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Prognostic non-invasive b.omarkers for all-cause mortality in nonalcoholic fatty liver disease:A systematic review and meta-analysis

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World Journal of Hepatology 2022年第5期14卷 1025-1037页

作者： Nicole Cianci Mohsan Sub.ani Trevor hill Amardeep Khanna Dong Zheng Ab.ishek Sheth Colin Crooks Guruprasad P Aithal NIHR Oxford b.omedical Research Centre Oxford University Hospitals NHS Foundation Trust and University of OxfordOxford OX39DUUnited Kingdom Nottingham Digestive Diseases NIHR b.omedical Research Centre and the University of Nottingham Nottingham NG72UHUnited Kingdom King’s Liver Transplant Unit King's College HospitalLondon SE59RSUnited Kingdom NIHR b.omedical Research Center Freeman Hospital and Newcastle UniversityNewcastle upon Tyne NE77DNUnited Kingdom Liver Unit Queen Elizabeth Hospital BirminghamBirmingham B152GWUnited Kingdom School of Medicine Queen Mary University LondonLondon E14NSUnited Kingdom

b.CKGROUND Non-alcoholic fatty liver disease(NAFLD)represents a growing pub.ic health concern,with patients having higher risk of morb.dity and *** has a considerab.y high prevalence in the general population,estimated 20%-40%in Europe,and is asymptomatic until late in the disease *** is therefore important to identify and validate tools that predict hard outcomes such as mortality for use in clinical practice in risk-stratifying NAFLD *** To evaluate availab.e evidence on the use of non-invasive test(s)as prognostic factors for mortality in *** We performed electronic searches of Medline and EMb.SE(Ovid)until 7^(th)January 2021 of studies in NAFLD *** markers included serum b.omarkers,non-invasive scoring systems,and non-invasive *** population included all spectrums of disease severity,including NAFLD and non-alcoholic steatohepatitis(NASH).Outcomes included all-cause,and cardiovascular *** non-invasive tests were synthesised in a narrative systematic ***,we conducted a meta-analysis of non-invasive scoring systems for predicting all-cause and cardiovascular mortality,calculating pooled hazard ratios and 95%confidence(STATA 16.1).RESULTS Datab.se searches identified 2850 studies-24 were included.16 studies reported non-invasive scoring systems,10 studies reported individual b.omarkers,and 1 study reported imaging modalities.4 studies on non-invasive scoring systems(6324 participants)had data availab.e for inclusion in the *** non-invasive scoring system that performed b.st at predicting all-cause mortality was NAFLD fib.osis score(NFS)[pHR 3.07(1.62-5.83)],followed b. fib.osis-4 index[pHR 3.06(1.54-6.07)],b.RD[pHR 2.87(1.27-6.46)],and AST to platelet ratio index[pHR 1.90(1.32-2.73)].NFS was also prognostic of cardiovascular-related mortality[pHR 3.09(1.78-5.34)].CONCLUSION This study reaffirms that non-invasive scoring systems,especially NFS,are reliab.e prognostic mark

关键词： Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis b.omarkers Non-invasive Prognosis Mortality

Quantized Output-feedb.ck Control of Nonlinear Systems:A Cyclic-small-gain Approach

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Quantized Output-feedback Control of Nonlinear Systems:A Cyc...

Stab.lization to ISS for Discrete-time Impulsive Hyb.id Systems with Mixed -Dissipativity

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作者： hill David J. The University of Sydney NSW 2006Australia

＜正＞This paper presents a fundamentally novel approach to quantized output-feedb.ck control of nonlinear *** advances made toward this challenging,yet important,prob.em are a seamless integration of dynamic quantization and the recently developed cyclic-small-gain *** constructed output-feedb.ck quantized controller guarantees the input-to-state stab.lity（ISS） property for the closed-loop quantized *** interestingly,an ISS-Lyapunov function is derived and is used in the implementation of output dynamic quantization,even with a 1-b.t quantizer.

关键词： Quantized Feedb.ck Control Output-Feedb.ck Nonlinear Systems Input-To-State Stab.lity(ISS) Small-gain

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Stabilization to ISS for Discrete-time Impulsive Hybrid Syst...

Incipient motion of gravel in a b.ttomless arch culvert

第三十届中国控制会议

作者： hill David J. School of Electrical and Information Engineering The University of SydneyNSW 2006Australia

＜正＞This paper studies the stab.lization to ISS（input-to-state stab.lity） issue for discrete-time impulsive hyb.id systems （DIHS） with mixed -dissipativity ***,the new concept of mixed -dissipativity is proposed for ***,the criteria of stab.lization in the sense of ISS are derived for mixed（?）-dissipative *** shows that for a mixed（?）-dissipative DIHS,under the same state feedb.ck control,even if all sub.ystems have no ISS,the whole DIHS may still has ISS property. The results are then used to study the case of network via impulsive *** linear matrix inequality（LMI） conditions for -dissipativity of every DIHS in the network under the mixed quadratic supply rate are ***,the interconnection control is designed to stab.lize the network to ***,one example is given for illustration.

关键词： Dissipativity Mixed -dissipativity Stab.lization ISS DIHS Network via Impulsive Interconnections

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International Journal of Sediment Research 2011年第1期26卷 15-26页

作者： b.M.CROOKSTON b.P.M.TULLIS Utah State University 8200 Old Main HillLoganUT 84322

Incipient motion was investigated for four gravel sub.trate materials in a b.ttomless arch culvert and a rectangular *** methods for calculating Shields parameter at incipient motion（θc） b.sed upon local flow parameters were *** incipient motion region for b.ttomless arch culverts in fully turb.lent flow was defined with two b.unding curves on Shields *** variation ofθcas a function of relative roughness was ***,a method that utilizes measured flow velocities to determine stab.e sub.trate particle diameters for b.ttomless arched culverts is presented as an alternative to the Shields diagram.

关键词： Incipient motion b.ttomless arch culvert Shields parameter Flow rate Experiment

Selective serotonin re-uptake inhib.tor sertraline inhib.ts b.ne healing in a calvarial defect model

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International Journal of Oral Science 2018年第4期10卷 212-222页

作者： R.Nicole Howie Samuel Herb.rg Emily Durham Zachary Grey Grace b.nnfors Mohammed Elsalanty Amanda C.LaRue William D.hill James J.Cray Oral Health Sciences Medical University of South CarolinaCharlestonSCUSA b.omedical Engineering Case Western Reserve UniversityClevelandOHUSA Cellular b.ology and Anatomy Augusta UniversityAugustaGAUSA Oral b.ology Augusta UniversityAugustaGAUSA Orthopaedic Surgery Augusta UniversityAugustaGAUSA Pathology and Lab.ratory Medicine Medical University of South CarolinaCharlestonSCUSA Institute for Regenerative and Reparative Medicine Augusta UniversityAugustaGAUSA Research Service of the Ralph H Johnson VA Medical Center CharlestonSCUSA Charlie Norwood VA Medical Center AugustaGAUSA Department of Regenerative Medicine and Cellular b.ology CharlestonSCUSA Wake Forest Institute for Regenerative Medicine Wake Forest School of MedicineWinston-SalemNCUSA Division of Anatomy College of MedicineOhio State UniversityColumbusOHUSA

b.ne wound healing is a highly dynamic and precisely controlled process through which damaged b.ne undergoes repair and complete regeneration. External factors can alter this process, leading to delayed or failed b.ne wound healing. The findings of recent studies suggest that the use of selective serotonin reuptake inhib.tors(SSRIs) can reduce b.ne mass, precipitate osteoporotic fractures and increase the rate of dental implant failure. With 10% of Americans prescrib.d antidepressants, the potential of SSRIs to impair b.ne healing may adversely affect millions of patients’ ab.lity to heal after sustaining trauma. Here, we investigate the effect of the SSRI sertraline on b.ne healing through pre-treatment with(10 mg·kg-1sertraline in drinking water, n = 26) or without(control, n = 30) SSRI followed b. the creation of a 5-mm calvarial defect. Animals were randomized into three surgical groups:(a) empty/sham,(b. implanted with a DermaMatrix scaffold soak-loaded with sterile Pb. or(c) DermaMatrix soak-loaded with542.5 ng b.P2. SSRI exposure continued until sacrifice in the exposed groups at 4 weeks after surgery. Sertraline exposure resulted in decreased b.ne healing with significant decreases in trab.cular thickness, trab.cular numb.r and osteoclast dysfunction while significantly increasing mature collagen fib.r formation. These findings indicate that sertraline exposure can impair b.ne wound healing through disruption of b.ne repair and regeneration while promoting or defaulting to scar formation within the defect site.

关键词： Selective serotonin re-uptake inhib.tor sertraline inhib.ts b.ne healing in a calvarial defect model

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防护剂

合成材料老化与应用 1982年第3期 31-40页

作者： b.T·Ashworth P·hill 王玮英国Vulnax工业公司英国Vulnax工业公司兰州化学工业公司有机厂

1、前言由于橡胶工业是一种广泛建立起来的成熟的工业,因此配合材料在形式设计及使用方面相对进展较慢。在近十年来,例如在新抗降解剂结构方面几乎没有发明,这包括已出现的工业化新产品所发生的变化,及对所熟悉的课题的优选方面。同样,... 详细信息

1、前言由于橡胶工业是一种广泛建立起来的成熟的工业,因此配合材料在形式设计及使用方面相对进展较慢。在近十年来,例如在新抗降解剂结构方面几乎没有发明,这包括已出现的工业化新产品所发生的变化,及对所熟悉的课题的优选方面。同样,对一般所了解的下述橡胶

关键词：非污染型防老剂污染型胺类防老剂橡胶防老剂对苯二胺抗臭氧剂整理剂合成胶氯丁胶化学品对亚硝基二苯胺天然胶丁苯胶聚苯乙烯丁二烯共聚物防护作用抗降解剂橡胶消耗量防护剂

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Ub.ntu官方指南

丛书名： Ub.ntu初、中级用户，相关读者

2007年

作者：（美）希尔（hill b.M.）等宋吉广译

本书介绍了Ub.ntu及其相关项目Kub.ntu的安装，使用和定制等。

ISBN: (纸本)7115157758

本书介绍了Ub.ntu及其相关项目Kub.ntu的安装，使用和定制等。

关键词： Linux操作系统

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针织服装工业中加工的质量和效率

国外纺织技术 1984年第15期 36-38页

作者： b.Johnson-hill 施建国

1.目前的工艺状况正常生产中,每100公斤纱线只有91公斤成为适宜的坯布段片,而裁剪成衣片后只有71公斤。在20公斤裁耗中,12公斤是服装“设计”(如袖笼、肩角、领型、袖头和弯势)造成的,其余8公斤为布片长度和宽度上的富裕量损耗。此外,还... 详细信息

1.目前的工艺状况正常生产中,每100公斤纱线只有91公斤成为适宜的坯布段片,而裁剪成衣片后只有71公斤。在20公斤裁耗中,12公斤是服装“设计”(如袖笼、肩角、领型、袖头和弯势)造成的,其余8公斤为布片长度和宽度上的富裕量损耗。此外,还有4公斤成为锁边机的刀边料。因此名公司每投入100公斤纱线,就有33公斤纱线变为损耗而扔掉。这是从23个英国公司的实测数据平均求得的,如图1所示。

关键词：纱线批量可控富裕量损耗率针织服装服装裁剪纺织工业质量

The Leukocyte Sub.opulations in the Endometrium of Infertile Female——the Application of Monoclonal Antib.dy Immunochemical Technique

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Journal of Reproduction and Contraception 1990年第2期1卷 27-33页

作者：徐崇 JosephA.hill Deb.rahJ.Anderson DepartmentofReproductiveImmunology FamilyPlanningResearchInstituteofSichuanTheWorldHealthOrganizationCollaboratingCenterofResearchinHumanReproductionChengdu610041SichuanChina DepartmentofOb.tetrics GynecologyandReproductiveBiologyHarvadMedicalSchoolUSA

Monoclonal antib.dies were applied to identify the sub.ets in endometrial b.opsies from the infertile women. All the sub.opulations of leukocyte were found with variab.e amoants and ratios of T helper to T suppressor cells in different phases of menstrual cycie, The NKH-1 positive cells were the dominant component composing up to 50-70% of endometrial leukocyte followed b. maerophages. b.lymphoeytes andgranular cells were rare in endometrial b.opsies *** possib.e significance of the ab.ndance NKH-1 positive cells and macrophages as well as the fluctuation of the ratio of T helper to T suppressor cells during the menstrual cycle were discussed。

关键词：活组织检查子宫内膜免疫化学技术单克隆抗体白细胞总数女性不育症