational Physics(ICP) ZHAW School of EngineeringWildbachstr.218400 WinterthurSwitzerland Center for Excellence in Nanoscience(CAS) Key Laboratory of Nanosystem and Hierarchical Fabrication(CAS)National Center for Nanoscience and TechnologyBeijing 100190People’s Republic of China Laboratory of Photonics and Interfaces Department of Chemistry and Chemical EngineeringSwiss Federal Institute of Technology Lausanne1015 LausanneSwitzerland

Perovskite solar cells(PSCs)have become the represent-atives of next generation of photovoltaics;nevertheless,their stability is insufficient for large scale deployment,particularly the reverse bias ***,we propose a transparent conducting oxide(TCO)and low-cost metal composite electrode to improve the stability of PSCs without sacrificing the *** TCO can block ion migrations and chemical reactions between the metal and perovskite,while the metal greatly enhances the conductivity of the composite *** a result,composite electrode-PSCs achieved a power conversion efficiency(PCE)of 23.7%(certified 23.2%)and exhibited excellent stability,maintaining 95%of the initial PCE when applying a reverse bias of 4.0 V for 60 s and over 92%of the initial PCE after 1000 h continuous light *** composite electrode strategy can be extended to different combinations of TCOs and *** opens a new avenue for improving the stability of PSCs.

关键词： Composite electrode Perovskite solar cells Stability Reverse bias Characterization

Impact of a Mass Campaign on the Evolution of the Fourth Wave of the Covid-19 Pandemic in the Central African Republic

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Journal of Tuberculosis Research 2024年第3期12卷 142-150页

作者： Clotaire Donatien Rafaï Pierre Somse Wilfrid Sylvain Nambei Ernest Lango-Yaya Marie-Roseline Darnycka Belizaire Ulrich Vickos Narcisse Patrice Komas Oscar Senzongo Luc Salva Heredeibona Ulrich Jeffrey Kotemossoua Rabbi Mermoz Senekian Simon Pounguinza Jephté Estimé Kaleb Christian-Diamant Mossoro-Kpinde Alain Le Faou Jean De Dieu Longo Norbert Richard Ngbale Abdoulaye Sepou François-Xavier Mbopi-Keou Gérard grésenguet Boniface Koffi National Laboratory of Clinical Biology and Public Health Bangui Central African Republic Faculty of Health Sciences University of Bangui Bangui Central African Republic Ministry of Health and Population Bangui Central African Republic World Health Organization Bangui Central African Republic Pasteur Institute of Bangui Bangui Central African Republic Faculty of Medicine Midwifery and Health Professions University of Lorraine Nancy France Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde Cameroun Community University Hospital Center of Bangui Bangui Central African Republic

Objective: In the context of increasing cases despite vaccination campaigns, a survey was conducted in the Bangui population from January 17 to 26, 2022, to evaluate the strains of Severe Acute Respiratory Infection Coronavirus 2 (SARS-Cov-2) circulating in a healthy population. Materials and methods: This study was conducted by taking nasopharyngeal samples from randomly selected volunteers. Antigen detection was performed systematically, and RT-PCR was done on the positive samples. Results and discussion: We collected 2,554 samples. Thirty were found RT-PCR positive (1.2%) and sent for viral genome sequencing. Twenty-eight SARS-Cov-2 strains belonged to the Omicron type, and only 2 to the Delta type. Conclusion: Thus, infections were uncommon in the tested population, but the presence of Omicron and Delta types raises concerns that vaccination may not be effective in fighting the virus, and newly designed vaccines should be implemented to better protect the population at risk of infection and reinfection by these variants.

关键词： COVID-19 SARS-CoV-2 Variants

Does size matter for resection of giant versus non-giant hepatocellular carcinoma?A meta-analysis

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World Journal of Gastrointestinal Surgery 2023年第2期15卷 273-286页

作者： Aaron JL Lee Andrew gr Wu Kuo Chao Yew Vishal G Shelat Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore Yong Loo Lin School of Medicine National University of SingaporeSingapore 117597Singapore Department of Gastroenterology and Hepatology Tan Tock Seng HospitalSingapore 308433Singapore Department of Hepato-Pancreatico-Biliary Surgery Tan Tok Seng HospitalSingapore 308433Singapore

BACKgrOUND Research on long-term survival after resection of giant(≥10 cm)and non-giant hepatocellular carcinoma(HCC)(<10 cm)has produced conflicting *** This study aimed to investigate whether oncological outcomes a... 详细信息

BACKgrOUND Research on long-term survival after resection of giant(≥10 cm)and non-giant hepatocellular carcinoma(HCC)(groups;however,this may have been confounded by reporting *** staging systems should account for the size differences.

关键词： Hepatectomy Giant hepatocellular carcinoma Resection Meta-analysis

Simultaneous 3D temperature and velocity field measurements of micro-flow with laser-induced fluorescence and micro-digital holographic particle tracking velocimetry: Numerical study

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Chinese Optics Letters 2015年第7期13卷 105-109页

作者：姚龙超吴学成阳静吴迎春高翔陈玲红 Gérard gréhan 岑可法 State Key Laboratory of Clean Energy Utilization Zhejiang University UMR 6614/CORIA CNRS Normandie Université

We propose a method for simultaneous 3D temperature and velocity measurement of a micro-flow field. The 3D temperature field is characterized with two-color laser-induced fluorescence particles which are tracked with micro-digital holographic particle tracking velocimetry. A diffraction-based model is applied to analyze defo- cused particles to determine the intensity ratio of two fluorescent dyes on the particle. The model is validated with experimental images. As the result shows that the intensity ratio nearly remains unchanged with respect to depth positions, defocused particles can be used as 3D temperature sensors. Numerical work is carried out to check the method, and 3D temperature and velocity field in a 120 μm × 120 μm× 80 μm test volume are retrieved.

关键词： Fluorescence Holography Laser optics Laser produced plasmas Numerical methods Velocimeters Velocity

Body composition changes after transjugular intrahepatic portosystemic shunt in patients with cirrhosis

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World Journal of Gastroenterology 2010年第3期16卷 348-353页

作者： Jonathan Montomoli Peter Holland-Fischer Giampaolo Bianchi Henning grФnbk Hendrik Vilstrup Giulio Marchesini Marco Zoli Department of Internal Medicine Aging and Nephrological DiseasesUniversity of Bologna Department of Medicine V Aarhus University Hospital

AIM:To investigate the effect of transjugular intra-hepatic porto-systemic shunt (TIPS) on malnutrition in portal hypertensive cirrhotic ***: Twenty-one patients with liver cirrhosis and clinical indications for TIPS insertion were investigated before and 1, 4, 12, 52 wk after TIPS. For each patient we assayed body composition parameters [dry lean mass, fat mass, total body water (TBW)], routine liver and kidney function tests, and free fatty acids (FFA). Glucose and insulin were measured for the calculation of the homeostasis model assessment insulin resistance (HOMA-IR); liver function was measured by the galactose elimination capacity (GEC); the severity of liver disease was graded by model for end-stage liver disease (MELD).RESULTS: Porto-systemic gradient decreased after TIPS (6.0±2.1 mmHg vs 15.8±4.8 mmHg, Pgroups according to initial body mass index. After TIPS, normal weight patients had an increase in dry lean mass (from 10.9±5.9 kg to 12.7±5.6 kg, P=0.031) and TBW (from 34.5±7.6 L to 40.2±10.8 L,P=0.007), as well as insulin (from 88.9±49.2 pmol/L to 164.7±107.0 pmol/L,P=0.009) and HOMA-IR (from 3.36%±2.18% to 6.18%±4.82%,P=0.023). In overweight patients only FFA increased significantly (from 0.59±0.24 mmol/L to 0.93±0.34 mmol/L, P=0.023).CONCLUSION: TIPS procedure is effective in lowering portal pressure in patients with portal hypertension and improves body composition without significant changes in metabolic parameters.

关键词： Insulin resistance Liver cirrhosis Malnutrition Portal hypertension Transjugular intrahepatic porto-systemic shunt