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Food Science and Human Wellness 2023年

作者： Liang Tao Zi-Lin Wang Min Yang Xin-Rui Kang Jia-He Dai cun-chao zhao Tian-Yi Dai Jun Sheng Yang Tian Puer University National Research and Development Professional Center for Moringa Processing Technology Yunnan Agricultural University Engineering Research Center of Development and Utilization of Food and Drug Homologous Resources Ministry of Education Yunnan Agricultural University Yunnan Provincial Engineering Research Center for Edible and Medicinal Homologous Functional Food Yunnan Agricultural University College of Food Science and Technology Yunnan Agricultural University

Moringa oleifera Lam. (M. oleifera Lam) is a Moringa genus in the Moringaceae family that is high in nutrients and has a wide range of applications. Phenolic compounds are widely found in plants and have various health benefits for the human body. With its high content and wide variety of phenolic compounds， M. oleifera Lam has been widely studied for its health benefits. The phenolic compounds in M. oleifera Lam (MOPCs) can be a potential source of functional food ingredients in pharmaceutical and industrial applications. Numerous studies have shown that MOPCs have antioxidant， anti-obesity， anti-diabetic， and antibacterial effects. Although the research on MOPCs has been gradually increasing， the extraction， isolation， identification， biological activities， and comprehensive application of MOPCs need a more systematic summary and generalization. Therefore， this paper reviews the isolation and extraction methods， structure identification， biological activities， and comprehensive applications to provide a further reference for the research and application of MOPCs.

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Moringia oleifera Lam. seeds isothiocyanate against skin photoaging by regulating p38MAPK-dependent autophagy signalling pathway

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Food Science and Human Wellness 2023年

作者： Min Yang Ling-Yan Su Liang Tao Ling-Fei Li Yi-Jin Wang Zi-Lin Wang cun-chao zhao QianQian-OuYang Jun Sheng Yang Tian College of Food Science and Technology Yunnan Agricultural University Yunnan Key Laboratory of Precision Nutrition and Personalized Food Manufacturing Yunnan Agricultural University PuEr University Marine Biomedical Research Institution Guangdong Medical University Engineering Research Center of Development and Utilization of Food and Drug Homologous Resources Ministry of Education Yunnan Agricultural University The Marine Biomedical Research Institute of Guangdong Zhanjiang China

People living long-term in areas with UV will cause premature photoaging. An abnormal reduction in autophagy is a key feature of photoaging， and p38MAPK has been regarded as a key regulator of autophagy. Isothiocyanate is one of the main active components of Moringa oleifera Lam. seeds. Studies have reported that MITC has anticancer， anti-inflammatory， cardiometabolic repair， nervous system protection， blood lipid regulation and diabetes prevention properties. However， the molecular mechanisms of MITC with protective effects against skin photoaging have not been studied thus far. In this study， we aimed to evaluate the antiphotoaging activity of MITC and to investigate the effect of p38MAPK-dependent autophagy in vivo and in vitro models of photoaging. In this research we found that MITC can reverse the intracellular ROS content and inhibit the activation of p38MAPK to improve the autophagy level， reduce the expression of MMPs， and finally protect against photoaging by UV. Our results will uncover the molecular mechanisms of MITC that play a role in the protective effects against skin photoaging， provide helpful information for developing MITC as an ant-photoaging plant material and improve the utilization of Moringa oleifera Lam. seeds.

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Amorphous oxide semiconductor for monolithic 3D DRAM: an enabler or passer-by?

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National Science Review 2024年第3期11卷 19-20页

作者： Shujuan Mao Guilei Wang chao zhao Beijing Superstring Academy of Memory Technology

Since dynamic random-access memory(DRAM) was invented in 1968 and put to market in the 1970s, 1 transistor plus 1 capacitor(1T1C)(Fig. 1a) cells have been used to take advantage of their structural simplicity and ease...

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How plants sense and respond to osmotic stress

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Journal of Integrative Plant Biology 2024年第3期66卷 394-423页

作者： Bo Yu Dai-Yin chao Yang zhao Shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesThe Chinese Academy of SciencesShanghai 200032China Key Laboratory of Plant Carbon Capture The Chinese Academy of SciencesShanghai 200032China National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyThe Chinese Academy of SciencesShanghai 200032China University of Chinese Academy of Sciences Beijing 100049China

Drought is one of the most serious abiotic stresses to land plants.Plants sense and respond to drought stress to survive under water deficiency.Scientists have studied how plants sense drought stress,or osmotic stress caused by drought,ever since Charles Darwin,and gradually obtained clues about osmotic stress sensing and signaling in plants.Osmotic stress is a physical stimulus that triggers many physiological changes at the cellular level,including changes in turgor,cell wall stiffness and integrity,membrane tension,and cell fluid volume,and plants may sense some of these stimuli and trigger downstream responses.In this review,we emphasized water potential and movements in organisms,compared putative signal inputs in cell wall-containing and cell wall-free organisms,prospected how plants sense changes in turgor,membrane tension,and cell fluid volume under osmotic stress according to advances in plants,animals,yeasts,and bacteria,summarized multilevel biochemical and physiological signal outputs,such as plasma membrane nanodomain formation,membrane water permeability,root hydrotropism,root halotropism,Casparian strip and suberin lamellae,and finally proposed a hypothesis that osmotic stress responses are likely to be a cocktail of signaling mediated by multiple osmosensors.We also discussed the core scientific questions,provided perspective about the future directions in this field,and highlighted the importance of robust and smart root systems and efficient source-sink allocations for generating future high-yield stress-resistant crops and plants.

关键词： cell volume drought membrane tension osmotic stress turgor

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Enhanced thermoelectric and mechanical properties of Bi0.5Sb1.5Te3 alloy with dispersed yttrium oxide ceramic nanoparticles

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Rare Metals 2024年第4期43卷 1758-1768页

作者： cun-Cheng Li Ming-Wei Zhang Ji-Wu Xin Lei Wei Wen-Yu zhao School of Materials Science and Engineering Shandong University of Technology School of Electrical and Electronic Engineering Nanyang Technological University State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology

Reducing thermal conductivity while avoiding adverse interfacial reactions during sintering is crucial for improving the thermoelectric performance of Bi2Te3-based composites.Inert ceramic nanoparticles are good candidates for achieving this goal.In this study,we designed and prepared a series of p-type Bi0.5Sb1.5Te3nanocomposites decorated with Y2O3ceramic nanoparticles via ball-milling dispersion and spark-plasma sintering.Owing to the chemical stability of the ceramics,no traces of atomic doping or interfacial reactions were observed.Transport measurements revealed that the Y2O3nanoparticles distributed along the grain boundaries acted as energy-dependent carrier-filtering centers to improve the scattering parameter and Seebeck coefficient,contributing to the elevated power factor even with a decreased electrical conductivity.Moreover,the incorporated Y2O3nanoparticles and various defect structures they induced effectively strengthened the phonon scattering and suppressed the lattice thermal conductivity.Consequently,a peak figure of merit（ZT） of 1.23 at 313 K was achieved for 0.4%Y2O3/Bi0.5Sb1.5Te3,which is 13% higher than that of the matrix.In addition,the Vickers hardness of the composite material was 35% higher than that of the matrix.This study demonstrates the effectiveness of ceramic nanoparticles in synergistic ally improving the thermoelectric and mechanical properties,which may be further extended to other thermoelectric systems.

关键词： Bi 0.5 Sb 1.5 Te 3 alloy Y 2 O 3 ceramic nanoparticles Microstructures Thermoelectric performance Mechanical properties

Coexistence of liver abscess, hepatic cystic echinococcosis and hepatocellular carcinoma: A case report

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World Journal of Clinical Cases 2024年第14期12卷 2404-2411页

作者： Ya-Wen Hu Yi-Lin zhao Jing-Xin Yan cun-Kai Ma Department of Interventional Therapy The Affiliated Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina West China Hospital Sichuan UniversityChengdu 610000Sichuan ProvinceChina

BACKGROUND Human cystic echinococcosis(CE)is a life-threatening zoonosis caused by the Echinococcus granulosus(sensu lato).Hepatocellular carcinoma(HCC)is a leading cause of cancer-related mortality in the world.The coexistence of CE and HCC is exceedingly rare,and only several well-documented cases have been reported.In addition to this coexistence,there is no report of the coexistence of CE,HCC,and liver abscess to date.Herein,we aimed to report a case of coexistence of liver abscess,hepatic CE,and HCC.CASE SUMMARY A 65-year-old herdsman presented to the department of interventional therapy with jaundice,right upper abdominal distension and pain for 10 d.Laboratory test showed that he had positive results for HBsAg,HBeAb,HBcAb,and echino-coccosis IgG antibody.The test also showed an increased level of alpha fetopro-tein of 3400 ng/mL.An abdominal computed tomography(CT)scan revealed an uneven enhanced lesion of the liver at the arterial phase with enhancement and was located S4/8 segment of the liver.In addition,CT scan also revealed a mass in the S6 segment of the liver with a thick calcified wall and according to current guideline and medical images,the diagnoses of hepatic CE(CE4 subtype)and HCC were established.Initially,transarterial chemoembolization was performed for HCC.In the follow-up,liver abscess occurred in addition to CE and HCC;thus,percutaneous liver puncture drainage was performed.In the next follow-up,CE and HCC were stable.The liver abscess was completely resolved,and the patient was discharged with no evidence of recurrence.CONCLUSION This is the first reported case on the coexistence of liver abscess,hepatic CE,and HCC.Individualized treatment and multidisciplinary discussions should be performed in this setting.Therefore,treatment and diagnosis should be based on the characteristics of liver abscess,hepatic CE,and HCC,and in future clinical work,it is necessary to be aware of the possibility of this complex composition of liver diseases.

关键词： Cystic echinococcosis Hepatocellular carcinoma Liver abscess Multidisciplinary discussions Case report

Grain-boundary segregation and grain growth in nanocrystalline substitutional solid solution alloys

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Journal of Materials Science & Technology 2024年第1期168卷 239-249页

作者： Fawei Tang chao Hou Hao Lu Zhi zhao Xiaoyan Song Faculty of Materials and Manufacturing Key Laboratory of Advanced Functional MaterialsMinistry of Education of ChinaBeijing University of TechnologyBeijing 100124China

A model for describing solute segregation at grain boundaries has been developed for substitutional solid solution alloys,which integrates multiple factors from atomic to microstructural scales.A concept of mo-lar Gibbs free energy of segregation was introduced to evaluate the segregating capability of the solute elements in a closed system,through which the influences of grain boundary structure,grain size,ma-terial composition,and external conditions were described.Based on the evaluation of various energy forms related to solute segregation and grain growth processes,the nature of the thermal stabilization of nanograin structures by solute segregation was disclosed.A criterion for the destabilization of nanostruc-tures,which is determined by the competition of the change rates between the molar Gibbs free energy of segregation and the total energy of grain boundaries with grain size,has been proposed.This study provided guideline to achieve high-temperature stability of nanograin structures of solid solution alloys even for the weakly segregating nanocrystalline systems.

关键词： Substitutional solid solution Grain boundary segregation Thermal stabilization Solute concentration Grain size

Lipid metabolism analysis in esophageal cancer and associated drug discovery

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Journal of Pharmaceutical Analysis 2024年第1期14卷 1-15页

作者： Ruidi Jiao Wei Jiang Kunpeng Xu Qian Luo Luhua Wang chao zhao Bionic Sensing and Intelligence Center Institute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong518000China Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhenGuangdong518116China School of Medicine Southern University of Science and TechnologyShenzhenGuangdong518000China University of Chinese Academy of Sciences Beijing100049China Shenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong518000China

Esophageal cancer is an upper gastrointestinal malignancy with a bleak prognosis.It is still being explored in depth due to its complex molecular mechanisms of occurrence and development.Lipids play a crucial role in cells by participating in energy supply,biofilm formation,and signal transduction processes,and lipid metabolic reprogramming also constitutes a significant characteristic of malignant tumors.More and more studies have found esophageal cancer has obvious lipid metabolism abnormalities throughout its beginning,progress,and treatment resistance.The inhibition of tumor growth and the enhancement of antitumor therapy efficacy can be achieved through the regulation of lipid metabolism.Therefore,we reviewed and analyzed the research results and latest findings for lipid metabolism and associated analysis techniques in esophageal cancer,and comprehensively proved the value of lipid metabolic reprogramming in the evolution and treatment resistance of esophageal cancer,as well as its significance in exploring potential therapeutic targets and biomarkers.

关键词： Lipid metabolism Esophageal cancer Progression Treatment resistance New therapeutic targets

Robust, breathable, and chemical-resistant polytetrafluoroethylene (PTFE) films achieved by novel in-situ fibrillation strategy for highperformance triboelectric nanogenerators

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Nano Research 2024年第3期17卷 1942-1951页

作者： Jialong Chai Guilong Wang Jinchuan zhao Guizhen Wang chao Wei Aimin Zhang Guoqun zhao Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) Shandong UniversityJinan 250061China Key Laboratory of Chinese Education Ministry for Tropical Biological Resources Hainan UniversityHaikou 570228China

In the era of advanced wearable electronic devices,the triboelectric nanogenerators(TENGs)as energy harvesting and self-powered sensing units hold great promise.Selecting appropriate triboelectric material is the crucial factor to optimize the performance of TENG,while polytetrafluoroethylene(PTFE)stands out as a highly versatile option among the various materials.In this study,we present an ultrafine nanofibrous PTFE(NF-PTFE)films prepared by novel in-situ fibrillation strategy as the triboelectric material in TENG devices.The innovative processing methodology facilely addresses the dilemma between high porosity and fine pore size of traditional porous PTFE films,meanwhile achieves exceptional mechanical strength,hydrophobicity,air permeability,and chemical resistance of the films.With the integration of nanofibrous PTFE films into contact-separation mode TENG and droplet-based TENG,these devices realize the peak electrical output of 131 V/10.8μA and 54 V/14μA with great durability,which surpass the performance of TENGs using traditional expanded PTFE films.Furthermore,a smart glove capable of recognizing hand gestures is proposed,which demonstrates the versatility,flexibility,and practicality of this material for potential use in smart devices.This reported NF-PTFE film provides insights for the design of high-performance TENG device for advanced wearable electrical applications.

关键词： polytetrafluoroethylene(PTFE) nanofibrous film hydrophobic triboelectric nanogenerator self-powered sensor

Understanding Discrepancy of Power System Dynamic Security Assessment with Unknown Faults: A Reliable Transfer Learning-based Method

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 427-431页

作者： chao Ren Han Yu Yan Xu zhao Yang Dong School of Computer Science and Engineering Nanyang Technological UniversitySingapore School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore

This letter proposes a reliable transfer learning(RTL)method for pre-fault dynamic security assessment(DSA)in power systems to improve DSA performance in the presence of potentially related unknown faults.It takes individual discrepancies into consideration and can handle unknown faults with incomplete data.Extensive experiment results demonstrate high DSA accuracy and computational efficiency of the proposed RTL method.Theoretical analysis shows RTL can guarantee system performance.

关键词： Adversarial training dynamic security assessment maximum classifier discrepancy missing data transfer learning