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Journal of Integrative Plant Biology 2011年第8期53卷 608-618页

作者： cuili liu li zhao guanghui yu Key Laboratory for Biotechnology of the State Ethnic Affairs Commission College of Life Sciences South-Central University for Nationalities Wuhan 430074 China

γ-Amino butyric acid （GABA） and proline play a crucial role in protecting plants during various environmental stresses. Their synthesis is from the common precursor glutamic acid, which is catalyzed by glutamate decarboxylase and △1-pyrroline-5-carboxylate synthetase respectively. However, the dominant pathway under water stress has not yet been established. To explore this, excised tobacco leaves were used to simulate a water-stress condition. The results showed GABA content was much higher than that of proline in leaves under water-deficit and non-water-deficit conditions. Specifically, the amount of GABA significantly increased compared to proline under continuous water loss for 16 h, indicating that GABA biosynthesis is the dominant pathway from glutamic acid metabolism under these conditions. Quantitative reverse transcription polymerase chain reaction and protein Western gel-blot analysis further confirmed this. To explore the function of GABA accumulation, a system producing superoxide anion （O 2 - ）, peroxide hydrogen （H 2 O 2 ）, and singlet oxygen （ 1 O 2 ） was employed to investigate the scavenging role on free-radical production. The results demonstrated that the scavenging ability of GABA for O 2 - , H 2 O 2 , and 1 O 2 was significantly higher than that of proline. This indicated that GABA acts as an effective osmolyte to reduce the production of reactive oxygen species under water stress.

关键词： glutamic acid proline reactive oxygen species water stress γ-amino butyric acid.

Multilayered regulation of secondary metabolism in medicinal plants

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Molecular Horticulture 2023年第1期3卷 234-257页

作者： Yan zhao Guanze liu Feng Yang Yanli liang Qingqing Gao Chunfan Xiang Xia li Run Yang guanghui Zhang Huifeng Jiang Lei yu Shengchao Yang Key Laboratory of Medicinal Plant Biology of yunnan Province National&Local Joint Engineering Research Center on Germplasms Innovation&Utilization of Chinese Medicinal Materials in Southwest ChinaYunnan Agricultural University650201 KunmingChina College of Agronomy&Biotechnology Yunnan Agricultural UniversityKunming 650201China Institute of Chinese Medicinal Materials Nanjing Agricultural UniversityNanjing 210095China Key Laboratory of Engineering Biology for Low‑Carbon Manufacturing Tianjin Institute of Industrial BiotechnologyChinese Academy of SciencesTianjin 300308China College of Agronomy Yunnan Urban Agricultural Engineering and Technological Research CenterKunming UniversityKunming 650214China

Medicinal plants represent a huge reservoir of secondary metabolites(SMs),substances with significant pharmaceutical and industrial ***,obtaining secondary metabolites remains a challenge due to their low-yield accumulation in medicinal plants;moreover,these secondary metabolites are produced through tightly coordinated pathways involving many spatiotemporally and environmentally regulated *** first regulatory layer involves a complex network of transcription factors;a second,more recently discovered layer of complexity in the regulation of SMs is epigenetic modification,such as DNA methylation,histone modification and small RNA-based mechanisms,which can jointly or separately influence secondary metabolites by regulating gene ***,we summarize the findings in the fields of genetic and epigenetic regulation with a special emphasis on SMs in medicinal plants,providing a new perspective on the multiple layers of regulation of gene expression.

关键词： Medicinal plants Secondary metabolism Multilayered regulation Transcription factors Epigenetic regulation

Perioperative toripalimab plus neoadjuvant chemotherapy might improve outcomes in resectable esophageal cancer:an interim analysis of a phase Ⅲ randomized clinical trial

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Cancer Communications 2024年第10期44卷 1214-1227页

作者： Yan Zheng guanghui liang Dongfeng yuan Xianben liu yufeng Ba Zimin Qin Sining Shen Zhenxuan li Haibo Sun Baoxing liu Quanli Gao Peng li Zongfei Wang Shilei liu Jianping Zhu Haoran Wang Haibo Ma Zhenzhen liu Fei zhao Jun Zhang He Zhang Daoyuan Wu Jinrong Qu Jie Ma Peng Zhang Wenjie Ma Ming Yan Yongkui yu Qing li Jiangong Zhang Wenqun Xing Department of Thoracic Surgery The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China Department of Immunotherapy The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China Department of Endoscopy The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China Department of Pathology The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China Department of Radiology The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China Department of Biobank The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China Department of Strategic Development The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenanP.R.China Department of Statistics LinkDoc Technology Co.LtdBeijingP.R.China Department of Cancer Epidemiology The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouP.R.China

Background:In the era of immunotherapy,neoadjuvant immunochemotherapy(NAIC)for the treatment of locally advanced esophageal squamous cell carcinoma(ESCC)is used clinically but lacks of high-level clinical *** study aimed to compare the safety and long-term efficacy of NAIC followed byminimally invasive esophagectomy(MIE)with those of neoadjuvant chemotherapy(NAC)followed by ***:A prospective,single-center,open-label,randomized phase Ⅲ clinical trial was conducted at Henan Cancer Hospital,Zhengzhou,*** were randomly assigned to receive either neoadjuvant toripalimab(240mg)plus paclitaxel(175 mg/m^(2))+cisplatin(75 mg/m^(2))(toripalimab group)or paclitaxel+cisplatin alone(chemotherapy group)every 3 weeks for 2 *** surgery,the toripalimab group received toripalimab(240 mg every 3 weeks for up to 6 months).The primary endpoint was event-free survival(EFS).The pathological complete response(pCR)and overall survival(OS)were key secondary *** events(AEs)and quality of life were also ***:Between May 15,2020 and August 13,2021,252 ESCC patients ranging fromT1N1-3M0 to T2-3N0-3M0were enrolled for interim analysis,with 127 in the toripalimab group and 125 in the chemotherapy *** 1-year EFS rate was 77.9%in the toripalimab group compared to 64.3%in the chemotherapy group(hazard ratio[HR]=0.62;95%confidence interval[CI]=0.39 to 1.00;P=0.05).The 1-year OS rates were 94.1%and 83.0%in the toripalimab and chemotherapy groups,respectively(HR=0.48;95%CI=0.24 to 0.97;P=0.037).The patients in the toripalimab group had a higher pCR rate(18.6%vs.4.6%;P=0.001).The rates of postoperative Clavien-Dindo grade Ⅲb or higher morbidity were 9.8%in the toripalimab group and 6.8%in the chemotherapy group,with no significant difference observed(P=0.460).The rates of grade 3 or 4 treatment-related AEs did not differ between the two groups(12.5%versus 12.4%).Conclusions:The interim results of this ongoing trial showed that in resec

关键词： esophageal squamous cell carcinoma minimally invasive esophagectomy neoadjuvant chemotherapy neoadjuvant immunochemotherapy survival

INFLUENCE OF CaF_(2)-4liF ADDITIVE ON SINTERING AND ENERGY STORAGE PERFORMANCE OF SrTiO_(3)CERAMICS

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Journal of Advanced Dielectrics 2011年第2期1卷 191-195页

作者： YIQIU li HANXING liu guanghui zhao JING XU yuNJIANG CUI MINGHE CAO HUA HAO ZHIYONG yu State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan 430070 HubeiP.R.China

The CaF_(2)-4liF additive was added into SrTiO_(3)ceramics in order to decrease the sintering temperature for compact pulse power *** crystalline structure,microstructure and energy storage performance of sintered ceramics were *** CaF_(2)-4liF additive to SrTiO_(3)ceramics contributes to a notably enhancement of the energy storage *** great enhancement in energy storage density occurred due to the notable increase in breakdown strength and the refinement of *** 2 at%additive,the samples exhibited an average breakdown strength of 31.8kV/mm,and an energy storage density of 1.212 J/cm^(3)which is about 1.4 times higher than pure SrTiO_(3).

关键词： SrTiO_(3)ceramics additive low-temperature sintering energy storage performance

Nondestructive visualization of graphene on Pt with methylene blue surface modification

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Science China Materials 2022年第10期65卷 2763-2770页

作者： He Kang Yanhui Zhang yun Wu Shike Hu Jing li Zhiying Chen Yanping Sui Shuang Wang Sunwen zhao Runhan Xiao guanghui yu Songang Peng Zhi Jin Xinyu liu State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Science and Technology on Monolithic Integrated Circuits and Modules Laboratory Nanjing Electronic Device InstituteNanjing 210016China Microwave Devices and Integrated Circuits Department Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029China

Efficient large-scale nondestructive quality assessment of graphene on Pt is essential to the in-depth growth research and practical applications of ***,we present a very simple method for directly observing the domains and defects in graphene on Pt using an ordinary optical *** was achieved by modifying graphene on Pt using methylene blue(MB).Because the chemical activities of graphene and Pt surface differ significantly,the adsorption and reaction of MB on graphene and platinum surface *** can determine the distribution of graphene crystal domains and defects by comparing the colors in the optical *** addition,this characterization method causes no obvious damage to the Pt substrate and ***,it does not affect the recycling of the substrate or the subsequent characterization or application of *** study provides a nondestructive method for measuring the quality of graphene on Pt on a large scale,as well as a reference for the characterization and doping of other two-dimensional materials.

关键词： graphene Pt nondestructive visualization surface modification methylene blue

裂纹倾斜角度对呼吸裂纹转子非线性刚度及动力学特性的影响

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中国电机工程学报 2022年第17期42卷 6368-6378页

作者：张广辉国阳王维强赵御勃李豫刘占生哈尔滨工业大学能源科学与工程学院黑龙江省哈尔滨市150001

基于应力强度因子建立了倾斜裂纹单元的刚度矩阵,比较不同裂纹倾斜角度下裂纹转子在一个稳态旋转周期内转轴刚度的时变特性;结合裂纹转子动力学建模,仿真给出倾斜裂纹转子的动力学响应。结果表明含有斜裂纹的转子系统表现出了较强的非... 详细信息

基于应力强度因子建立了倾斜裂纹单元的刚度矩阵,比较不同裂纹倾斜角度下裂纹转子在一个稳态旋转周期内转轴刚度的时变特性;结合裂纹转子动力学建模,仿真给出倾斜裂纹转子的动力学响应。结果表明含有斜裂纹的转子系统表现出了较强的非线性特征,在弯曲方向上的耦合刚度显著大于含有横向裂纹的转子系统的耦合刚度。随着裂纹倾斜角的增大,受裂纹转子刚度的非线性变化的影响,转子在弯曲方向的基频、2倍频和3倍频振幅增大,而5倍频振幅的幅值随着裂纹倾斜角度的增大而减小,与2倍频分析得出的规律相反。随着裂纹倾斜角的变化,基频振动幅值的变化幅度约为1%,2倍频振动幅值变化约为20%,3倍频振动幅值变化约为4.7%,5倍频振动幅值变化约为25%。

关键词：裂纹转子倾斜裂纹呼吸效应非线性动力学

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基于云计算的海量视频转换平台的设计

实验技术与管理 2012年第3期29卷 98-100,119页

作者：李英壮刘曌李先毅于广辉大连理工大学网络与信息化中心辽宁大连116024

随着三网融合的进程不断加快,视频转换业务呈现出数据海量化、多平台共存、编码标准多样的显著特征。云计算技术作为一种商业计算模型,具有低价高效、支持虚拟化、高可扩展性、通用性等特点。文章从视频转换业务的角度出发,基于云计算... 详细信息

随着三网融合的进程不断加快,视频转换业务呈现出数据海量化、多平台共存、编码标准多样的显著特征。云计算技术作为一种商业计算模型,具有低价高效、支持虚拟化、高可扩展性、通用性等特点。文章从视频转换业务的角度出发,基于云计算和视频转换技术,提出了一种基于云计算的海量视频转换平台的设计方案,详细设计了平台的架构,叙述了云控制层、集群控制层、节点控制层的具体功能以及具体的工作流程。

关键词：海量视频转换云计算云平台三网融合

Outcome comparison of pyrotinib with current standard of care in the second/third line setting in advanced non-small cell lung cancer patients with HER2 mutation

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Chinese Medical Journal 2023年第7期136卷 848-850页

作者： Shiqi Mao libo Luo Shuo Yang Yan Wang Fei Zhou Jia yu Bin Chen guanghui Gao Xuefei li Chao zhao Lei Cheng Yiwei liu Wanying Wang Keyi Jia Chuchu Shao Xinyu liu Xiaoxia Chen Chunxia Su Caicun Zhou Fengying Wu Shengxiang Ren Department of Medical Oncology Shanghai Pulmonary HospitalCancer InstituteTongji University School of MedicineShanghai 200433China Department of Lung Cancer and Immunology Shanghai Pulmonary HospitalTongji University School of MedicineShanghai 200433China

To the Editor:In recent years,impressive outcomes have been achieved in patients harboring human epidermal growth factor receptor 2(HER2)mutations,which accounts for 1%to 4%of cases in non-small cell lung cancer(NSCLC).

关键词： patients lung cancer

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氯化镁熔滴相变冷却过程的数值模拟

材料与冶金学报 2023年第2期22卷 178-184页

作者：赵传进吴彦铮刘军祥于庆波李光辉东北大学冶金学院沈阳110819

采用转杯粒化法将氯化镁破碎成小颗粒并进行余热回收,利用Fluent软件模拟研究了粒化后熔滴的冷却行为,以SST k-ω湍流模型和焓法模型为基础,分析了熔滴直径、初始速度及初始温度对熔滴冷却行为的影响规律.结果表明:氯化镁熔滴的直径越大... 详细信息

采用转杯粒化法将氯化镁破碎成小颗粒并进行余热回收,利用Fluent软件模拟研究了粒化后熔滴的冷却行为,以SST k-ω湍流模型和焓法模型为基础,分析了熔滴直径、初始速度及初始温度对熔滴冷却行为的影响规律.结果表明:氯化镁熔滴的直径越大,表面凝固时间和完全凝固时间越长,凝固速率的变化在凝固后期比凝固前期越小;熔滴的初始速度越大,凝固速率越快,表面换热能力越强,但换热能力的增幅随着初始速度的增大而下降;熔滴初始温度与完全凝固时间的相关性并不大,但较高的初始温度会延长熔滴表面凝固的时间.该研究结果可为转杯粒化氯化镁装置的结构设计提供参考.

关键词：转杯粒化固相体积分数熔滴冷却

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超磁分离污泥与剩余污泥协同水解酸化

环境工程学报 2020年第1期14卷 86-95页

作者：刘杰赵峰辉于德爽林甲陈光辉李传举张帆王钧北京首创股份有限公司北京100044 青岛大学环境科学与工程学院青岛266071

以超磁分离污泥作为研究对象,用2种不同的剩余污泥作为接种污泥,维持温度在30℃,探究了剩余污泥对超磁分离污泥厌氧水解酸化产物及产率的影响。结果表明:随着剩余污泥接种量的增加,混合污泥SCOD的析出量也逐渐增加;接种剩余污泥量的增... 详细信息

以超磁分离污泥作为研究对象,用2种不同的剩余污泥作为接种污泥,维持温度在30℃,探究了剩余污泥对超磁分离污泥厌氧水解酸化产物及产率的影响。结果表明:随着剩余污泥接种量的增加,混合污泥SCOD的析出量也逐渐增加;接种剩余污泥量的增加促进了混合污泥VFAs的生成;各种污泥产VFAs中,乙酸均具有明显优势,并会促进丙酸的累积;混合污泥较之于超磁分离和剩余污泥具有快速、高效的产酸优势,且随着剩余污泥接种量的增加,加快了水解酸化的速率并且加深了酸化的程度,但会延长其达到最大值的时间。污泥产酸发酵获得内碳源的同时,还存在着N元素的释放,且随着剩余污泥接种量的增加,这种伴随现象更明显。对比2种剩余污泥(W1、W2)发现,W1作为接种污泥时,并没有明显的P元素的释放;当W2作为接种污泥时,伴随着比较明显的P元素的释放。综合考虑剩余污泥对于超磁分离污泥水解酸化效果的影响发现,当剩余污泥接种量W1为12.2%,W2为13.6%时,既可以为系统提供更多的SCOD,又可以避免过高的氮负荷。

关键词：超磁分离污泥剩余污泥水解酸化内碳源