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Obesity and kidney disease： hidden consequences of the epidemic

肾脏病与透析肾移植杂志 2017年第1期26卷 1-7页

作者： csaba p.kovesdy Susan Furth Carmine Zoccali Division of Nephrology Department of Medicine University of Tennessee Health Science Center Memphis TNUnited States Nephrology Section Memphis VA Medical Center Memphis TN United States Department of pediatrics Perelman School of Medicine at the University of Pennsylvania Philadelphia PAUnited States CNR-IFC Clinical Epidemiology and pathophysiology of Renal Diseases and Hypertension Reggio Calabria Italy

Obesity has become a worldwide epidemic,and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes,cardiovascular disease and also for Chronic Kidney Disease. A high body mass index is one of the strongest risk factors for new-onset Chronic Kidney Disease. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing Chronic Kidney Disease in the long-term. The incidence of obesity-related glomerulopathy has increased ten-fold in recent years. Obesity has also been shown to be a risk factor for nephrolithiasis,and for a number of malignancies including kidney cancer. This year the World Kidney Day promotes education on the harmful consequences of obesity and its association with kidney disease,advocating healthy lifestyle and health policy measures that makes preventive behaviors an affordable option.

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