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Nano Research 2023年第2期16卷 2968-2979页

作者： Yuna Zhang cuili xue Yuli Xu Shengsheng Cui Alexander A.Ganeev Kistenev Yury V Anna Gubal Victoria Chuchina Han Jin Daxiang Cui Department of Instrument Science and Engineering School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China St Petersburg University 7/9 Universitetskaya Emb.St Petersburg 199034Russia Tomsk State University Lenina Av.36TomskTomsk 634050Russia National Engineering Research Center for Nanotechnology Shanghai 200241China

Metal-organic frameworks(MOFs)have attracted widespread interest due to their unique and unprecedented advantages in microstructures and ***,surface-enhanced Raman scattering(SERS)technology has also rapidly developed into a powerful fingerprint spectroscopic technique that can provide rapid,non-invasive,non-destructive,and ultra-sensitive detection,even down to single molecular ***,a considerable amount of researchers combined MOFs with the SERS technique to further improve the sensing performance and broaden the applications of SERS ***,representative synthesis strategies of MOFs to fabricate SERS-active substrates are summarized and their applications in ultra-sensitive biomedical trace detection are also ***,relative barriers,advantages,disadvantages,future trends,and prospects are particularly discussed to give guidance to relevant researchers.

关键词： metal-organic framework(MOF) surface-enhanced Raman scattering(SERS) synthesis strategy biomedical trace detection

Artificial intelligence in theranostics of gastric cancer, a review

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Medical Review

Medical Review 2023年第3期3卷 214-229页

作者： Yiqian Zha cuili xue Yanlei Liu Jian Ni Jesus M.De La Fuente Daxiang Cui Institute of Nano Biomedicine and Engineering Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment InstrumentSchool of Sensing Science and EngineeringShanghai Jiao Tong UniversityShanghaiChina National Engineering Research Center for Nanotechnology ShanghaiChina Institute of Aragon Nanoscience University of ZaragozaZaragozaSpain

Gastric cancer (GC) is one of the commonestcancers with high morbidity and mortality in the *** to realize precise diagnosis and therapy of GC ownsgreat clinical requirement. In recent years, artificial intelligence (AI) has been actively explored to apply to earlydiagnosis and treatment and prognosis of gastric carcinoma. Herein, we review recent advance of AI in earlyscreening, diagnosis, therapy and prognosis of stomachcarcinoma. Especially AI combined with breath screeningearly GC system improved 97.4 % of early GC diagnosisratio, AI model on stomach cancer diagnosis system of salivabiomarkers obtained an overall accuracy of 97.18 %, speci-ficity of 97.44 %, and sensitivity of 96.88 %. We also discussconcept, issues, approaches and challenges of AI applied instomach cancer. This review provides a comprehensive viewand roadmap for readers working in this field, with the aimof pushing application of AI in theranostics of stomachcancer to increase the early discovery ratio and curativeratio of GC patients.

关键词： artificial intelligence diagnosis gastric cancer prognosis screening therapy

Remote Tracking Gas Molecular via the Standalone-Like Nanosensor-Based Tele-Monitoring System

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Nano-Micro Letters 2021年第2期13卷 207-220页

作者： Han Jin Junkan Yu Daxiang Cui Shan Gao Hao Yang Xiaowei Zhang Changzhou Hua Shengsheng Cui cuili xue Yuna Zhang Yuan Zhou Bin Liu Wenfeng Shen Shengwei Deng Wanlung Kam Waifung Cheung Institute of Micro-Nano Science and Technology School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China National Engineering Research Center for Nanotechnology Shanghai 200240People’s Republic of China School of Electrical Engineering and Computer Science Ningbo UniversityNingbo 315211People’s Republic of China State Key Laboratory of Pathogen and Biosecurity Institute of Microbiology and EpidemiologyAcademy of Military Medical SciencesBeijing 100071People’s Republic of China Ningbo Materials Science and Technology Institute Chinese Academy of SciencesNingbo 315201People’s Republic of China College of Chemical Engineering Zhejiang University of TechnologyHangzhou 310014People’s Republic of China Qi Diagnostics Ltd HongkongPeople’s Republic of China

Remote tracking the variation of air quality in an effective way will be highly helpful to decrease the health risk of human short-and long-term exposures to air ***,high power consumption and poor sensing performance remain the concerned issues,thereby limiting the scale-up in deploying air quality tracking ***,we report a standalone-like smart device that can remotely track the variation of air pollutants in a power-saving ***,the created smart device demonstrated satisfactory selectivity(against six kinds of representative exhaust gases or air pollutants),desirable response magnitude(164–100 ppm),and acceptable response/recovery rate(52.0/50.5 s),as well as linear response relationship to *** aging for 2 weeks,the created device exhibited relatively stable sensing performance more than 3 ***,a photoluminescence-enhanced light fidelity(Li-Fi)telecommunication technique is proposed and the Li-Fi communication distance is significantly ***,our reported standalone-like smart device would sever as a powerful sensing platform to construct high-performance and low-power consumption air quality wireless sensor networks and to prevent air pollutant-induced diseases via a more effective and low-cost approach.

关键词： Metal-organic framework-derived polyhedral ZnO Perovskite quantum dots Nanosensor NO2 Tele-monitoring system

基于锌墨水的打印技术用于制备可降解式传感器

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仪器仪表学报 2020年第8期41卷 84-90页

作者：薛翠丽衣宁崔大祥上海交通大学电子信息与电气工程学院上海200240 美国宾州州立大学工程科学与力学系宾夕法尼亚州16801 天津大学精密仪器与光电子工程学院天津300072

瞬态电子器件能够在外界触发条件下完全分解,可有效解决电子废弃物污染问题,在植入式医疗设备、环境监测系统和数据安全等领域中具有广阔的应用前景。首先,研发了基于锌纳米颗粒的墨水配方,使用20%锌纳米颗粒作为导电材料,质量相同的2-... 详细信息

瞬态电子器件能够在外界触发条件下完全分解,可有效解决电子废弃物污染问题,在植入式医疗设备、环境监测系统和数据安全等领域中具有广阔的应用前景。首先,研发了基于锌纳米颗粒的墨水配方,使用20%锌纳米颗粒作为导电材料,质量相同的2-丁醇和乙二醇混合作为溶剂,具有良好的可打印性、稳定性和导电性。其次,使用Sonoplot MicroplotterⅡ打印机,探究分配电压、打印速度等参数对打印效果的影响。最后,通过光子烧结方式对打印的锌导线进行后处理以获得良好的导电性能(5.2×103 S/m),同时探究烧结参数对导电性的影响。采用基于墨水的打印技术和光子烧结制备瞬态电子器件,具有工艺简单、成本低、可设计性强的优势。

关键词：瞬态电子器件锌纳米颗粒墨水打印技术光子烧结

基于多种群遗传算法的反舰导弹攻击策略优化研究

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战术导弹技术 2014年第6期 45-49页

作者：薛翠利赵魏北京机电工程研究所北京100074

为了根据敌编队具体编成情况,制定合理的攻击策略,将防空导弹和"密集阵"的火力拦截作为反舰导弹攻击过程中的威胁,建立攻击策略优化模型。运用多种群遗传算法优化求解,得到最小攻击威胁下攻击阶段的划分、目标的分配以及对应的最优攻击... 详细信息

为了根据敌编队具体编成情况,制定合理的攻击策略,将防空导弹和"密集阵"的火力拦截作为反舰导弹攻击过程中的威胁,建立攻击策略优化模型。运用多种群遗传算法优化求解,得到最小攻击威胁下攻击阶段的划分、目标的分配以及对应的最优攻击方向。针对具体编队目标,进行计算及结果分析,结果表明,该模型和方法是有效的,可为打击舰船编队的战术制定提供理论参考依据。

关键词：多种群遗传算法反舰导弹舰船编队攻击策略

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导弹发射条件对初段飞行性能的影响分析

战术导弹技术 2006年第2期 9-13页

作者：薛翠利关成启查旭王长青中国航天科工集团公司第三研究院北京100074

以导弹箱式发射方式为例,推导出了四段运动方程式,求出了对应于不同情况下导弹运动参数的变化规律,研究了导弹从助推器点火到导弹加速到给定飞行速度这一过程的飞行特性,分析了导弹出箱初始条件的变化和对导弹飞行性能的影响.仿真结果表... 详细信息

以导弹箱式发射方式为例,推导出了四段运动方程式,求出了对应于不同情况下导弹运动参数的变化规律,研究了导弹从助推器点火到导弹加速到给定飞行速度这一过程的飞行特性,分析了导弹出箱初始条件的变化和对导弹飞行性能的影响.仿真结果表明,该理论模型和发射条件对初段飞行性能影响的分析是合理的.

关键词：发射条件飞行性能影响分析

一种远程亚声速无人飞行器舱内温度控制方法研究

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战术导弹技术 2014年第5期 30-33页

作者：薛翠利张立强北京机电工程研究所北京100074

以远程亚声速无人飞行器为研究对象,研究利用空气冷却解决舱内温度控制问题的方法。基于飞行试验实测数据采用集总参数法分析无人飞行器制冷量需求,提出一种适合远程亚声速无人飞行器的温控系统,以典型舱段为例建立模型,仿真和飞行试验... 详细信息

以远程亚声速无人飞行器为研究对象,研究利用空气冷却解决舱内温度控制问题的方法。基于飞行试验实测数据采用集总参数法分析无人飞行器制冷量需求,提出一种适合远程亚声速无人飞行器的温控系统,以典型舱段为例建立模型,仿真和飞行试验结果表明该方法可行。

关键词：远程亚声速无人飞行器温度控制

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导弹箱式发射的仿真研究

战术导弹技术 2006年第1期 84-88页

作者：薛翠利关成启查旭王长青中国航天科工集团公司第三研究院北京100074

建立了导弹箱式发射的数学模型,并对该数学模型进行计算机仿真.通过仿真,分析了导弹质量、质心、助推器推力、推力偏心、偏斜和适配器位置等因素对导弹发射安全性的影响.该数学模型具有一定的通用性,仿真结论具有工程应用价值.

关键词：箱式发射安全性仿真

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北苍术与关苍术的高效薄层指纹图谱比较研究

中药新药与临床药理 2022年第1期33卷 97-104页

作者：李定发梁渐崧潘英杰陈紫颖李秀枝吴佳璇薛翠丽广东一方制药有限公司广东佛山528244 广东省中药配方颗粒企业重点实验室广东佛山528244

目的建立苍术药材的高效薄层指纹图谱(HPTLC)方法,用于鉴别北苍术和关苍术。方法采用硅胶G60薄层板,石油醚(60~90℃)-丙酮(9∶2)为展开剂,10%硫酸乙醇溶液显色,采用HPTLC技术在366 nm波长下测得北苍术与关苍术的薄层色谱图谱,以指纹图... 详细信息

目的建立苍术药材的高效薄层指纹图谱(HPTLC)方法,用于鉴别北苍术和关苍术。方法采用硅胶G60薄层板,石油醚(60~90℃)-丙酮(9∶2)为展开剂,10%硫酸乙醇溶液显色,采用HPTLC技术在366 nm波长下测得北苍术与关苍术的薄层色谱图谱,以指纹图谱系统解决方案软件建立共有模式,并进行相似度评价、聚类分析(HCA)、主成分分析(PCA)及正交偏最小二乘判别分析(OPLS-DA)。结果北苍术、关苍术的指纹图谱分别含有9个共有峰,二者均指认了白术内酯Ⅲ、苍术素。北苍术、关苍术与其各自共有模式的相似度分别为0.89~0.99、0.51~0.99,其中关苍术批间差异较大;关苍术与北苍术共有模式相比,相似度很低,在0.29~0.33之间;PCA及OPLS-DA均可将北苍术和关苍术样品明显区分开,并筛选出峰4、峰5、峰6、峰7、峰8、峰10(苍术素)6个差异性化合物。结论所建立的高效薄层指纹图谱分析方法简便,重复性好,专属性强,可为北苍术和关苍术的品种鉴别及质量评价提供参考依据。

关键词：北苍术关苍术高效薄层指纹图谱化学计量学品种鉴别白术内酯Ⅲ 苍术素

Screening of Host Proteins Interacting with PorcineEpidemic Diarrhea Virus (PEDV) N Protein by YeastTwo-hybrid System

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Animal Husbandry and Feed Science 2018年第4期10卷 267-271页

作者： Wang Zhongze Qin cuili Kong Ning Zuo Yewen Wang Meng Zheng Hao Tong Wu Li Liwei Yu Hai Li Zhili Shan Tongling Tong Guangzhi Li xue Henan University of Science and Technology Luoyang 471023 China Shanghai Institute of Veterinary Medicine Chinese Academy of Agricultural Sciences Shanghai 200241 China 不详

[Objective] The paper was to obtain host proteins interacting with porcine epidemic diarrhea virus （PEDV） N protein. [Method] The re-combinant vector pGBKT7-N of PEDV N gene was constructed and used as the bait plasmid to screen the proteins interacting with N protein ofPEDV from the cDNA library of porcine alveolar macrophage （PAM） by yeast two-hybrid method. [Result] There was no toxicity and self activationof bait protein in yeast hybridization system, and six proteins （FTH1, LGALS3, CORO1C, SNRPG, KRTAP5-3, ZNF598） interacting with N proteinwere indentified. It was confirmed that LGALS3 and SNRPG had specific interaction with N protein by return experiment and co-immunoprecipitation（CoIP） test. [Conclusion] The study lays a foundation for further studying the function of PEDV N protein and the pathogenic mechanism of PEDV.

关键词： Porcine epidemic diarrhea virus (PEDV) Yeast two-hybrid N protein Protein interaction