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玲珑金矿田48号矿脉蚀变钾长石稳定结构态温度估算及其找矿意义

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地质找矿论丛 2021年第1期36卷 29-38页

作者：张腾飞王翠芝吕古贤张宝林焦建刚刘维民杨桂彬常增沛严千豪陈振福州大学紫金矿业学院福州350108 中国地质科学院地质力学研究所北京100081 中国科学院地质与地球物理研究所北京100029 长安大学西安710054 山东黄金矿业(玲珑)有限公司山东招远265406 山东正元地球物理信息技术有限公司济南250101

胶东大开头金矿区位于玲珑断裂和破头青断裂夹持区。48号脉位于玲珑金矿田大开头矿区的西南侧,金矿床为石英脉型—蚀变岩型,围岩有二长花岗岩、钾化花岗岩、绢英岩化花岗岩、绢英岩、黄铁绢英岩、煌斑岩等。本文以玲珑金矿田大开头矿区4... 详细信息

胶东大开头金矿区位于玲珑断裂和破头青断裂夹持区。48号脉位于玲珑金矿田大开头矿区的西南侧,金矿床为石英脉型—蚀变岩型,围岩有二长花岗岩、钾化花岗岩、绢英岩化花岗岩、绢英岩、黄铁绢英岩、煌斑岩等。本文以玲珑金矿田大开头矿区48号脉矿体两侧钾化花岗岩中钾长石为研究对象,通过X射线粉晶衍射、电子探针等方法研究钾长石晶体结构态及其类别、形成温度与稳定结构态温度,研究结果表明:①48号脉矿体中钾长石应为最大微斜长石;②矿脉两侧钾化蚀变时的温度为410℃~470℃,稳定结构态温度为244℃~274.6℃;③钾长石形成稳定结构态的热液温度环境有利于金的沉淀富集,该类钾长石是深部找矿的良好标志。

关键词：钾长石化二长石温度计长石结构态玲珑金矿田山东省

An appropriate treatment interval does not afect the prognosis of patients with breast Cancer

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Holistic Integrative Oncology 2022年第1期1卷 127-133页

作者： Wei Gao Jiaxing wang Sifei Yin cuizhi Geng Binghe Xu East Tianshan Avenue Shijiazhuang 050035HebeiChina Department of Chemical and Systems Biology Stanford UniversityStanfordCalifornia 94305USA National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Purpose:Major public health emergencies may lead to delays or alterations in the treatment of patients with breast cancer at each stage of diagnosis and *** much do these delays and treatment changes afect treatment outcomes in patients with breast cancer?Methods:This review summarized relevant research in the past three decades and identifed the efect of delayed treatment on the prognosis of patients with breast cancer in terms of seeking medical treatment,neoadjuvant treatment,surgery,postoperative chemotherapy,radiotherapy,and targeted ***:Delay in seeking medical help for≥12weeks afected the *** treatment within 4 weeks of diagnosis did not afect patient *** neoadjuvant chemotherapy within 8 weeks after diagnosis,receiving surgical treatment at 8 weeks or less after the completion of neoadjuvant chemotherapy,and receiving radiotherapy 8 weeks after surgery did not afect patient *** chemotherapy did not increase the risk of relapse in patients with luminal A breast *** 4 weeks of delay in the start of postoperative chemotherapy in patients with luminal B,triple-negative,or HER2-positive breast cancer treated with trastuzumab will adversely afect the *** treatment delays in patients with HER2-positive breast cancer should not exceed 60days after surgery or 4months after *** within 8 weeks after surgery did not increase the risk of recurrence in patients with early breast cancer who were not undergoing adjuvant ***:Diferent treatments have diferent time sensitivities,and the careful evaluation and management of these delays will be helpful in minimizing the negative efects on patients.

关键词： Treatment delay Risk evaluation Prognosis Breast cancer

Establishment of Molecular Biological Method for Identification of Bacteria by 16S rDNA and gyrB Gene

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Asian Agricultural Research 2023年第4期15卷 21-25页

作者： Xiaxia HOU Yunxia wang cuizhi LI Zhiyong LU Inner Mongolia Yili Industrial Group Co. Ltd.Hohhot 010110China

[Objectives]The paper was to establish a molecular biological method for identification of bacterial strains.[Methods]The thalli of standard bacterial strains existing in the laboratory were collected and genomic DNA was extracted for amplification of 16S rDNA and gyrB *** 16S rDNA and gyrB gene sequences were obtained after *** were aligned and analyzed via EzBioCloud and NCBI database,and phylogenetic trees were constructed to determine the species relationship of ***,they were compared with known strains.[Results]This method could identify 5 standard strains accurately to the species *** 16S rDNA and gyrB gene sequences were aligned and analyzed in EzBioCloud database and NCBI *** strain with the max score was consistent with the known *** the query cover and ident were both above 99%.[Conclusions]The established molecular biological method for identification of bacterial strains by 16S rDNA and gyrB gene has good accuracy,which effectively solves the problem that the laboratory identification of bacteria relies on traditional methods and the accuracy can not be guaranteed,and further improves the identification ability of laboratory bacterial strains.

关键词： 16S rDNA gyrB Bacterial identification Molecular biological method

Evaluation on Uncertainty of Detection Results of Aerobic Plate Count

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Asian Agricultural Research 2021年第6期13卷 59-63页

作者： Yunxia wang Lijuan JING cuizhi LI Zhiyong LU Lijun LIU Quality Management Department Inner Mongolia Yili Industrial Group Co. Ltd. Hohhot 010110 China

[Objectives]To determine the aerobic plate count(APC)in the milk samples,evaluate the uncertainty of the test results,and to provide a scientific basis for the quality control of the testing process.[Methods]In compliance with the national food safety standard Food Microbiological Examination:Aerobic Plate Count(GB 4789.2-2016),the aerobic plate count in the milk samples was *** source of the uncertainty of the test result was analyzed and a mathematical model was established in accordance with Evaluation and Expression of Uncertainty in Measurement(JJF 1059.1-2012).Then,the introduced uncertainty components were evaluated to determine the uncertainty of the final combined aerobic plate count.[Results]The expanded uncertainty of the test result of the aerobic plate count in the milk samples was 0.0434,and the logarithmic value interval of the results was(3.924,4.010),and the antilogarithm was taken to get the aerobic plate count in the sample to be 8395-10233 CFU/mL.[Conclusions]This method can effectively evaluate the uncertainty of the aerobic plate count,and ensure the accurate and scientific laboratory test data.

关键词： Aerobic plate count(APC) Uncertainty Quality assurance Food safety

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延迟治疗对乳腺癌患者预后的影响

中华医学杂志 2020年第36期100卷 2804-2807页

作者：王嘉兴耿翠芝河北医科大学第四医院乳腺中心石家庄050035

本文综合分析了国内外相关研究,提出了延迟治疗对乳腺癌患者预后的影响因素:(1)就医延迟时间:≥12周影响患者预后;(2)手术时间:病理诊断后4周内、新辅助化疗后不超过8周接受手术治疗对患者预后不会产生影响;(3)化疗时间:确诊后8周内开... 详细信息

本文综合分析了国内外相关研究,提出了延迟治疗对乳腺癌患者预后的影响因素:(1)就医延迟时间:≥12周影响患者预后;(2)手术时间:病理诊断后4周内、新辅助化疗后不超过8周接受手术治疗对患者预后不会产生影响;(3)化疗时间:确诊后8周内开始新辅助化疗以及术后4周内进行辅助化疗均不会缩短患者生存时间;(4)靶向治疗时间:HER2阳性乳腺癌患者靶向治疗延迟不应超过乳腺癌确诊后4个月;(5)放疗时间:保乳患者的手术或化疗结束8周内接受放疗不影响局部复发率。

关键词：乳腺肿瘤治疗延迟风险评估预后

Application of Six Sigma DMAIC Method in Improving the Good Rate of Blank Value of Cytological Method for Dairy Products

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Asian Agricultural Research 2021年第10期13卷 48-53页

作者： Yunxia wang Shuhuan ZHAO Lijun LIU Xue HU cuizhi LI Zhiyong LU Inner Mongolia Yili Industrial Group Co. Ltd.Hohhot 010110China

In this paper,the six Aigma DMAIC method was used to systematically analyze and study the process affecting the good rate of blank value of cytological method for dairy *** data collection,analysis and verification in each link,the room for improvement in the experimental process was identified.C&E matrix and FMEA were used to analyze the factors affecting the good rate of blank *** the DOE experiment design method and risk analysis,the main influencing factors were optimized and *** optimized experimental conditions were:silica gel activation temperature(500±50)℃,activation time(23±1)h,cells adherent rate(95±1)%,and single-use of 1.5 mL conical *** the above conditions,the good rate of blank value of cytological method was improved from 52.8%to 100%.The improvement of these conditions is of great significance to ensure the accuracy of results,save the testing cost and improve the testing efficiency.

关键词： Six Sigma DMAIC Dairy product Good rate

Multicenter phaseⅡstudy of apatinib single or combination therapy in HER2-negative breast cancer involving chest wall metastasis

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Chinese Journal of Cancer Research 2021年第2期33卷 243-255页

作者： Huiping Li cuizhi Geng Hongmei Zhao Hanfang Jiang Guohong Song Jiayang Zhang Yaxin Liu Xinyu Gui Jing wang Kun Li Zhongsheng Tong Fangyuan Zhao Junlan Yang Guoliang Chen Qianyu Liu Xu Liang Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Breast OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Breast Disease Diagnostic and Therapeutic Center the Fourth Affiliated Hospital of Hebei Medical UniversityShijiazhuang 050019China Department of General Surgery Peking University Third HospitalBeijing 100191China Department of Breast Oncology Key Laboratory of Breast Cancer Prevention and TherapyNational Clinical Research Center for CancerTianjin Medical University Cancer Institute and HospitalTianjin 30060China Department of the Public Health Sciences University of ChicagoChicago 60637USA Department of Medical Oncology Chinese PLA General HospitalBeijing 100853China Jiangsu Hengrui Medicine Co.Ltd. Shanghai 200120China

Objective:Breast cancer(BC)with chest wall metastasis(CWM)usually shows rich *** trial explored the clinical effect of apatinib on human epidermal growth factor receptor 2(HER2)-negative advanced BC involving ***:This trial involved four centers in China and was conducted from September 2016 to March *** received apatinib 500 mg/d[either alone or with endocrine therapy if hormone receptor-positive(HR+)]until disease progression or unacceptable ***-free survival(PFS)was the primary ***:We evaluated 26 patients for *** median PFS(mPFS)and median overall survival(mOS)were4.9[range:2.0-28.5;95%confidence interval(95%CI):2.1-8.3]months and 18(range:3-55;95%CI:12.9-23.1)months,*** objective response rate(ORR)was 42.3%(11/26),and the disease-control rate was76.9%(20/26).In the subgroup analysis,HR+patients compared with HR-negative patients had significantly improved mPFS of 7.0(95%CI:2.2-11.8)months vs.2.3(95%CI:1.2-3.4)months,respectively(P=0.001);and mPFS in patients without or with chest wall radiotherapy was 6.4(95%CI:1.6-19.5)months vs.3.0(95%CI:1.3-4.6)months,respectively(P=0.041).In the multivariate analysis,HR+status was the only independent predictive factor for favorable PFS(P=0.014).Conclusions:Apatinib was highly effective for BC patients with CWM,especially when combined with endocrine *** improved significantly in patients with HR+status who did not receive chest wall ***,adverse events were serious and should be carefully monitored from the beginning of apatinib treatment.

关键词： Apatinib advanced breast cancer chest wall metastasis HER2-negative

Fluorescence-based PCR Detection of Goat Milk Powder Mixed with Cow Milk

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Asian Agricultural Research 2021年第8期13卷 43-45,48页

作者： Yunxia wang Lijuan JING Zhijun LI cuizhi LI Zhiyong LU Lijun LIU Quality Management Department Inner Mongolia Yili Industrial Group Co. Ltd. Hohhot 010110 China Quality Management Department of Yogurt Division Inner Mongolia Yili Industrial Group Co. Ltd. Hohhot 010110 China

[Objectives]To amplify and identify the specific gene fragments of cattle and sheep by real-time fluorescence-based PCR,and quickly and accurately identify the adulteration problem of goat milk powder according to the differences of mitochondrial genes among different species.[Methods]The specificity,limit of detection and repeatability test were carried out by isolating somatic cells,extracting template DNA and determining the reaction conditions of real-time fluorescence-based PCR.[Results]The real-time fluorescence-based PCR method could be used to identify the bovine and ovine-derived materials of milk powder with high specificity,high sensitivity and good repeatability,and the limit of detection of milk components in goat milk powder could reach 0.01%.[Conclusions]The real-time fluorescence-based PCR method can be used to quickly and accurately detect the milk components in goat milk powder,and provide some technical support for the adulteration detection of dairy industry.

关键词： Goat milk powder Cow milk Real-time fluorescence-based PCR Animal origin

Transplantation of human limbal cells cultivated on amniotic membrane for reconstruction of rat corneal epithelium after alkaline burn

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Chinese Medical Journal 2005年第11期118卷 927-935页

作者： SONGE YANGWei cuizhi-hua DONGYu SUIDong-ming GUANXiao-kang MAYang-ling DepartmentofOphthalmology FirstAffiliatedHospitalJilinUniversityChangchun130021China StemCellResearchCentre PekingUniversityBeijing100008China

BACKGROUND: The transplantation of limbal epithelial cells cultivated on amniotic membrane is a newly developed treatment for limbal stem cell deficiency. The purpose of our study was to investigate the biological characteristics of limbal epithelial cells and evaluate the effect of transplantation of cultivated human limbal epithelial cells on ocular surface reconstruction in limbal stem cell deficiency rat model. METHODS: Human limbal cells were isolated and cultivated in vitro. Cytokeratins 3, 12, and 19 (K3, K12 and K19) and p63 were detected by immunofluorescent staining or RT-PCR. BrdU labelling test was used to identify the slow cycling cells in the cultures. Limbal stem cell deficiency was established in rat cornea by alkali burn. Two weeks after injury, the rats received transplants of human limbal stem cells cultivated on amniotic membrane carrier. The therapeutic effect was evaluated by slit lamp observation, Hemotoxin and Eosin (HE) staining and immunofluorescent staining. RESULTS: On day 7 in primary culture, p63 and K19 were strongly expressed by most cells but only a few cells expressed K3. On days 14 and 21, p63 and K19 were still expressed by a majority of cells, but the expressive intensity of p63 decreased in a number of cells, while the proportion of K3 positive cells increased slightly and some cells coexpressed p63 and K3. RT-PCR showed that gene expression of both p63 and K12 were positive in cultivated limbal cells, but in mature superficial epithelial cells, only K12 was detected. BrdU labelling test showed that most cells were labelled with BrdU after 7 days' labelling and BrdU label retaining cells were observed after chasing for 21 days with BrdU free medium. For in vivo test, slit lamp observation, HE staining and immunofluorescent staining showed that the rats receiving transplant of human limbal stem cells cultivated on amniotic membrane grew reconstructed corneas with intact epithelium, improved transparency and slight or no neovascul

关键词： Amnion Animals Bromodeoxyuridine Burns, Chemical Cells, Cultured Cornea Epithelium Humans Male Phenotype Rats Rats, Sprague-Dawley Research Support, Non-U.S. Gov't Stem Cell Transplantation