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3D micropattern force triggers YAP nuclear entry by transport across nuclear pores and modulates stem cells paracrine

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National Science Review 2023年第8期10卷 180-193页

作者： Yan Li Zhenyu Zhong cunjing xu Xiaodan Wu Jiaqi Li Weiyong Tao Jianglin Wang Yingying Du Shengmin Zhang Advanced Biomaterials and Tissue Engineering Center Huazhong University of Science and Technology Department of Biomedical Engineering Huazhong University of Science and Technology Research Base of Regulatory Science for Medical Devices National Medical Products Administration&Institute of Regulatory Science for Medical Devices Huazhong University of Science and Technology

Biophysical cues of the cellular microenvironment tremendously influence cell behavior by mechanotransduction. However, it is still unclear how cells sense and transduce the mechanical signals from 3D geometry to regulate cell function. Here, the mechanotransduction of human mesenchymal stem cells(MSCs) triggered by 3D micropatterns and its effect on the paracrine of MSCs are systematically investigated. Our findings show that 3D micropattern force could influence the spatial reorganization of the cytoskeleton, leading to different local forces which mediate nucleus alteration such as orientation,morphology, expression of Lamin A/C and chromatin condensation. Specifically, in the triangular prism and cuboid micropatterns, the ordered F-actin fibers are distributed over and fully transmit compressive forces to the nucleus, which results in nuclear flattening and stretching of nuclear pores, thus enhancing the nuclear import of YES-associated protein(YAP). Furthermore, the activation of YAP significantly enhances the paracrine of MSCs and upregulates the secretion of angiogenic growth factors. In contrast, the fewer compressive forces on the nucleus in cylinder and cube micropatterns cause less YAP entering the *** skin repair experiment provides the first in vivo evidence that enhanced MSCs paracrine by 3D geometry significantly promotes tissue regeneration. The current study contributes to understanding the in-depth mechanisms of mechanical signals affecting cell function and provides inspiration for innovative design of biomaterials.

关键词： bioactive materials tissue regeneration 3D micropattern force paracrine mechanotransduction

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Albumin-assembled copper-bismuth bimetallic sulfide bioactive nanosphere as an amplifier of oxidative stress for enhanced radio-chemodynamic combination therapy

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Regenerative Biomaterials 2022年第1期9卷 585-596页

作者： Weiyong Tao Zhan Tuo Feige Wu Ketao Mu cunjing xu Yuxiao Shi Zeyu Sun Yifan Wang Yan Li Zhenyu Zhong Lei Zhou Jianglin Wang Jie Liu Yingying Du Shengmin Zhang Advanced Biomaterials and Tissue Engineering Center Huazhong University of Science and TechnologyWuhan 430074China NMPA Research Base of Regulatory Science for Medical Devices&Institute of Regulatory Science for Medical Devices Huazhong University of Science and TechnologyWuhan 430074China Department of Biomedical Engineering Huazhong University of Science and TechnologyWuhan 430074China Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Biomedical Engineering Sun Yat-sen UniversityGuangzhouGuangdong 510006China

The tumor microenvironment with overexpressed hydrogen peroxide(H_(2)O_(2))and reinforced antioxidative system(glutathione,GSH)becomes a double-edged sword for the accessibility of *** reactive oxygen species(ROS)are easily quenched by the developed antioxidative network,ROS-based treatments such as chemodynamic therapy(CDT)and radiotherapy(RT)for killing cancer cells are severely *** overcome such limitations,a bioactive nanosphere system is developed to regulate intracellular oxidative stress for enhanced radio-chemodynamic combination therapy by using bovine serum albumin(BSA)based bioactive nanospheres that are BSA assembled with in situ generated copper-bismuth sulfide nanodots and diallyl trisulfide(DATS).The copper-bismuth sulfide nanodots react with H_(2)O_(2)to produce·OH and release Cu^(2+).Then,the Cu^(2+)further depletes GSH to generate Cu^(+)for more·OH generation in the way of Fenton-like *** a cascade reaction can initiate·OH generation and GSH consumption to realize *** elevation of ROS triggered by the DATS from BBCD nanospheres further augments the breaking of redox balance for the increased oxidative stress in 4T1 *** the sensitization of increased oxidative stress and high Z element Bi,an enhanced radio-chemodynamic combination therapy is *** current work provides an enhanced radio-chemodynamic combination treatment for the majority of solid tumors by using the co-assembled bioactive nanospheres as an amplifier of oxidative stress.

关键词： bioactive materials nanosphere assembly bismuth-copper radio-chemodynamic therapy

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Synthesis of nano onion-like fullerenes by using Fe/Al_2O_3 as catalyst by chemical vapor deposition

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Chinese Science Bulletin 2009年第1期54卷 137-141页

作者： LIU xuGuang1,2,WANG cunjing1,2,YANG YongZhen1,3,GUO XingMei1,2,WEN HaiRong1,2 & xu BingShe1,3 1 Key Laboratory of Interface Science and Engineering in Advanced Materials,Ministry of Education,Taiyuan University of Tech-nology,Taiyuan 030024,China 2 College of Chemistry and Chemical Engineering,Taiyuan University of Technology,Taiyuan 030024,China 3 College of Materials Science and Engineering,Taiyuan University of Technology,Taiyuan 030024,China Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of Education Taiyuan University of Technology Taiyuan China College of Chemistry and Chemical Engineering Taiyuan University of Technology Taiyuan China College of Materials Science and Engineering Taiyuan University of Technology Taiyuan China

Nano-carbon materials were synthesized by the catalytic decomposition of acetylene at 400℃ by using Fe/Al2O3 as catalyst. The product was refluxed in 36% concentrated HCl at 60℃ for 48 h in order to re-move the catalyst support. The samples were examined by scanning and high resolution transmission electron microscopy,energy dispersive spectroscopy and X-ray diffraction. The results show that nano onion-like fullerenes encapsulating a Fe3C core were obtained. These had a structure of stacked graphitic fragments,with diameters ranging from 15―50 nm. When the product was further heat-treated at 1100℃ for 2 h,nano onion-like fullerenes with a clear concentric graphitic layer structure were obtained. The growth mechanism of nano onion-like fullerenes encapsulating metal cores is suggested to follow a vapor-solid growth model.

关键词：纳米碳材料化学蒸发沉积作用合成增长机制

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村景AI助力乡村建设评价

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世界建筑 2022年第11期 20-21页

作者：陈怡帆许伟攀李郇中山大学

随着乡村振兴战略的不断推进与深化,通过乡村建设评价查找和解决乡村建设中存在的短板和问题显得尤为重要。然而,由于村庄的分布散、规模庞大的特征,基于问卷统计的传统调查方式在收集乡村人居环境数据的工作中十分耗时耗力。研究借助... 详细信息

随着乡村振兴战略的不断推进与深化,通过乡村建设评价查找和解决乡村建设中存在的短板和问题显得尤为重要。然而,由于村庄的分布散、规模庞大的特征,基于问卷统计的传统调查方式在收集乡村人居环境数据的工作中十分耗时耗力。研究借助互联网开发了乡村建设协作平台——“村景拍拍”,通过众包的方式收集乡村图文,建立全国性的大规模村景图片数据库。本文进一步借助人工智能图像解译技术对村景图片的要素进行检测、识别与评估,初步实现对乡村建设的智能化评价。

关键词：乡村建设评价众包平台村景图像解译

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