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Acute necrotizing pancreatitis: Surgical indications and technical procedures

World Journal of Clinical Cases 2014年第12期2卷 840-845页

作者： José Manuel Aranda-Narváez Antonio Jesús González-Sánchez María custodia montiel-casado Alberto Titos-García Julio Santoyo-Santoyo General Digestive and Transplantation Surgery Department University Regional Hospital 29010 Málaga Spain

Necrosis of pancreatic parenchyma or extrapancreatic tissues is present in 10%-20% of patients with acute pancreatitis, defining the necrotizing presentation frequently associated with high morbidity and mortality rates. During the initial phase of acute necrotizing pancreatitis the most important pillars of medical treatment are fluid resuscitation, early enteral nutrition, endoscopic retrograde colangiopancreatography if associated cholangitis and intensive care unit support. When infection of pancreatic or extrapancreatic necrosis occurs, surgical approach constitutes the most accepted therapeutic option. In this context, we have recently assited to changes in time for surgery(delaying the indication if possible to around 4 wk to deal with "walledoff" necrosis) and type of access for necrosectomy: from a classical open approach(with closure over large-bore drains for continued postoperative lavage or semiopen techniques with scheduled relaparotomies), trends have changed to a "step-up" philosophy with initial percutaneous drainage and posterior minimally invasive or endoscopic access to the retroperitoneal cavity for necrosectomy if no improvement has been previously achieved. These approaches are progressively gaining popularity and morbidity and mortality rates have decreased significantly. Therefore, a staged, multidisciplinary, step-up approach with minimally invasive or endoscopic access for necrosectomy is widely accepted nowadays for management of pancreatic necrosis.

关键词： Acute pancreatitis Necrotizing pancreatitis Surgery Open necrosectomy Minimal access retroperitoneal pancreatic necrosectomy Video-assisted retroperitoneal debridement

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Posterior approach (Kraske procedure) for surgical treatment of presacral tumors

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World Journal of Gastrointestinal Surgery 2012年第5期4卷 126-130页

作者： José Manuel Aranda-Narváez Antonio Jesús GonzálezSánchez custodia montiel-casado Belinda Sánchez-Pérez Carolina Jiménez-Mazure Marta Valle-Carbajo Julio Santoyo-Santoyo Department of General Digestive Surgery and Abdominal Organs TransplantationUniversity Hospital Carlos HayaCarlos Haya Avenue29010MálagaSpain

Presacral tumors are rare,but can comprise a great variety of histological *** tumors are the most *** the diagnosis is established,surgical resection is essential because of the potential for malignancy or *** biopsy is not necessary or may be even *** decide the best surgical approach(abdominal,sacral or combined) an individual and multidisciplinary analysis must be carried *** report three cases of cystic presacral masses in which a posterior approach(Kraske procedure) enabled complete resection,the only way to decrease local *** patients had a satisfactory recovery.A brief overview of retrorectal tumors is presented,focusing on classification,clinical presentation,diagnosis and surgical management.

关键词： Presacral tumors Posterior approach Surgical management

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New open clusters found by manual mining of data based on Gaia DR2

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Research in Astronomy and Astrophysics 2021年第5期21卷 147-154页

作者： Juan casado Facultad de Ciencias Universidad Autnoma de Barcelona08193BellaterraCataloniaSpain

The physical nature of a series of 20 new open clusters is confirmed employing existing data on putative star members,mainly from the second Gaia Data Release(DR2).The clusters were discovered as overdensities of stars by visual inspection of either photographic DSS plates or proper motion plots of random source *** reported objects are not present in the most comprehensive or recent catalogs of stellar clusters and *** all of them,clumps of comoving stars are revealed in the proper motion *** parallaxes of the clumped stars are compatible with the real existence of open clusters over narrow ranges of *** density calculations,free of most noise from non-member sources,allow differentiating a cluster core and an extended cluster corona in some ***-magnitude diagrams generally show a definite main sequence that allows confirmation of the physical existence of the clusters and some of their *** of the new clusters seem to form a double system with a common *** of the new clusters challenge the claim of near completeness of the known OC population in the distance range from 1.0 to 1.8 kpc from the Sun(Kharchenko et al.).

关键词： astronomical databases:miscellaneous parallaxes proper motions(stars:)Hertzsprung-Russell CCM diagrams(Galaxy:)open clusters associations:individual

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Some Smoothness Results for Classical Problems in Optimal Design and Applications

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Chinese Annals of Mathematics,Series B 2015年第5期36卷 703-714页

作者： Juan casado-DIAZ Dpto.de Ecuaciones Diferenciales y Analisis Numerico University of Seville41012 SevillaSpain

The author considers two classical problems in optimal design consisting in maximizing or minimizing the energy corresponding to the mixture of two isotropic materials or two-composite material. These results refer to... 详细信息

关键词： Optimal design Two-phase material Non-existence Relaxation

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CD34^(+ )progenitor cells as diagnostic and therapeutic targets in Alzheimer's disease

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Neural Regeneration Research 2023年第3期18卷 535-536页

作者： Daniel Romaus-Sanjurjo Antía custodia Alberto Ouro Tomás Sobrino NeuroAging Group(NEURAL) Clinical Neurosciences Research Laboratory(LINC)Health Research Institute of Santiago de Compostela(IDIS)Santiago de CompostelaSpain

Alzheimer’s disease(AD)is the main neurodegenerative disease leading to dementia and cognitive impairment in the *** AD to be an epidemic,an increase from the current 50 million to more than 150 million patients is e... 详细信息

关键词： Alzheimer progenitor impairment

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The challenge of applying governance and sustainable development to wildland fire management in Southern Europe

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Journal of Forestry Research 2011年第4期22卷 627-639页

作者： Susana Aguilar Cristina montiel Complutense University of Madrid Somosaguas Campus Pozuelo de Alarcón 28223 Spain

This paper discusses participatory processes in wildland fire management （WFM）. Participation is an essential element of both the European Sustainable Development （SD） Strategy and the White Paper on Governance. Governance end SD have thus become an interconnected challenge to be applied to WFM （as a sub-area in forest policy）, amongst other policies. An overspread weakness in WFM is lack of real participation of stakeholders. Absence of （or deficient） participation can seriously impair contribution of this group to WFM in high-risk areas and runs counter governance and the SDS. Further, this weakness might prevent an efficient use of fire as a land management tool （prescribed burning, PB） and as a technique for fighting wildfire （suppression fire, SF）. Even though these fire practices have been well known in many different places, they have been increasingly neglected or Prohibited over time in Southern Europe. At present, forest and fire fighting administrations are turning their eyes back on them and analyzing the benefits of using fire in relation to preventive and suppressive actions. Therefore, participatory and diffusion mechanisms （the latter adopting the shape of national and international experts＇ networks） are required in order to solve the so- called fire paradox： that is, the need to move from a one-dimensinnal perception of the negative impacts of fire to a more sophisticated one that also stresses its positive effects. Governance, based on broad social participation, and diffusion, through fire networks, are of utmost importance in order, first, to diminish long-standing suspicion amongst different interests as to the use of fire and, secondly, to diffuse best practices associated with PB and SF. Most importantly, the ELI should exercise its environmental leadership so that these new fire practices and sustainable WFM are diffused across the international arena.

关键词： governance sustainable development forestry policy wild-fire management social participation

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New approaches in angiogenic targeting for colorectal cancer

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World Journal of Gastroenterology 2007年第44期13卷 5857-5866页

作者： Aleix Prat Esther casado Javier Cortés Department of Medical Oncology Vall d'Hebron University Hospital Barcelona Spain Department of Medical Oncology Vall d'Hebron University Hospital Barcelona Spain Department of Medical Oncology Hospital General de Manresa Barcelona Spain

Colorectal carcinoma （CRC） is one of the leading causes of cancer death worldwide. In the last decade, the addition of irinotecan and oxaliplatin to standard fluorouracil-based chemotherapy regimens have set the new benchmark of survival for patients with metastatic CRC at approximately 20 too. Despite these advances in the management of CRC, there is a strong medical need for more effective and well-tolerated therapies. The dependence of tumor growth and metastasis on blood vessels makes angiogenesis a rational target for therapy. One of the major pathways involved in this process is the vascular endothelial growth factor （VEGF） and its receptors （VEGFR）. In 2004, the first agent targeting angiogenesis, bevacizumab （BV）, was approved as an adjunct to first-line cytotoxic treatment of metastatic CRC. The role of BV as part of adjuvant treatment and in combination with other targeted therapies is the subject of ongoing trials. However, BV is associated with an increase in the risk of arterial thromboembolic events, hypertension and gastrointestinal perforations and its use must be cautious. Novel VEGFR TK inhibitors with different ranges of nanomolar potencies, selectivities, and pharmacokinetic properties are entering phase 111 trials for the treatment of cancer. Conversely, one of these novel agents, vatalanib, has been shown not to confer survival benefit in first and second-line treatment of advanced CRC. The basis of these findings is being extensively evaluated. Ongoing and new well-designed trials will define the optimal clinical application of the actual antiangiogenic agents, and, on the other hand, intensive efforts in basic research will identify new agents with different antiangiogenic approaches for the treatment of CRC. In this review we discuss and highlight current and future approaches in angiogenic targeting for CRC.

关键词： Angiogenesis inhibitors Vascular endothelial growth factor VEGF receptors Bevacizumab Vatalanib Colorectal carcinoma

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Potential role of the IL-33/ST2 axis in celiac disease

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Cellular & Molecular Immunology 2017年第3期14卷 285-292页

作者： Lopez-casado MA Lorite P Palomeque T Torres MI Department of Pediatrics Gastroenterology Hospital Virgen de las Nieves Granada Spain Department of Experimental Biology University of Jaen Jaen Spain

The IL-33/ST2 axis has been implicated in the pathogenesis of several tissue-specific autoimmune diseases. Celiac disease （CD） is the only autoimmune disease in which both the major genetic factors （HLA-DQ2/DQ8） and etiologic ones （dietary gluten） for susceptibility are known. We have measured serum levels and determined intestinal tissue expression of IL-33 and its receptor soluble ST2 in patients with CD to investigate their association with disease activity. Serum and tissue levels of both IL-33 and sST2 were significantly higher in patients with CD compared with those in control patients without CD. We show that toxic peptides extracted from barley and wheat gliadin significantly stimulate the production of IL-33 and ST2 in cultured peripheral blood mononuclear cell from celiac patients, strongly implicating the IL-33/ST2 axis in the pathogenesis of CD. The higher levels of IL-33 and its receptor ST2 in tissue and serum reflect an active inflammatory state and may represent a potential biomarker for disease activity. A better understanding of IL-33/ ST2 release, mode of action, and regulation will be crucial to develop therapeutics that target the IL-33/ST2 pathway to treat CD.

关键词： celiac disease gluten peptides IL-33 ST2

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Impact of socioeconomic and health-related factors on consumption of homeopathic and natural remedies in Spain in 2006, 2011 and 2017

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Journal of Integrative Medicine 2022年第1期20卷 52-56页

作者： Jose Antonio Castilla-Jimena Isabel Ruiz-Perez Jesus Henares-montiel Andalusian School of Public Health 1801J GranadaSpain Unit of Clinical Management of Preventive Medicine and Public Health and Occupational Medicine Puerto del Mar University Hospital11009 CadizSpain Consortium for Networked Biomedical Research in Epidemiology and Public Health 28029 MadridSpain Institute for Biosanitary Research(ibs.GRANADA) 18012 GranadaSpain

Objective: Complementary and alternative medicine use and type of use may be influenced by sociodemographic and economic determinants through which we could identify characteristics of patients with greater trend to use it. This paper aims to describe the changes in the consumption of homeopathic and natural remedies in Spain for three time points in order to discern changes in rate of consumption, associated factors and whether their use has been affected by a period of economic ***: This study utilized 2006, 2011 and 2017 cross-sectional data from the Spanish National Health Survey, a nationally representative survey of the population aged more than 15 years old and resident in Spain. Independent bivariate and multivariate descriptive analyses for each of the 3 years studied were ***: The rate of consumption of both homeopathic and natural remedies has decreased over the periods studied. In spite of this decrease, the consumer profile appears to remain stable over the three periods. The sociodemographic factors associated with their consumption were being female, being 30–64 years old, being separated/divorced, having higher education qualifications, being employed and belonging to a higher social class. Psychiatric morbidity, chronic health problems such as pain, mental health problems or malignant tumors, and absence of major cardiovascular events were the clinical factors ***: It can be concluded that beyond the economic situation, the use of homeopathic and natural remedies obeys to the needs of the patients related to their state of health and the response they receive from the health system. It may be that women have different needs and expectations of the healthcare system and, given this breach of expectations, seek remedy to alleviate their needs outside the system and conventional medicine.

关键词： Complementary and alternative medicine Homeopathic remedies Natural remedies Economic recession Gender differences

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COX-2 in liver,from regeneration to hepatocarcinogenesis:What we have learned from animal models?

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World Journal of Gastroenterology 2010年第12期16卷 1430-1435页

作者： Paloma Martín-Sanz Rafael Mayoral Marta casado Lisardo Boscá Biomedical Network Center for the Study of Hepatic and Digestive Diseases(CIBERehd) Department of Metabolism and Cell Signaling Institute of Biomedical Research "Alberto Sols"(CSIC-UAM) Department of Pathology and Molecular and Cellular Therapy Institute of Biomedicine of Valencia(IBV-CSIC)

The use of animals lacking genes or expressing genes under the control of cell-specific promoters has signifi cantly increased our knowledge of the genetic and molecular basis of physiopathology,allowing testing of functional hypotheses and validation of biochemical and pharmacologic approaches in order to understand cell ***,with unexpected frequency,gene knockout animals and,more commonly,animal models of transgenesis give experimental support to even opposite conclusions on gene *** we summarize what we learned on the role of cyclooxygenase 2(COX-2) in liver and revise the results obtained in 3 independent models of mice expressing a COX-2 transgene specifi cally in the *** challenge with pro-inflammatory stimuli,the animals behave very differently,some transgenic models having a protective effect but others enhancing the *** addition,one transgene exerts differential effects on normal liver physiology depending on the transgenic animal model used.

关键词： Cyclooxygenase 2 Prostaglandins Liver diseases Apoptosis Inflammation Animal models

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