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Moxibustion eases chronic inflammatory visceral pain through regulating MEK, ERK and CREB in rats

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World Journal of Gastroenterology 2017年第34期23卷 6220-6230页

作者： Zhi-Yuan Li Yan Huang Yan-Ting Yang Dan zhang Yan Zhao Jue hong Jie Liu Li-Jie Wu cui-hong zhang Huan-Gan Wu Ji zhang Xiao-Peng Ma Shanghai University of Traditional Chinese Medicine Huangpu Hospital of Integrated Traditional Chinese and Western Medicine Shanghai Shanghai Research Institute of Acupuncture and Meridian Yunnan University of Traditional Chinese Medicine

AIM To investigate the effects of herb-partitioned moxibustion(HPM) on phosphorylation of mitogen-activated extracellular signal-regulated kinase(MEK)1, extracellular signal-regulated kinase(ERK)1/2 and c AMP response element binding protein(CREB) in spinal cord of rats with chronic inflammatory visceral pain(CIVP), and to explore the central mechanism of HPM in treating *** Male Sprague-Dawley rats were randomized into normal, model, HPM, sham-HPM, MEK-inhibitor and dimethyl sulfoxide(DMSO) groups. The CIVP model was established using an enema mixture of trinitrobenzene sulfonic acid and ethanol. HPM was applied at bilateral Tianshu(ST25) and Qihai(CV6) acupoints in the HPM group, while in the sham-HPM group, moxa cones and herb cakes were only placed on the same points but not ignited. The MEK-inhibitor and DMSO groups received L5-L6 intrathecal injection of U0126 and 30% DMSO, respectively. Abdominal withdrawal reflex(AWR), mechanical withdrawal threshold(MWT) and thermal withdrawal latency(TWL) were applied for the assessment of pain behavior. The colonic tissue was observed under an optical microscope after hematoxylin-eosin staining. Expression of phosphor(p)MEK1, p ERK1/2 and p CREB in rat spinal cord was detected using Western blotting. The levels of MEK, ERK and CREB m RNA in rat spinal cord were detected using real-time polymerase chain reaction. RESULTS Compared with the normal group, the AWR scores were increased significantly(P < 0.01) and the MWT and TWL scores were decreased significantly(P < 0.05) in the model, sham-HPM and DMSO groups. Compared with the model group, the AWR scores were decreased significantly(P < 0.01) and the MWT and TWL scores were increased significantly in the HPM and MEK-inhibitor groups(P < 0.05). Compared with the sham-HPM and DMSO groups, the AWR scores were decreased significantly(P < 0.01) and the MWT and TWL scores were increased significantly(P < 0.05) in the HPM and MEK-inhibitor groups. Compared with the norma

关键词： Herb-partitioned moxibustion Chronic inflammatory visceral pain Pain behavior Analgesia MEK Extracellular signal-regulated kinase c AMP response element binding protein Signaling pathway

Inflammatory airway features and hypothalamic-pituitary- adrenal axis function in asthmatic rats combined with chronic obstructive pulmonary disease

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Chinese Medical Journal 2010年第13期123卷 1720-1726页

作者： CAI cui zhang hong-ying LE Jing-jing DONG Jing-cheng cui Yan XU Chang-qing LIU Bao-jun WU Jin-feng DUAN Xiao-hong CAO Yu-xue Lab of Integrative Medicine for Lung Inflammation and Cancers Huashan Hospital Fudan University Shanghai 200040 China

Background Bronchial asthma （BA） and chronic obstructive pulmonary disease （COPD） are both inflammatory airway diseases with different characteristics. However, there are many patients who suffer from both BA and COPD. This study was to evaluate changes of inflammatory airway features and hypothalamic-pituitary-adrenal （HPA） axis function in asthmatic rats combined with COPD. Methods Brown Norway （BN） rats were used to model These three models were compared and evaluated with the inflammatory airway diseases of BA, COPD and COPD＋BA. respect to clinical symptoms, pulmonary histopathology, airway hyperresponsiveness （AHR）, inflammatory cytokines and HPA axis function. Results The inflammatory airway features and HPA axis function in rats in the COPD＋BA model group were greatly influenced. Rats in this model group showed features of the inflammatory diseases BA and COPD. The expression of inflammatory cytokines in this model group might be up or downregulated when both disease processes are present. The levels of corticotrophin releasing hormone mRNA and corticosterone in this model group were both significantly decreased than those in the control group （P 〈0.05）. Conclusions BN rat can be used as an animal model of COPD＋BA. By evaluating this animal model we found that the features of inflammation in rats in this model group seem to be exaggerated. The HPA axis functions in rats in this model group have been disturbed or impaired, which is prominent at the hypothalamic level.

关键词： chronic obstructive pulmonary disease bronchial asthma inflammatory airway disease hypothalamic-pituitary-adrenal axis

Green Project System Design of Machine Process Factory

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厦门大学学报（自然科学版） 2002年第S1期41卷 77-78页

作者： CHEN Jian-fei, LI Jian-hua, cui Jiang-hong, zhang Su-x iang, LI Chun-guang, NIU Yong-sheng (Department of Mechanical Engineering, Zhongyuan Institute of Technolog y, Zhengzhou 450007, China)

As the specialty of the product and the dim conscio us ness of environmental protection, the status of dirty, chaos and difference is l ong-term existed in the machine process factory. It seriously affects workers’ work and living environment, and restricts the total level of the environment p rotection in our country. The project is the fatal scientific research task of H enan province in 2001. As the members’ endeavor of task group, we have finished the total plan of green project system and some other key equipment to the mach ine process factory, such as the design of conveyer of chip, hydraulic former of chip, rough conveyer and dirt collector. And the green project system is made i nto model that the manufacturer can select. This item is a fire-new work. We ho pe that the expert of machine, environment protection and government official ca n put forward some advices by lodging this article. We contribute for our countr y’ environment protection and make it attain a new level.

关键词： environment protection green project machining chip transportation

Neural mechanisms of implicit cognitive reappraisal in panic disorder: an fMRI study

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Neural mechanisms of implicit cognitive reappraisal in panic...

Comparative study on epidemiological and etiological characteristics of patients with acute diarrhea with febrile or non-febrile symptoms in China

中国神经科学学会第十二届全国学术会议

作者： HAI-YANG WANG cui-hong zhang GUO-QING XU MING-FEI NI BING-WEI zhang Department of Neurology and Psychiatry First Affiliated Hospital of Dalian Medical University Department of Psychology Dalian Medical University Department of Radiology First Affiliated Hospital of Dalian Medical University

Objective Panic disorder（PD） is a acute anxiety disorder, and its etiology and mechanism is still unclear. Considering empirical studies which explored the mechanism of panic disorder used to be limited in the field of deliberate emotion regulation, the present research focused on the emotion disorder and the symptom happened spontaneously and out of unawareness, which are the core symptom of panic subjects. By using neuropsychology scale, emotional experience self-report, and functional magnetic resonance imaging（fMRI）, the social psychological features, unconscious regulation of emotion, and brain processing of implicit cognitive reappraisal were investigated. Methods: Functional magnetic resonance imaging was conducted on 26 panic disorder patients and 25 healthy controls while they passively viewed unpleasant images that were previously neutrally or negatively described. At the same time, the 4-point scale was used to record the emotional self-report. Before the task, Cognitive Emotion Regulation Questionnaire（CERQ） was obtained from both panic and control group. The withingroup analysis, group comparison and correlation analysis were analyzed in the neuropsychology scale, emotional experience self-report and fMRI data. Result:（1） PD group scored significantly higher on the strategies catastrophizing and rumination, and significantly lower on the strategies positive reappraisal and putting into perspective than control group.（2） The interaction effect of group x description was found in the 4-point scale of picture valence.（3） In control group, dorsolateral and dorsomedial prefrontal cortices, lateral orbitofrontal cortex, and temporal cortex, and decreased activation in the amygdala was observed when unpleasant images were preceded by neutral/positive versus negative descriptions.（4） Compared with control group, decreased activity in prefrontal areas including the dorsolateral and dorsomedial prefrontal cortices, and temporal cortex, and increased activation in

关键词： panic disorder emotion regulation cognitive reappraisal fMRI prefrontal cortex

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Infectious Diseases of Poverty 2023年第4期12卷 17-28页

作者： Tao Wang Gang Wang Chun-Xi Shan Yan-Qun Sun Xiang Ren Lin-Jie Yu Yi-Fei Wang Sheng-hong Lin Xiao-Ai zhang Hao Li cui-hong zhang Meng-Jie Geng Wei-Zhong Yang Li-Ping Wang Wei Liu Li-Qun Fang Department of Epidemiology and Biostatistics School of Public HealthWuhan UniversityWuhanHubeiPeople’s Republic of China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology20 Dong-Da StreetFengtai DistrictBeijing100071People’s Republic of China Nanjing Center for Disease Control and Prevention NanjingPeople’s Republic of China Division of Infectious Disease Key Laboratory of Surveillance and Early-Warning On Infectious DiseaseChinese Center for Disease Control and PreventionNo.155 Changbai RoadChangping DistrictBeijing102206People’s Republic of China Chinese Center for Disease Control and Prevention BeijingPeople’s Republic of China

Background Acute diarrhea with fever can potentially represent a more severe form of the disease compared to non-febrile diarrhea. This study was to investigate the epidemiological characteristics and enteric pathogen composition of febrile-diarrheal patients, and to explore factors including pathogens associated with fever by age *** A nationwide surveillance study of acute diarrheal patients of all ages was conducted in 217 sentinel hospitals from 31 provinces (autonomous regions or municipalities) in China between 2011 and 2020. Seventeen diarrhea-related pathogens, including seven viruses and ten bacteria, were investigated and their association with occurrence of fever symptoms was assessed using multivariate logistic *** A total of 146,296 patients with acute diarrhea (18.6% with fever) were tested. Th diarrheal children below 5 years had the highest frequency of fever (24.2%), and related to significantly higher prevalence of viral enteropathogens (40.2%) as compared with other age groups (P < 0.001). Within each age group, the febrile-diarrheal patients were associated with a significantly higher prevalence of bacterial pathogens than afebrile-diarrheal patients (allP < 0.01). There was discrepancy when each pathogen was compared, i.e., nontyphoidalSalmonella (NTS) was over-represented in febrile vs non-febrile patients of all age groups, while the febrile vs non-febrile difference for diarrheagenicEscherichia coli (DEC) was only significant for adult groups. The multivariate analysis revealed significant association between fever and infection with rotavirus A among children [odds ratio (OR) = 1.60], for DEC in adult groups (OR = 1.64), for NTS in both children (OR = 2.95) and adults (OR = 3.59).Conclusions There are significant discrepancy of the infected enteric pathogens in patients with acute diarrhea with fever between age groups, and it is valuable for priority detection of NTS and rotavirus A in patients with children < 5 years

关键词： Acute diarrhea Epidemiology Enteropathogens Fever China

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卡瓦内悬挂管柱承载能力的再分析

石油大学学报（自然科学版） 1998年第2期22卷 89-92页

作者：崔孝秉张宏石油大学机电工程学院

以往在国内外对卡瓦内悬挂管柱承载能力的研究中，出现了多种研究模型，但其求解方法均不同程度地存在一些问题和不足。鉴于求解方法对油井特别是深井和超深井的套管柱设计十分重要，对原有文献中存在的问题进行了剖析，并按原有模型进... 详细信息

以往在国内外对卡瓦内悬挂管柱承载能力的研究中，出现了多种研究模型，但其求解方法均不同程度地存在一些问题和不足。鉴于求解方法对油井特别是深井和超深井的套管柱设计十分重要，对原有文献中存在的问题进行了剖析，并按原有模型进行了正确的计算。

关键词：油气开采卡瓦套管柱设计受力分析数学模型

Zebrafish Musashi2s play different roles in early development

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Zebrafish Musashi2s play different roles in early developmen...

3个时期莫莫格国家级自然保护区景观格局和湿地水文连通性变化及其驱动因素分析

2012全国发育生物学大会

作者： Dong-rui Ji,Shi-cui zhang,hong-yan Li Institute of Evolution and Marine Biodiversity,Ocean University of China

Musashi(Msi) is an evolutionarily conserved family of RNA-binding proteins(RBPs).Zebrafish Msil has been shown to play roles in CNS development,but the function of Msi2 remains unclear in early *** identified that there were two members of Msi2 in zebrafish,zMsi2a and zMsi2b,that originated from the teleost genome duplication during evolution.A series of splice variants were detected for *** mount in situ hybridization revealed that zMsi2a and zMsi2b were both maternally expressed and exhibited overlapping and distinct zygotic expression patterns. zMsi2a was initially expressed on cranial ganglion and tail from segmentation stage(14 somites),and later on cranial ganglion,diencephalon,telencephalon,hindbrain and ***2b was first expressed on polster at 14 somites stage, then expressed ubiquitously,and later expressed intensely on neural system,in a tissue-specific *** of zMsi2a did not impair early development,while overexpression of zMsi2b resulted in malformation of embryos with short body axis and *** of zMsi2a caused the shortening of embryonic anterioposterior axis,curled tail and yolk extension defection,while knockdown of zMsi2b had no obvious influence on *** of zMsi2a function induced a dramatic loss of gata1,pu.1,runx1,cmyb expression at 7 somites *** data together suggest that zMsi2a is involved in the process of hematopoiesis. Conclusions:Our results indicate that duplicated Msi2 is a neofunctionalized gene and plays a novel role in early development of zebrafish.

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湿地科学 2016年第6期14卷 866-873页

作者：崔桢沈红章光新中国科学院湿地生态与环境重点实验室中国科学院东北地理与农业生态研究所吉林长春130102 中国科学院大学北京100049

利用遥感影像数据的分类解译结果,从湿地面积时空变化、景观破碎度变化和水文连接度等角度,对1992年、2005年和2015年莫莫格国家级自然保护区的景观格局变化特征和湿地水文连通性变化进行定量分析,研究了该保护区湿地的景观格局和水文... 详细信息

利用遥感影像数据的分类解译结果,从湿地面积时空变化、景观破碎度变化和水文连接度等角度,对1992年、2005年和2015年莫莫格国家级自然保护区的景观格局变化特征和湿地水文连通性变化进行定量分析,研究了该保护区湿地的景观格局和水文连通性;利用长时间序列的年降水量、年平均气温、年径流量和年平均水位数据,探讨了气候、水文和人类活动对该区湿地的影响因素。研究结果表明,与1992年相比,2015年莫莫格保护区湿地总面积共减少了45.99 km2,其中,沼泽和洪泛湿地的面积分别减少了95.27 km2和52.76 km2;与1992年相比,2005年和2015年湿地景观明显破碎化,尤其以沼泽区景观破碎最严重;与1992年相比,受湿地景观破碎的影响,2005年和2015年湿地水文连接性变差。极端干旱和洪水事件直接影响整个莫莫格湿地的水源补给和水域覆盖面积;河流径流量和水位变化直接导致其与周边洪泛湿地的水力联系发生改变,进而影响洪泛湿地的消长;研究区的人类活动主要是保护区内的湿地开垦和流域内的水利工程建设。

关键词：莫莫格国家级自然保护区沼泽洪泛湿地景观格局水文连通性驱动因素

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei zhang Jian Wu Hui hong Wei Quan Xinyu Qiao Chun cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon