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Stereoselective metabolic disruption of cypermethrin by remolding gut homeostasis in rat

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Journal of Environmental Sciences 2023年第4期126卷 761-771页

作者： Quan Zhang Sijia Gu Yanwang Shitao Hu Siqing Yue cui wang Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province College of EnvironmentZhejiang University of TechnologyHangzhou 310032China School of Life Science Zhejiang Chinese Medical UniversityHangzhou 310053China

Cypermethrin(CYP), a prototypical synthetic pyrethroid, reportedly causes metabolic disruption, while its stereoselective impact remains elusive. This study initially revealed that only α-CYP caused significant weight loss at 8.5 mg/(kg·day) in rats. All three CYP isomers caused the accumulation of hepatic glycogen, and hyperlipemia phenotype as the increment of total triglyceride. Rats treated with α-CYP had markedly high blood glucose levels and homeostasis model assessment of insulin resistance index. The systematic inflammation of θ-CYP group rats was evidenced by high lipopolysaccharide-binding protein levels and abnormalities of leukocytes indices. By examining the gut microbiome, we found thatα-CYP-treated rats had low contents of Firmicutes and high levels of Verrucomicrobia while Elusimicrobia was enriched in the β-CYP group. The increasing alpha diversity in the θ-CYP group may be due to the dominance of pathogenic bacteria and the increase of probiotics to counteract adverse effects. Exclusively, the α-CYP group enriched total short-chain fatty acids(SCFAs), whereas most SCFAs depleted in the θ-CYP group. The correlation analysis further found Firmicutes, an energy storage modulator, was positive to body weight(BW),while SCFAs exerted the opposite, confirming the low BW in α-CYP. Blood glucose that correlated well with SCFAs and Verrucomicrobia can be accounted for the discrepancy betweenα-CYP and θ-CYP. Overall, the three isomers exerted stereoselective glycolipid disruption in rats, and gut homeostasis acted as vital indicators.

关键词： Cypermethrin Stereoisomeric selectivity Gut microbiota Short-chain fatty acids Glycolipid metabolism

Geochemical characteristics and oil family classi-fication of crude oils from the Markit Slope in the southwest of the Tarim Basin, Northwest China

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Chinese Journal Of Geochemistry 2011年第3期30卷 359-365页

作者： cui Jmgwei wang Tieguan LI Meijun State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum Beijing 102249 China

Based on the chromatograms of oils and saturated hydrocarbons, biomarkers and stable carbon isotope analyses, the geochemical characteristics and oil family Classification of crude oils from the Markit Slope in the southwest of the Tarim Basin were investigated. The results showed that crude oils from the Markit Slope are divided into two oil family Classification. Oils collected from the Bashituo oilfield in the western part of the Markit Slope are characterized by high contents of tricyclic terpanes, pregnane, and homopregnane, low contents of garmmacerane (G/H>C28 -32‰ and -30.6‰, respectively), with the distribution type of steranes being C27>C28<

关键词：麦盖提斜坡地球化学特征塔里木盆地中国西北地区西南部分类家庭原油

Quantification of albumin in urine using preconcentration and near-infrared diffuse reflectance spectroscopy

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Chinese Chemical Letters 2016年第10期27卷 1597-1601页

作者： Xiao-Xu Ma cui-cui wang Wen-Sheng Cai Xue-Guang Shao Research Center for Analytical Sciences College of ChemistryNankai UniversityTianjin 3000TIChina Tianjin Key Laboratory of Biosensing and Molecular Recognition Tianjin 300071China State Key Laboratory of Medicinal Chemical Biology Tianjin 300071China Collaborative Innovation Center of Chemical Science and Engineering Tianjin 300071China

Urinary albumin is an important diagnostic and prognostic marker for cardiorenal disease, Recent studies have shown that elevation of albumin excretion even in normal concentration range is associated with increased cardiorenal risk. Therefore, accurate measurement of urinary albumin in normal concentration range is necessary for clinical diagnosis. In this work, thiourea-functionalized silica nanoparticles are prepared and used for preconcentration of albumin in urine. The adsorbent with the analyte was then used for near-infrared diffuse reflectance spectroscopy measurement directly and partial least squares model was established for quantitative prediction. Forty samples were taken as calibration set for establishing PLS model and 17 samples were used for validation of the method. The correlation coefficient and the root mean squared error of cross validation is 0.9986 and 0.43, respectively. Residual predictive deviation value of the model is as high as 18.8. The recoveries of the 17 validation samples in the concentration range of 3.39-24.39 mg/L are between 95.9%-113.1%. Therefore. the method may urovide a candidate method to auantifv albumin excretion in urine_

关键词： Near-infrared diffuse reflectancespectroscopyQuantitative determinationMultivariate calibrationUrinary albuminThiourea-functionalized silicananoparticles

Effect of casting speed on surface quality of horizontal direct chill casting 7075 aluminum alloy ingot

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Acta Metallurgica Sinica(English Letters) 2011年第5期24卷 399-404页

作者： Qingfeng ZHU Zhihao ZHAO Jianzhong cui Xiangjie wang Ke QIN Key Laboratory of Electromagnetic Processing of Materials Ministry of Education Northeastern University Shenyang 110819 China

7075 aluminum alloy ingot with the diameter izontal direct chill casting in different casting of 100 mm has been produced by horspeed. The effect of the casting speed on the ingot surface and subsurface layer was studied by surface observation and subsurface structure analysis. It was found that increasing the casting speed results in the adding of segregation knots in the ingot surface. The thickness of the dendrite microstrueture layer in the subsurface reduces with increasing the casting speed. And the elements of Zn, Cu and Mg enrich in the coarse dendrite microstructure layer of the ingot.

关键词： Horizontal direct chill casting Casting speed 7075 aluminumalloy Surface quality

Effect of organic binders on the activation and properties of indurated magnetite pellets

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International Journal of Minerals,Metallurgy and Materials 2021年第7期28卷 1145-1152页

作者： cui wang Chen-yang Xu Zheng-jian Liu Yao-zu wang Rong-rong wang Li-ming Ma State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Department of Ferrous Metallurgy RWTH Aachen UniversityIntzestraße 152072 AachenGermany

In the ironmaking process,the addition of an organic binder to replace a portion of bentonite has the potential to improve the per-formance of *** interaction between original bentonite(OB)and organic binder was *** indicated that the micromor-phology of organic composite bentonite(OCB)became porous and the infrared difference spectrum exhibited a curved *** addition,the residual burning rates of OB and organic binder were determined to be 82.72%and 2.30%,***,the influence of OCB on the properties of pellets was *** compressive strength of OCB-added green pellets(14.7 N per pellet)was better than that of OB-ad-ded pellets(10.3 N per pellet).Moreover,the range of melting temperature of OCB-added green pellets(173℃)was narrower than that of OB-added pellets(198℃).The compressive strength of OCB-added green pellets increased from 2156 to 3156 N per pellet with the increase in roasting temperature from 1200 to 1250℃.

关键词： pellets organic composite bentonite softening-melting property interaction behavior

Effects of Nonlinear Couplings on Entanglement in a Two-Qutrit Heisenberg XXX Chain under an Inhomogeneous Magnetic Field

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Communications in Theoretical Physics 2011年第3期55卷 431-433页

作者： QIN Meng GE Xing ZHAI Xiao-Yue LIU cui-cui wang Bi-Li Institute of Science PLA University of Science and Technology Nanjing 211101 China

This paper investigates the entanglement of a two-qutrit Heisenberg XXX chain with nonlinear couplings under an inhomogeneous magnetic field. By the concept of negativity, we find that the critical temperature increases with the increase of inhomogeneous magnetic field b. Our study indicates that for any ｜K｜〉｜J｜, or ｜K｜〈｜J｜ entanglement always exists for certain regions. We also find that at the critical point, the entanglement becomes a nonanalytic function of B and a quantum phase transition occurs.

关键词： entanglement negativity nonlinear couplings inhomogeneous magnetic field

Design and experimental confirmation of a novel switched hyperchaotic system

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The Journal of China Universities of Posts and Telecommunications 2009年第2期16卷 122-128页

作者： ZHANG Ya-jun wang cui-ping wang Guang-yi XU Ning wang Zhong-lin School of Electronics Information Hangzhou Dianzi University Hangzhou 310018 China Department of Physics and Electronics Binzhou University Binzhou 256600 China

To generate complex pseudo-noise （PN） sequences for chaos-based communications, this article presents a novel switched hyperchaotic model, which is constructed based on a modified Chen system by introducing a dynamical controller. The system consists of two different hyperchaotic subsystems and can change its behavior randomly via a switching function. Basic dynamical behaviors of the hyperchaotic system are further investigated. Furthermore, the switched system is confirmed by its positive Lyapunov exponents and laboratory measurements by an electronic circuit.

关键词： chaos-based communication hyperchaos circuit realization

Dynamic Recrystallization Behavior of Bimodal Size SiCpReinforced Mg Matrix Composite during Hot Deformation

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Acta Metallurgica Sinica(English Letters) 2016年第6期29卷 527-537页

作者： cui-Ju wang Kun-Kun Deng Shan-Shan Zhou Wei Liang Shanxi Key Laboratory of Advanced Magnesium-based Materials College of Materials Science and EngineeringTaiyuan University of Technology

The（submicron＋micron） bimodal size Si Cp-reinforced Mg matrix composite was compressed at the temperature of 270–420 °C and strain rate of 0.001–1 s^-1. Then, dynamic recrystallization（DRX） behavior of the composite was investigated by thermodynamic method and verified by microstructure analysis. Results illustrated that the composite possess the lower critical strain and higher DRX ratio as compared to monolithic Mg alloys during hot deformation process. The predicted DRX ratio increased with the proceeding of compression, which was well consistent with the experimental value. Results from thermodynamic calculation suggested that the occurrence of DRX could be promoted by Si Cp, which would be further proved by microstructure analysis. Formation of particle deformation zone around micron Si Cp played a significant role in promoting DRX nucleation. Nevertheless, the distribution of submicron Si Cp was increasingly uniform with the proceeding of compression, which could fully restrain grain growth. Therefore, the corporate effects of micron and submicron Si Cp on DRX contributed to the improvement of DRXed ratio and the refinement of grain size for the composite during compression process.

关键词： Magnesium matrix composite Deformation Dynamic recrystallization Microstructure Thermodynamic analysis

Effect of the W-beam central guardrails on wind-blown sand deposition on desert expressways in sandy regions

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Journal of Arid Land 2020年第1期12卷 154-165页

作者： wang cui LI Shengyu LEI Jiaqiang LI Zhinong CHEN Jie Xinjiang Institute of Ecology and Geography Chinese Academy of SciencesUrumqi 830011China College of Resource and Environment Sciences Xinjiang UniversityUrumqi 830046China Xinjiang Academy of Transportation Sciences Urumqi 830000China University of Chinese Academy of Sciences Beijing 100049China

Many desert expressways are affected by the deposition of the wind-blown sand,which might block the movement of vehicles or cause accidents.W-beam central guardrails,which are used to improve the safety of desert expressways,are thought to influence the deposition of the wind-blown sand,but this has yet not to be studied *** address this issue,we conducted a wind tunnel test to simulate and explore how the W-beam central guardrails affect the airflow,the wind-blown sand flux and the deposition of the wind-blown sand on desert expressways in sandy *** subgrade model is 3.5 cm high and 80.0 cm wide,with a bank slope ratio of 1:*** W-beam central guardrails model is 3.7 cm high,which included a 1.4-cm-high W-beam and a 2.3-cm-high stand *** wind velocity was measured by using pitot-static tubes placed at nine different heights(1,2,3,5,7,10,15,30 and 50 cm)above the floor of the *** vertical distribution of the wind-blown sand flux in the wind tunnel was measured by using the sand sampler,which was sectioned into 20 *** addition,we measured the wind-blown sand flux in the field at K50 of the Bachu-Shache desert expressway in the Taklimakan Desert on 11 May 2016,by using a customized 78-cm-high gradient sand sampler for the sand flux structure *** by the subgrade leads to the formation of two weak wind zones located at the foot of the windward slope and at the leeward slope of the subgrade,and the wind velocity on the leeward side weakens *** W-beam central guardrails decrease the leeward wind velocity,whereas the velocity increases through the bottom gaps and over the top of the W-beam central *** vertical distribution of the wind-blown sand flux measured by wind tunnel follows neither a power-law nor an exponential function when affected by either the subgrade or the W-beam central *** 0.0H and 0.5H(where H=3.5 cm,which is the height of the subgrade),the sand transport is less a

关键词： wind velocity field wind-blown sand flux W-beam central guardrails sand deposition desert expressway wind tunnel test Taklimakan Desert