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Old canalicular laceration repair:a retrospective study of the curative effects and prognostic factors

International Journal of Ophthalmology(English edition) 2017年第6期10卷 902-907页

作者： Fang Bai Hai Tao Yan Zhang Peng wang cui Han Yi-Fei Huang Ye Tao The Lacrimal Center of Ophthalmology Armed Police General Hospital of China Beijing 100039 China

AIM： To investigate the epidemiology and surgical outcomes of old canalicular laceration and analyze the variables impacting on the prognosis of reparation. METHODS： A retrospective review of all old canalicular laceration repairs from Jan. 1, 2008 to Dec. 30, 2015 was performed. Analyzed data included demographics, mechanisms of injury, the time from injury to repair, causes for delayed repair, old associated injuries, the types of surgery, and the effects of repair using canaliculus anastomosis combined with bicanalicular stent intubation. RESULTS： Totally 148 patients with old canalicular laceration received surgical repair and were enrolled. The mean age at presentation was 32.52 years old （ranged from 3 to 63 years old）. The 110 patients （74.32%） were male and 127 patients （85.81%） were adults （__.18 years old）. The old upper, lower, and bicanalicular lacerations were found in 5 （3.38%）, 39 （26.35%）, and 104 patients （70.27%）, respectively. The mechanism of old injury was primarily due to motor vehicle accidents （n=53, 35.81%）. The mean time from injury to repair was 43.61mo （ranged from 1 to 360mo）. Associated old ocular and orbit injuries were found in 65 patients （43.92%）, and chronic dacryocystitis in 18 patients （12.16%）. The main cause of delayed repair was that doctors or patients didn＇t pay attention to the canalicular laceration because of the concurrent severe injuries （n=71, 47.97%）. Totally 136 patients （91.89%） with old canalicular laceration underwent canaliculus anastomosis combined with bicanalicular stent intubation. In all of them, 20 patients （13.51%） were combined with dacryocystorhinostomy. In these cases, 132 patients （97.06%） attained anatomic success, 121 patients （88.97%）reported no epiphora （functional success）, 11 patients （8.09%） reported significant epiphora anesis （functional improvement）, and 4 （2.94%） reported no significant anesis （functional failure）. Rates of anatomic success and functional success were significantly correla

关键词： old canalicular laceration canalicular repair bicanalicular stent

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Biomimetic transformation of gentiopicroside to erythrocentaurin

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Chinese Chemical Letters 2009年第2期20卷 150-152页

作者： cui Ling wang Jian Li Liu Zhu Lan Liu Xin Sheng Li Xiao Yong Cao School of Life Science Northwest University Xi'an 710069 China Department of Biology Shaanxi University of Technology Hanzhong 723001 China

Biomimetic transformation of gentiopicroside was carded out by β-glucosidase at pH 7.0 for 3 days at 37 ℃. Two products, erythrocentaurin and 5,6-dihydro-5-formyl-6-methyl-1H,3H-pyrano[3,4-c]pyran-1-one were isolate... 详细信息

关键词： Gentiopicroside Biomimetic transformation β-Glucosidase Erythrocentaurin 5,6-Dihydro-5-formyl-6-methyl-1H,3H-pyrano[3,4-c]pyran-1-one

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Porcine Interleukin-2 Expression in Insect Cells and Its Enhancement of Pig Immunity to Swine Influenza Virus Inactivated Vaccine

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Agricultural Sciences in China 2010年第8期9卷 1211-1220页

作者： CHEN Hong-ying ZHANG Hong-ying HUANG Yan-quan cui Bao-an wang Zhen-ya wang Yan-bin LIU Jin-peng CHAO An-jun College of Animal Husbandry and Veterinary Henan Agricultural University Zhengzhou 450002 P.R.China

Mature porcine interleukin-2 （pIL-2） gene was amplified by PCR from the plasmid pGEM-T-pIL2 and cloned into the baculovirus pFastBacTM Dual vector of the Bac-to-Bac baculovirus expression system under the control of the PH promoter. Recombinant plL-2 （rpIL-2） expressed in Sf9 insect cells was detected by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunofluorescence assay. Western blot analysis confirmed that the rpIL-2 protein had a molecular mass of 20 kDa, which was larger than the molecular mass of the mature protein predicted based on its peptide sequence. The rpIL-2 protein induced in vitro proliferation of ConA-stimulated porcine splenocytes and enhanced in vivo protective immune responses induced by vaccinating the pigs with inactivated oil emulsion vaccine against swine influenza virus. The results showed that the rpIL-2 expressed in Sf9 insect cells has immunoenhancement effects; the finding lays the foundation for the preparation of a specific recombinant IL-2 protein and the development of a novel immune adjuvant of vaccines against various infectious porcine pathogens to increase the immunoprotective efficacy of vaccines.

关键词： porcine interleukin-2 Sf9 insect cells expression inactivated vaccine swine influenza virus

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A Viologen-bearing Coordination Polymer with Multi-stimuli Responsive Behaviors

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Chinese Journal of Structural Chemistry 2022年第2期41卷 43-48,I0008页

作者： AN Miao-Miao cui Jing-wang TAN Bin CHEN Yun-Rui ZHANG Jie School of Chemistry and Chemical Engineering MOE Key Laboratory of Cluster ScienceBeijing Key Laboratory of Photoelectronic/Electrophotonic Conversion MaterialsBeijing Institute of TechnologyBeijing 102488China

A viologen-bearing Zn(Ⅱ) coordination polymer,[Zn(Bpybc)SO_(4)]·H_(2)O,has been successfully synthesized and structurally *** title compound exhibits sunlight and UV-induced photochromism,thermoschromism,and amine-s... 详细信息

关键词： viologens coordination polymer multi-stimuli response

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Developmental and epileptic encephalopathy 44 due to compound heterozygous variants in the UBA5 gene:a case report

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Acta Epileptologica 2023年第4期6卷 264-271页

作者： Suli Zhang Shuangzhu Lin Wanqi wang Yuru Gan cui wang Bangtao Li Qiming Pang Department of Neuroscience Hainan Women and Children’s Medical CenterHaikou570100China Diagnosis and Treatment Center for Children First Affiliated HospitaltoChangchun University of Chinese MedicineChangchun130021China Changchun University of Chinese Medicine Changchun University of Chinese Medicine Graduate SchoolChangchun130000China

Background Developmental and epileptic encephalopathy(DEE)is a group of rare inherited disorders characterized by intellectual disability,delayed development,epileptic seizures,and other related ***44 is caused by mutations in the UBA5 gene,which encodes a ubiquitin-like protein involved in protein degradation and cell ***,there is limited information on the genotype–phenotype correlation of DEE44,and its clinical features remain to be fully *** presentation We report a 12-month-old infant who presented with epileptic spastic seizures beginning at 4 months of age,accompanied by overall developmental delay,short stature,microcephaly,inability to hold his head upright,chasing vision,and high muscle tone in the *** findings showed compound heterozygous mutations of the UBA5 gene:NM_024818 c.562C>T(p.R188X)from the mother and NM_024818 c.214C>T(p.R72C)from the *** This case report expands the clinical spectrum of DEE44 and highlights the importance of considering DEE44 in the differential diagnosis of developmental delay and epilepsy,even in the absence of classical symptoms suggestive of the *** hope that this case report will advance the understanding of DEE44 and improve the expertise of clinicians and early diagnose of this disease.

关键词： Infantile spasms Epilepsy Developmental and epileptic encephalopathy UBA5 gene

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Phase equilibria in Co-Ti-Re ternary system

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Rare Metals 2023年第8期42卷 2736-2746页

作者： Ling-Ling Li cui-Ping wang Shui-Yuan Yang Jia-Jia Han Yong Lu Jin-Bin Zhang Xing-Jun Liu College of Materials and Fujian Provincial Key Laboratory of Materials Genome Xiamen UniversityXiamen 361005China College of Materials Science and Engineering Guangdong Ocean UniversityYangjiang 529500China Xiamen Key Laboratory of High-Performance Metals and Materials Xiamen UniversityXiamen 361005China School of Materials Science and Engineering Institute of Materials Genome and Big DataHarbin Institute of TechnologyShenzhen 518055China

The phase equilibria in the Co-Ti-Re ternary system at 800,1000,1100 and 12000C were studied combined with electron probe microanalyzer(EPMA),X-ray diffraction(XRD),scanning electron microscope(SEM)and transmission electron microscope(TEM).The new phaseτwith a large solubility was discovered at all four isothermal sections,and its structure still needs a further study.A large solubility of Re in the CoTi phase was *** solubility of Re in the Co_(3)Ti phase is6.1%at 800℃,8.7%at 1000℃and 7.7%at 1100℃.The present work could be significant for alloy design of Co-based alloys and thermodynamic analysis of the Co-TiRe ternary system.

关键词： Isothermal section Phase equilibria Co-Ti-Re Co-based supperalloys

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A step-by-step multiple stimuli-responsive metal-phenolic network prodrug nanoparticles for chemotherapy

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Nano Research 2022年第2期15卷 1205-1212页

作者： Xiaoqing Yi Weijia Zeng cui wang Ying Chen Liangyuan Zheng Xinlin Zhu Yuqiu Ke Xiaoyan He Ying Kuang Qitong Huang Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases Ministry of EducationKey Laboratory of Biomaterials and Biofabrication in Tissue Engineering of Jiangxi ProvinceGannan Medical UniversityGanzhou 341000China Faculty of Materials Metallurgy and Chemistry Jiangxi University of Science and TechnologyGanzhou 341000China School of Life Sciences Anhui Medical UniversityHefei 230032China

Currently,chemotherapy is the main clinical therapy of ***,most chemotherapeutic drugs such as doxorubicin and paclitaxel(PTX)have poor water solubility,leading to low bioavailability and serious side *** now,although a variety of nanoparticulate drug delivery systems have been designed to ameliorate the above disadvantage of chemotherapy drugs,their application is still severely limited due to the complex preparation,poor stability,low drug loading,and premature drug ***,a metal phenolic network-based drug delivery system with superior stability,satisfactory drug loading capacity,good biocompatibility,reduced undesired premature release,and excellent anti-tumor ability has been established for achieving step-by-step multiple stimuli-responsive drug ***,the redox-responsive dimeric paclitaxel(diPTX)prodrug was *** diPTX@Fe&tannic acid(diPTX@Fe&TA)complex nanoparticles with satisfactory PTX loading capacity were obtained by deposition of Fe&TA network complex on the nanocore of diPTX rapidly with a simple *** diPTX@Fe&TA nanoparticles have a hydrodynamic diameter of 152.6±1.2 nm,long-term colloidal stability,and high PTX loading content of 24.7%.Besides,diPTX@Fe&TA could expose to the acidic lysosomal environment and the reduction cytoplasmic environment continuously,resulting in the sequential release of diPTX and PTX when it was phagocytosed by tumor ***,PTX showed almost no release under physiological condition(pH 7.4),which effectively inhibited the undesirable premature release of *** importantly,diPTX@Fe&TA could suppress the growth of tumor effectively in vivo,along with negligible toxicity for *** work developed a simple and novel approach for the construction of a stepwise multiple stimuli-responsive drug delivery system with superior stability and satisfactory drug loading capacity to inhibit tumor growth effectively.

关键词： drug delivery step-by-step multiple stimuli-responsive metal-phenolic network superior stability

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Fast Electrical Detection of Carcinoembryonic Antigen Based on AlGaN/GaN High Electron Mobility Transistor Aptasensor

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Chinese Physics Letters 2017年第9期34卷 87-90页

作者： Xiang-Mi Zhan Quan wang Kun wang Wei Li Hong-Ling Xiao Chun Feng Li-Juan Jiang cui-Mei wang Xiao-Liang wang Zhan-Guo wang Key Lab of Semiconductor Materials Science Institute of Semiconductors Chinese Academy of Sciences Beijing 100083 School of Microelectronics University of Chinese Academy of Sciences Beijing 100049 Beijing Key Laboratory of Low Dimensional Semiconductor Materials and Devices Beijing 100083

As one of the most important tumor-associated antigens of colorectal adenocarcinoma, the carcinoembryonic antigen （CEA） threatens human health seriously ali over the globe. Fast electrical and highly sensitive detection of the CEA with A1GaN/GaN high electron mobility transistor is demonstrated experimentally. To achieve a low detection limit, the Au-gated sensing area of the sensor is functionalized with a CEA aptamer instead of the corresponding antibody. The proposed aptasensor has successfully detected different concentrations （ranging from 50picogram/milliliter （pg/ml） to 50 nanogram/milliliter （ng/ml）） of CEA and achieved a detection limit as low as 50pg/ml at Vas = 0.5 V. The drain-source current shows a c/ear increase of 11.5μA under this bias.

关键词： CEA GaN Fast Electrical Detection of Carcinoembryonic Antigen Based on AlGaN/GaN High Electron Mobility Transistor Aptasensor

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Screening compounds against HCV based on MAVS/IFN-β pathway in a replicon model

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World Journal of Gastroenterology 2010年第44期16卷 5582-5587页

作者： Qiu-Xia Fu Li-cui wang Shuai-Zheng Jia Bo Gao Yong Zhou Juan Du Ying-Li wang Xiao-Hui wang Jian-Chun Peng Lin-Sheng Zhan Laboratory of Blood-Borne Virus Beijing Institute of Transfusion Medicine Beijing 100850 China

AIM:To develop a sensitive assay for screening compounds against hepatitis C virus (HCV).METHODS:The proteolytic cleavage of NS3/4A on enhanced yellow fluorescent protein (eYFP)-mitochondrial antiviral signaling protein (MAVS) was examined by reporter enzyme secreted placental alkaline phosphatase (SEAP),which enabled us to perform ongoing monitoring of anti-HCV drugs through repeated *** localization of eYFP-MAVS was assessed by fluorescence *** localization and protein levels were examined by Western ***:HCV NS3/4A protease cleaved eYFP-MAVSfrom mitochondria to block the activation of interferon (IFN)-β promoter,thus resulting in downregulation of SEAP *** decrease in SEAP activity was proportional to the dose of active NS3/4A *** this reporter assay was used to detect anti-HCV activity of IFN-α and cyclosporine ***:Our data show that this reporter system is a sensitive and quantitative reporter of anti-HCV *** system will constitute a new tool to allow the efficient screening of HCV inhibitors.

关键词： Mitochondrial antiviral signaling protein Hepatitis C virus Interferon-β Drug screening

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Poly(ethylene glycol)-supported Piperazine——Synthesis and Application in Knoevenagel Condensation

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Chemical Research in Chinese Universities 2010年第2期26卷 263-267页

作者： wang cui-e JIN Jie ZHANG Min YU Shu-yan SHANG Yong-jia HU Jin-song College of Chemistry and Materials Science Anhui Key Laboratory of Functional Molecular SolidsAnhui Key Laboratory of Molecular Based Materials Anhui Normal University Wuhu 241000 P. R. China

A soluble, poly（ethylene glycol）-supported piperazine catalyst was prepared. This soluble catalyst efficiently catalyzes the Knoevenagel condensation of various aromatic aldehydes with diethyl malonate or ethyl acetoacetate in a homogeneous phase to afford the desired alkenes in good purity and yield with a facile work-up process. It was found that the polymer reagent could be repeatedly used at least four times without the too much loss of activity. The catalyst has shown a good activity, stability, and recycling capability.

关键词： Piperazine Polymer-supported catalyst Knoevenagel condensation

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