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Significance of Immunoglobulin E in Umbilical Blood in Relation to an Allergic Family History, Seasonality, Child Immunity and the Impact of Applied Non-pathogenic E. coli on Children＇s Microbiome

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Journal of Life Sciences 2017年第3期11卷 105-124页

作者： Liska Jiri Siala Konrad culakova blanka Holecek Vaclav Sobotova Stepanka Sykora Josef SefrnaFrantisek Newborn Department Mulac Hospital Pilsen 301 00 Czech Republic Department of Clinical Chemistry and Hematology Mulac Hospital Pilsen 30100 Czech Republic Department of Pediatrics Faculty of Medicine Faculty Hospital Charles University Pilsen 301 00 Czech Republic Department of Health Accounting and Statistics University Hospital Pilsen 301 00 Czech Republic

We examined IgE levels in 4,312 samples of umbilical blood taken from children born into families with a positive history of allergy in one or both parents from 1998-2015. At the age often days, those with high IgE were given Colinfant Newborn （a lyophilized non-pathogenic strain of E. coli） for one month, three times weekly. At 15 months and three years we investigated the levels of IgE, IgA and IgG, and the incidence of illness and allergy. The results revealed that allergy and high umbilical IgE is strongly linked with family history （p 〈 0.001）. We also detected differences in seasonality, especially with regards to pollen allergies. About 80% of children treated with Colinfant had significantly reduced IgE and morbidity at 13-15 months and 3 years, and furthermore without any clinical signs of allergy. Surprisingly 20% of treated children did not have reduced IgE, and yet they did not have any clinical signs of allergy. Normalization of IgA and IgG was seen in 90% of treated subjects （p 〈 0.001）. These levels significantly are correlated with an almost negligible morbidity up to 4 years of life. Our study strongly suggests a positive effect of physiological E. coli on the microbiome of children as evidenced by a significantly reduced incidence of allergy and morbidity when applied early in life.

关键词： Microbiome allergy immunology newborn probiotics.

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