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Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury:state of the art and future perspectives

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Neural Regeneration Research 2025年第11期20卷 3151-3171页

作者： Fatima Aldali Chunchu Deng Mingbo Nie Hong chen Department of Rehabilitation Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

“Peripheral nerve injury”refers to damage or trauma affecting nerves outside the brain and spinal *** nerve injury results in movements or sensation impairments,and represents a serious public health *** severed peripheral nerves have been effectively joined and various therapies have been offered,recovery of sensory or motor functions remains limited,and efficacious therapies for complete repair of a nerve injury remain *** emerging field of mesenchymal stem cells and their exosome-based therapies hold promise for enhancing nerve regeneration and *** stem cells,as large living cells responsive to the environment,secrete various factors and *** latter are nano-sized extracellular vesicles containing bioactive molecules such as proteins,microRNA,and messenger RNA derived from parent mesenchymal stem *** have pivotal roles in cell-to-cell communication and nervous tissue function,offering solutions to changes associated with cell-based *** ongoing investigations,mesenchymal stem cells and mesenchymal stem cell-derived exosome-based therapies are in the exploratory stage.A comprehensive review of the latest preclinical experiments and clinical trials is essential for deep understanding of therapeutic strategies and for facilitating clinical *** review initially explores current investigations of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in peripheral nerve injury,exploring the underlying ***,it provides an overview of the current status of mesenchymal stem cell and exosomebased therapies in clinical trials,followed by a comparative analysis of therapies utilizing mesenchymal stem cells and ***,the review addresses the limitations and challenges associated with use of mesenchymal stem cell-derived exosomes,offering potential solutions and guiding future directions.

关键词： clinical trials exosome extracellular vesicles mesenchymal stem cells nerve regeneration peripheral nerve injury pre-clinical experiments

Dynamic Measurement of Task Scheduling Algorithm in Multi-Processor System

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Journal of Shanghai Jiaotong university(Science) 2019年第3期24卷 372-380页

作者： XIE ying WU Jinzhao chen Jianying cui Mengtian School of Computer Science and Technology Southwest Minzu UniversityChengdu 610041China Guangxi Key Laboratory of Hybrid Computational and IC Design Analysis Guangxi University for NationalitiesNanning 530006China chengdu Institute of Computer Application Chinese Academy of SciencesChengdu 610041China University of Chinese Academy of Sciences Beijing 100049China

It is important to evaluate function behaviors and performance features of task scheduling algorithm in the multi-processor system.A novel dynamic measurement method(DMM)was proposed to measure the task scheduling algorithm’s correctness and *** a multi-processor system,task scheduling problem is represented by a combinatorial evaluation model,interactive Markov chain(IMC),and solution space of the algorithm with time and probability metrics is described by action-based continuous stochastic logic(aCSL).DMM derives a path by logging runtime scheduling actions and corresponding *** judging whether the derived path can be received by task scheduling IMC model,DMM analyses the correctness of *** judging whether the actual values satisfy label function of the initial state,DMM analyses the dependability of *** simulation shows that DMM can effectively characterize the function behaviors and performance features of task scheduling algorithm.

关键词： multi-processor task scheduling algorithm IMC aCSL dynamic measurement

N-Derivations for Finitely Generated Graded Lie Algebras

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Algebra Colloquium 2016年第2期23卷 205-212页

作者： Haifeng Lian cui chen Department of Mathematics Fujian Agriculture and Forestry University Fuzhou 350002 China Department of Mathematics and Physics Fujian University of Technology Fuzhou 350108 China

The N-derivation is a natural generalization of derivation and triple derivation. Let L be a finitely generated Lie algebra graded by a finite-dimensional Cartan subalgebra. In this paper, a sufficient condition for the Lie N-derivation algebra of Lcoinciding with the Lie derivation algebra of L is given. As applications, any N-derivation of the SchrSdinger- Virasoro algebra, generalized Witt algebra, Kac-Moody algebra or their Borel subalgebra is a derivation.

关键词： derivation Cartan subalgebra Virasoro algebra Kac-Moody algebra

DS-MMAC:A Delay-Sensitive Multi-Channel MAC Protocol for Ambient Assistant Living Systems

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China Communications 2016年第5期13卷 38-46页

作者： Haiming chen Li cui Institute of Computing Technology Chinese Academy of Sciences

In Ambient Assistant Living(AAL) systems, it is a fundamental problem to ensure prompt delivery of detected events, such as irregular heart rate or fall of elderly, to a central processing device(e.g. gateway node). Most of recently proposed MAC protocols for low-power embedded sensing systems(e.g. wireless sensor networks) are designed with energy efficiency as the first goal, so they are not suitable for AAL systems. Although some multi-channel MAC protocols have been proposed to address the problem, most of those protocols ignore the cost of channel switching, which can have reverse effect on network performance, especially latency of data delivery. In this paper, we propose a Delay-Sensitive Multi-channel MAC protocol(DS-MMAC) for AAL systems, which can provide high packet delivery ratio and bound low latency for data delivered to the gateway node. The novelty of the protocol is that an efficient distributed time slot scheduling and channel assignment algorithm is combined with the process of route establishment, which takes the channel switching cost into account and reduces endto-end delay to meet the required delay bound of each data flow. The performance of the proposed protocol is evaluated through extensive simulations. Results show that DS-MMAC can bound low latency for delivering detected events in AAL system to the gateway, while providing high delivery reliability and low energy consumption.

关键词： ambient assistant living multi-channel mac channel switching slot scheduling channel assignment

Lasry-Lions, Lax-Oleinik and generalized characteristics

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Science China Mathematics 2016年第9期59卷 1737-1752页

作者： chen cui chenG Wei Department of Mathematics Nanjing University

In the recent works, an intrinsic approach of the propagation of singularities along the generalized characteristics was obtained, even in global case, by a procedure of sup-convolution with the kernel the fundamental solutions of the associated Hamilton-Jacobi equations. In the present paper, we exploit the relations among Lasry-Lions regularization, Lax-Oleinik operators(or inf/sup-convolution) and generalized characteristics, which are discussed in the context of the variational setting of Tonelli Hamiltonian dynamics, such as Mather theory and weak KAM(Kolmogorov-Arnold-Moser) theory.

关键词： Hamilton-Jacobi equations weak KAM theory generalized characteristics

BF_3-promoted annulation of azonaphthalenes and ynamides for synthesis of benzo[e]indoles

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Chinese Chemical Letters 2021年第1期32卷 421-424页

作者： Changwei chen Sunliang cui College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310058China

A novel BF_(3)-promoted [3+2] annulation of azonaphthalenes and ynamides is *** protocol provides a modular and efficient entry to functionalized amino benzo[e]indole derivatives smoothly.

关键词： Azonaphthalenes Ynamides Annulation Benzo[e]indoles

Anti-programmed death 1 antibody in the treatment of coexistent Mycobacterium fortuitum and lung cancer: A case report

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World Journal of Clinical Cases 2022年第12期10卷 3801-3807页

作者： cui-cui Zhang Peng chen Department of Thoracic Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060China

BACKGROUND Nontuberculous mycobacterium(NTM) refers to all mycobacteria except Mycobacterium tuberculosis and Mycobacterium leprae, also known as environmental Mycobacterium. The patients with lung cancer and NTM are somewhat special;the two diseases are inevitably influenced by each other. It brings difficulties and challenges to the choice of treatment. Recently, cancer immunotherapy has been considered one of the pillars for the treatment of lung cancer. However, the clinical experience in the application of immune checkpoint inhibitors is scarce for lung cancer patients with pulmonary tuberculosis, and lung cancer with NTM is even more rare. Although it ameliorates lung cancer, immunotherapy with immune checkpoint inhibitors presents complications of infectious diseases, including tuberculosis and *** SUMMARY A 61-year-old male patient visited a doctor in May 2019. His admitting diagnoses were:(1) Cancer of the left lung with a pathological diagnosis of poorly differentiated non-small cell carcinoma, likely poorly differentiated adenocarcinoma, clinical stage Ⅲb(T3N3M0);and(2) Mycobacterium fortuitum(M. fortuitum) infection. We chose to proceed with pembrolizumab treatment. After two treatment cycles, a chest computed tomography scan showed a new irregular subpleural mass in the anterior segment of the left upper lobe of the lung, a reduction in the mediastinal enlarged lymph node, and no other obvious changes. Next, an ultrasound-guided biopsy of the new tumor was performed. Pathological examination showed that a large number of carbon particles were deposited in the alveolar tissue with histiocyte reaction and multinucleated giant cell formation. The tuberculosis(TB) specialist suggested that anti-TB therapy be combined with continued antitumor treatment. The patient continued to be treated with pembrolizumab. After 14 cycles, the lesion shrunk by 79%, there was no recurrence of M. fortuitum infection, and there were no intolerable adverse ***

关键词： Mycobacterium fortuitum Nontuberculous mycobacterium Non-small cell lung cancer Immune checkpoint inhibitors Case report

An Improved Cooperative Team Spraying Control of a Diffusion Process With a Moving or Static Pollution Source

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IEEE/CAA Journal of Automatica Sinica 2020年第2期7卷 494-504页

作者： Juan chen Baotong cui Yang Quan chen Bo Zhuang Key Laboratory of Advanced Process Control for Light Industry(Ministry of Education)and School of IoT Engineering Jiangnan UniversityWuxi 214122China Mechatronics Embedded Systems and Automation LaboratoryUniversity of CaliforniaMerced CA 95343 USA

This paper is concerned with a control problem of a diffusion process with the help of static mesh sensor networks in a certain region of interest and a team of networked mobile actuators carrying chemical *** major contribution of this paper can be divided into three parts:the first is the construction of a cyber-physical system framework based on centroidal Voronoi tessellations(CVTs),the second is the convergence analysis of the actuators location,and the last is a novel proportional integral(PI)control method for actuator motion planning and neutralizing control(e.g.,spraying)of a diffusion process with a moving or static pollution source,which is more effective than a proportional(P)control *** optimal spraying control cost function is ***,the minimization problem of the spraying amount is ***,a new CVT algorithm based on the novel PI control method,henceforth called PI-CVT algorithm,is introduced together with the convergence analysis of the actuators location via a PI control ***,a modified simulation platform called diffusion-mobile-actuators-sensors-2-dimension-proportional integral derivative(Diff-MAS2D-PID)is *** addition,a numerical simulation example for the diffusion process is presented to verify the effectiveness of our proposed controllers.

关键词： Centroidal Voronoi tessellations(CVTs) diffusion processes mobile actuator-sensor networks(MAS-Net) PI control

Development and application of an online testing system for clinical nurses

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International Journal of Nursing Sciences 2015年第3期2卷 313-316页

作者： Jin-rui cui ying chen Hai-yan Zhang Department of Nursing Tongji Medical CollegeHuazhong University of Science and TechnologyTongji HospitalChina

The online assessment is a new examination system which has a broad application in many research fields such as medical science and has been proved to be effective,reliable,and *** aim of this study was to establish an online testing system for clinical nurses and to assess its effectiveness compared with traditional paper-based tests in China.A randomized controlled trial was performed,a total of 1802 nurses were recruited and randomly assigned to take either the paper-formatted test or the online *** the paper quality,examinee's performance and nurses'assessments of online testing system were *** results shown that online assessment system for clinical nurses had a comparable examination effects with traditional paper-based format,and the nurse spoke highly of its effectiveness and *** data suggest that online nursing assessments should be considered a dependable replacement for paper test.

关键词： Application effects Clinical nurses Online assessment system Paper-based format