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Parallel screening and cheminformatics modeling of flavonoid activated aptasensors

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Synthetic and Systems Biotechnology 2022年第4期7卷 1148-1158页

作者： Yu Xiu Ni Zhang Pranesha Prabhakaran Sungho Jang Qipeng Yuan curt MBreneman Gyoo Yeol Jung Wanwipa Vongsangnak Mattheos A.G.Koffas Beijing Key Laboratory of Bioactive Substances and Functional Food Beijing Union UniversityBeijing100029China Department of Chemical and Biological Engineering Center for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNY12180USA State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing100029China Department of Chemistry and Chemical Biology Rensselaer Polytechnic InstituteTroyNY12180USA Interdisciplinary Graduate Programs in Bioscience Faculty of ScienceKasetsart UniversityBangkok10900Thailand Omics Center for Agriculture BioresourcesFoodand HealthKasetsart University(OmiKU)BangkokThailand Division of Bioengineering College of Life Sciences and BioengineeringIncheon National University119 Academy-roYeonsu-guIncheon22012South Korea Department of Bioengineering and Nano-Bioengineering Incheon National University119 Academy-roYeonsu-guIncheon22012South Korea Research Center for Bio Materials&Process Development Incheon National University119 Academy-roYeonsu-guIncheon22012South Korea Department of Chemical Engineering Pohang University of Science and Technology77 Cheongam-roNam-guPohangGyeongbuk37673South Korea School of Interdisciplinary Bioscience and Bioengineering Pohang University of Science and Technology77 Cheongam-roNam-guPohangGyeongbuk37673South Korea Department of Zoology Faculty of ScienceKasetsart UniversityBangkok10900Thailand

A parallel screening of 27 different flavonoids and chalcones was conducted using 6 artificial naringenin-activated riboswitches(M1,M2,M3,O,L and H).A quantitative structure-property relationship approach was applied to understand the physicochemical properties of the flavonoid structures resulting in specificity differences relied on the fluorescence intensity of a green fluorescent protein *** models of riboswitches M1,M2 and O that had good predictive power were constructed with descriptors selected for their high *** electronegativity and hydrophilicity of the flavonoids structures were identified as two properties that increased binding affinity to RNA *** groups at the C-3′and C-4’positions of the flavonoid molecule were strictly required for ligand-activation with riboswitches M1 and *** O and L preferred multi-hydroxylated flavones as *** on the A ring of the flavonoid molecule were not important in the molecular recognition process.O-glycosylated derivatives were not recognized by any of the riboswitches,presumably due to steric *** the challenges of detecting RNA conformational change after ligand binding,the resulting models elucidate important physicochemical features in the ligands for conformational structural studies of artificial aptamer complexes and for design of ligands having higher binding specificity.

关键词： Riboswitch RNA device Flavonoids Structure-property relationships Physicochemical properties

Void fill and support techniques to stabilize drift excavated through a transition zone mined by a TBM at the Stillwater mine

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International Journal of Mining Science and Technology 2017年第1期27卷 71-76页

作者： Johnson Josh Jacobs curt Ferster Mark Tadolini Stephen Stillwater Mining Company NyeMT 59061USA Minova GeorgetownKYUSA

Stillwater Mining Company is the only U.S. producer of platinum group metals （PGMs） and the largest producer outside of South Afiica and Russia. The company controls a considerable portion of the J-M reef and is currently developing the ＂Blitz Project,＂ which will provide a main haulage level, ore pass systems, backfill plants, and fiow-through ventilation to increase production and ensure sustainable extraction of this critical strategic mineral. While driving two sub-parallel footwall laterals 8125 m in length, one of the development drifts experienced a massive fall in a geologically disturbed area created by a mafic dike intrusion. Combinations of a void fill material （Tekseal）, polyurethane injection, fore poling coupled with steel arches, and supplemental bolting allow safe and efficient advance through this geologically dis- turbed zone. This paper presents the details of this project.

关键词： TBM Ground Dike Cutterhead

High level of deoxycholic acid in human bile does not promote cholesterol gallstone formation

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World Journal of Gastroenterology 2003年第7期9卷 1576-1579页

作者： Ulf Gustafsson Staffan Sahlin curt Einarsson Department of Surgery Danderyd HospitalStockholmSweden Division of Gastroenterology and Hepatology Department of MedicineHuddinge University HospitalKarolinska InstitutetStockholmSweden

AIM:To study whether patients with excess deoxycholic acid (DCA) differ from those with normal percentage of DCA with respect to biliary lipid composition and cholesterol saturation of gallbladder bile. METHODS:Bile was collected during operation through puncturing into the gallbladder from 122 cholesterol gallstone patients and 46 gallstone-free subjects undergoing *** data,biliary lipids,bile add composition, presence of crystals and nucleation time were analyzed. RESULTS:A subgroup of gallstone patients displayed a higher proportion of DCA in bile than gallstone free subjects. By choosing a cut-off level of the 90th percentile,a group of 13 gallstone patients with high DCA levels (mean 50 percent of total bile acids) and a large group of 109 patients with normal DCA levels (mean 21 percent of total bile acids) were *** mean age of the patients with high DCA levels was higher than that of the group with normal levels (mean age:62 years vs45 years) and so was the mean BMI (28.3 vs.24.7).Plasma levels of cholesterol and triglycerides were slightly higher in the DCA excess groups compared with those in the normal DCA *** was no difference in biliary lipid composition,cholesterol saturation,nucleation time or occurrence of cholesterol crystals in bile between patients with high and normal levels of DCA. CONCLUSION:Gallstone patients with excess DCA were of older age and had higher BMI than patients with normal *** two groups of patients did not differ with respect to biliary lipid composition,cholesterol saturation,nucleation time or occurrence of cholesterol *** is concluded that DCA in bile does not seem to contribute to gallstone formation in cholesterol gallstone patients.

关键词： Adolescent Adult Aged Aged, 80 and over Bile Body Mass Index Cholesterol Crystallization Deoxycholic Acid Female Gallstones Humans Lipids Male Middle Aged Research Support, Non-U.S. Gov't

Homeomorphic extension of strongly spirallike mappings in C^n

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Science China Mathematics 2010年第1期53卷 87-100页

作者： curt Paula KOHR Gabriela KOHR Mirela Faculty of Economics and Business Administration Babes-Bolyai University 58-60 Teodor Mihali Str.400591 Cluj-NapocaRomania Faculty of Mathematics and Computer Science Babes-Bolyai University1 M.Kogaǎlniceanu Str.400084 Cluj-NapocaRomania

In this paper we consider a proper subclass nA of the full class of spirallike mappings on the Euclidean unit ball Bn in Cn with respect to a given linear operator A. We use the method of subordination chains to obtain an upper growth result for nA , and we obtain various examples of mappings in the same class of normalized biholomorphic mappings on the unit ball Bn in Cn . We also prove that the class nA is compact, while the full class of spirallike mappings with respect to a linear operator need not be compact in dimension n≥2, even when the operator is diagonal. This is one of the motivations for considering the class nA . Finally we prove that if f is a quasiregular strongly spirallike mapping on Bn such that ||[Df(z)]-1 Af(z)|| is uniformly bounded on Bn , then f extends to a homeomorphism of R2n onto itself. In addition, if A + A* = 2aI n for some a >0, this extension is also quasiconformal on R2n .

关键词： Biholomorphic mapping quasiregular mapping quasiconformal mapping spirallikeness strongly spirallikeness subordination subordination chain

Gallbladder bile composition in patients with Crohn's disease

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World Journal of Gastroenterology 2006年第1期12卷 70-74页

作者： Annika Lapidus Jan-Erikkerlund curt Einarsson Centre of Gastrointestinal Disease Ersta HospitalDepartment of SurgeryDanderyd Hospital and Department of Gastroenterology and HepatologyKarolinska Institutet at Karolinska University Hospital HuddingeStockholmSweden

AIM： To further elucidate the pathogenesis and mechanisms of the high risk of gallstone formation in Crohn＇s disease. METHODS： Gallbladder bile was obtained from patients with Crohn＇s disease who were admitted for elective surgery （27 with ileal/ileocolonic disease and 7 with Crohn＇s colitis）. Fourteen gallstone patients served as controls. Duodenal bile was obtained from ten healthy subjects before and after the treatment with ursodeoxycholic acid. Bile was analyzed for biliary lipids, bile acids, bilirubin, crystals, and crystal detection time （CDT）. Cholesterol saturation index was calculated. RESULTS： The biliary concentration of bilirubin was about 50% higher in patients with Crohn＇s disease than in patients with cholesterol gallstones. Ten of the patients with Crohn＇s disease involving ileum and three of those with Crohn＇s colitis had cholesterol saturated bile. Four patients with ileal disease and one of those with colonic disease displayed cholesterol crystals in their bile. About 1/3 of the patients with Crohn＇s disease had a short CDT. Treatment of healthy subjects with ursodeoxycholic acid did not increase the concentration of bilirubin in duodenal bile. Several patients with Crohn＇s disease, with or without ileal resection/disease had gallbladder bile supersaturated with cholesterol and short CDT and contained cholesterol crystals. The biliary concentration of bilirubin was also increased in patients with Crohn＇s colitis probably not due to bile acid malabsorption. CONCLUSION： Several factors may be of importance for the high risk of developing gallstones of both cholesterol and pigment types in patients with Crohn＇s *** skillful technical assistance of Ms Lisbet Benthin and Ms Ingela Arvidsson is acknowledged.

关键词： Bile acid Biliary lipid composition Bilirubin Crohn's disease Gallstone disease

Diagnosis and management of microscopic colitis

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World Journal of Gastroenterology 2008年第48期14卷 7280-7288页

作者： curt Tysk Johan Bohr Nils Nyhlin Anna Wickbom Sune Eriksson Department of Medicine Division of Gastroenterology rebro University Hospital and School of Health and Medical Sciences rebro University Department of Pathology rebro University Hospital

Microscopic colitis, comprising collagenous and lymphocytic colitis, is characterized clinically by chronic watery diarrhea, and a macroscopically normal colonic mucosa where diagnostic histopathological features are seen on microscoplc incidence of each disorder examination. The annual is 4-6/100000 inhabitants, with a peak incidence in 60-70-year-old individuals and a noticeable female predominance for collagenous colitis. The etiology is unknown. Chronic diarrhea, abdominal pain, weight loss, fatigue and fecal incontinence are common symptoms, which impair the health-related quality of life of the patient. There is an association with other autoimmune disorders such as celiac disease, diabetes mellitus, thyroid disorders and arthritis. Budesonide is the best-documented shortterm treatment, but the optimal long-term strategy needs further study. The long-term prognosis is good and the risk of complications including colonic cancer is low.

关键词： Microscopic colitis Collagenous colitis Lymphocytic colitis Chronic diarrhea Budesonide

A 4-year retrospective study of add-on therapy to the fixed combination of dorzolamide/timolol for the treatment of POAG

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 330-334页

作者： curt Hartleben-Matkin Diddier Prada Rafael Mancilla-Vences Glaucoma Service Instituto de Oftalmología Fundación Conde de Valenciana Unidad de Investigación Biomédica en Cáncer Instituto Nacional de Cancerología de México Departamento de Informática Biomédica Faculty of Medicine Universidad Nacional Autónoma de México(UNAM) Laboratory of Environmental Epigenetics Harvard School of Public Health

AIM:To evaluate the long-term response to the fixed combination of dorzolamide/timolol in patients with primary open angle glaucoma(POAG)and the addition of other intraocular pressure(IOP)lowering medications such as prostaglandin analogs and ***:A retrospective,non-randomized,and descriptive clinical study was performed with 182 eyes diagnosed with *** were divided into three groups:a group with fixed combination of dorzolamide/timolol only,a second group with prostaglandin analogs plus fixed combination of dorzolamide/timolol,and a third group with the addition of brimonidine to the same fixed *** data were gathered retrospectively and the differences between groups were ***:IOP was reduced satisfactorily in all three groups;however,a progressive IOP reduction was noted in the group with the fixed combination plus prostaglandin *** this group,a progressive,significant and more homogeneous response of the reduction was noted in comparison with the other ***:IOP reduction was efficacious in all three *** addition of prostaglandin analogs showed progressive IOP reduction,progressive responseand absence of long-term *** did not show a significant additive effect.

关键词： fixed combination, Cosopt® , dorzolamide/timolol, prostaglandin analogs, brimonidine, glaucoma

Challenges and opportunities for nanomaterials in spectral splitting for high-performance hybrid solar photovoltaic-thermal applications:A review

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Nano Materials Science 2020年第3期2卷 183-203页

作者： Gan Huang Sara Riera curt Kai Wang Christos N.Markides Clean Energy Processes(CEP)Laboratory Department of Chemical EngineeringImperial College LondonSouth Kensington CampusLondon SW72AZUnited Kingdom Institute of Refrigeration and Cryogenics Zhejiang UniversityHangzhou310027China

Hybrid photovoltaic-thermal(PV-T)collectors,which are capable of cogenerating useful thermal energy and electricity from the same aperture area,have a significantly higher overall efficiency and ability to displace emissions compared to independent,separate photovoltaic panels,solar thermal collectors or combinations *** splitting has emerged as a promising route towards next-generation high-performance PV-T collectors,and nanotechnology plays an important role in meeting the optical and thermal requirements of advanced spectral splitting PV-T collector *** paper presents a comprehensive review of spectral splitting technologies based on nanomaterials for PV-T *** nanomaterials(nanofluids,nanofilms and nanowires)suitable for achieving spectral splitting based on reflection,diffraction,refraction and/or absorption approaches in PV-T collectors are presented,along with the associated challenges and opportunities of these design *** requirements from such materials in terms of optical properties,thermal properties,stability and cost are discussed with the aim of guiding future research and innovation,and developing this technology towards practical *** and nanofilms are currently the most common nanomaterials used for spectral splitting,with significant progress made in recent years in the development of these ***,there still remains a considerable gap between the optical properties of currently-available filters and the desired properties of ideal *** to instruct and guide the future development of filter materials,a simple generalized method is further proposed in this paper to identify optimal filters and efficiency limits of spectral splitting PV-T systems for different *** is found that the optimal filter of a spectral splitting PV-T system is highly sensitive to the value of thermal energy relative to that of electricity,which therefore depends strongly on

关键词： thermal splitting performance

Bile acid formation in primary human hepatocytes

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World Journal of Gastroenterology 2000年第4期6卷 522-525页

作者： curt Einarsson Ewa Ellis Anna Abrahamsson Bo-Gran Ericzon Ingemar Bjrkhem Magnus Axelson Division of Gastroenterology and Hepatology Department of Medicine Department of Transplantation Surgery Department of Clinical Chemistry Karolinska Institutet at Huddinge University Hospital StockholmSweden Department of Clinical Chemistry Karolinska Institutet at Karolinska Hospital StockholmSweden

AIM To evaluate a culture system for bile acidformation in primary human hepatocytes incomparison with HepG2 *** Hepatocytes were isolated fromnormal human liver tissue and were cultured inserum-free William’s E *** medium wascollected and renewed every 24 *** acids andtheir precursors in media were finally analysed bygas chromatography-mass *** Cholic acid(CA)andchenodeoxycholic acid(CDCA)conjugated withglycine or taurine accounted for 70% and 25% oftotal steroids.A third of CDCA was alsoconjugated with sulphuric *** thyroid hormone alone or in combination didnot significantly effect bile acid *** of cyclosporin A(10 μmol/L)inhibited thesynthesis of CA and CDCA by about 13% and30%,*** Isolated human hepatocytes inprimary culture behave as in the intact liver byconverting cholesterol to conjugated CA *** is in contrast to cultured HepG2 cells,which release large amounts of bile acidprecursors and unconjugated bile acids into themedium.

关键词： bile acid formation cell culture cholesterol metabolism cyclosporin human hepatocytes