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Research progress and future prospects in the service security of key blast furnace equipment

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International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2121-2135页

作者： Yanxiang Liu Kexin Jiao Jianliang zhang cui Wang Lei zhang Xiaoyue Fan School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Research Institute of Macro-Safety Science University of Science and Technology BeijingBeijing 100083China

The safety and longevity of key blast furnace(BF)equipment determine the stable and low-carbon production of *** pa-per presents an analysis of the heat transfer characteristics of these components and the uneven distribution of cooling water in parallel pipes based on hydrodynamic principles,discusses the feasible methods for the improvement of BF cooling intensity,and reviews the pre-paration process,performance,and damage characteristics of three key equipment pieces:coolers,tuyeres,and hearth ***-thermoere,to attain better control of these critical components under high-temperature working conditions,we propose the application of optimized technologies,such as BF operation and maintenance technology,self-repair technology,and full-lifecycle management ***,we propose further researches on safety assessments and predictions for key BF equipment under new operating conditions.

关键词： blast furnace equipment service security blast furnace campaign self-repair

Impact of H_(2)S on Hg^(0)capture performance over nitrogen-doped carbon microsphere sorbent:experimental and theoretical insights

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Frontiers of Chemical Science and Engineering 2024年第3期18卷 89-100页

作者： Guopei zhang Xiaoyang zhang Xiangwen Xing Xiangru Kong Lin cui Dong Yong National Engineering Laboratory for Reducing Emissions from Coal Combustion Shandong UniversityJinan250061China Bingtuan Energy Development Institute Shihezi UniversityShihezi832000China

A nitrogen-doped carbon microsphere sorbent with a hierarchical porous structure was synthesized via aggregation-hydrothermal *** Hg^(0)adsorption performance of the nitrogen-doped carbon microsphere sorbent was tested and compared with that of the coconut shell activated carbon prepared in the *** effect of H_(2)S on Hg^(0)adsorption was also *** nitrogen-doped carbon microsphere sorbent exhibited superior mercury removal performance compared with that of coconut shell activated *** the absence of H_(2)S at a low temperature(≤100℃),the Hg^(0)removal efficiency of the nitrogen-doped carbon microsphere sorbent exceeded 90%.This value is significantly higher than that of coconut shell activated carbon,which is approximately 45%.H_(2)S significantly enhanced the Hg^(0)removal performance of the nitrogen-doped carbon microsphere sorbent at higher temperatures(100–180℃).The hierarchical porous structure facilitated the diffusion and adsorption of H_(2)S and Hg^(0),while the nitrogen-containing active sites significantly improved the adsorption and dissociation capabilities of H_(2)S,contributing to the generation of more active sulfur species on the surface of the nitrogen-doped carbon microsphere *** formation of active sulfur species and HgS on the sorbent surface was further confirmed using X-ray photoelectron spectroscopy and Hg^(0)temperature-programmed desorption *** functional theory was employed to elucidate the adsorption and transformation of Hg^(0)on the sorbent surface.H_(2)S adsorbed and dissociated on the sorbent surface,generating active sulfur species that reacted with gaseous Hg^(0)to form HgS.

关键词： nitrogen-doped carbon microsphere H_(2)S Hg^(0)removal adsorption mechanism

MnO_(2)-coated nanodiamond-driven photodynamic therapy for enhanced antitumor effect by addressing hypoxia and glutathione depletion

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Particuology 2024年第9期92卷 305-315页

作者： Jicheng cui Dongmei zhang Hui Qiao Zeyu Yan Wenxia zhang Yingqi Li Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Institute of Molecular ScienceShanxi UniversityTaiyuan030006China Taiyuan Central Hospital Taiyuan030009China School of Chemistry and Chemical Engineering Shanxi UniversityTaiyuan030006China

The generation of reactive oxygen species(ROS)at the tumor site to induce destruction is emerging as a novel strategy for cancer treatment,which involves photodynamic therapy(PDT).Nevertheless,tumors typically create a hypoxic environment and are equipped with an endogenous antioxidant defense system that could potentially impede the efficiency of the therapeutic *** overcome these drawbacks,herein,a tumor microenvironment-responsive the ND-PAA-CD-Ce6@MnO_(2)(NPCC@M)delivery system was fabricated by disulfide bond coupling chlorin e6(Ce6)to nanodiamond(ND)and further wrapped by MnO_(2)nanosheets to facilitate *** use of disulfide bond not only stabilizes Ce6 in the blood circulation to prevent premature leakage,but also destroys the antioxidant barrier of overexpressed glutathione(GSH)in tumor ***,the outer MnO_(2)was rapidly degraded by the endogenous hydrogen peroxide(H_(2)O_(2))in the acidic pH and GSH within the tumor cells,which leads to an abundance of O_(2)and while increases the level of 1O_(2)under laser *** results eventually broke the redox homeostasis and attenuate hypoxia,thereby inducing apoptosis and necrosis of tumor *** in vitro and in vivo biological effect has revealed a good biosafety profile and a high tumor suppression *** a novel ND-based system with tumor microenvironment-modulating capability to elevate oxygen content and promote GSH consumption in tumor cells opens new opportunities for enhanced ROS treatment paradigms.

关键词： Nanodiamond Photodynamic Chlorin e6 MnO_(2) Tumor suppression

Selection of dialysis methods for end-stage kidney disease patients with diabetes

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World Journal of Diabetes 2024年第9期15卷 1862-1873页

作者： Yao-hua Hu Ya-Li Liu Ling-Fei Meng Yi-Xian zhang Wen-Peng cui Department of Nephrology The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina

The increasing prevalence of diabetes has led to a growing population of endstage kidney disease(ESKD)patients with ***,kidney transplantation is the best treatment option for ESKD patients;however,it is limited by the lack of ***,dialysis has become the standard treatment for ESKD ***,the optimal dialysis method for diabetic ESKD patients remains *** patients with diabetes often present with complex conditions and numerous ***,these patients face a high risk of infection and technical failure,are more susceptible to malnutrition,have difficulty establishing vascular access,and experience more frequent blood sugar fluctuations than the general ***,this article reviews nine critical aspects:Survival rate,glucose metabolism disorder,infectious complications,cardiovascular events,residual renal function,quality of life,economic benefits,malnutrition,and volume *** study aims to assist clinicians in selecting individualized treatment methods by comparing the advantages and disadvantages of hemodialysis and peritoneal dialysis,thereby improving patients’quality of life and survival rates.

关键词： Diabetes End-stage kidney disease Hemodialysis Peritoneal dialysis Dialysis methods selection

Manufacturing CAR-NK against tumors: Who is the ideal supplier?

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Chinese Journal of Cancer Research 2024年第1期36卷 1-16页

作者： Feifei Guo Yi zhang Jiuwei cui The First Hospital of Jilin University Cancer CenterChangchun 133021China

Chimeric antigen receptor-natural killer(CAR-NK) cells have emerged as another prominent player in the realm of tumor immunotherapy following CAR-T cells. The unique features of CAR-NK cells make it possible to compensate for deficiencies in CAR-T therapy, such as the complexity of the manufacturing process, clinical adverse events, and solid tumor challenges. To date, CAR-NK products from different allogeneic sources have exhibited remarkable anti-tumor effects on preclinical studies and have gradually been applied in clinical ***, each source has advantages and disadvantages. Selecting a suitable source may help maximize CAR-NK cell efficacy and increase the feasibility of clinical transformation. Therefore, this review discusses the development and challenges of CAR-NK cells from different sources to provide a reference for future exploration.

关键词： CAR-NK cells cord blood iPSC NK-92 cells peripheral blood

Thermogalvanic hydrogel-based e-skin for self-powered on-body dual-modal temperature and strain sensing

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Microsystems & Nanoengineering 2024年第2期10卷 293-302页

作者： Zhaosu Wang Ning Li Xinru Yang Zhiyi zhang Hulin zhang Xiaojing cui College of Electronic Information and Optical Engineering Taiyuan University of TechnologyTaiyuan030024China College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan030024China School of Physics and Information Engineering Shanxi Normal UniversityTaiyuan030031China

Sensing of both temperature and strain is crucial for various diagnostic and therapeutic ***,we present a novel hydrogel-based electronic skin(e-skin)capable of dual-mode sensing of temperature and *** thermocouple ion selected for this study is the iodine/triiodide(I−/I3−)redox couple,which is a common component in everyday *** leveraging the thermoelectric conversion in conjunction with the inherent piezoresistive effect of a gel electrolyte,self-powered sensing is achieved by utilizing the temperature difference between the human body and the external *** composite hydrogels synthesized from polyvinyl alcohol(PVA)monomers using a simple freeze‒thaw method exhibit remarkable flexibility,extensibility,and adaptability to human *** incorporation of zwitterions further augments the resistance of the hydrogel to dehydration and low temperatures,allowing maintenance of more than 90%of its weight after 48 h in the *** its robust thermal current response,the hydrogel was encapsulated and then integrated onto various areas of the human body,including the cheeks,fingers,and ***,the detection of the head-down state and the monitoring of foot movements demonstrate the promising application of the hydrogel in supervising the neck posture of sedentary office workers and the activity *** successful demonstration of self-powered on-body temperature and strain sensing opens up new possibilities for wearable intelligent electronics and robotics.

关键词： hydrogel modal utilizing

A lithium–tin fluoride anode enabled by ionic/electronic conductive paths for garnet-based solid-state lithium metal batteries

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Rare Metals 2024年第2期43卷 575-587页

作者： Lei zhang Qian-Kun Meng Xiang-Ping Feng Ming Shen Yu-Qing zhang Quan-Chao Zhuang Run-Guo Zheng Zhi-Yuan Wang Yan-hua cui Hong-Yu Sun Yan-Guo Liu School of Materials Science and Engineering Northeastern UniversityShenyang110819China School of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao066004China School of Materials and Physics China University of Mining&TechnologyXuzhou221116China Institute of Electronic Engineering China Academy of Engineering PhysicsMianyang621900China

The high energy density and stability of solid-state lithium metal batteries(SSLMBs)have garnered great ***-type oxides,especially Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO),with high ionic conductivity,wide electrochemical window,and stability to Li metal anode,are promising solid-state electrolyte(SSEs)materials for ***,Li/LLZTO interface issues including high interface resistance,inhomogeneous Li deposition,and Li dendrite growth have hindered the practical application of ***,a multi-functional Li–SnF_(2) composite anode with Li,LiF,and Li-Sn alloy was specifically designed and *** composite anode improves the wettability to LLZTO,constructing an intimate contact interface between it and ***,ionic/electronic conductive paths in situ formed at the interface can effectively uniform Li deposition and suppress Li *** solid-state symmetric cell exhibits low interface resistance(11Ω·cm^(2)) and high critical current density(1.3 mA·cm^(−2))at 25℃.The full SSLMB based on LiFePO_(4) or LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2) cathode also shows stable cycling performance and high rate *** work provides a new composite anode strategy for achieving high-energy density and high-safety SSLMBs.

关键词： Solid-state lithium metal batteries(SSLMBs) Lithium-tin fluoride anode Ionic/electronic conductive Interface resistance Lithium dendrite

Single-cell transcriptomics reveals T-cell heterogeneity and immunomodulatory role of CD4+T native cells in Candida albicans infection

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BIOCELL 2024年第9期48卷 1355-1368页

作者： KERAN JIA YANHAO zhang MENGYU JIANG MENGGE cui JIA WANG JIAJIA zhang HUIHAI ZHAO MENGYAN LI hua WANG QUANMING ZOU HAO ZENG National Engineering Research Center of Immunological Products Department of Microbiology and Biochemical PharmacyCollege of PharmacyArmy Medical UniversityChongqing400038China Department of Clinical Laboratory The 980th Hospital of PLA Joint Logistics Support Force(Bethune International Peace Hospital)Shijiazhuang050082China

Objective:Candida albicans is a common fungal pathogen that triggers complex host defense mechanisms,including coordinated innate and adaptive immune responses,to neutralize invading fungi *** the immune microenvironment has the potential to inform the development of therapeutic strategies for fungal ***:The study analyzed individual immune cell profiles in peripheral blood mononuclear cells from Candida albicans-infected mice and healthy control mice using single-cell transcriptomics,fluorescence quantitative PCR,and Western *** investigated intergroup differences in the dynamics of immune cell subpopulation infiltration,pathway enrichment,and differentiation during Candida albicans ***:Our findings indicate that infiltration of CD4^(+)naive cells,regulatory T(Treg)cells,and Microtubules(MT)-associated cells increased after infection,along with impaired T cell ***,CD4^(+)T cells and plasma cells were enhanced after infection,suggesting that antibody production is dependent on T *** addition,we screened 6 hub genes,transcription factor forkhead box protein 3(Foxp3),cytotoxic T-lymphocyte associated protein 4(CTLA4),Interleukin 2 Receptor Subunit Beta(Il2rb),Cd28,C-C Motif Chemokine Ligand 5(Ccl5),and Cd27 for alterations associated with CD4^(+)T cell ***:These results provide a comprehensive immunological landscape of the mechanisms of Candida albicans infection and greatly advance our understanding of adaptive immunity in fungal infections.

关键词： Candida albicans Single-cell transcriptomics Immune microenvironment Fungal infections Hub gene

Explainable Neural Network for Sensitivity Analysis of Lithium-ion Battery Smart Production

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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 1944-1953页

作者： Kailong Liu Qiao Peng Yuhang Liu Naxin cui Chenghui zhang School of Control Science and Engineering Shandong UniversityJinan 250061China Information Technology Analytics&Operations groupQueen’s University BelfastBelfast BT71NNUK

Battery production is crucial for determining the quality of electrode,which in turn affects the manufactured battery *** battery production is complicated with strongly coupled intermediate and control parameters,an efficient solution that can perform a reliable sensitivity analysis of the production terms of interest and forecast key battery properties in the early production phase is urgently *** paper performs detailed sensitivity analysis of key production terms on determining the properties of manufactured battery electrode via advanced data-driven *** be specific,an explainable neural network named generalized additive model with structured interaction(GAM-SI)is designed to predict two key battery properties,including electrode mass loading and porosity,while the effects of four early production terms on manufactured batteries are explained and *** experimental results reveal that the proposed method is able to accurately predict battery electrode properties in the mixing and coating *** addition,the importance ratio ranking,global interpretation and local interpretation of both the main effects and pairwise interactions can be effectively visualized by the designed neural *** to the merits of interpretability,the proposed GAM-SI can help engineers gain important insights for understanding complicated production behavior,further benefitting smart battery production.

关键词： Battery management battery manufacturing data science explainable artificial intelligence sensitivity analysis