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国外医学（肿瘤学分册） 1991年第1期18卷 28-30页

作者： curley sa & roh ms 卢光增

近年在结直肠癌的检出与治疗中出现了一些强调联合应用多种检查方法的新技术和新观念,包括内镜超声显像、癌胚抗原与单克隆抗体等。对早期病例可采取更保守的手术,某些病例可加用术后放疗和自身肿瘤疫苗免疫疗法。随访则强调适当的措施... 详细信息

近年在结直肠癌的检出与治疗中出现了一些强调联合应用多种检查方法的新技术和新观念,包括内镜超声显像、癌胚抗原与单克隆抗体等。对早期病例可采取更保守的手术,某些病例可加用术后放疗和自身肿瘤疫苗免疫疗法。随访则强调适当的措施与频度,强调早期发现复发和转移,以便采取能治愈的措施。

关键词：结肠癌直肠癌诊断

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Brassinosteroids enhance salicylic acid-mediated immune responses by inhibiting BIN2 phosphorylation of clade I TGA transcription factors in Arabidopsis

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Molecular Plant 2022年第6期15卷 991-1007页

作者： Yeong-Woo Kim Ji-Hyun Youn Jeehee roh Jeong-Mok Kim Seong-Ki Kim Tae-Wuk Kim Department of Life Science Hanyang UniversitySeoul 04763Republic of Korea Department of Life Science Chung-Ang UniversitySeoul 06973Republic of Korea Research Institute for Convergence of Basic Science Hanyang UniversitySeoul 04763Republic of Korea Hanyang Institute of Bioscience and Biotechnology Hanyang UniversitySeoul 04763Republic of Korea

salicylic acid (sa) plays an important role in plant immune response, including resistance to pathogens and systemic acquired resistance. Two major components, NONEXPRESSOR OF PATHOGENESIS-RELATED GENES (NPRs) and TGACG motif-binding transcription factors (TGAs), are known to mediate sa signaling, which might also be orchestrated by other hormonal and environmental changes. Nevertheless, the molecular and functional interactions between sa signaling components and other cellular signaling pathways remain poorly understood. Here we showed that the steroid plant hormone brassinosteroid (BR) promotes sa responses by inactivating BR-INSENSITIVE 2 (BIN2), which inhibits the redox-sensitive clade I TGAs in Arabidopsis. We found that both BR and the BIN2 inhibitor bikinin synergistically increase sa-mediated physiological responses, such as resistance to Pst DC3000. Our genetic and biochemical analyses indicated that BIN2 functionally interacts with TGA1 and TGA4, but not with other TGAs. We further demonstrated that BIN2 phosphorylates Ser-202 of TGA4, resulting in the suppression of the redox-dependent interaction between TGA4 and NPR1 as well as destabilization of TGA4. Consistently, transgenic Arabidopsis overexpressing TGA4-YFP with a S202A mutation displayed enhanced sa responses compared to the wild-type TGA4-YFP plants. Taken together, these results suggest a novel crosstalk mechanism by which BR signaling coordinates the sa responses mediated by redox-sensitive clade I TGAs.

关键词： brassinosteroid salicylic acid immune responses BIN2 clade I TGA

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Radiofrequency electric-field heating behaviors of highly enriched semiconducting and metallic single-walled carbon nanotubes

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Nano Research 2015年第9期8卷 2859-2870页

作者： Stuart J. Corr Mustafa Raoof Brandon T. Cisneros Alvin W. Orbaek Matthew A. Cheney Justin J. Law Nadia C. Lara Andrew R. Barron Lon J. Wilsor Steven A. curley Division of Surgery Baylor College of Medicine Houston TX 77030 USA Department of Surgical Oncology University of Texas M.D. Anderson Cancer Center Houston TX 77030 USA Department of Chemistry and the Richard E. Smalley Institute for Nanoscale Science and Technology Rice University Houston TX 77005 USA Department of Surgery The University of Arizona College of Medicine Tucson AZ 85724 USA Department of Chemistry and Biochemistry University of California San Diego La Jolla CA 92093 USA College of Engineering Swansea University Singleton Park Swansea SA2 8PP Wales UK Department of Mechanical Engineering and Materials Science Rice University Houston TX 77005 USA

It is theorized that enhanced thermal heating may result from exposing single-walled carbon nanotubes （SWNTs） embedded in a conductive host to radiofrequency （RF） electric fields. We examine the RF-induced （13.56 MHz） heating behaviors of 95% metallic- and semiconducting-enriched SWNTs （m-/s-SWNTs） suspended in aqueous solutions with varying NaC1 molarity （0.001 mM-1 M）. The heating effects were only evident for host molarities below 1 mM （equivalent to 0.1 S/m） at which the s-SWNT heating rates dominated those of the m-SWNTs. The heating effects were localized to aligned and aggregated ＂SWNT ropes＂ -1 cm in length that formed in suspension, parallel to the electric-field vector, during the RF exposure. For molarities above 1 mM, no enhancements were evident, owing to the large heating effects of the bulk ionic NaC1 suspensions, which were observed in previous studies. Although larger enhancement effects proportional to the host conductivity have been theoretically predicted for m-/s-SWNT suspensions, this was not observed most likely because of the aggregation and screening effects, which diminished the scattered electric field near the m-/s-SWNTs. Our research may further the development of better nanoparticle heating agents for applications such as non-invasive RF-induced cancer hyperthermia.

关键词： rad.iofrequency,carbon nanotubes,metallic,semiconducting,hyperthermia

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Clinical assessment and identification of immuno-oncology markers concerning the 19-gene based risk classifier in stage Ⅳ colorectal cancer

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World Journal of Gastroenterology 2019年第11期25卷 1341-1354页

作者： Jong Lyul Lee Seon Ae roh Chan Wook Kim Yi Hong Kwon Ye Jin Ha Seon-Kyu Kim Seon-Young Kim Dong-Hyung Cho Yong Sung Kim Jin Cheon Kim Department of Surgery University of Ulsan College of Medicine Institute of Innovative Cancer Research Asan Medical Center Medical Genomics Research Center Korea Research Institute of Bioscience and Biotechnology School of Life Sciences Kyungpook National University

BACKGROUND Genomic profiling of tumors has contributed to the understanding of colorectal cancer(CRC), facilitating diagnosis, prognosis and selection of treatments,including targeted regimens. A report suggested that a 19-gene-based risk classifier(TCA19) was a prognostic tool for patients with stage III CRC. The survival outcomes in patients with stage IV CRC are still poor and appropriate selection of targeted therapies and immunotherapies is *** To assess clinical implication of TCA19 in patients with stage IV CRC, and to identify TCA19 with involvement in *** A retrospective review of the medical records of 60 patients with stage IV CRC was conducted, assessing clinicopathological variables and progression-free survival(PFS). TCA19 gene expression was determined by quantitative polymerase chain reaction(qPCR) in matched normal and tumor tissues taken from the study cohort. Expression of potential immune-oncology regulatory proteins and targets was examined by immunohistochemistry(IHC), western blot, immunofluorescence staining in tissues from a validation cohort of 10 patients, and in CRC cell lines co-cultured with monocyte in *** In the patients with TCA19 score higher than the median, the PFS rates of eight patients who received the targeted regimens were significantly higher than the PFS rates of four patients who received 5-fluorouracil-based regimen(P = 0.041).In multivariate analysis, expression of signaling lymphocytic activation molecule family, member 7(SLAMF7) and triggering receptor expressed on myeloid cells 1(TREM1) was associated with PFS in the 60-patient cohort. After checking another 10 validate set, the expression of the IHC, the level of real-time qPCR,and the level of western blot were lower for SLAMF7 and higher for TREM7 in primary and metastatic tumors than in normal tissues. In CRC cells expressing SLAMF7 that were co-cultured with a monocytic cell line, levels of CD 68 and CD73 were significant

关键词： Colorectal cancer Prognosis Immunotherapy Signaling lymphocytic activation molecule family,member 7 Triggering receptor expressed on myeloid cells 1

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