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Global Classical Solutions to Partially Dissipative Quasilinear Hyperbolic Systems with One Weakly Linearly Degenerate Characteristic

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Chinese Annals of Mathematics,Series B 2012年第3期33卷 333-350页

作者： Peng QU cunming liu School of Mathematical Sciences Fudan UniversityShanghai 200433China

For a kind of partially dissipative quasilinear hyperbolic systems without Shizuta-Kawashima condition,in which all the characteristics,except a weakly linearly degenerate one,are involved in the dissipation,the globa... 详细信息

关键词： Global classical solution Quasilinear hyperbolic system Weak lineardegeneracy Partial dissipation

Asymptotic Stability of Equilibrium State to the Mixed Initial-Boundary Value Problem for Quasilinear Hyperbolic Systems

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Chinese Annals of Mathematics,Series B 2015年第3期36卷 323-344页

作者： Yanzhao LI cunming liu School of Mathematical Sciences Fudan University School of Mathematics Taiyuan University of Technology

Under the internal dissipative condition, the Cauchy problem for inhomogeneous quasilinear hyperbolic systems with small initial data admits a unique global C1 solution, which exponentially decays to zero as t →＋∞, while if the coefficient matrix 19 of boundary conditions satisfies the boundary dissipative condition, the mixed initialboundary value problem with small initial data for quasilinear hyperbolic systems with nonlinear terms of at least second order admits a unique global C1 solution, which also exponentially decays to zero as t →＋∞. In this paper, under more general conditions, the authors investigate the combined effect of the internal dissipative condition and the boundary dissipative condition, and prove the global existence and exponential decay of the C1 solution to the mixed initial-boundary value problem for quasilinear hyperbolic systems with small initial data. This stability result is applied to a kind of models, and an example is given to show the possible exponential instability if the corresponding conditions are not satisfied.

关键词： Quasilinear hyperbolic system Mixed initial-boundary value problem Classical solution Asymptotic stability

Enabling Reaction Selectivity of Platinum Catalysts by Photoinduced Electronic Effects

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Precision Chemistry 2023年第4期1卷 248-255页

作者： Kowsalya Devi Rasamani Xinyan Dai Matthew Messner cunming liu Xiaoyi Zhang Yugang Sun Department of Chemistry Temple UniversityPhiladelphiaPennsylvania 19122USA

Reaction selectivity is crucial to producing target molecules of importance with minimum *** work reports an efficient and green strategy to improve reaction selectivity in visible-light-mediated chemical transformations by employing Pt/SiOx photocatalysts,which is ascribed to light-induced surface electronic modification in the small Pt *** strategy has been successfully applied to synthesize commercially valuable but thermodynamically unfavorable arylhydroxylamines with high selectivity via partial hydrogenation of the respective *** modification of the small Pt nanocrystals with triethanolamine(TEA)molecules further optimizes the Pt electronic structure to favor the reaction *** light-induced surface electronic structure alterations and the TEA chemical modification act synergistically to prevent the readsorption of desorbed electron-rich *** prevents the complete hydrogenation of arylhydroxylamines to respective anilines,leading to high arylhydroxylamine selectivity of 81−91%.In addition,photoillumination of Pt nanocrystals always accelerates the reaction kinetics significantly regardless of their surface modification.

关键词： selective photocatalysis enhanced plasmonic absorption hot-electron-driven chemistry photoinduced adsorption/desorption dielectric scattering resonance selective hydrogenation

A clinical investigation of the relationship between different sedation depths and the restlessness after using midazolam as an adjuvant during regional anesthesia

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Journal of Nanjing Medical University 2006年第5期20卷 316-318页

作者： cunming liu Guolou Zhang Mei Gao Zhongyun Wang Qianqing Wang Chuanbao Han Xiufeng Hao Department of Anesthesiology the First Affiliated Hospital of Nanjing Medical University Nanjing 210029 P.R.China

Objective： To investigate the relationship between different sedation depth and the restlessness after using midazolam as an adjuvant during regional anesthesia. Methods ： One hundred and fifty patients undergoing regional anesthesia were randomly divided into three groups. In group A, the patients were sedated at the level of OAA/S IV with midazolam during regional anesthesia. In group B and C, the sedation depths were kept at the levels of Ⅲ and Ⅱrespectively. The changes of BP, HR and SpO2 were recorded before and after midazolam. The rate of restlessness was also evaluated. Results： Blood pressures decreased in certain degree at 5 and 10 min after midazolam compared with those before in all three groups. BP decreased over 20% of the baseline in 4 cases in group A, in 5 cases in group B, and in 5 cases in group C. There was no significant difference in BP dropping among three groups. Compared with group B and C SpO2 dropped significantly at 3 and 5 rain after midazolam in group C, in which SpO2 was less than 93% in 8 cases. The restlessness rate in group C was 22%, which was significantly higher than those in group A （2% ,P〈0.01） and group B（4% ,P〈0.05）. Conclusion： The sedation depth is related to the rate of restlessness when midazolam is used as an adjuvant during regional anesthesia. It is suggested that the appropriate sedation depth for the patients under regional anesthesia is OAA/S Ⅲ.

关键词： midazolam sedation regional anesthesia restlessness

腹腔镜结直肠手术中气管导管套囊压力控制对术中血流动力学及术后咽喉痛的影响

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南京医科大学学报（自然科学版） 2024年第8期44卷 1100-1105页

作者：刘超吉林刘存明南京医科大学盐城临床医学院盐城市第三人民医院麻醉科江苏盐城224001 南京医科大学第一附属医院麻醉与围术期医学科江苏南京210029

目的:探讨腹腔镜结直肠手术中气管导管套囊压力控制对术中血流动力学及术后咽喉痛的影响。方法:选择行腹腔镜结直肠癌根治手术的患者94例。采用随机数字表将患者随机分为H组(导管套囊压力控制组,n=48)和L组(指感法组,n=46)。H组患者套... 详细信息

目的:探讨腹腔镜结直肠手术中气管导管套囊压力控制对术中血流动力学及术后咽喉痛的影响。方法:选择行腹腔镜结直肠癌根治手术的患者94例。采用随机数字表将患者随机分为H组(导管套囊压力控制组,n=48)和L组(指感法组,n=46)。H组患者套囊压力控制在25~30 cmH2O,L组患者仅监测套囊压力。所有患者监测并记录麻醉诱导前(T0)、气管插管后(T1)、建立气腹前(T2)、建立气腹后(T3)、头低足高位后(T4)、气管拔管前(T5)、气管拔管后(T6)时间点的心率(heart rate,HR)、平均动脉压(mean arterial pressure,MAP),以及T1~T5时间点的套囊压力和气道压力。同时调查患者术后2 h、12 h及24 h的咽痛、声嘶情况。结果:L组的HR、MAP、套囊压力在T1~T5均明显高于H组(P0.05)。结论:腹腔镜手术中,控制气管导管套囊压力可以降低术后咽痛的发生率,并保持术中血流动力学的相对稳定。

关键词：气管插管套囊压力结直肠癌咽喉痛血流动力学

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胃部超声在胃排空延迟患者麻醉中的应用进展

临床麻醉学杂志 2022年第6期38卷 654-657页

作者：陈慧刘存明南京医科大学第一临床医学院 211166 南京医科大学第一附属医院麻醉科

利用胃部超声技术评估胃内容物的性质以及胃液量具有可靠性高、操作简便、学习曲线短等优点。胃排空延迟患者在围术期有着更高的反流误吸风险。目前胃部超声技术多应用于不存在明显胃排空障碍的患者,对于某些存在胃排空延迟危险因素的患... 详细信息

利用胃部超声技术评估胃内容物的性质以及胃液量具有可靠性高、操作简便、学习曲线短等优点。胃排空延迟患者在围术期有着更高的反流误吸风险。目前胃部超声技术多应用于不存在明显胃排空障碍的患者,对于某些存在胃排空延迟危险因素的患者,胃部超声在评估胃内容物性质和量的可行性及可靠性方面仍存在诸多争议。本文就胃部超声技术在一些常见的胃排空延迟患者中的应用现状进行综述,为胃部超声技术的合理使用提供参考。

关键词：胃超声反流误吸麻醉

丙泊酚在克罗恩病患者无痛胃肠镜检查中的半数有效剂量

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临床麻醉学杂志 2023年第6期39卷 577-581页

作者：刘婷婷刘存明南京医科大学第一临床医学院 211166 南京医科大学第一附属医院麻醉科

目的采用序贯法测定丙泊酚在克罗恩病患者无痛胃肠镜检查中的半数有效剂量(ED_(50))。方法选择克罗恩病患者24例(D组)和正常体检患者23例(C组),男23例,女24例,年龄18~64岁,BMI 18~30 kg/m^(2),ASAⅠ或Ⅱ级。常规行HR、BP、SpO_(2)和BIS... 详细信息

目的采用序贯法测定丙泊酚在克罗恩病患者无痛胃肠镜检查中的半数有效剂量(ED_(50))。方法选择克罗恩病患者24例(D组)和正常体检患者23例(C组),男23例,女24例,年龄18~64岁,BMI 18~30 kg/m^(2),ASAⅠ或Ⅱ级。常规行HR、BP、SpO_(2)和BIS监测,静脉推注丙泊酚行无痛胃肠镜检查。根据序贯法确定D组丙泊酚初始剂量2.2 mg/kg,C组初始剂量2.4 mg/kg。当BIS为60时进镜,若出现阳性反应,则下一例剂量增加0.2 mg/kg,否则减少0.2 mg/kg。阳性反应定义为麻醉诱导后患者BIS无法降至60,或入镜时出现呛咳或体动反应2级及以上。记录既往行无痛胃肠镜和全麻次数以及低血压和呼吸抑制的发生情况。采用概率回归分析法计算两组的ED_(50)、ED_(95)和95%可信区间(CI),比较两组ED_(50)和ED_(95)。结果与C组比较,D组既往行无痛胃肠镜和全麻的次数明显增多(P<0.05)。D组使用丙泊酚行无痛胃肠镜检查的ED_(50)为2.80 mg/kg(95%CI 2.72~2.88 mg/kg),ED_(95)为3.20 mg/kg(95%CI 3.12~3.32 mg/kg),C组使用丙泊酚行无痛胃肠镜检查的ED_(50)为2.42 mg/kg(95%CI 2.38~2.46 mg/kg),ED_(95)为2.60 mg/kg(95%CI 2.51~2.70 mg/kg)。D组使用丙泊酚行无痛胃肠镜检查的ED_(50)、ED_(95)明显高于C组(P<0.05)。两组低血压和呼吸抑制发生情况差异无统计学意义。结论丙泊酚在克罗恩病患者行无痛胃肠镜检查中的ED_(50)为2.80 mg/kg(95%CI 2.72~2.88 mg/kg),体检患者的ED_(50)为2.42 mg/kg(95%CI 2.38~2.46 mg/kg)。克罗恩病患者可能因曾反复多次行丙泊酚麻醉导致其使用丙泊酚行无痛胃肠镜的用药量高于体检患者,需要增加丙泊酚用量才能满足临床镇静需求。

关键词：克罗恩病体检丙泊酚无痛胃肠镜半数有效剂量

阿片类药物致肠功能障碍的发生机制及防治措施

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中华麻醉学杂志 2020年第12期40卷 1533-1536页

作者：郭敏娜刘存明南京医科大学第一附属医院麻醉与围术期医学科 210029

阿片类药物致肠功能障碍(OIBD)与阿片受体的分布特点有关。阿片受体分布广泛,不仅存在于中枢和外周神经系统,还存在于肠神经系统,使阿片类药物在镇痛的同时带来胃肠道副作用。经典的阿片类受体分为μ受体(MOR)、δ受体(DOR)和κ受体(KOR... 详细信息

阿片类药物致肠功能障碍(OIBD)与阿片受体的分布特点有关。阿片受体分布广泛,不仅存在于中枢和外周神经系统,还存在于肠神经系统,使阿片类药物在镇痛的同时带来胃肠道副作用。经典的阿片类受体分为μ受体(MOR)、δ受体(DOR)和κ受体(KOR)。三种受体在肠神经系统中均有广泛分布,肌间神经丛的阿片受体调节胃肠推进运动,黏膜下神经丛的阿片受体可介导肠液分泌。在生理条件下,内源性阿片肽参与调节肠蠕动和肠液分泌,并发挥免疫调节的作用。然而在病理条件下,阿片类药物可呈剂量依赖性地抑制围术期肠功能恢复,严重者可发生术后肠梗阻。慢性疼痛患者长期使用阿片类药物,可发生食管功能障碍、胃轻瘫、便秘、肠麻痹综合征以及肛门括约肌功能障碍等全消化道不良反应。本文介绍OIBD的发生机制和防治措施,旨在为建立OIBD系统的治疗方案提供参考。

关键词：阿片类药物肠功能障碍阿片受体胃轻瘫内源性阿片肽外周神经系统肠神经系统肌间神经丛

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艾司氯胺酮的临床应用进展

临床麻醉学杂志 2023年第4期39卷 414-417页

作者：杨春刘寒玉刘存明南京医科大学第一附属医院麻醉与围术期医学科 210029

艾司氯胺酮是一种高亲和性的N-甲基-D-天冬氨酸(NMDA)受体非竞争性抑制药,同时具备麻醉和镇痛作用。除了广泛应用于围术期麻醉诱导与维持、急慢性疼痛的治疗与管理外,艾司氯胺酮在精神疾病和急危重症诊疗等多学科和领域同样有较好的临... 详细信息

艾司氯胺酮是一种高亲和性的N-甲基-D-天冬氨酸(NMDA)受体非竞争性抑制药,同时具备麻醉和镇痛作用。除了广泛应用于围术期麻醉诱导与维持、急慢性疼痛的治疗与管理外,艾司氯胺酮在精神疾病和急危重症诊疗等多学科和领域同样有较好的临床应用。艾司氯胺酮国内应用于临床时间尚短,本文拟对其作用机制、药理学特点、围术期应用、疼痛管理中的应用现状以及不良反应进行综述,为临床提供参考。

关键词：艾司氯胺酮麻醉疼痛