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DNA-PKcs subunits in radiosensitization by hyperthermia on hepatocellular carcinoma hepG_2 cell line

World Journal of Gastroenterology 2002年第5期8卷 797-803页

作者： Walter J.curran George Iliakis Department of Radiation Oncology of Kimmel Cancer Center Thomas Jefferson UniversityPhiladelphiaPA 19107USA

AIM: To investigate the role of DNA-PKcs subunits inradiosensitization by hyperthermia on hepatocellularcarcinoma HepG2 cell ***: Hep G2 cells were exposed to hyperthermiaand irradiation. Hyperthermia was given at 45.5 ℃Cellsurvival was determined by an in vitro clonogenic assay forthe cells treated with or without hyperthermia at varioustime points. DNA DSB rejoining was measured usingasymmetric field inversion gel electrophoresis (AFIGE). TheDNA-PKcs activities were measured using DNA-PKcs enzymeassay ***: Hyperthermia can significantly enhanceirradiation-killing cells. Thermal enhancement ratio ascalculated at 10 % survival was 2.02. The difference inradiosensitivity between two treatment modes manifestedas a difference in the α components and the almost sameβ components, which α value was considerably higher inthe cells of combined radiation and hyperthermia ascompared with irradiating cells (1.07 Gy-1 versus 0.44 Gy1). Survival fraction showed 1 logarithm increase after an8-hour interval between heat and irradiation, whereas DNA-PKcs activity did not show any recovery. The cells wereexposed to heat 5 minutes only, DNA-PKcs activity wasinhibited at the nadir, even though the exposure time waslengthened. Whereas the ability of DNA DSB rejoining wasinhibited with the increase of the length of hyperthermictime. The repair kinetics of DNA DSB rejoining aftertreatment with Wortmannin is different from thehyperthermic group due to the striking high slow ***: Determination with the cell extracts andthe peptide phosphorylation assay, DNA-PKcs activity wasinactivated by heat treatment at 45.5 C, and could notrestore. Cell survival is not associated with the DNA-PKcsinactivity after heat. DNA-PKcs is not a unique factor affectingthe DNA DSB repair. This suggests that DNA-PKcs do notplay a crucial role in the enhancement of cellularradiosensitivity by hyperthermia.

关键词：肝癌放射治疗放射敏感性催化作用 DNA激酶

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Adherence to treatment guidelines in the pharmacological management of chronic heart failure in an Australian population

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Journal of Geriatric Cardiology 2011年第2期8卷 88-92页

作者： Dao-Kuo Yao Le-Xin Wang Shane curran Patrick Ball Department of Cardiology Beijing Friendship Hospital Capital Medical University Beijing 100050 China School of Biomedical Sciences and Centre for Inland Health Charles Sturt University Wagga Wagga NSW2678 Australia Department of Emergency Medicine Wagga Wagga Base Hospital and Rural Clinical School University of New South Wales Wagga Wagga NSW 2650 Australia

Background To document the pharmacotherapy of chronic heart failure （CHF） and to evaluate the adherence to treatment guidelines in Australian population. Methods The pharmacological management of 677 patients （female 46.7%, 75.5 ±11.6 years） with CHF was retrospectively analyzed. Results The use of angiotensin converting enzyme （ACE） inhibitors/angiotensin receptor blockers （ARB） and β-blockers were 58.2 % and 34.7 %, respectively. Major reasons for non-use of ACE inhibitors/ARBs were hyperkalemia and elevated serum creatinine level. For patients who did not receive β-blockers, asthma and chronic obstructive pulmonary disease were the main contraindications. Treatment at or above target dosages for ACE inhibitors/ARBs and β-blockers was low for each medication （40.3% and 28.9%, respectively）. Conclusions Evidenced-based medical therapies for heart failure were under used in a rural patient population. Further studies are required to develop processes to improve the optimal use of heart failure medications.

关键词： heart failure ACE inhibitors angiotensin receptor β-blockers prognosis

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Cynicism in British post-war culture

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作者： (1985-)curran Kieran

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A state-of-the-art integrative approach to studying neck biomechanics in vivo

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Science China(Technological Sciences) 2020年第7期63卷 1235-1246页

作者： ZHOU Yu CHOWDHURY Suman REDDY curran WAN Bocheng BYRNE Ryan YIN Wei ZHANG Xudong Department of Industrial&Systems Engineering Texas A&M UniversityCollege StationTX 77843USA Department of Biomedical Engineering Texas A&M UniversityCollege StationTX 77843USA Department of Mechanical Engineering Texas A&M UniversityCollege StationTX 77843USA Department of Industrial Manufacturing&Systems EngineeringTexas Tech UniversityLubbockTX 79409.USA Department of Mechanical Engineering&Materials Science University of PittsburghPittsburghPA 15261USA

Neck injuries are significant causes of morbidity and mortality, and their chronic forms due to repetitive or sustained physical acts(e.g., prolonged use of mobile phone with a dropped head) are becoming increasingly more prevalent. Many injuries are preventable but the prevention and control requires a clear basic understanding of the neck biomechanics. In this paper, we describe a first-of-its-kind study that integrates a gamut of state-of-the-art imaging modalities(dynamic radiography, computed tomography(CT), and magnetic resonance imaging(MRI)) and biodynamic measurements(motion capture, electromyography(EMG), force sensing), thereby investigating holistically the in vivo responses of the neck and its various interconnected musculoskeletal components during functional activities. We present a sample of findings to illustrate how the integrations at multiple levels can enable creating truly subject-specific neck musculoskeletal models and attaining novel insights that otherwise would be unattainable by a singular or subset of approaches.

关键词： neck injury neck biomechanics in vivo integration

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Active power regulation of wind power systems through demand response

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Science China(Technological Sciences) 2012年第6期55卷 1667-1676页

作者： MIAO WeiWei JIA HongJie WANG Dan PARKINSON Simon craw.ord curran DJILALI Ned Key Laboratory of Smart Grid of Ministry of Education Tianjin UniversityTianjin 300072China Institute for Integrated Energy Systems University of VictoriaVictoria BC V8W3P6Canada

With the specific characteristics of low-carbon intensity and economy,wind power has been widely promoted around the *** to the variable and intermittent nature of wind power production,the system has to frequently redispatch generators in order to ensure the effective use of wind power whilst maintaining system *** this way,traditional generation costs are increased and the social benefit of wind power decreases *** this paper,a new regulation strategy based on power flow tracing was proposed,taking advantage of a comfort-constrained demand response strategy to follow the fluctuations of wind farm output,with the remaining imbalance of active power compensated by traditional *** showed that compared with conventional regulation,demand response could reduce the gross operating costs of the system,and the rapid response could help maintaining system stability in case of *** strategy in this paper also applies to other large-scale integration problems associated with renewable energy resources which display short-term production variability.

关键词： wind power active power regulation power flow tracing demand response heat pump

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Visible-Light-Induced Radical Cascade Cyclization： Synthesis of（20S）-Camptothecin, SN-38 and Irinotecan

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Chinese Journal of Chemistry 2018年第11期36卷 1035-1040页

作者： Yao Yuan Wuheng Dong Xiaoshuang Gao Xiaomin Xie Dennis P. curran Zhaoguo Zhang Shanghai Key Laboratory for Molecular Engineering Of Chiral Drugs School of Chemistry and Chemical Engineering Shanghai Jiao Tong Uni- versity 800 Dongchuan Road Shanghai 200240 China Department of Chemistry University of Pittsburgh Pittsburgh Pennsyl-vania PA 15260 USA

(20 S )‐Camptothecin, irinotecan and SN‐38 were successfully synthesized by a photocatalyzed radical cascade cyclization from an N ‐propargyl iodopyridinone and an arylisonitrile under visible light with a ruthenium catalyst. This synthetic method provided a useful entry into composing camptothecin family of antitumor agents in good yields under mild reaction conditions without the use of heavy metal reagents.

关键词： photocatalysis radicals camptothecin irinotecan SN‐38 ruthenium

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Case report of a traumatic rectal neuroma

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Gastroenterology Report 2016年第4期4卷 331-333,I0003页

作者： Thomas curran Vitaliy Poylin Robert Kane Anna Harris Jeffrey DGoldsmith Deborah Nagle Department of Surgery Division of Colorectal SurgeryBeth Israel Deaconess Medical CenterBostonMAUSA Department of Radiology Beth Israel Deaconess Medical CenterBostonMAUSA Department of Pathology Beth Israel Deaconess Medical CenterBostonMAUSA

Traumatic neuroma is a well-recognized complication of lower extremity amputation,yet has also been noted to occur *** report a clinical case and English-language literature review of traumatic rectal neuroma,a well-k... 详细信息

关键词： Traumatic rectal neuroma transanal endoscopic microsurgery

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Accounting fundamentals Michael G. curran, Jr. 7th ed.

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2006年

作者： Michael G. curran Jr.

来源：畅想之星图书光盘版（南... 评论

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The Role of Blockchain in Cyber Security

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Semiconductor Science and Information Devices 2021年第1期3卷 1-9页

作者： Dylan Rafferty Kevin curran School of Computing Engineering&Intelligent SystemsUlster UniversityUK

2021 Cyber security breaches are on the rise *** to the introduction of legislation like the EU’s General Data Protection Regulation(GDPR),companies are now subject to further financial penalties if they fail to meet requirements in protecting user *** 2018,75%of CEOs and board members considered cyber security and technology acquisitions among their top priorities,and blockchain based solutions were among the most considered *** is a decentralised structure that offers multiple security benefits over traditional,centralised network architec*** two approaches are compared in this chapter in areas such as data storage,the Internet of Things(IoT)and Domain Name System(DNS)in order to determine blockchain’s potential in the future of cyber security.

关键词： Blockchain Cybersecurity Distibuted ledgers Bitcoin Cryptocurrencies

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Chinese FDI in the French and Australian Wine Industries： Liabilities of Foreignness and Country of Origin Effects

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Frontiers of Business Research in China 2015年第3期9卷 443-480页

作者： Louise curran Michael Thorpe Toulouse Business School Toulouse 31068 France Curtin Business School Curtin University Perth WA 6845 Australia

This paper explores the recent evolution of Chinese investment in the wine industries in the Bordeaux region of France and Western Australia （WA）. The study identifies variations in the nature of the investments undertaken, which are not always consistent with existing theory. We explore how these differences impact on the liability of foreignness （LOF） experienced （Eden and Miller, 2004; Zaheer, 1995）. We find evidence of all three of the categories of hazards identified by Eden and Miller （2004）, with unfamiliarity being particularly significant, especially for wholly owned investments. We postulate that differences in context between home and host countries are a key factor explaining both the observed difficulties and the differences in experiences. The findings of our work on LOF, in terms of its nature and mitigating strategies, resonate well with existing theory, although we also find evidence of a Country of Origin （COO） effect, both in terms of Liability of Origin （LOR） and Assets of Foreigrmess （AOF）. The variations in entry mode and LOF, however, are less consistent with existing research and pose questions in relation to the interaction between the home and host contexts, company strategy and LOF.

关键词： foreign direct investment (FDI) China wine liability offoreignness (LOF) country of origin

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