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Intra-continental deformation and tectonic evolution of the West Junggar Orogenic Belt,Central Asia:Evidence from remote sensing and structural geological analyses

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Geoscience Frontiers 2020年第2期11卷 651-663页

作者： Wei-cui Ding Ting-Dong Li xuan-Hua Chen Jian-Ping Chen Sheng-Lin xu Yi-Ping Zhang Bing Li Qiang Yang School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China SinoProbe Center Chinese Academy of Geological Sciences and China Geological SurveyBeijing 100037China Center for Hydrogeology and Environmental Geology CGSBaodingHebei 071051China

The West Junggar Orogenic Belt(WJOB)in northwestern Xinjiang,China,is located in the core of the western part of the Central Asian Orogenic Belt(CAOB).It has suffered two stage tectonic evolutions in Phanerozoic,before and after the ocean–continental conversion in Late *** later on intracontinental deformation,characterized by the development of the NE-trending West Junggar sinistral strike-slip fault system(WJFS)since Late Carboniferous and Early Permian,and the NW-trending Chingiz-Junggar dextral strike-slip fault(CJF)in Mesozoic and Cenozoic,has an important significance for the tectonic evolution of the WJOB and the *** this paper,we conduct geometric and kinematic analyses of the WJOB,based on field geological survey and structural interpretation of remote sensing image *** some piercing points such as truncated plutons and anticlines,an average magnitude of^73 km for the left-lateral strike-slip is calculated for the Darabut Fault,a major fault of the *** partial of the displacement should be accommodated by strike-slip fault-related folds developed during the strike-slip *** and curved faults,asymmetrical folds,and irregular contribution of ultramafic bodies,implies potential opposite vertical rotation of the Miao’ergou and the Akebasitao batholiths,resulted from the sinistral strike-slipping along the Darabut *** to conjugate shearing set of the sinistral WJFS and the dextral CJF since Early Mesozoic,superimposed folds formed with N–S convergence in southwestern part of the WJOB.

关键词： Remote sensing Structural analysis Strike-slip fault system Darabut fault West Junggar Central Asian orogenic belt

The choice of a neoadjuvant chemotherapy cycle for breast cancer has significance in clinical practice: results from a population-based, real world study

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Cancer Biology & Medicine 2022年第5期19卷 755-767页

作者： Litong Yao Zhiyuan Pang Mozhi Wang Mengshen Wang xiangyu Sun Mingke cui Yanfu Zheng Xinyan Li Haoran Dong Qiang Zhang Yingying xu Department of Breast Surgery the First Affiliated Hospital of China Medical UniversityShenyang 110001China Department of Breast Surgery Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital&InstituteShenyang 110042China

Objective:Neoadjuvant chemotherapy(NAC)is currently used in both early stage and locally advanced breast *** survival benefits of standard ***-standard NAC cycles are still *** study aimed to investigate the relationship between NAC cycles and survival based on real world ***:We identified patients diagnosed with invasive primary breast cancers who underwent NAC followed by *** who received at least 4 NAC cycles were defined as having received standard cycles,while patients who received less than 4 NAC cycles were defined as having received non-standard ***-Meier curves and Cox proportional hazard models were used to estimate the disease-free survival(DFS)and overall survival(OS).Results:Of the 1,024 included patients,700 patients received standard NAC cycles and 324 patients received non-standard NAC *** DFS estimates were 87.1%and 81.0%(P=0.007)and the OS estimates were 90.0%and 82.6%(P=0.001)in the standard and non-standard groups,*** multivariate analyses,patients treated with standard NAC cycles showed significant survival benefits in both DFS[hazard ratio(HR):0.62,95%confidence interval(CI):0.44–0.88]and OS(HR:0.54,95%CI:0.37–0.79).Using stratified analyses,standard NAC cycles were associated with improved DFS(HR:0.59,95%CI:0.36–0.96)and OS(HR:0.49,95%CI:0.28–0.86)in the HER2 positive *** DFS(HR:0.50,95%CI:0.25–0.98)and OS(HR:0.45,95%CI:0.22–0.91)benefits were shown for the triple negative ***:Standard NAC cycles were associated with a significant survival benefit,especially in patients with HER2 positive or triple negative breast cancer.

关键词： Breast cancer neoadjuvant chemotherapy treatment cycles real world analysis survival analysis

Reflectivity forward modeling and a CSSI method seismic inversion study of igneous intrusive area,coked area,and gas-enriched area located within a coal seam

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Mining Science and Technology 2009年第4期19卷 457-462页

作者： xu Yong-zhong cui Ruo-fei HUANG Wei-chuan CHEN Tong-jun CHEN Shi-zhong DONG Shou-hua School of Resource and Geosciences China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China Institute of Geophysics China Earthquake Administration Beijing 100081 China

We applied the reflectivity method and the constrained sparse spike inverse modeling(CSSI) method to the interpretation of coal field lithologic seismic *** introducing the principles of these two methods we discuss some parameters of a geological model involving possible gas enriched areas or intruded igneous *** geological model was constructed and a 60 Hz seismic response profile was obtained looking for igneous rock intrusion and coked areas of the coal seam using the reflectivity *** from synthesized logging data from two wells and a synthesized seismic wavelet we calibrated the model to show accurate ***,we predicted the lithology within a 10 m igneous rock area,a 3 m coal seam area,and a coked area using the CSSI *** results show that the CSSI technique can identify hard to recognize lithologic features that normal profil-ing methods might *** can quantitatively analyze and evaluate the intrusive area,the coked area,and the gas-enriched area.

关键词： CSSI reflectivity method igneous rock coal seam coked area gas-enriched area

Targeted drug delivery strategies for the treatment of rheumatoid arthritis

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Science China(Life Sciences) 2021年第7期64卷 1187-1189页

作者： Jinxia Zhang Ling Jiang Lihong Sun Ping Wang Suhui Sun Menghong xu Lulu zhang Shumin Wang Xiaolong Liang Ligang cui Department of Ultrasound Peking University Third HospitalBeijing 100191China

A chronic autoimmune disease named rheumatoid arthritis(RA)is characterized mainly by synovitis,which has high morbidity,disability and mortality *** addition,the aetiology and pathogenesis of RA have not been fully *** is usually accompanied by persistent arthritic pain,swelling,stiffness,and functional disorders;in severe cases,it may result in cardiovascular,pulmonary,psychological and skeletal diseases(Scott et al.,2010).

关键词： mortality cardiovascular diseases

Degradation of tetracycline hydrochloride by ultrafine TiO_(2) nanoparticles modified g-C_(3)N_(4) heterojunction photocatalyst:Influencing factors,products and mechanism insight

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Chinese Chemical Letters 2022年第3期33卷 1337-1342页

作者： Bin Zhang xu He Chengze Yu Guocheng Liu Dong Ma Chunyue cui Qinghua Yan Yingjie Zhang Guangshan Zhang Jun Ma Yanjun Xin Qingdao Engineering Research Center for Rural Environment Water Resources Protection and Utilization Center for Rural AreasQingdao Agricultural UniversityQingdao 266109China State Key Laboratory of Urban Water Resource and Environment Harbin Institute of TechnologyHarbin 150090China School of Marine Science and Technology Sino-Europe Membrane Technology Research Institute Harbin Institute of TechnologyWeihai 264209China

The unique heterojunction photocatalyst of graphite carbon nitride (g-C_(3)N_(4)) modified ultrafine TiO_(2) (g-C_(3)N_(4)/TiO_(2)) was successfully fabricated by electrochemical etching and co-annealing method. However, the effects of various environmental factors on the degradation of TC by g-C_(3)N_(4)/TiO_(2) and the internal reaction mechanism are still unclear. In this study, the effects of initial pH, anions, and cations on the photocatalytic degradation of tetracycline hydrochloride (TC) by g-C_(3)N_(4)/TiO_(2) were systematically explored, and the scavenging experiment and intermediate detection were conducted to better reveal the mechanism on photocatalytic degradation of TC. The results showed that the removal efficiency of photocatalytic degradation of TC by g-C_(3)N_(4)/TiO_(2) could reach 99.04% under Xenon lamp irradiation within 120 min. The unique g-C_(3)N_(4)/TiO_(2) heterojunction photocatalyst showed excellent photocatalytic performance for the degradation of TC at pH 3~7, and possesses outstanding anti-interference ability to NO_(3)^(-), Cl^(-), Na^(+), Ca^(2+) and Mg^(2+) ions in natural waters during the photocatalytic degradation TC process. Superoxide radicals (O_(2)^(·-)) and hydroxyl radicals (^(·)OH) were proved as the main reactive species for TC degradation, and the possible mechanism of the unique photocatalytic system for g-C_(3)N_(4)/TiO_(2) was also proposed. The above results can provide a reliable basis and theoretical guidance for the design and application of visible photocatalyst with high activity to degrade the actual wastewater containing TC.

关键词： Photocatalytic TiO_(2) G-C3N4 Tetracycline hydrochloride Mechanism

Engineering G-quadruplex aptamer to modulate its binding specificity

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National Science Review 2021年第4期8卷 107-113页

作者： Long Li Shujuan xu xueyu Peng Yuzhuo Ji He Yan Cheng cui Xiaowei Li Xiaoshu Pan Lu Yang Liping Qiu Jianhui Jiang Weihong Tan Department of Chemistry and Department of Physiology and Functional Genomics Center for Research at the Bio/Nano Interface Health Cancer Center UF Genetics InstituteMcKnight Brain Institute University of Florida Molecular Science and Biomedicine Laboratory State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical Engineering College of Biology Aptamer Engineering Center of Hunan ProvinceHunan University Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical Engineering College of Biology Aptamer Engineering Center of Hunan ProvinceHunan University Institute of Molecular Medicine(IMM) Renji HospitalShanghai Jiao Tong University School of Medicine and College of Chemistry and Chemical EngineeringShanghai Jiao Tong University

The use of aptamers in bioanalytical and biomedical applications exploits their ability to recognize cell surface protein receptors. Targeted therapeutics and theranostics come to mind in this regard. However,protein receptors occur on both cancer and normal cells; as such, aptamers are now taxed with identifying high vs. low levels of protein expression. Inspired by the flexible template mechanism and elegant control of natural nucleic acid-based structures, we report an allosteric regulation strategy for constructing a structure-switching aptamer for enhanced target cell recognition by engineering aptamers with DNA intercalated motifs(i-motifs) responsive to the microenvironment, such as p H. Structure-switching sensitivity can be readily tuned by manipulating i-motif sequences. However, structure-switching sensitivity is difficult to estimate, making it equally difficult to effectively screen modified aptamers with the desired sensitivity. To address this problem, we selected a fluorescent probe capable of detecting G-quadruplex in complicated biological media.

关键词： G-quadruplex aptamer i-motif binding specificity cell microenvironment

石菖蒲生长过程中β-细辛醚积累特征及其饮片品质研究

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天津中医药大学学报 2024年第6期43卷 511-517页

作者：张志聪袁忠诚徐健杨静崔英王跃飞柴欣天津中医药大学中医药研究院现代中药创制全国重点实验室组分中药国家重点实验室天津市中药化学与分析重点实验室天津301617 现代中医药海河实验室天津301617

[目的]基于气相色谱法建立石菖蒲及其挥发油中β-细辛醚的含量测定方法,比较不同产地石菖蒲饮片品质,并研究石菖蒲生长过程中不同药用部位β-细辛醚的积累规律,为合理开发和利用石菖蒲药材资源提供理论依据。[方法]采用水蒸气蒸馏法提... 详细信息

[目的]基于气相色谱法建立石菖蒲及其挥发油中β-细辛醚的含量测定方法,比较不同产地石菖蒲饮片品质,并研究石菖蒲生长过程中不同药用部位β-细辛醚的积累规律,为合理开发和利用石菖蒲药材资源提供理论依据。[方法]采用水蒸气蒸馏法提取不同产地饮片挥发油,计算挥发油得率;采用气相色谱法测定饮片及其挥发油中β-细辛醚含量;采集不同月份石菖蒲新鲜全草,利用气相色谱法测定不同药用部位中β-细辛醚含量。[结果]不同产地饮片中β-细辛醚含量、挥发油含量以及挥发油中β-细辛醚含量差异较大,四川产地饮片指标含量差异较小;在研究期限内石菖蒲中β-细辛醚含量(以干质量计)2月最高,7月次之;石菖蒲叶基中β-细辛醚含量高于根茎,叶中几乎不含β-细辛醚。[结论]建立的检测方法简便快速、定量准确、重复性好,可用于石菖蒲的质量评价。以挥发油含量和β-细辛醚计,四川产地饮片品质较佳;以β-细辛醚计,石菖蒲在2月、7月采收较佳,根茎和叶基质量较好。

关键词：石菖蒲气相色谱 β-细辛醚挥发油采收时间药用部位

Dealloying corrosion of anodic and nanometric Mg41Nd5 in solid solution-treated Mg-3Nd-1Li-0.2Zn alloy

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Journal of Materials Science & Technology 2021年第24期83卷 161-178页

作者： Gui-Jia Gao Mei-Qi Zeng En-Liang Zhang Rong-Chang Zeng Lan-Yue cui Dao-kui xu Feng-Qin Wang M.Bobby Kannan Corrosion Laboratory for Light Metals College of Materials Science and EngineeringShandong University of Science and TechnologyQingdao266590China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou450002China Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Engineering University of NewcastleCallaghanNew South Wales 2308Australia

The microstructure and chemical compositions of the solid solution-treated Mg-3 Nd-1 Li-0.2 Zn alloy were characterized using optical microscope,scanning electron microscope(SEM),transmission electron microscope(TEM),electron probe micro-analyzer(EPMA)and X-ray photoelectron spectroscopy(XPS).The corrosion behaviour of the alloy was investigated via electrochemical polarization,electrochemical impedance spectroscopy(EIS),hydrogen evolution test and scanning Kelvin probe(SKP).The results showed that the microstructure of the as-extruded Mg-3 Nd-1 Li-0.2 Zn alloy containedα-Mg matrix and nanometric second phase Mg_(41)Nd_(5).The grain size of the alloy increased significantly with the increase in the heat-treatment duration,whereas the volume fraction of the second phase decreased after the solid solution *** surface film was composed of oxides(Nd_(2)O_(3),Mg O,Li_(2)O and Zn O)and carbonates(Mg CO3 and Li_(2)CO3),in addition to *** as-extruded alloy exhibited the best corrosion resistance after an initial soaking of 10 min,whereas the alloy with 4 h-solution-treatment possessed the lowest corrosion rate after a longer immersion(1 h).This can be attributed to the formation of Nd-containing oxide film on the alloys and a dense corrosion product *** dealloying corrosion of the second phase was related to the anodic Mg_(41)Nd_(5)with a more negative Volta potential relative toα-Mg *** preferential corrosion of Mg_(41)Nd_(5)is proven by in-situ observation and *** solid solution treatment of Mg-3 Nd-1 Li-0.2 Zn alloy led to a shift in corrosion type from pitting corrosion to uniform corrosion under long-term exposure.

关键词： Magnesium alloy Corrosion Second phase Rare metal Dealloying

Genome-wide identification of abscisic acid(ABA) receptor pyrabactin resistance 1-like protein(PYL) family members and expression analysis of PYL genes in response to different concentrations of ABA stress in Glycyrrhiza uralensis

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Chinese Journal of Natural Medicines 2020年第8期18卷 606-611页

作者： cui Ying-Xian xu Zhi-Chao CHEN Xin-Lian NIE Li-Ping WU Li-Wei WANG Yu SONG Jing-Yuan YAO Hui Key Lab of Chinese Medicine Resources Conservation State Administration of Traditional Chinese Medicine of the People’s Republic of ChinaInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Engineering Research Center of Chinese Medicine Resources Ministry of EducationBeijing 100193China

As abscisic acid(ABA)receptor,the pyrabactin resistance 1-like(PYR/PYL)protein(named PYL for simplicity)plays an important part to unveil the signal transduction of ABA and its regulatory *** uralensis,a drought-tolerant medicinal plant,is a good model for the mechanism analysis of ABA response and active compound ***,knowledge about PYL family in *** remains largely ***,10 PYLs were identified in *** *** analysis indicated that PYLs in ***(Gu PYLs)are relatively *** analysis showed that Gu PYL1-3 belongs to subfamily I,Gu PYL4-6 and Gu PYL10 belong to subfamily II and Gu PYL7-9 belongs to subfamily *** addition,transcriptome data presented various expression levels of Gu PYLs under different exogenous ABA *** expression pattern of Gu PYLs was verified by Quantitative real-time polymerase chain reaction(q RT-PCR).The study proved that Gu PYL4,Gu PYL5,Gu PYL8 and Gu PYL9 genes are significantly up-regulated by ABA stress and the response process is *** study paves the way for elucidating the regulation mechanism of ABA signal to secondary metabolites and improving the cultivation and quality of *** using agricultural strategies.

关键词： Glycyrrhiza uralensis Abscisic acid Pyrabactin resistance 1-like(PYR/PYL)protein family Gene expression Signaling pathway Stress responses