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Chemerin deficiency regulates adipogenesis is depot different through TIMP1

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Genes & Diseases 2021年第5期8卷 698-708页

作者： Cheng-Long Huang Liu-Ling Xiao Min Xu Jun Li Shu-Fen Li cui-song zhu Yu-Li Lin Rui He Xi Li Biology Science Institutes Chongqing Medical UniversityChongqing400016PR China Center for Translational Research in Hematologic Malignancies Houston Methodist Cancer CenterHouston Methodist Research InstituteHoustonTX 77030USA Key Laboratory of Metabolic Molecular Medicine The Ministry of EducationDepartment of Biochemistry and Molecular BiologyFudan University Shanghai Medical CollegeShanghai200032PR China Shanghai Public Health Clinical Center Fudan UniversityShanghai201508PR China Department of Immunology Fudan University Shanghai Medical CollegeShanghai200032PR China

Adipocytes and immune cells are vital for the development of adipose ***-pokines secreted by adipocytes regulate adipogenesis and body *** is one of the ***,the function and mechanism of chemerin in adipose tissue are not fully *** with wild type(WT)mice,Rarres2^(-/-)mice gained weight and significantly increased fat distribution in subcutaneous adipose tissue(SAT),rather than visceral adipose tissue(VAT)on high fat diet(HFD).PPARg and C/EBPa,the master regulators of adipogenesis,were up-regulated in SAT and down-regulated in VAT in Rarres2^(-/-)mice comparing with WT *** of chemerin deficiency or not,the ratio of adipocyte-progenitors to total cells and the differentiation capacity of adipocyte-progenitors were similar in SAT and VAT,but macrophage infiltration in VAT was more severe than in SAT in Rarres2^(-/-)***,CD45þimmune cells supernatant from Rarres2^(-/-)SAT pro-moted the differentiation of adipocyte-progenitors and 3T3-L1 *** array assay of CD45þimmune cells supernatant revealed that metalloproteinase inhibitor 1(TIMP1),an in-hibitor of adipogenesis,was reduced in Rarres2^(-/-)SAT,but increased in Rarres2^(-/-)*** we specifically knocked down chemerin in SAT,TIMP1 was down-regulated and adipogenesis was promoted with reducing infiltration of *** present study demonstrates that the effects of chemerin on adipose tissue is depot different,and specific knock down chemerin in SAT promote adipogenesis and improve glucose tolerance test(GTT)and insulin tolerance test(ITT).This suggests a potential therapeutic target for chemerin in the treatment of obesity related metabolic disorder.

关键词： Adipogenesis Adipose tissue depot Chemerin Inflammation TIMP1

Impacts of the annual cycle of background SST in the tropical Pacific on the phase and amplitude of ENSO

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 12-17页

作者： song Jiang Congwen zhu Ning Jiang State Key Laboratory of Severe Weather(LASW) Chinese Academy of Meteorological SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina

The dominant annual cycle of sea surface temperature(SST)in the tropical Pacific exhibits an antisymmetric mode,which explains 83.4%total variance,and serves as a background of El Niño-Southern Oscillation(ENSO).However,there is no consensus yet on its anomalous impacts on the phase and amplitude of *** on data during 1982-2022,results show that anomalies of the antisymmetric mode can affect the evolution of ENSO on the interannual scale via Bjerknes feedback,in which the positive(negative)phase of the antisymmetric mode can strengthen El Niño(La Niña)in boreal winter via an earlier(delayed)seasonal cycle transition and larger(smaller)annual *** magnitude of the SST anomalies in the equatorial eastern Pacific can reach more than±0.3◦C,regulated by the changes in the antisymmetric mode based on random sensitivity *** reveal the spatial pattern of the annual cycle associated with the seasonal phase-locking of ENSO evolution and provide new insight into the impact of the annual cycle of background SST on ENSO,which possibly carries important implications for forecasting ENSO.

关键词： Annual cycle SST anomaly Antisymmetric mode ENSO

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锚网喷索联合支护在软岩巷道的设计与应用

煤炭工程 2007年第11期39卷 12-14页

作者：宋子玉崔松竹长春煤炭设计研究院吉林长春130012

随着采深的增加,软岩巷道的支护问题日益突出。论文以理论分析与工程实际相结合,阐述了锚网喷支护结构与喷射混凝土、锚索、锚注加固技术组合使用的联合支护结构,并介绍了预应力锚索、可拉伸锚杆、锚注技术及支护参数。

关键词：软岩联合支护锚杆支护参数

A new horizon for neuroscience:terahertz biotechnology in brain research

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Neural Regeneration Research 2025年第2期20卷 309-325页

作者： Zhengping Pu Yu Wu Zhongjie zhu Hongwei Zhao Donghong cui Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry Kangci Hospital of JiaxingTongxiangZhejiang ProvinceChina Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of ScienceShanghaiChina National Facility for Protein Science in Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina

Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain *** this article,we review the development of terahertz biotechnology and its applications in the field of *** evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin *** vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric *** the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic ***,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical *** review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.

关键词： biological effect brain neuron neuropsychiatry neuroscience non-thermal effect terahertz imaging terahertz radiation terahertz spectroscopy terahertz technology

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关于刨煤机应用情况及建议

煤炭工程 2007年第8期39卷 55-56页

作者：石延国崔松竹长春高新技术开发区管委会吉林长春130012 长春煤炭设计研究院吉林长春130012

文章通过介绍国产刨煤机和德国刨煤机在国内的使用情况,阐述了目前国产刨煤机使用情况,同时总结了德国刨煤机技术特征及优势,并提出引进德国刨煤机核心技术的建议。

关键词：薄煤层刨煤机核心技术应用情况

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提高综采放顶煤工作面采出率的措施

煤矿开采 2007年第5期12卷 39-40页

作者：宋子玉崔松竹长春煤炭设计研究院吉林长春130012

在目前的装备和技术水平下,进一步降低初采和末采损失、上下端头损失的可能性较小,但是降低落煤损失的潜力较大。阐述了放顶煤液压支架架型、放煤步距、采放比、放煤工艺等对降低落煤损失的影响,旨在为同行提供参考。

关键词：综采放顶煤采出率途径

基于多尺度融合金字塔焦点网络的接触网零部件检测

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工程科学学报 2025年第2期47卷 315-327页

作者：朱新宇崔浩锐宋洋中国民用航空飞行学院航空电子电气学院广汉618307 西南交通大学利兹学院成都611756

作为高铁牵引供电系统的重要组成部分,接触网系统承担着向动车组传输电能的重要功能.实际工程运营表明,受弓网交互产生的持续冲击以及外部环境的影响,接触网支撑部件可能会出现“松、脱、断、裂”等缺陷,导致接触网结构可靠性下降,严重... 详细信息

作为高铁牵引供电系统的重要组成部分,接触网系统承担着向动车组传输电能的重要功能.实际工程运营表明,受弓网交互产生的持续冲击以及外部环境的影响,接触网支撑部件可能会出现“松、脱、断、裂”等缺陷,导致接触网结构可靠性下降,严重影响接触网系统稳定运行.因此,及时精确定位接触网支撑部件(CSCs),对保障高铁安全运行和完善接触网检修维护策略具有重大意义.然而,CSCs的检测通常面临着零部件种类多、尺度差异大、部分零部件微小的问题.针对以上问题,本文提出一种基于多尺度融合金字塔焦点网络的接触网零部件检测算法,将平衡模块和特征金字塔模块相结合,提高对小目标的检测性能.首先,设计了可分离残差金字塔聚合模块(SRPAM),用于优化模型多尺度特征提取能力、扩大感受野,缓解CSCs检测的多尺度问题;其次,设计了一种基于平衡特征金字塔的路径聚合网络(PA-BFPN),用于提升跨层特征融合效率和小目标检测性能.最后,通过对比试验、可视化实验和消融实验证明了所提方法的有效性和优越性.其中,所提的MFPFCOS在CSCs数据集上的检测精度(mAP)能够在达到48.6%的同时,实现30的FLOPs(Floating point operations per second),表明所提方法能够在检测精度和检测速度之间保持良好的平衡.

关键词：深度学习目标检测接触网支撑组件(CSCs) 路径聚合特征金字塔(PA-FPN) 空洞空间卷积池化金字塔(ASPP)

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普惠金融发展对长三角地区城乡收入差距的影响--基于静态空间面板模型的分析

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沈阳工业大学学报（社会科学版） 2022年第6期15卷 537-542页

作者：陈燕玲宋翠竹安徽大学经济学院合肥230601

实施长三角一体化发展战略是对我国改革开放空间布局的进一步完善,缩小城乡收入差距是实现长三角一体化的重要举措。基于2005-2019年长三角地区27个核心城市的面板数据,通过静态空间面板模型分析,研究普惠金融如何影响城乡收入差距。研... 详细信息

实施长三角一体化发展战略是对我国改革开放空间布局的进一步完善,缩小城乡收入差距是实现长三角一体化的重要举措。基于2005-2019年长三角地区27个核心城市的面板数据,通过静态空间面板模型分析,研究普惠金融如何影响城乡收入差距。研究结果表明,城乡收入差距在长三角各地区之间空间聚集效应明显,普惠金融发展与城乡收入差距之间存在非完全一致的倒U型关系。据此提出,长三角地区应加大普惠金融供给力度、加强区域内普惠金融合作以及优化普惠金融外部环境。

关键词：长三角一体化普惠金融城乡收入差距空间计量面板模型

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Protein-based functional hydrogel improves cutaneous nerve repair and diabetic wound healing

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Nano Research 2025年第1期18卷 586-596页

作者： Hanzhi Lu Mingrui cui Yi Wang Xinran Du Xinyi Zhou Yuhan Fang Xiaoyan Gao Ying Peng Jianyong zhu Guang Yang Fulun Li Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine College of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620China Clinical Laboratory Medicine Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

Cutaneous nerve regeneration in diabetic wounds remains a challenge for current clinical ***,a natural protein-based functional hydrogel is developed using keratin as the sole matrix,and protocatechuic aldehyde(PA)and zinc ions as the building blocks through dual-dynamic crosslinking reactions of thiol-aldehyde addition and catecholzinc ions *** unique structural design endows the hydrogel with excellent injectability,skin adhesion,self-healing and antibacterial ability,and *** addition,this hydrogel acts as a drug carrier for the loading and sustained release of phellopterin(PP),a natural compound extracted from traditional Chinese medicine Angelica *** findings demonstrate that the PP-loaded hydrogel promotes cutaneous nerve regeneration,angiogenesis and tissue remodeling in the full-thickness wounds in both db/db and streptozotocin-induced C57BL/6 diabetic mice,notably by the synergistic effect of zinc ions and PP,showing a great potential in diabetic wound therapy.

关键词： functional hydrogel cutaneous nerve regeneration dynamic crosslinking diabetic wounds