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Sequence analysis for the complete proviral genome of reticuloendotheliosis virus Chinese strain HA9901

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Science China(Life Sciences) 2006年第2期49卷 149-157页

作者： WANG Yu cui Zhizhong jiang Shijin College of Animal Science and Veterinary Medicine Shandong Agricultural University Taian 271018 China College of Animal Science and Veterinary Medicine Shandong Agricultural University Taian 271018 China College of Animal Science and Veterinary Medicine Shandong Agricultural University Taian 271018 China

The genomic DNA extracted from chicken embryo fibroblast (CEF) infected with a Chi-nese field isolate HA9901 of reticuloendotheliosis virus (REV) was used as the template to amplify the REV proviral genomic cDNA by PCR with 6 pairs of primers according to published sequences. Six overlapping fragments were amplified, cloned into the TA vector and sequenced, including a fragment which was amplified from the circular proviral cDNA and covering both 5′- and 3′-ends. The complete sequence of the whole genome was established and analyzed with a DNAstar software. Comparisons of the sequence with two other strains demonstrated that the genomes of REV were relatively con-servative, the homogenecity for all genes or LTR fragments of the 3 strains was over 92%, no matter whether they were isolated from different species and regions in different years. But, the homology of Chinese strain HA9901 to a fowl pox virus-associated strain from Chickens was higher than that to strain SNV isolated from ducks.

关键词： reticuloendotheliosis virus, the genomic sequence, homology comparison.

Correlation of genes associated with drug response to prognosis of large cell lung carcinoma

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Chinese Journal of Cancer 2011年第7期30卷 497-504页

作者： Cheng Chen Xiang-Li jiang cui-cui Zhang Kai Li Department of Medical Thoracic Oncology TianjinMedical University Cancer Institute and Hospital Tianjin 300060 P. R.China.

Platinum-based chemotherapy remains the main treatment of advanced lung cancer. However, platinum resistance has become a major treatment obstacle. Novel therapies, particularly tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR-TKI) and agents that target vascular endothelial growth factor (VEGF), have improved the treatment. Both chemotherapy and targeted therapy have their molecular mechanisms. This study aimed to determine the mutation, amplification, or expression status and interrelationships of the epidermal growth factor receptor (EGFR), K-Ras proto-oncogene, excision repair cross-complementation group 1 (ERCC1), and VEGF genes as well as their correlations to prognosis of large cell lung carcinoma (LCLC) after EGFR-targeted therapy, chemotherapy, and anti-VEGF therapy. EGFR and K-Ras mutations in 60 specimens of LCLC were detected by direct DNA sequencing. EGFR, ERCC1, and VEGF protein expression was detected by immunohistochemistry (IHC). EGFR gene copy number was detected by fluorescence in situ hybridization (FISH). One (1.7%) patient had an EGFR L858M point mutation in exon 21, 3 (5.0%) had K-Ras mutations, and 10 (19.6%) had EGFR amplification (FISH positive). Positive rates of EGFR, ERCC1, and VEGF proteins were 38.3%, 56.7%, and 70.0%, respectively. EGFR amplification was positively correlated to EGFR protein expression (r = 0.390, P = 0.005). The positive rate of VEGF protein was significantly higher in patients with lymph node metastasis than in those without (84.6% vs. 58.8%, P = 0.046). No significant correlations were observed among the EGFR, K-Ras, ERCC1, and VEGF genes. EGFR gene amplification and the low rate of EGFR mutation suggest that patients with LCLC are likely to obtain little benefit from anti-EGFR therapies.

关键词：相关基因表皮生长因子受体血管内皮生长因子药物反应肺癌预后细胞基因突变检测

Complex Modified Projective Synchronization for Fractional-order Chaotic Complex Systems

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International Journal of Automation and computing 2018年第5期15卷 603-615页

作者： cui-Mei jiang Shu-Tang Liu Fang-Fang Zhang College of Control Science and Engineering Shandong University School of Electrical Engineering and Automation Qilu University of Technology

The aim of this paper is to study complex modified projective synchronization（CMPS） between fractional-order chaotic nonlinear systems with incommensurate orders. Based on the stability theory of incommensurate fractional-order systems and active control method, control laws are derived to achieve CMPS in three situations including fractional-order complex Lorenz system driving fractional-order complex Chen system, fractional-order real Rssler system driving fractional-order complex Chen system, and fractionalorder complex Lorenz system driving fractional-order real Lü system. Numerical simulations confirm the validity and feasibility of the analytical method.

关键词： Fractional-order system chaotic complex system incommensurate order complex modified projective synchronization(CMPS) active control.

Parity-dependent skin effects and topological properties in the multilayer nonreciprocal Su−Schrieffer−Heeger structures

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Frontiers of physics 2024年第3期19卷 115-133页

作者： Jia-Rui Li cui jiang Han Su Di Qi Lian-Lian Zhang Wei-jiang Gong College of Sciences Northeastern UniversityShenyang 110819China Basic Department Shenyang Institute of EngineeringShenyang 110136China

We concentrate on the skin effects and topological properties in the multilayer non-Hermitian Su−Schrieffer−Heeger (SSH) structure, by taking into account the nonreciprocal couplings between the different sublattices in the unit cells. Following the detailed demonstration of the theoretical method, we find that in this system, the skin effects and topological phase transitions induced by nonreciprocal couplings display the apparent parity effect, following the increase of the layer number of this SSH structure. On the one hand, the skin effect is determined by the parity of the layer number of this SSH system, as well as the parity of the band index of the bulk states. On the other hand, for the topological edge modes, such an interesting parity effect can also be observed clearly. Next, when the parameter disorders are taken into account, the zero-energy edge modes in the odd-layer structures tend to be more robust, whereas the other edge modes are easy to be destroyed. In view of these results, it can be ascertained that the findings in this work promote to understand the influences of nonreciprocal couplings on the skin effects and topological properties in the multilayer SSH lattices.

关键词： multilayer SSH lattice nonreciprocal couplings band structure skin effect

Identification of Molecular Markers for a Aphid Resistance Gene in Sorghum and Selective Efficiency Using These Markers

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Journal of Integrative Agriculture 2012年第7期11卷 1086-1092页

作者： CHANG Jin-hua cui jiang-hui XUE Wei ZHANG Qing-wen College of Agriculture and Biotechnology China Agricultural University Beijing 100096 P.R.China College of Agriculture Agricultural University ofHebei Baoding 071001 P.R.China Student Employment Guidance Center Baoding Vocational and Technical College Baoding 071001 P.R.China

In this study, an F2 segregated population obtained by hybridization between the aphid-sensitive sorghum strain Qiansan and aphid-resistant cultivar Henong 16 was used to establish an aphid-resistant pool and an aphid-sensitive pool. 192 pairs of AFLP （amplified fragment length polymorphism） marker primers were screened in these pools using BSA （bulked segregant analysis）. Three pairs of EcoR I-CTG/Mse I-CCT, EcoR I-CTG/Mse I-CAT, and EcoR I-AGT/Mse I-CCC showed linkage with aphis resistance. EcoR I-CTG/Mse I-CCT-475, EcoR I-CTG/Mse I-CAT-390, and EcoR I-AGT/Mse I-CCC- 350 （E42/M52-350） were mapped within 6, 10, and 13 cM distances with the aphid-resistant gene by using Mapmaker 3.0 software. The bands amplified by EcoR I-CTG/Mse I-CCT-475 and EcoR I-CTG/Mse I-CAT-390 were extracted, cloned, and sequenced. Specific primers of SCAR （sequence characterized amplified regions） were then designed from these bands. A specific band of 300 bp was amplified by a pair of SCAR primers designed based on the sequence obtained from the EcoR I-CTG/Mse I-CAT-390 marker. The SCAR marker was named SCAS0. The marker was used to detect the F2, BC1, and F2：3 populations. The selective efficiency was 86.8, 91.1, and 86.3% in the BC1, F2, and F2：3 populations, respectively. The average selective efficiency was 88.2%.

关键词： sorghum bicolor aphid resistance gene molecular marker SCAR molecular assistant selection

Geometrical Structures and Activities of Free Radical Scavenging Studies of Baicalein and Scutellarein

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Chinese Journal of Structural Chemistry 2020年第1期39卷 57-65,2页

作者： QIU Song-Shan jiang cui-cui ZHOU Ru-Jin LI Chun-Hai Development Centre of Technology for Fruit&Vegetable Storage and Processing Engineering School of Biology and Food EngineeringGuangdong University of Petrochemical TechnologyMaoming 525000China

In order to study the free radical scavenging capacity and molecular structures of baicalein and scutellarein,the structure-activity relationship of these two molecules was *** geometric structures of the compounds were optimized by DMol3 code based on density functional *** theoretical parameters of the atomic charge distribution,the distribution of molecular frontier orbital,the energy difference and Fukui functions were ***,superoxide anion free radical and 1,1-diphenyl-2-picrylhydrazyl radical(DPPH)methods were used to determine the scavenging capacity of the *** results showed that the scavenging rate of DPPH radicals and superoxide anion radicals increased with the increase of sample concentration,and had a dose-effect *** radical-scavenging activities in the order of baicalein>scutellarein>BHT were *** p-π conjugation of the hydroxyl oxygen atom influenced the certain ability to repelling electrons in the molecular structures of baicalein and scutellarein based on the data of the atomic charge distribution,the distribution of molecular frontier orbital,the energy difference and Fukui *** groups were more susceptible to attack and exhibit free radical scavenging *** oxygen atom in the phenolic hydroxyl group of the molecule structure of the samples may be the reaction active sites where the electrophilic reaction *** results offer useful theoretical bases for the research and application of antioxidant activities of substances containing such molecular structures.

关键词： density functional theory baicalein scutellarein free radical scavenging

Influence of initial check, information exchange, final accuracy check, reaction information nursing on the psychology of elderly with lung cancer

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World Journal of Clinical Cases 2024年第4期12卷 737-745页

作者： cui jiang Jing Ma Wen He Hai-Ying Zhang The Second Ward of Thoracic Radiotherapy Hubei Cancer Hospital Affiliated to Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430079Hubei ProvinceChina Nursing School Henan University of Science and TechnologyLuoyang 471000Henan ProvinceChina Department of Intensive Care Unit Wuhan First HospitalWuhan 430033Hubei ProvinceChina Department of Nursing Huangpi District People′s Hospital of WuhanWuhan 430300Hubei ProvinceChina

BACKGROUND As one of the fatal diseases with high incidence,lung cancer has seriously endangered public health and *** patients usually have poor self-care and are more likely to show a series of psychological *** To investigate the effectiveness of the initial check,information exchange,final accuracy check,reaction(IIFAR)information care model on the mental health status of elderly patients with lung *** This study is a single-centre *** randomly recruited 60 elderly patients with lung cancer who attended our hospital from January 2021 to January *** elderly patients with lung cancer were randomly divided into two groups,with the control group taking the conventional propaganda and education and the observation group taking the IIFAR information care model based on the conventional care *** differences in psychological distress,anxiety and depression,life quality,fatigue,and the locus of control in psychology were compared between these two groups,and the causes of psychological distress were *** After the intervention,Distress Thermometer,Hospital Anxiety and Depression Scale(HADS)for anxiety and the HADS for depression,Revised Piper’s Fatigue Scale,and Chance Health Locus of Control scores were lower in the observation group compared to the pre-intervention period in the same group and were significantly lower in the observation group compared to those of the control group(P<0.05).After the intervention,Quality of Life Questionnaire Core 30(QLQ-C30),Internal Health Locus of Control,and Powerful Others Health Locus of Control scores were significantly higher in the observation and the control groups compared to the pre-intervention period in their same group,and QLQ-C30 scores were significantly higher in the observation group compared to those of the control group(P<0.05).CONCLUSION The IIFAR information care model can help elderly patients with lung cancer by reducing their anxiety and depression,

关键词： Initial check,information exchange,final accuracy check,reaction information care model Lung cancer Mental health

PIPBQ Effect Aware SER Analysis for Combinational Logic Circuits

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Journal of Electronic Science and Technology 2016年第1期14卷 60-67页

作者： Ai-Bin Yan Hua-Guo Liang Zheng-Feng Huang Zhi Wang cui-Yun jiang the School of Computer and Information Hefei University of Technology the School of Electronic Science & Applied Physics Hefei University of Technology the School of Mathematics Hefei University of Technology

Technology scaling results in the propagation-induced pulse broadening and quenching（PIPBQ） effect become more *** order to effectively evaluate the soft error rate for combinational logic circuits,a soft error rate analysis approach considering the PIPBQ effect is *** different original pulse propagating through logic gate cells,pulse broadening and quenching are measured by *** that,electrical effect look-up tables（EELUTs） for logic gate cells are created to evaluate the PIPBQ *** paths are accurately retrieved by the proposed re-convergence aware sensitized path search ***,by propagating pulses on these paths to simulate fault injection,the PIPBQ effect on these paths can be quantified by *** a result,the soft error rate of circuits can be effectively computed by the proposed *** results verify the soft error rate improvement comparing with the PIPBQ-not-aware method.

关键词： Pulse broadening and quenching effect re-convergence single event transient soft error rate

Primary pancreatic paraganglioma harboring lymph node metastasis: A case report

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World Journal of Clinical Cases 2021年第27期9卷 8071-8081页

作者： cui-Nan jiang Xiao Cheng Jing Shan Mei Yang Yu-Qing Xiao Department of Hepatopancreatobiliary Surgery Chengdu Third People’s HospitalChengdu 610031Sichuan ProvinceChina Department of Pathology Chengdu Third People’s HospitalChengdu 610031Sichuan ProvinceChina Department of Gastroenterology Chengdu Third People’s HospitalChengdu 610031Sichuan ProvinceChina

BACKGROUND Primary pancreatic paragangliomas are extremely rare *** by the diagnostic efficacy of histopathological examination,their malignant behavior is thought to be associated with local invasion or metastasis,with only four malignant cases reported in the literature to *** pancreatic paragangliomas share similar imaging features with other types of pancreatic neuroendocrine neoplasms,they are difficult to diagnose accurately without the support of pathological *** primary pancreatic paragangliomas are rare,especially those accompanied by lymph node metastasis,there is currently no consensus on ***,we report a case of primary pancreatic paraganglioma with lymph node *** SUMMARY A mass located in the pancreatic body was incidentally discovered on computed tomography in a 41-year-old Tibetan *** pancreatectomy was subsequently performed and a 4.1 cm×4.2 cm tumor was found embedded in the body of the pancreas during *** examination confirmed the characteristics of paraganglioma in which the neoplastic chief cells were arranged in a classic Zellballen pattern under hematoxylin-eosin ***,immunohistochemistry demonstrated that the sustentacular cells in the tumor tissue were positive for S-100 protein,and neoplastic cells and pancreatic draining lymph nodes were positive for chromogranin A and synaptophysin;thus,the presence of lymph node metastasis(two of the eight resected pancreatic draining lymph nodes)was also confirmed.A diagnosis of primary pancreatic paraganglioma with lymph node metastasis was finally *** patient remained disease-free for 1 year after the *** A definite diagnosis of pancreatic paraganglioma mainly depends on postoperative histopathological and immunohistochemical *** resection may be the first treatment of choice for patients with primary pancreatic paraganglioma that has metastasized to the lymph nodes.

关键词： Paraganglioma Pancreas Lymph node metastasis Distal pancreatectomy Case report