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Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1318-1331页

作者： Pedro Casado Ana Rio-Machin Juho JMiettinen Findlay Bewicke-Copley Kevin Rouault-Pierre szilvia Krizsan Alun Parsons Vinothini Rajeeve Farideh Miraki-Moud David CTaussig csaba Bödör John Gribben Caroline Heckman Jude Fitzgibbon Pedro R.Cutillas Cell Signalling and Proteomics Group Centre for Genomics and Computational BiologyBarts Cancer InstituteQueen Mary University of LondonLondon EC1M6BQUK Centre for Genomics and Computational Biology Barts Cancer InstituteQueen Mary University of LondonLondon EC1M6BQUK Institute for Molecular Medicine Finland-FIMM HiLIFE-Helsinki Institute of Life ScienceiCAN Digital Precision Cancer Medicine FlagshipUniversity of HelsinkiHelsinkiFinland Centre for Haemato-Oncology Barts Cancer InstituteQueen Mary University of LondonLondon EC1M6BQUK HCEMM-SU Molecular Oncohematology Research Group 1st Department of Pathology and Experimental Cancer ResearchSemmelweis University BudapestBudapestHungary Cancer Research UK Cancer Therapeutics Unit Division of Cancer TherapeuticsThe Institute of Cancer ResearchSuttonUK a The Alan Turing Institute The British Library2QR96 Euston RdLondon NW12DBUK

Acute myeloid leukaemia(AML)patients harbouring certain chromosome abnormalities have particularly adverse *** these patients,targeted therapies have not yet made a significant clinical *** understand the molecular landscape of poor prognosis AML we profiled 74 patients from two different centres(in UK and Finland)at the proteomic,phosphoproteomic and drug response phenotypic *** data were complemented with transcriptomics analysis for 39 *** integration highlighted a phosphoproteomics signature that define two biologically distinct groups of KMT2A rearranged leukaemia,which we term MLLGA and *** presented increased DOT1L phosphorylation,HOXA gene expression,CDK1 activity and phosphorylation of proteins involved in RNA metabolism,replication and DNA damage when compared to MLLGB and no KMT2A rearranged *** was particularly sensitive to 15 compounds including genotoxic drugs and inhibitors of mitotic kinases and inosine-5-monosphosphate dehydrogenase(IMPDH)relative to other ***-risk KMT2A-MLLT3 cases were mainly represented in a third group closer to MLLGA than to *** expression of IMPDH2 and multiple nucleolar proteins was higher in MLLGA and correlated with the response to IMPDH inhibition in KMT2A rearranged leukaemia,suggesting a role of the nucleolar activity in sensitivity to *** summary,our multilayer molecular profiling of AML with poor prognosis and KMT2A-MLLT3 karyotypes identified a phosphoproteomics signature that defines two biologically and phenotypically distinct groups of KMT2A rearranged *** data provide a rationale for the potential development of specific therapies for AML patients characterised by the MLLGA phosphoproteomics signature identified in this study.

关键词： metabolism signature biologically

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Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease

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World Journal of Gastroenterology 2016年第26期22卷 6027-6035页

作者： Dániel szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J szabó ádám Vannay Erna sziksz csaba Bereczki Gábor Veres Department of Pediatrics and Pediatric Health Care Center University of Szeged H-6725 Szeged Hungary 1st Department of Pediatrics Semmelweis University H-1083 Budapest Hungary 2nd Department of Pathology Semmelweis University H-1091 Budapest Hungary 1st Department of Pediatrics Semmelweis University and MTA-SE Pediatrics and Nephrology Research Group H-1083 Budapest Hungary

AIM: To evaluate the role of microRNA (miR)-146a, -155 and -122 in the duodenal mucosa of pediatric patients with Crohn’s disease (CD) and the effect of transforming growth factor-β (TGF-β) on these miRs in duodenal epithelial and fibroblast ***: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed (CD inflamed: n = 10) and intact (CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children (C: n = 10) were examined. Expression of miR-146a, -155 and -122 was determined by real-time polymerase-chain reaction (PCR). The expression of the above miRs was investigated in recombinant human TGF-β (1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells (CCL-241) and primary duodenal fibroblast cells derived from healthy children as ***: Expression of miR-146a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD (CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, P ≤ 0.01) and to the control group (CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, P ≤ 0.05). The expression of miR-155 was significantly increased in the inflamed region of the duodenum compared to the control group (CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, P ≤ 0.001). The expression of miR-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of miR-155 in small intestinal epithelial cells (TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, P ≤ 0.05) and also the expression of miR-146a (TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, P ≤ 0.01) and miR-155 (TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, P ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated control

关键词： Inflammatory bowel disease Crohn’ s disease Pediatric MicroRNAs Transforming growth factor-β

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Genetic divergence of astroviruses from chickens

Genetic divergence of astroviruses from chickens

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The 15th World Veterinary Poultry Congress

作者： Tamas Mato Robert Glavits Eva Ivanics csaba Nemes Vilmos Palya CEVA-Phylaxia Biologicals Co. BudapestHungary Central Veterinary Institute BudapestHungary. Central Veterinary Institute BudapestHungary. Central Veterinary Institute BudapestHungary. CEVA-Phylaxia Biologicals Co. BudapestHungary

＜正＞Introduction Astroviruses in poultry have been associated with enteritis,uneven growth and increased mortality in young turkeys and chickens,nephritis in chickens and a fatal hepatitis in *** serologically and g...

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变态反应基础知识(三)——变态反应疾病的诊断

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英国医学杂志中文版 1998年第3期1卷 135-138页

作者： csaba Rusznak Robert J Davies 邢军 a registrar in respiratory medicine and allergy professor of respiratory medicine in the department of asthma and allergy at the London Chest Hospital

变态反应疾病可侵及人体各个器官,以变应性鼻炎最多见,下呼吸道、结膜、皮肤以及胃肠道也常受累。变态反应疾病是一种常见疾病,且患病率逐年增高。准确诊断出变应原是建议患者避免接触变应原及环境控制的关键环节。虽然变态反应疾病可... 详细信息

变态反应疾病可侵及人体各个器官,以变应性鼻炎最多见,下呼吸道、结膜、皮肤以及胃肠道也常受累。变态反应疾病是一种常见疾病,且患病率逐年增高。准确诊断出变应原是建议患者避免接触变应原及环境控制的关键环节。虽然变态反应疾病可发生于任何年龄段。

关键词：变态反应疾病变应性鼻炎嗜酸粒细胞环境控制点刺试验鼻分泌物涂片运动性哮喘下呼吸道试验结果交叉过敏反应

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Investigation of Yield Regulation of Red Grapes on the Concentration of Some Crucial Wine Components

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Agricultural Sciences 2016年第4期7卷 279-286页

作者： Kinga K. Rácz Miklós Kállay Nóra Bakos-Barczi László Rácz csaba Csutorás Department of Viniculture Corvinus University Budapest Hungary Eger Crown Winehouse Ltd. Demjén Hungary Institute of Food Science Eszterházy Károly University Eger Hungary

An essential concept of making quality wine is that the quality comes from the vineyard. The dissolved materials and components determine the value of wine. Their amount and proportion are essentially influenced by grape variety, terroir, the way of cultivation, weather conditions, grape quality, the time of vintage and the method of grape and wine processing. In the present study the effect on wine quality of different ways of yield regulations was examined in wines of three consecutive years. Besides basic parameters, total polyphenol and resveratrol contents were determined in wines of Blaufr?nkisch and Merlot varieties. Our measurements were carried out by spectrophotometry, gas and liquid chromatography. Our investigations confirmed that yield regulation led to increased extract content and outstanding quality of the produced wine.

关键词： Yield Regulation Polyphenol Resveratrol Gas Chromatography Liquid Chromatography

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矿泉浴疗预防学:新的研究方法

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中国疗养医学 2011年第11期20卷 1055-1056页

作者：张倩王江 csaba Varga 武汉后方基地襄樊干休所 441000

这篇文章描述了一种研究矿泉浴疗在预防医学中应用的策略。以预防为目的矿泉浴及饮用矿泉水是能够应用于人群中开展流行病学分析的。应用完全的化学分析(包括高精确有机分析)及特定毒性试验检测医疗矿泉水样本和医疗泥样本,可以计算出... 详细信息

这篇文章描述了一种研究矿泉浴疗在预防医学中应用的策略。以预防为目的矿泉浴及饮用矿泉水是能够应用于人群中开展流行病学分析的。应用完全的化学分析(包括高精确有机分析)及特定毒性试验检测医疗矿泉水样本和医疗泥样本,可以计算出预防应用矿泉疗法的毒理学风险。

关键词：矿泉浴疗预防医学

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在FPGA中实现高级视频分析功能

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中国电子商情 2013年第12期 60-62页

作者： csaba Rekeczky Gusztav Bartfai Bob Siller Eutecus公司 Eutecus HU欧洲部 Altera

FPGA逐渐成为具有嵌入式视频分析功能产品开发的最佳选择,这些产品应用于商业智能视频监控（IVS）、军事情报、监视和侦查（ISR）以及汽车辅助驾驶（ADAS）等领域.这些市场,大量的新器件和应用中各种各样的吞吐量处理需求一直在急速增长... 详细信息

FPGA逐渐成为具有嵌入式视频分析功能产品开发的最佳选择,这些产品应用于商业智能视频监控（IVS）、军事情报、监视和侦查（ISR）以及汽车辅助驾驶（ADAS）等领域.这些市场,大量的新器件和应用中各种各样的吞吐量处理需求一直在急速增长.对于这些应用,要求以等于或者高于视频帧速率的速度来分析多路百万像素视频输入,以便提供精确可靠的结果.取决于具体应用,这些处理需求会有很大的差别,因此,需要创新的硅片体系结构和算法以解决这些难题,以尽可能低的复杂度和系统成本来提供灵活的最优解决方案.

关键词：视频监控 FPGA 功能产品开发商业智能军事情报体系结构系统成本

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Structure and Tone Change of the Press in View of the Reports of the Public Mood in the Era of Change of Regime(October 1988-January 1989)

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Cultural and Religious Studies 2018年第8期6卷 449-455页

作者： csaba Katona Hungarian Academy of Sciences BudapestHungary

1988 and 1989 was the dawn of Hungarian change of *** impact of the upcoming change is also well-documented in informers'reports of the public *** lecture examines the structure and tone of the press from this particular aspect from October 1988 to January *** the reports of the public mood were reflected on the free press?Membership of a state party is accustomed to the fact that the caring state determines what needs to be *** media products and their multi-faceted vision caused them serious *** reports of the public mood,it is not to be overlooked that their creators have been working on *** of informers recorded what readers of the reports of the public mood *** wrote what they really *** people were shocked to see more newspapers,magazines,and TV *** demanded their banning *** media activity was considered by many sources as self-directed and *** reported that many people agreed with the *** most people wrote that conflicting news is causing serious *** sudden freedom came to surprise most of the *** following quotation summarizes this:"The majority did not know what was right,what could be done,and what could not be *** variety of newspapers does not help clarity of vision but the difficulty of orientation".

关键词： change of regime Hungary reports of the public mood structure and tone change of the press

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Alteration of Cylindrospermopsin Content of <i>Aphanizomenon ovalisporum</i>(Cyanobacteria, Nostocales) due to Step-Down from Combined Nitrogen to Dinitrogen

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Advances in Microbiology 2013年第8期3卷 557-564页

作者： Gábor Vasas Gyula Surányi István Bácsi Márta M-Hamvas csaba Máthé Sándor Gonda George Borbely Department of Botany Faculty of Science University of Debrecen Debrecen Hungary Department of Hidrobiology Faculty of Science University of Debrecen Debrecen Hungary

In this study we show that cylindrospermopsin (a cyanotoxin) content of filaments of Aphanizomenon ovalisporum ILC164 depended on growth on combined nitrogen or nitrogen fixation. Our results also demonstrated that the shift down of cyanobacterial filaments from combined nitrogen to dinitrogen fixing condition resulted in a significant decrease of cylindrospermopsin pool size which resumed a growth rate dependent manner as the heterocyst and nitrogenase formation appeared. The current study indicated that alteration of nitrogen metabolism of Aphanizomenon ovalisporum (Forti) induced changes in cyanotoxin (cylindrospermopsin) metabolism. In addition, this is the first report that isolated heterocysts, the differentiated anaerobic cells for nitrogen fixation of cyanobacteria, did not contain cylindrospermopsin.

关键词： Cylindrospermopsin Cyanobacteria Heterocyst Nitrogen Starvation Nitrogenase Cyanotoxin

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Windows访问令牌窃取提升进程权限

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黑客防线 2010年第2期 46-49页

作者： csaba Barta 武云龙（译）党壮（译）

本文详细介绍了如何在Windows系统上通过偷取其他进程的访问令牌来改变我们进程权限的方法。

关键词：提权令牌进程

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