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Protective effect of liraglutide on the myocardium of type 2 diabetic rats by inhibiting polyadenosine diphosphate-ribose polymerase-1

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World Journal of Diabetes 2023年第2期14卷 110-119页

作者： Dong-Dong Xue Xiang zhang De-Wei Li Yan-Lan Yang jing-jin Liu Department of Endocrinology Shanxi Provincial People's HospitalTaiyuan 030000Shanxi ProvinceChina Department of Thyroid Surgery Shanxi Provincial People's HospitalTaiyuan 030000Shanxi ProvinceChina Department of Endocrine Shanxi Provincial People's HospitalTaiyuan 030012Shanxi ProvinceChina

BACKGROUND In recent years,studies have found that the occurrence and development of diabetic cardiomyopathy(DCM)is closely related to an increase in polyadenosine diphosphate-ribose polymerase-1(PARP-1)***-1 activation could be involved in the pathophysiological process of DCM by promoting oxidative stress,the inflammatory response,apoptosis and myocardial *** To investigate the mechanism of liraglutide in improving myocardial injury in type 2 diabetic rats,further clarified the protective effect of liraglutide on the heart,and provided a new option for the treatment of *** Forty healthy male SD rats aged 6 wk were randomly divided into two groups,a normal control group(n=10)and a model group(n=30),which were fed an ordinary diet and a high-sugar and high-fat diet,*** successful modeling,the rats in the model group were fed a high-glucose and high-fat diet for 4 wk and randomly divided into a model group and an intervention group(further divided into a high-dose group and a low-dose group).The rats were fed a high-glucose and high-fat diet for 8 wk and then started drug *** samples were collected from the abdominal aorta to detect fasting blood glucose and lipid *** heart tissue was dissected,and its weight was used to calculate the heart weight *** and eosin staining was used to observe the pathological changes in the myocardium and the expression of PARP-1 in the heart by *** The body weight and heart weight index of rats in the model group were significantly increased compared with those in the normal control group,and those in the intervention group were decreased compared with those in the model group,with a more obvious decrease observed in the high-dose group(P<0.05).In the model group,myocardial fibers were disordered,and inflammatory cells and interstitial fibrosis were *** cardiomyopathy of rats in the intervention group was improved to di

关键词： Liraglutide animal models Type 2 diabetic rats Polyadenosine diphosphate-ribose polymerase-1 Haematoxylin and eosin staining Immunohistochemistry

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Effect of PAHs on Routine Blood and Immunoglobulin Indices of Residents Living in Areas Polluted by Coking

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Biomedical and Environmental Sciences 2020年第4期33卷 286-293页

作者： zhang Ting ZHOU Xiao Lin YANG jin zhang Chao MENG Qian Qian XUE Zhen Wei LI Wei Bin AN Quan LIU Zhan Qi YANG Jia Qiao State Environmental Protection Key Laboratory of Environment and Health(Taiyuan) Department of Radiological and Environmental medicineChina Institute for Radiation Protection(CIRP)Taiyuan 030001ShanxiChina Shanxi Provincial Key Laboratory of Environmental Hazards and Human Health School of Public HealthShanxi Medical UniversityTaiyuan 030001ShanxiChina

Incomplete combustion of bituminous coal will produce a large number of coke oven emissions(COEs).Polycyclic aromatic hydrocarbons(PAHs)account for the largest proportion of these *** enter the human body mainly through the respiratory tract,digestive tract,and skin[1],becoming hydroxyl PAHs(OH-PAHs)following their metabolism by the human body and are ultimately excreted mainly in urine.

关键词： Blood metabolism urine

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Analysis of risk factors for hospital mortality in patients with chronic obstructive pulmonary diseases requiring invasive mechanical ventilation

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Chinese Medical Journal 2007年第4期120卷 287-293页

作者： LIU Hui zhang Tian-tuo YE jin Department of Internal Medicine Division of Pulmonary andCritical Care Department of Otolaryngology Head and Neck Surgery

Background Accurate prediction for prognosis is important for hospitalized patients with chronic obstructive pulmonary disease （COPD） requiring invasive mechanic ventilation （IMV） and for their family members to make end-of-life decisions. The response to therapy in such a patient population has rarely been investigated. The aim of the study was to evaluate the risk factors in these patients and investigate their response to IMV and the relationship between their responses and prognosis. Methods A cohort of 138 patients with COPD requiring IMV≥12 hours for acute respiratory failure of diverse etiological factors during a 4-year period were retrospectively studied using prospectively gathered data. All variables potentially related to hospital mortality were evaluated by univariate and multiple stepwise logistic regression analysis. Results The mean age of all patients investigated was （65.7±11.6） years and the hospital mortality was 39.9% （31.1% with COPD exacerbation）. Correction of acidosis （pHi〉7.30） was seen in 58 patients （69.9%） in survivors but only 12 patients （21.8%） in nonsurvivors （P〈0.05） after ventilation. Using multivariate logistic analysis, the variables independently associated with hospital mortality were a higher acute physiology score before intubation, lower pH value measured 24 hours after the onset of ventilation and development of multiorgan dysfunction syndrome （MODS）. Conclusions In COPD patients requiring IMV, the postintubation pH value can not only reflect patients＇ response to treatment, but also serve as an independent determinant of hospital mortality apart from other risk factors such as a higher preintubation APACHE II score and development of MODS. A close correlation between the response to IMV and prognosis was proved in these patients.

关键词： chronic obstructive pulmonary disease invasive mechanical ventilation mortality respiratory failure

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Load transfer laws of tensile anchors in rock masses with weak interlayers based on a shear-slipping updating model

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Journal of Mountain Science 2022年第3期19卷 812-825页

作者： WANG Yan XIANG Xin LI Chang-dong ZHU Guo-qiang SONG Cheng-bin XIAN jin-ye zhang Jia-jun Faculty of Engineering China University of GeosciencesWuhan 430074China China Three Gorges Corporation Limited Beijing 100038China Three Gorges Research Center for Geo-hazards Ministry of Education China University of GeosciencesWuhan 430074China

The load transfer characteristics of a tensile anchor in the rock mass with weak interlayers were investigated,considering the nonuniform stress of the horizontally layered rock mass along *** improved shear-slipping model was proposed to describe the stress evolution characteristics of the bolt-rock *** on the improved model,analytical solutions of the axial force,shear stress distribution and load-displacement relationship considering the residual stress stage were *** effects of the stratigraphic sequence,pulling force and bolt diameter on the stress distribution of the anchorage interface were evaluated by using analytical *** results were verified by applying the finite difference numerical simulation *** sensitivity of each parameter to the axial force and shear stress of the rock bolt was determined based on calculation of the sensitivity *** study results show that the axial force and shear stress tend to decrease nonuniformly along the rock bolt towards the anchorage *** to the existence of weak interlayers,the shear stress mutates at the weak and hard rock interface,and the axial force appears to“rebound”at the bottom of the anchored *** has more significant effects on the axial force and shear stress at the bottom of the anchor than at the top of the *** pulling force is more sensitive to the anchor stress than stratigraphic sequence when the bolt diameter is *** study provides a theoretical framework for the fundamental problem of tensile bolts in horizontally or vertically laminated rock masses,providing a theoretical basis for anchor design.

关键词： Weak interlayer Tensile anchor Residual stress Shear-slipping updating model Sensitivity

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Abnormalities of electroencephalography microstates in patients with depression and their association with cognitive function

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World Journal of Psychiatry 2024年第1期14卷 128-140页

作者： Rui-Jie Peng Yu Fan jin Li Feng Zhu Qing Tian Xiao-Bin zhang Suzhou Medical College Soochow UniversitySuzhou 215123Jiangsu ProvinceChina Department of Psychiatry Suzhou Psychiatric HospitalThe Affiliated Guangji Hospital of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina

BACKGROUND A growing number of recent studies have explored underlying activity in the brain by measuring electroencephalography(EEG)in people with ***,the consistency of findings on EEG microstates in patients with depression is poor,and few studies have reported the relationship between EEG microstates,cognitive scales,and depression severity *** To investigate the EEG microstate characteristics of patients with depression and their association with cognitive *** A total of 24 patients diagnosed with depression and 32 healthy controls were included in this study using the Structured Clinical Interview for Disease for The Diagnostic and Statistical Manual of Mental Disorders,Fifth *** collected information relating to demographic and clinical characteristics,as well as data from the Repeatable Battery for the Assessment of Neuropsychological Status(RBANS;Chinese version)and *** Compared with the controls,the duration,occurrence,and contribution of microstate C were significantly higher[depression(DEP):Duration 84.58±24.35,occurrence 3.72±0.56,contribution 30.39±8.59;CON:Duration 72.77±10.23,occurrence 3.41±0.36,contribution 24.46±4.66;Duration F=6.02,P=0.049;Occurrence F=6.19,P=0.049;Contribution F=10.82,P=0.011]while the duration,occurrence,and contribution of microstate D were significantly lower(DEP:Duration 70.00±15.92,occurrence 3.18±0.71,contribution 22.48±8.12;CON:Duration 85.46±10.23,occurrence 3.54±0.41,contribution 28.25±5.85;Duration F=19.18,P<0.001;Occurrence F=5.79,P=0.050;Contribution F=9.41,P=0.013)in patients with depression.A positive correlation was observed between the visuospatial/constructional scores of the RBANS scale and the transition probability of microstate class C to B(r=0.405,P=0.049).CONCLUSION EEG microstate,especially C and D,is a possible biomarker in *** with depression had a more frequent transition from microstate C to B,which may relate to more negative ruminati

关键词： Depression Electroencephalography Microstates Cognitive functions

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Exogenous GSH protects tomatoes against salt stress by modulating photosystem Ⅱ efficiency, absorbed light allocation and H2O2-scavenging system in chloroplasts

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Journal of Integrative Agriculture 2018年第10期17卷 2257-2272页

作者： ZHOU Yan DIAO Ming CUI jin-xia CHEN Xian-jun WEN Ze-lin zhang Jian-wei LIU Hui-ying Department of Horticulture Agricultural College Shihezi University Shihezi 832003 P.R. China Key Laboratory of Special Fruits and Vegetables Cultivation Physiology and Germplasm Resources Utilization of Xinjiang Production and Construction Crops Shihezi 832003 P.R.China

The effects of exogenous GSH（reduced glutathione）on photosynthetic characteristics,photosystem Ⅱ efficiency,absorbed light energy allocation and the H2O2-scavenging system in chloroplasts of salt-stressed tomato（Solanum lycopersicum L.）seedlings were studied using hydroponic experiments in a *** of exogenous GSH ameliorated saline-induced growth inhibition,the disturbed balance of Na＋ and Cl- ions and Na＋/K＋ ratios,and the reduction of the net photosynthetic rate（Pn）.GSH also increased the maximal photochemical efficiency of PSⅡ（Fv/Fm）,the electron transport rate（ETR）,the photochemical quenching coefficient（qP）,and the non-photochemical quenching coefficient（NPQ）.In addition,GSH application increased the photochemical quantum yield（Y（Ⅱ））and relative deviation from full balance between the photosystems（β/α-1）and decreased the PSⅡ excitation pressure（1-qP）and quantum yield of non-regulated energy dissipation（Y（NO））in leaves of salt-stressed tomatoes without BSO（L-buthionine-sulfoximine,an inhibitor of key GSH synthesis enzymeγ-glutamylcysteine synthetase）or with ***,the addition of GSH depressed the accumulation of H2O2 and malondialdehyde（MDA）,induced the redistribution of absorbed light energy in PSⅡ reaction centers,and improved the endogenous GSH content,GSH/GSSH ratio and activities of H2O2-scavenging enzymes（including superoxidase dismutase（SOD）,catalase（CAT）,peroxidase（POD）and key enzymes in the AsA-GSH cycle and Grx system）in the chloroplasts of salt-stressed plants with or without ***,GSH application alleviates inhibition of salt-induced growth and photosynthesis mainly by overcoming stomatal limitations,improving the PSⅡ efficiency,and balancing the uneven distribution of light energy to reduce the risk of ROS generation and to mediate chloroplast redox homeostasis and the antioxidant defense system to protect the chloroplasts from oxidative ***,GSH may be used as a potential tool for alleviating salt stress in to

关键词： tomato reduced glutathione NaCl stress chloroplast photosynthesis antioxidant enzyme

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Monolithic three-dimensional integration of aligned carbon nanotube transistors for high-performance integrated circuits

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InfoMat 2023年第7期5卷 81-92页

作者： Chenwei Fan Xiaohan Cheng Lin Xu Maguang Zhu Sujuan Ding Chuanhong jin Yunong Xie Lian-Mao Peng Zhiyong zhang Key Laboratory for the Physics and Chemistry of Nanodevices and Center for Carbon-based Electronics School of ElectronicsPeking UniversityBeijingthe People's Republic of China State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhouthe People's Republic of China

Carbon nanotube field-effect transistors(CNT FETs)have been demonstrated to exhibit high performance only through low-temperature fabrication process and require a low thermal budget to construct monolithic three-dimensional(M3D)integrated circuits(ICs),which have been considered a promising tech-nology to meet the demands of high-bandwidth computing and fully func-tional ***,the lack of high-quality CNT materials at the upper layer and a low-parasitic interlayer dielectric(ILD)makes the reported M3D CNT FETs and ICs unable to provide the predicted high *** this work,we demonstrate a multilayer stackable process for M3D integration of high-performance aligned carbon nanotube(A-CNT)transistors and ICs.A low-κ(-3)interlayer SiO_(2)layer is prepared from spin-on-glass(SOG)through processes with a highest temperature of 220℃,presenting low parasitic capaci-tance between two transistor layers and excellent planarization to offer an ideal surface for the A-CNT and device fabrication process.A high-quality A-CNT film with a carrier mobility of 650 cm 2 V^(-1)s^(-1)is prepared on the ILD layer through a clean transfer process,enabling the upper CNT FETs fabri-cated with a low-temperature process to exhibit high on-state current(1 mAμm^(-1))and peak transconductance(0.98 mSμm^(-1)).The bottom A-CNT FETs maintain pristine high performance after undergoing the ILD growth and upper FET *** a result,5-stage ring oscillators utilizing the M3D architecture show a gate propagation delay of 17 ps and an active region of approximately 100μm 2,representing the fastest and the most compact M3D ICs to date.

关键词： carbon nanotube field-effect transistors monolithic 3D integration ring oscillator

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Exponential Stability of a Robot with Safety System

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Journal of Systems Science and Information 2009年第3期7卷 201-214页

作者： Lihua jin Aidong jin Yufeng zhang Department of Mathematics Science College Yanbian University Yanji 133002 China Teachers college Yanbian University Yanji 133002 China

This paper presents the analysis of exponential stability of a system consisting of a robot and its associated safety mechanism. The system have various modes of failures and is repairable. The paper investigates the nonnegative stead-state solution of system,the existence of strictly dominant eigenvalue and restriction of essential spectrum growth bound of the system operator. The essential spectral radius of the system operator is also discussed before and after perturbation. The results show that the dynamic solution of the system is exponential stab＇flity and converges to the steady-state solution.

关键词： repairable system nonnegative solution simple eigenvalue strictly domi- nant eigenvalue essential spectrum perturbation exponential stability

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Precise control of bainite micro-morphology and the effects on the mechanical properties of ultrahigh-strength complex-phase sheet steel

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Baosteel Technical Research 2023年第1期17卷 32-38页

作者： zhang Hanlong jin Xinyan zhang Yulong Research Institute Baoshan Iron&Steel Co.Ltd.Shanghai 201999China State Key Laboratory of Development and Application Technology of Automotive Steels(Baosteel) Shanghai201999China

Bainite, the main microstructure of ultrahigh-strength complex-phase(CP) sheet steel, usually exhibits various micro-morphologies when subjected to different austempering *** the current study, conventional austempering treatment at the bainite nose temperature resulted in two bainite types with distinct micro-morphologies: polygonal blocky bainite and acicular bainite, which resulted in large fluctuations in the mechanical properties of CP steel, particularly yield strength and hole expansion ***, the precise control of bainite micro-morphology was studied and applied to separate the two bainite types through austempering *** two bainite types of different micro-morphologies had different effects on the mechanical properties of CP steel: the acicular bainite favored hole expansion and flangeability but deteriorated ductility, while the polygonal blocky bainite favored ductility but deteriorated hole expansion and ***, two types of ultrahigh-strength CP steels of different mechanical properties can be stably manufactured through the precise control of bainitic micro-morphology to satisfy the specific demands of vehicle components in terms of the mechanical properties of CP steels.

关键词： UHSS microstructure control austempering bainite:

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论深入实施创新驱动发展战略的“三引擎”

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经济体制改革 2016年第1期 14-19页

作者：张述存山东省社会科学院

从表征看,当前我国经济的新常态是国内外经济周期性波动的结果,但其实质则是经济发展由投资驱动和要素驱动向创新驱动转变的必然选择。深入实施创新驱动发展战略,应充分发挥政府、市场、社会"三引擎"的作用。其中,政府应施力于创新政策... 详细信息

从表征看,当前我国经济的新常态是国内外经济周期性波动的结果,但其实质则是经济发展由投资驱动和要素驱动向创新驱动转变的必然选择。深入实施创新驱动发展战略,应充分发挥政府、市场、社会"三引擎"的作用。其中,政府应施力于创新政策体系,打造创业创新生态;市场应依托互联网平台,全面践行大众创业、万众创新;社会第三方应着力于提升服务能力,开掘多元智慧。

关键词：创新驱动三引擎政府市场社会

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