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Chinese Medical Sciences Journal 2016年第2期31卷 89-94页

作者： Min Xu Zheng-song Gu cun-zu wang Xiao-feng Lu Ding-chao Xiang Zhi-cheng Yuan Qiao-yu Li Min Wu Department of Neurosurgery Kunshan Hospital of Traditional Chinese MedicineKunshan Affiliated Hospital of Nanjing University of Chinese Medicine Department of Neurosurgery Northern Jiangsu People's Hospital Department of Neurosurgery Zhenjiang Hospital of Traditional Chinese Medicine Department of Neurosurgery Wound Institute of Jiangsu University Department of Neurosurgery Zhenjiang First People's Hospital Department of Neurosurgery the Affiliated Hospital of Jiangsu University

Objective In cerebral aneurysm clipping and embolization, blood pressure control and temporaryparent artery blocking are common methods to prevent aneurysm rupture. Their influence on the prognosis isuncertain. In thi... 详细信息

关键词： cerebral aneurysm intraoperative blood pressure control prognosis temporary parent artery blocking

Correlation between type 2 diabetes mellitus remission and intrapancreatic fat deposition

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World Journal of Clinical Cases 2024年第21期12卷 4536-4542页

作者： Jiang Liu Yue Luo Yin-Rong Zhu zu-Tao Wu Yan Hou Yu-Jie Xu Li Li cun-Wen Ma Division of Endocrinology Wenshan Hospital Affiliated to Kunming University of Science and TechnologyWenshan 663000Yunnan ProvinceChina Department of Radiological Medicine Wenshan Hospital Affiliated to Kunming University of Science and TechnologyWenshan 663000Yunnan ProvinceChina

BACKGROUND Intrapancreatic fat deposition(IPFD)exerts a significant negative impact on patients with type 2 diabetes mellitus(T2DM),accelerates disease deterioration,and may lead to impairedβ-cell quality and *** To investigate the correlation between T2DM remission and *** We enrolled 80 abdominally obese patients with T2DM admitted to our institution from January 2019 to October 2023,including 40 patients with weight lossinduced T2DM remission(research group)and 40 patients with short-term intensive insulin therapy-induced T2DM remission(control group).We comparatively analyzed improvements in IPFD[differential computed tomography(CT)values of the spleen and pancreas and average CT value of the pancreas];levels of fasting blood glucose(FBG),2-h postprandial blood glucose(2hPBG),and insulin;and homeostasis model assessment of insulin resistance(HOMA-IR)*** analysis was performed to explore the association between T2DM remission and *** After treatment,the differential CT values of the spleen and pancreas,FBG,2hPBG,and HOMA-IR in the research group were significantly lower than those before treatment and in the control group,and the average CT value of the pancreas and insulin levels were significantly *** analysis revealed that the greater the T2DM remission,the lower the amount of IPFD.

关键词： Intrapancreatic fat deposition Type 2 diabetes mellitus Type 2 diabetes mellitus remission Computed tomography value of pancreas Abdominal obesity

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壶瓶山国家级自然保护区毛冠鹿适生区评估

中国环境科学 2024年第5期44卷 2619-2629页

作者：刘祺唐涛李建军康祖杰于桂清杨存存中南林业科技大学计算机与数学学院湖南长沙410004 中南林业科技大学林学院湖南长沙410004 南方森林资源经营与监测国家林业与草原局重点实验室湖南长沙410004 湖南壶瓶山国家级自然保护区管理局湖南常德415319

壶瓶山国家级自然保护区(简称:壶瓶山保护区)被选为华南虎(Pantheratigrisamoyensis)的野化放归基地,评估华南虎的适生区是实施野化放归的首要工作.毛冠鹿(Elaphoduscephalophus)是保护区华南虎的3种主要猎物之一,评估其适生区能为有效... 详细信息

壶瓶山国家级自然保护区(简称:壶瓶山保护区)被选为华南虎(Pantheratigrisamoyensis)的野化放归基地,评估华南虎的适生区是实施野化放归的首要工作.毛冠鹿(Elaphoduscephalophus)是保护区华南虎的3种主要猎物之一,评估其适生区能为有效估计华南虎的适生区提供了参考.已有毛冠鹿生境选择研究未考虑气候因子和气候变化对其适生区利用与分布的影响.本文利用毛冠鹿的分布数据和环境因子,运用参数组合优化后的MaxEnt模型,评估了毛冠鹿在当前(1970~2000年)气候情景下的适生区利用特征和分布;并分别预测了SSP126(严格环保政策下的低碳排放量情景)和SSP585(宽松的环保政策下的高碳排放量情景)未来2种气候情景中,2050s(2040~2060年)和2090s(2080~2100年)2个时期的毛冠鹿适生区.最后,将不同时期的适生区划分为高、中、低3个等级.结果显示:最湿季度降水量和最冷季度平均温度对毛冠鹿生境选择的影响贡献为56%;当前气候情景下,高、中适生区总面积为486.5km^(2),占保护区总面积的72.9%;未来气候情景下,在SSP126情景中,高、中适生区总面积为553.7km^(2)(2050s)和597.2km^(2)(2090s),分别占保护区总面积的83.0%(2050s)和89.4%(2090s);在SSP585情景中,高、中适生区总面积为382.0km^(2)(2050s)和139.5km^(2)(2090s),分别占保护区总面积的57.2%(2050s)和20.9%(2090s).结果表明气候因子是毛冠鹿生境选择的主要影响因子;人类不同的发展路径将引起气候条件发生变化,这将对毛冠鹿的适生区分布产生显著影响.因此,必须考虑气候因子和气候变化对毛冠鹿生境选择的影响,才可以准确评估和预测壶瓶山保护区内毛冠鹿的适生区分布与变化.研究结果为毛冠鹿种群的保护策略的制定和华南虎野化放归计划的实施提供了重要参考.

关键词：壶瓶山保护区毛冠鹿 MaxEnt模型气候变化适生区

Inhibition of CK2 Activity by TCDD via Binding to ATP-competitive Binding Site of Catalytic Subunit： Insight from Computational Studies

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Chemical Research in Chinese Universities 2013年第2期29卷 299-306页

作者： XU Xian-jin CANNISTRARO Salvatore BIZZARRI Anna-rita ZENG Yi CHEN Wei-zu wang cun-xin College of Life Science and Bioengineering Beijing University of Technology Beijing 100124 P. R. China Biophysics and Nanoscience Centre CNISM Dipartimento di Biologia ed Ecologia(DEB) Universita della Tuscia Viterbo 01100 Italy

Alternative mechanisms of toxic effects induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin（TCDD）, instead of the binding to aryl hydrocarbon receptor（AhR）, have been taken into consideration. It has been recently shown that TCDD reduces rapidly the activity of CK2（casein kinase II） both in vivo and in vitro. It is found that TCDD has high molecular similarities to the known inhibitors of CK2 catalytic subunit（CK2a）. This suggests that TCDD could also be an ATP-competitive inhibitor of CK2a. In this work, docking TCDD to CK2 was carried out based on the two structures of CK2a from maize and human, respectively. The binding free energies of the predicted CK2a-TCDD complexes estimated by the molecular mechanics/Poisson-Boltzmann surface area（MM/PBSA） method are from -85.1 kJ/mol to -114.3 kJ/mol for maize and are from -96.1 kJ/mol to -118.2 kJ/mol for human, which are comparable to those estimated for the known inhibitor and also ATP with CK2a. The energetic analysis also reveals that the van der Waals interaction is the dominant contribution to the binding free energy. These results are also useful for designing new drugs for a target of overexpressing CK2 in cancers.

关键词： Casein kinase II Dioxin Inhibitor Modeling Binding free energy

Environmental characteristics of sandstorm of Minqin Oasis in China for recent 50 years

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Journal of Environmental Sciences 2005年第5期17卷 857-860页

作者： ZHANG Ke-cun QU Jian-jun zu Rui-ping FANG Hai-yan Key Laboratory of Desert and Desertification Cold and Arid Regions Environmental and Engineering Research Institute. Chinese Academy ofSciences Lanzhou 730000 China

The purpose of this present study is to investigate the frequency and variation of sandstorm in Minqin Oasis. Using daily observational data of sandstorm and other meteorologic data from 1954 to 2000, we have illuminated the relationship between sandstorm, meteorological parameters and human activities. The results of the analysis show that the highest frequency of sandstorms occurrence and their duration mainly focus on March, April and May, especially in April. Most of sandstorms occur from midday to nightfall, but relative few appear from midnight to forenoon, which apparently correlates to the daily variations of atmospheric thermal stability within atmospheric boundary layer. Monthly mean and annual mean duration of sandstorms coincide well with the frequencies of sandstorm occurrence.

关键词： Minqin Oasis sandstorm environmental characteristics

Exploring binding mode for styrylquinoline HIV-1 integrase inhibitors using comparative molecular field analysis and docking studies

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Acta Pharmacologica Sinica 2004年第7期25卷 104-112页

作者： Xiao-hui MA, Xiao-yi ZHANG, Jian-jun TAN, Wei-zu CHEN, cun-xin wang2 College of LifeScience and Bioengineering, Beijing University of Technology, Beijing 100022, China College of Life Science and Bioengineering Beijing University of Technology 北京 100022

AIM: To understand pharmacophore properties of styrylquinoline derivatives and to design inhibitors of HIV-1 integrase. METHODS: Comparative molecular field analysis (CoMFA) was performed to analyze three-dimen- sional quantitative structure-activity relationship (3D-QSAR) of styrylquinoline derivatives. Thirty-eight compounds were randomly divided into a training set of 28 compounds and a test set of 10 compounds. The stability of 3D- QSAR models was proved by the analysis of cross-validated and non-cross-validated methods. Moreover, the binding mode of these compounds and integrase was constructed by AutoDock program. RESULTS: The CoMFA model of the training compounds was reasonably predicted with cross-validated coefficient (q2) and conventional (r2) values (up to 0.696 and 0.754). Then the model was validated by the test set. The resulting CoMFA maps visualized structural requirements for the biological activity of these inhibitors. Docking results showed that a carboxyl group at C-7 and a hydroxyl group at C-8 in the quinoline subunit, bound closely to the divalent metal cofactor (Mg2+) around the integrase catalytic site. Moreover, there is a linear correlation between the binding energy of the inhibitors with integrase and their inhibitory effect. CONCLUSIONS: The present study indicated that the CoMFA model together with docking results could give us helpful hints for drug design as well as interpre- tation of the binding affinity between these inhibitors and integrase.

关键词： HIV integrase inhibitors quinolines comparative molecular field analysis AutoDock

Aerobic exercise combined with huwentoxin-I mitigates chronic cerebral ischemia injury

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Neural Regeneration Research 2017年第4期12卷 596-602页

作者： Hai-feng Mao Jun Xie Jia-qin Chen Chang-fa Tang Wei Chen Bo-cun Zhou Rui Chen Hong-lin Qu Chu-zu Wu Key Laboratory of Physical Fitness and Exercise Rehabilitation of Hunan Province Hunan Normal University College of Physical Education Yichun University

Ca2＋ channel blockers have been shown to protect neurons from ischemia, and aerobic exercise has significant protective effects on a variety of chronic diseases. The present study injected huwentoxin-I （HWTX-I）, a spider peptide toxin that blocks Ca2＋ channels, into the caudal vein of a chronic cerebral ischemia mouse model, once every 2 days, for a total of 15 injections. During this time, a subgroup of mice was subjected to treadmill exercise for 5 weeks. Results showed amelioration of cortical injury and improved neurological function in mice with chronic cerebral ischemia in the HWTX-I ＋ aerobic exercise group. The combined effects of HWTX I and exercise were superior to HWTX-I or aerobic exercise alone. HWTX-I effectively activated the Notch signal transduction pathway in brain tissue. Aerobic exercise up-regulated synaptophysin mRNA expression. These results demonstrated that aerobic exercise, in combination with HWTX-I, effectively relieved neuronal injury induced by chronic cerebral ischemia via the Notch signaling pathway and promoting synaptic regeneration.

关键词： nerve regeneration chronic cerebral ischemia aerobic exercise huwentoxin-I Notch signaling pathway calcium overload neuralregeneration

Nervus cutaneus femoris posterior pedicle flap for repairing large soft tissue defects at the heel or inferior segment of the shank

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Chinese Journal of Traumatology 2009年第5期12卷 -页

作者： wang Rui-ying HU Jun-zu XIN Lin-wei TANG Ji-cun GAO Yan Department of Orthopaedics Affiliated Hospital of Guilin Medical College GuilJn 541001 China

Objective: To investigate the clinical effect of the nervus cutaneus femoris posterior pedicle flap on repairing large soft tissue defects at the heel or inferior segment of the ***: Totally 14 cases were followed up for 8-22 months (mean 15.5 months) to observe the clinical effects of nervus cutaneus femoris posterior pedicle flap on repairing large soft tissue defects of the heel or inferior segment of the shank. Among them, there were 3 patients afflicted with infection and cutaneous defects in the middle and inferior segment of the shank after internal fixation of open fracture, 4 patients with soft tissue defects of the ankle and uncovered tendo calcaneus, and 7 patients with soft tissue defects of the heel and exposed ***: The flaps survived well in 13 cases and partial necrosis occurred in 1 case that was thereafter cured with changing dressing. Various extents of pain and stiffness of the knee joints were present in all cases and disappeared through 1-8 weeks' (mean 3.2 weeks) functional exercises. The last follow-up showed that all the flaps kept good texture and satisfactory ***: The nervus cutaneus femoris posterior pedicle flap, having the advantages of simple surgical procedures, anastomosing the nerves and restoring the sensation of recipient site, can be used for recovering large soft tissue defects of the shank and ankle.

关键词： Surgical flaps Soft tissue injuries Heel

High-throughput real-time assay based on molecular beacons for HIV-1 integrase 3'-processing reaction

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Acta Pharmacologica Sinica 2007年第6期28卷 811-817页

作者： Hong-qiu HE~2,Xiao-hui MA~(2,4),Bin LIU~2,Xiao-yi ZHANG~2,Wei-zu CHEN~2,cun-xin wang~(2,3),Shao-hui CHENG~(2,3)~2 College of Life Science and Bioengineering,Beijing University of Technology,Beijing 100022,China College of Life Science and Bioengineering Beijing University of Technology Beijing China Department of Pharmacentical and Biomedical Sciences University of Georgia Athens USA

Aim:To develop a high-throughput real-time assay based on molecular beaconsto monitor the integrase 3’-processing reaction in vitro and apply it to ***:The recombinant human immunodeficiency virus (HIV)-1integrase (IN) is incubated with a 38 mer oligonucleotide substrate,a sequenceidentical to the U5 end of HIV-1 long terminal repeats (LTR).Based on the fluores-cence properties of molecular beacons,the substrate is designed to form a stem-loop structure labeled with a fluorophore at the 5’ end and a quencher at the 3’ *** cleaves the terminal 3’-dinucleotide containing the quencher,resulting in anincrease in fluorescence which can be monitored on a *** this assay,tests were performed to investigate the effects of substrates,enzyme and the metal ion concentrations on the IN activity and optimal param-eters were ***,2 IN inhibitors were employed to test the perfor-mance of this assay in antiviral compound ***:The fluorescentintensity of the reaction mixture varies linearly with time and is proportional to thevelocity of the 3’-processing *** were performed and the results showedthat the optimal rate was obtained for a reaction mixture containing 50 mg/L recom-binant HIV-1 IN,400 nmol/L substrate,and 10 mmol/L Mn2+.The IN 3’-processingreaction under the optimal conditions showed a more than 18-fold increase in thefluorescence intensity compared to the enzyme-free *** IC50values ofthe IN inhibitors obtained in our assay were similar to the values obtained from aradiolabeled substrate ***:Our results demonstrated that this is afast,reliable,and sensitive method to monitor HIV IN 3’-processing reaction andthat it can be used for inhibitor screening.

关键词： HIV integrase 3’-processing molecular beacons

美国老年移民的社会融入研究——密西根州老年华人与墨西哥人的比较视角

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华侨华人历史研究 2020年第3期 21-31页

作者：田烨王存祖兰州大学西北少数民族研究中心/历史文化学院甘肃兰州730000

论文采取问卷调查、个案访谈和实地考察的形式,从经济生活、政治参与、社会交往、文化认同四个方面,对美国密西根州老年华人和老年墨西哥人这两个移民群体的社会融入情况进行了比较研究。研究发现,两个群体的就业参与率、公民投票率等... 详细信息

论文采取问卷调查、个案访谈和实地考察的形式,从经济生活、政治参与、社会交往、文化认同四个方面,对美国密西根州老年华人和老年墨西哥人这两个移民群体的社会融入情况进行了比较研究。研究发现,两个群体的就业参与率、公民投票率等量化指标要远远低于外来移民的平均水平,文化认同上表现出对母国文化和传统习俗的坚守,社会交往呈现出族群内交往的特征。而两者相比较,老年华人的社会融入程度比老年墨西哥人更低。美国社会中的种族歧视是导致老年华人和老年墨西哥人社会融入程度偏低的外部原因,老年华人与老年墨西哥人的文化背景、价值观念、民族特性是导致其社会融入程度偏低的内部原因。他们往往重视经济利益而忽视政治权利,坚守文化认同而疏于社会参与,缺乏融入美国社会的环境和动力,从而形成了美国社会中的"隔坨"和"平行社会"。

关键词：移民研究比较研究华人墨西哥人社会融入