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Combining thermal scanning probe lithography and dry etching for grayscale nanopattern amplification

Microsystems & Nanoengineering 2024年第1期10卷 335-344页

作者： Berke Erbas Ana Conde-Rubio Xia Liu Joffrey Pernollet Zhenyu Wang Arnaud Bertsch Marcos Penedo Georg Fantner Mitali Banerjee Andras kis.Giovanni Boero Juergen Brugger Microsystems Laboratory École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Center of MicroNanoTechnology(CMi) EPFLLausanne 1015Switzerland Laboratory of Nanoscale Electronics and Structures École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Laboratory for Bio-and Nano-Instrumentation École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Laboratory of Quantum Physics Topology and CorrelationsÉcole Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Present address:Institute of Materials Science of Barcelona ICMAB-csIC Campus UABBellaterra 08193Spain Present address:School of Integrated Circuits and Electronics MIIT Key Laboratory for Low-Dimensional Quantum Structure and DevicesBeijing Institute of TechnologyBeijing 100081China

Grayscale structured surfaces with nanometer-scale features are used in a growing number of applications in optics and *** scanning probe lithography achieves a lateral resolution below 10 nm and a vertical resolution below 1 nm,but its maximum depth in polymers is ***,we present an innovative combination of nanowriting in thermal resist and plasma dry etching with substrate cooling,which achieves up to 10-fold amplification of polymer nanopatterns into SiO_(2) without proportionally increasing surface *** nanopatterns in SiO_(2) with 400 nm pitch and 150 nm depth are fabricated free of shape distortion after dry *** exemplify the possible applications of the proposed method,grayscale dielectric nanostructures are used for scalable manufacturing through nanoimprint lithography and for strain nanoengineering of 2D *** a method for aspect ratio amplification and smooth grayscale nanopatterning has the potential to find application in the fabrication of photonic and nanoelectronic devices.

关键词： lithography thermal pattern

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Palynostratigraphy and Paleoenvironment of Bukit Tigapuluh Area in the Jambi Subbasin from Oligocene to Miocene

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Journal of Geoscience and Environment Protection 2024年第9期12卷 113-151页

作者： Sapto kis.Daryono Carolus Prasetyadi Eko Teguh Paripurno Sutanto Aditya Zaenalfi Faozi Geological Engineering Department Faculty of Technology Mineral Universitas Pembangunan Nasional Veteran Yogyakarta Kota Yogyakarta Indonesia

The Oligocene-Miocene trajectory exposed at the Lubuk Lawas and Lubuk Bernai Stratigraphic Tracks in Bukit Tigapuluh, Jambi Subbasin, Indonesia, archives remnants of equatorial vegetation during extreme global warming and near the beginning of the East Java-Eurasia microcontinent collision, and was carried out using mapping surface analysis, petrological analysis, sedimentology, stratigraphy and palinology. The rock units were deposited during one sedimentation phase, that is the continental deposition phase, which consists of conglomerates, gravel sandstones and sandstones that fill the basin followed by transgressive deposits associated with the deepening of the basin environment. Three palynozones Meyeripollis naharkotensis (Oligocene), Florschuetzia trilobata (Early Miocene) and Florschuetzia meridionalis (Middle Miocene) were identified stratigraphically on the basis of these pollen. The rock layers are deposits from the Early Oligocene to Middle Miocene from bottom to top. The depositional environment changed over time, passing from a narrow, steep-sided tectonic basin, during the Early to Late Oligocene, followed by a lacustrine basin to a palustine with oceanic influence, as a result of distensive E-W movement between the Jambi Fault and the Sunda Fault in the Late Oligocene to the Middle Miocene. Occurrence of taxonomically highly diverse angiosperm pollen in all three palynozones attests to an extremely rich inland and nearshore tropical flora under a strong seasonal rainfall regime. The climate remained warm and became increasingly humid towards the end of the Miocene. The nature of the environment is related to the dynamics of the opening of the basin opening.

关键词： Oligocene Miocene Palynostratigraphy Paleoenvironment Paleogeography Jambi Subbasin Indonesia

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Minimally invasive image-guided therapy of primary and metastatic pancreatic cancer

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World Journal of Gastroenterology 2021年第27期27卷 4322-4341页

作者： Andras Bibok Dae Won Kim Mokenge Malafa Bela kis Department of Diagnostic Imaging and Interventional Radiology H.Lee Moffitt Cancer CenterTampaFL 33612United States Department of Transplantation&Surgery Radiology UnitSemmelweis UniversityBudapest 1085Hungary Department of Gastrointestinal Oncology H.Lee Moffitt Cancer CenterTampaFL 33612United States

Pancreatic cancer is a challenging malignancy with limited treatment options and poor life *** only curative option is surgical resection,but only 15%-20%of patients are resectable at presentation because more than 50%of patients has distant metastasis at diagnosis and the rest of them has locally advanced pancreatic cancer(LAPC).The standard of care first line treatment for LAPC patients is chemotherapy with or without radiation *** developments in minimally invasive ablative techniques may add to the treatment armamentarium of *** are increasing number of studies evaluating these novel ablative techniques,including radiofrequency ablation,microwave ablation,cryoablation and irreversible *** studies which included pancreatic tumor ablation,demonstrated improved overall survival in LAPC ***,the exact protocols are yet to set up to which stage of the treatment algorithm ablative techniques can be added and in what kind of treatment *** with metastatic pancreatic cancer has dismal prognosis with 5-year survival is only 3%.The most common metastatic site is the liver as 90%of pancreatic cancer patients develop liver *** is the primary treatment option for patients with metastatic pancreatic ***,when the tumor is not responding to chemotherapy or severe drug toxicity develops,locoregional liver-directed therapies can provide an opportunity to control intrahepatic disease progression and improve survival in selected *** the last decade new therapeutic options arose with the advancement of minimally invasive technologies to treat pancreatic cancer *** new therapies have been a topic of increasing interest due to the severe prognostic implications of locally advanced and metastatic pancreatic cancer and the low comorbid risk of these *** review summarizes new ablative options for patients with LAPC and percutaneous liver-directed th

关键词： Pancreatic neoplasms Interventional radiology Ablation techniques Electroporation Radiofrequency ablation Therapeutic embolization

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Comparison of long-term outcome between patients aged 〈 65 years vs. ≥ 65 years after atrial fibrillation ablation

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Journal of Geriatric Cardiology 2017年第9期14卷 569-574页

作者： Zsuzsanna kis.Anna ME Noten Mihran Martirosyan Astrid A Hendriks Rohit Bhagwandien Tamas Szili-Torok Department of Cardiology Erasmus MC University Medical Center Rotterdam the Netherlands

Background Atrial fibrillation （AF） is the most frequent arrhythmia, and its prevalence is increasing with aging. We aimed to com-pare the long-term outcome data of patients 〈 65 years vs.≥ 65 years who underwent catheter ablation （CA） for drug-refractory AF. MethodsConsecutive patients with primary pulmonary vein isolation performed between March 2001 and December 2011, and those who completeda five-year of follow-up were divided into two groups： patients aged 〈 65 years into group 1, and patients aged ≥ 65 into group 2. Long-termoutcome data concerning mortality, thromboembolic events （TE） and success rates were compared between these groups. Results A totalnumber of 390 patients were included, group 1 contained 310 patients, and 80 patients in group 2. In group 2, patients had more often impairedrenal function （P 〈 0.001） and thyroid disease （P = 0.047）. A total of fifteen patients died during the 6.63 ± 2.1 years of follow-up, with a sig-nificantly higher incidence in the older group （8/80 vs. 7/310 patients, P = 0.004）. The majority of fatal outcome was due to cancerous dis-eases in both groups. No difference was observed concerning the long-term TE rate （12/310 vs. 4/80 patients, P = 0.75）. Rhythm controlfailed in 25.9% of the patients, with no difference between the groups： 26.4% in group 1 vs. 23.7% in group 2 （P = 0,67）, ConclusionsDespite growing prevalence of AF in aging population, the elderly patients are underrepresented in CA procedures. Similar clinical successand TE complication rate are observed between the age-groups. Our data suggest more liberal criteria might be applied while selecting pa-tients for AF ablation.

关键词： Atrial fibrillation Catheter ablation Clinical outcome The elderly Thromboembolic complication

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Relation of the IGF/IGF1R system to autophagy in colitis and colorectal cancer

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World Journal of Gastroenterology 2017年第46期23卷 8109-8119页

作者： Ferenc Sipos Hajnal Székely Imre Dániel kis.Zsolt Tulassay Gyorgyi Muzes 2nd Department of Internal Medicine Semmelweis University Faculty of Medicine Semmelweis University Molecular Medicine Research Group Hungarian Academy of Sciences

Metabolic syndrome(Met S), as a chronic inflammatory disorder has a potential role in the development of inflammatory and cancerous complications of the colonic tissue. The interaction of DNA damage and inflammation is affected by the insulin-like growth factor 1 receptor(IGF1 R) signaling pathway. The IGF1 R pathway has been reported to regulate autophagy, as well, but sometimes through a bidirectional context. Targeting the IGF1 R-autophagy crosstalk could represent a promising strategy for the development of new antiinflammatory and anticancer therapies, and may help for subjects suffering from Met S who are at increased risk of colorectal cancer. However, therapeutic responses to targeted therapies are often shortlived, since a signaling crosstalk of IGF1 R with other receptor tyrosine kinases or autophagy exists, leading to acquired cellular resistance to therapy. From a pharmacological point of view, it is attractive to speculate that synergistic benefits could be achieved by inhibition of one of the key effectors of the IGF1 R pathway, in parallel with the pharmacological stimulation of the autophagy machinery, but cautiousness is also required, because pharmacologic IGF1 R modulation can initiate additional, sometimes unfavorable biologic effects.

关键词： Insulin-like growth factor IGF1R Autophagy Colitis Colorectal cancer Metabolic syndrome

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The archaeogenomic validation of Saint Ladislaus'relic provides insights into theárpád dynasty's genealogy

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Journal of Genetics and Genomics 2023年第1期50卷 58-61页

作者： Gergely I.B.Varga Lilla Alida Kristóf Kitti Maár Luca kis.Oszkár Schütz Orsolya Váradi Bence Kovács Alexandra Gînguță Balázs Tihanyi Péter L.Nagy Zoltán Maróti Emil Nyerki Tibor Török Endre Neparáczki Department of Archaeogenetics Institute of Hungarian ResearchH-1014 BudapestHungary Doctoral School of History University of SzegedSzegedHungary Department of Genetics University of SzegedH-6726 SzegedHungary Department of Biological Anthropology University of SzegedH-6726 SzegedHungary Department of Molecular Biology and Biotechnology Faculty of Biology and GeologyBabes-Bolyai University400006 Cluj-NapocaRomania Praxis Genomics LLC AtlantaUSA Department of Pediatrics and Pediatric Health Center University of SzegedH-6725 SzegedHungary

The house of Arp ad ruled Hungary for more than four centuries,establishing dynastical relationships with numerous European nobleand ruling houses,and giving many Catholic saints and blesseds to the Catholic *** were one of the significant dynasties of Medieval Europe(Krist o and Makk,1996).The knight-king Saint Ladislaus I(c.1040-1095,reign:1077-1095)is one of the most outstanding kings of this *** addition to the hand relic(the Holy Right)of King Saint Stephanus I(c.975-1038,reign:1000/1001-1038),the skull relic in the Saint Ladislaus’Herma(Fig.1A-1C)preserved in the Cathedral of Gy or,is one of the most important relics for Hungarians(Klaniczai,2000).

关键词： relic provides insights into the The archaeogenomic validation of Saint Ladislaus d dynasty’s genealogy

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Inhibitory Effect of Alpha‑Mangostin to Dengue Virus Replication and Cytokines Expression in Human Peripheral Blood Mononuclear Cells

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Natural Products and Bioprospecting 2019年第5期9卷 345-349页

作者： Zaenal Sugiyanto Benediktus Yohan Soeharyo Hadisaputro Edi Dharmana Catharina Suharti Winarto kis.Djamiatun Fifin LRahmi R.Tedjo Sasmono Faculty of Health Science Dian Nuswantoro UniversityJl.Imam Bonjol 270Semarang 50131Indonesia Doctoral Program in Medical and Health Sciences Faculty of MedicineDiponegoro UniversityJl.Prof.Sudarto SHTembalangSemarang 50275Indonesia Eijkman Institute for Molecular Biology Ministry of ResearchTechnology and Higher EducationJl.Diponegoro 69Jakarta 10430Indonesia Faculty of Medicine Diponegoro UniversityJl.Prof.Sudarto SHTembalangSemarang 50275Indonesia

Massive pro-inflammatory cytokines production has been correlated with the pathogenesis of severe dengue *** active compound of mangosteen fruit pericarps,α-mangostin,has been commonly used as traditional medicine and dietary *** examined the effect ofα-mangostin against dengue virus(DENV)infection in human peripheral blood mononuclear cells(PBMC)by the measurement of virus titer and TNF-αand IFN-γcytokines concentration post *** concentration ofα-mangostin inhibited virus replication and reduced inflammatory cytokines expression at 24-and 48-h post *** results support the potential use ofα-mangostin as anti-antiviral and anti-inflammatory therapies in the treatment of dengue.

关键词： Dengue Antiviral Mangostin Cytokine PBMC

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Effect of resistance training on non-alcoholic fatty-liver disease a randomized-clinical trial

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World Journal of Gastroenterology 2014年第15期20卷 4382-4392页

作者： Shira Zelber-Sagi Assaf Buch Hanny Yeshua Nahum Vaisman Muriel Webb Gil Harari Ofer kis.Naomi Fliss-Isakov Elena Izkhakov Zamir Halpern Erwin Santo Ran Oren Oren Shibolet Department of Gastroenterology Tel Aviv Medical Center6423906 Tel-AvivIsrael School of Public Health University of Haifa3498838 HaifaIsrael The Sackler Faculty of Medicine Tel-Aviv University6997801 Tel AvivIsrael Wingate Institute for Physical Education and Sport 4290200 NetanyaIsrael

AIM: To evaluate the effect of resistance training (RT) on non alcoholic liver disease (NAFLD) patients.

关键词： Resistance exercise Obesity Nutrition Physical activity Abdominal fat

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Feasibility study applied to mapping tidal effects in the Pannonian basin--An effort to check location dependencies atμGal level

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Geodesy and Geodynamics 2018年第3期9卷 237-245页

作者： G.Papp J.Benedek P.Varga M.kis.A.Koppan B.Meurers R.Leonhardt M.K.Baracza Geodetic and Geophysical Institute Research Centre for Astronomy and Earth SciencesHungarian Academy of Sciences.9400 SopronHungary Geological and Geophysical Institute of Hungary 1145 BudapestHungary University of Vienna Department of Meteorology and Geophysics1090 WienAustria Zentralanstalt fur Meteorologie and Geodynamik 1190 ViennaAustria University of Miskolc Department of Geophysics3515 Miskolc-EgyetemvarosHungary

This paper summarizes the main instrumental and methodological points of the tidal research which was performed in the framework of the National Scientific Research Fund Project K101603. Since the project is still running the tidal analysis results published here are only preliminary. Unmodelled tidal effects have been highlighted in some recent absolute gravity measurements carried out in the Pannonian basin resulting in a periodic modulation exceeding the typical standard deviations （±1microGal） of the drop sets. Since the most dominant source of the daily gravity variation is the bulk tidal effect, the goal of the project is to check its location dependency at BGal level. Unfortunately Hungary has had no dedicated instrumentation, so an effort was made to make the available LaCoste- Romberg spring G meters capable for continuous recording. As a reference instrument the GWR SG025 operated in the Conrad Observatory, Austria was also used and in the mean time of the project, a Scintrex CG-5 became also available, Eventually 6 instruments at 5 different locations were operated for 3 9 months mainly in co-located configuration. Although many experiments （moving mass calibrations） were done to determine the scale factors and scale functions of the instruments, the direct comparison of the tidal parameters obtained from the observations is still questionable. Therefore the ratio of the delta factors of O1 and M2 tidal constituents was investigated supposing that M2 is much more influenced by the ocean loading effect than O1. The slight detected increase of δ（O1 ）/δ（M2）（≈0.2%） toward east does not contradict to theory. This result has to be validated in the near future by analyzing available ocean loading models.

关键词： Gravity tide mapping Spring gravity meters Instrumental tests Co-located observations Location dependence of delta factors

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Combined Treatment with Buserelin+Cabergoline in Patient with Prostate Cancer and Pituitary Macroprolactinoma

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Journal of Cancer Therapy 2010年第4期1卷 214-218页

作者： Mihaly Gervain Erika Voros Andor HMolnar Gyongyi Karcsu-kis.Ferenc Laszlo Department of Urology City HospitalOroshazaHungary Euromedic Diagnostics SzegedHungary Department of Physiology Anatomy and NeurosciencesUniversity of SzegedSzegedHungary

Twelve years following hemicolectomy for colon adenocarcinoma, a 75-year-old patient with prostate cancer was treated for 4 weeks with the antiandrogen nilutamide and then with the long-acting GnRH agonist buserelin. The serum testosterone and prostate-specific antigen levels had decreased dramatically after 3 months of treatment. After 2 years of buserelin administration, the hormonal state was examined. Serum estradiol, testosterone, DHEA, DHEAS, FSH and LH levels proved to be suppressed, but the serum PRL concentration was extremely high (3 365 mIU/l). The pituitary MRI revealed a macroadenoma. The patient was treated with the dopamine agonist cabergoline, together with buserelin. After 9 months of this combined treatment, the prostate-specific antigen and testosterone levels were very low;the serum estradiol, DHEA, DHEAS, FSH and LH concentrations remained suppressed. The serum PRL level fell dramatically to 6.95 mIU/l, and a significant reduction in tumor size was observed on MRI. In conclusion: Combined buserelin + cabergoline treatment proved a highly successful procedure to cure this patient with prostate carcinoma and subsequent pituitary macroprolactinoma.

关键词： Prostate cancer Prolactinoma Buserelin Cabergoline

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