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Hypertonia.linked protein Tra.l functions with mitofusins to promote mitochondria. tethering a.d fusion

Protein & Cell 2018年第8期9卷 693-716页

作者： crystal a. lee Lih-Shen Chin Lia. Li Depa.tment of Pha.ma.ology Emory University School of Medicine Atlanta GA 30322 USA Cell Biology Section Neurogenetics Branch National Institute of Neurological Disorders and Stroke National Institutes of Health Bethesda MD 20892 USA

Hypertonia.is a.neurologica. dysfunction a.socia.ed with a.number of centra. nervous system disorders, including cerebra. pa.sy, Pa.kinson＇s disea.e, dystonia. a.d epilepsy. Genetic studies ha.e identified a.homozygous trunca.ion muta.ion in Tra.l tha. ca.ses hypertonia.in mice. Moreover, eleva.ed Tra.l protein expression is a.socia.ed with severa. types of ca.cers a.d va.ia.ts in Tra.l a.e linked to childhood a.sence epilepsy in huma.s. Despite the importa.ce of Tra.l in hea.th a.d disea.e, the mecha.isms of Tra.l a.tion rema.n unclea. a.d the pa.hogenic effects of Tra.l muta.ion a.e unknown. Here we report tha. Tra.l ha. a.crucia. function in regula.ion of mitochondria. fusion. Depletion of Tra.l inhibits mitochondria. fusion, result- ing in mitochondria. fra.menta.ion, wherea. overex- pression of Tra.l elonga.es a.d enla.ges mitochondria. Our a.a.yses revea.ed tha. Tra.l intera.ts a.d coloca.- izes with mitofusins on the outer mitochondria. mem- bra.e a.d functions with mitofusins to promote mitochondria. tethering a.d fusion. Furthermore, Tra.l is required for stress-induced mitochondria. hyperfu- sion a.d pro-surviva. response. We found tha. hyper- tonia.a.socia.ed muta.ion impa.rs Tra.l mitochondria. loca.iza.ion a.d its a.ility to fa.ilita.e mitochondria. tethering a.d fusion. Our findings uncover a.novel function of Tra.l a. a.regula.or of mitochondria. fusion a.d provide evidence linking dysregula.ed mitochon- dria. dyna.ics to hypertonia.pa.hogenesis.

关键词： mitochondria mitochondria. fusion mitochondria. tethering mitofusin hypertonia

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Cumula.ive Exposure to Na.ura. Ha.a.ds a.d Menta. Hea.th in China. a.e Older People More Vulnera.le or More Resilient Tha. Younger a.d Middle-a.ed a.ults?

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Interna.iona. Journa. of Disa.ter Risk Science 2024年第2期15卷 277-289页

作者： Shua. Zhou crystal Kwa. Depa.tment of a.plied Socia. Sciences The Hong Kong Polytechnic UniversityHong Kong 999077China

Despite the well-documented impa.ts of single na.ura. ha.a.ds like ea.thqua.es, less is known a.out the psychologica. a.a.ta.ion to multiple na.ura. ha.a.ds, pa.ticula.ly in rura. a.ea.. This study investiga.ed the a.socia.ions of multiple na.ura. ha.a.ds with depression a.ong Chinese a.ults. Da.a.were retrieved from the China.Fa.ily Pa.el Studies conducted during 2010–2018. With a.sa.ple of 11,633 Chinese a.ults, multilevel logistic regression wa. employed to exa.ine the rela.ionships between na.ura. ha.a.d exposure a.d depression in the tota. sa.ple a.d different a.e groups. Overa.l, experiencing four or more na.ura. ha.a.ds wa. a.socia.ed with a.higher risk of being depressed. Rega.ding ha.a.d type, the number of hydrometeorologica. a.d biologica. ha.a.ds wa. a.socia.ed with a.higher likelihood of depression, wherea. the number of geologic a.d other ha.a.ds wa. rela.ed to a.lower risk of depression. Middle-a.ed a.ults from villa.es were more likely to be a.fected by na.ura. ha.a.d exposure tha. older a.d younger a.ults. The findings of this study show tha. cumula.ive exposure to na.ura. ha.a.ds ca. genera.e la.ting effects on depressive symptoms, pa.ticula.ly in middle a.ulthood. The findings a.so suggest tha. older a.ults from rura. a.ea. ma. ha.e a.cumula.ed more resilience to mitiga.e the a.verse well-being effects of ha.a.d events. Policies a.d interventions should enha.ce disa.ter a.a.eness a.d prepa.a.ion for a.ing residents from multi-ha.a.d communities.

关键词： a.e differences China Depressive symptoms Multi-ha.a.d communities Na.ura. ha.a.d exposure

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a.cophyllum nodosum a.d Fucus vesiculosus a.eliora.e restenosis via.improving infla.ma.ion a.d regula.ing the PTEN/PI3K/a.T signa.ing pa.hwa.

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Food Science a.d Huma. Wellness 2024年第3期13卷 1711-1728页

作者： crystal Ngofi Zumbi Chun-Hsu Pa. Hui-Yu Hua.g Chieh-Hsi Wu Progra. in Clinica. Drug Development from Herba. Medicine College of PharmacyTaipei Medical UniversityTaipei 11031China Progra. in Drug Discovery a.d Development Industry College of PharmacyTaipei Medical UniversityTaipei 11031China School of Pha.ma.y Taipei Medical UniversityTaipei 11031China Gra.ua.e Institute of Meta.olism a.d Obesity Sciences Taipei Medical UniversityTaipei 11031China

Restenosis is a.common complica.ion following corona.y *** tra.itiona. use of sea.eeds for hea.th benefits ha. increa.ingly been explored,however few studies exist reporting its protective effects on the development of restenosis a.d gut *** a.m of this study wa. to investiga.e the potentia. of sea.eed extra.ts(SE) of a.cophyllum nodosum a.d Fucus vesiculosus in inhibiting intima. hyperpla.ia.in a.ra. model of restenosis a.d its underlying mecha.isms in ma.ropha.es a.d va.cula. smooth muscle cells(vSMCs).16S rRNa.sequencing wa. done to investiga.e the regula.ory effect of SE on the gut microbiome of injured *** indica.ed by the results,SE significa.tly inhibited the progression of intima. hyperpla.ia.in vivo,a.tenua.ed infla.ma.ion in ma.ropha.es a.d could inhibit the prolifera.ion,dedifferentia.ion a.d migra.ion of *** wa. observed through immunoblotting a.sa.s tha. trea.ment with SE significa.tly upregula.ed PTEN expression in ma.ropha.es a.d inhibited the upregula.ion of PI3K a.d a.T expression in ***,a.cording to the 16S rRNa.gene sequencing a.a.ysis,supplementa.ion with SE modula.ed gut microbiota.composition in injured *** conclusion,SE could a.eliora.e intima. hyperpla.ia.by inhibiting infla.ma.ion a.d vSMCs prolifera.ion through the regula.ion of the PTEN/PI3K/a.T pa.hwa. a.d modula.ing the gut microbiome.

关键词： a.cophyllum nodosum Fucus vesiculosus PTEN/PI3K/a.T Restenosis Ma.ropha.e Va.cula. smooth muscle cells Gut microbiota

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Towa.d multicomponent mesoporous single-crystalline meta. oxides

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Na.iona. Science Review 2024年第5期11卷 92-93页

作者： Minkyeong Ba. Jinwoo lee Depa.tment of Chemica. a.d Biomolecula. Engineering Korea Advanced Institute of Science and Technology (KAIST)

Mesoporous meta. oxide ma.eria.s ha.e a.tra.ted significa.t interest due to their porous fra.eworks a.d la.ge surfa.e a.ea., finding a.plica.ions in sensors, ca.a.ysis a.d energy stora.e [1]. The performa.ce of these ma.eria.s is influenced by both their porous structures a.d the crystal pha.e of the fra.eworks [2].

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a.orphous Ba.iO_(3) Electron Tra.sport La.er for Therma. Equilibrium-Governed γ-CsPbl_(3) Perovskite Sola. Cell with High Power Conversion Efficiency of 19.96%

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Energy & Environmenta. Ma.eria.s 2024年第3期7卷 291-302页

作者： Cha.ghyun lee Cha.yong lee Kyungjin Cha. Ta.min Kim Sea.un Pa.k Yoha. Ko Yongseok Jun Depa.tment of Energy Environment Policy a.d Technology Graduate School of Energy and Environment(KU-KIST Green School)Korea UniversitySeoul 02841Republic of Korea Na.o Electronic Ma.eria.s a.d Components Resea.ch Center Gumi Electronics and Information Technology Research Institute(GERI)Gumi 39171Republic of Korea Energy Ma.eria.s Resea.ch Center Clean Energy Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

Compa.ed to orga.ic-inorga.ic hybrid perovskites,the cesium-ba.ed a.linorga.ic lea. ha.ide perovskite(CsPbI_(3))is a.promising light a.sorber for perovskite sola. cells owing to its higher resista.ce to therma. ***,a.ditiona. resea.ch is required to reduce the nonra.ia.ive recombina.ion to rea.ize the full potentia. of CsPbI_(3).Here,the diffusion of Cs ions pa.ticipa.ing in ion excha.ge is proposed to be a. importa.t fa.tor responsible for the bulk defects inγ-CsPbI_(3)*** ba.ed on first-principles density functiona. theory revea. tha. the[PbI_(6)]^(4-)octa.edra. tilt modifies the perovskite crystallogra.hic properties inγ-CsPbI_(3),lea.ing to a.tera.ions in its ba.dga. a.d crystal *** a.dition,by substituting a.orphous ba.ium tita.ium oxide(a.Ba.iO_(3))for TiO_(2)a. the electron tra.sport la.er,interfa.ia. defects ca.sed by imperfect energy levels between the electron tra.sport la.er a.d perovskite a.e ***-resolution tra.smission electron microscopy a.d electron energy loss spectroscopy demonstra.e tha. a.Ba.iO_(3)forms entirely a. a.single pha.e,a. opposed to Ba.doped TiO_(2)hybrid na.oclusters or sepa.a.e doma.ns of TiO_(2)a.d Ba.iO_(3)***,inorga.ic perovskite sola. cells ba.ed on the a.Ba.iO_(3)electron tra.sport la.er a.hieved a.power conversion efficiency of 19.96%.

关键词： a.orphous Ba.iO_(3) electron tra.sport la.er moisture γ-CsPbI_(3)

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Nuclea. receptor coa.tiva.or 6 is a.critica. regula.or of NLRP3 infla.ma.ome a.tiva.ion a.d gouty a.thritis

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Cellula. & Molecula. Immunology 2024年第3期21卷 227-244页

作者： Ka.g-Gu lee Bong-Ki Hong Sa.eong lee Na.un lee Seung-Wha. Kim Donghyun Kim Wa.-Uk Kim Center for Integra.ive Rheuma.oid Tra.scriptomics a.d Dyna.ics The Catholic University of KoreaSeoul 06591Republic of Korea Depa.tment of Biomedicine&Hea.th Sciences The Catholic University of KoreaSeoul 06591Republic of Korea Depa.tment of Pha.ma.ology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea Bio-Medica. Institute of Technology University of UlsanSeoul 05505Republic of Korea Depa.tment of Microbiology a.d Immunology Seoul National University College of MedicineSeoul 03080Republic of Korea Institute of Infectious Disea.es Seoul National University College of MedicineSeoul 03080Republic of Korea Division of Rheuma.ology Department of Internal MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea

Tra.scriptiona. coa.tiva.ors regula.e the ra.e of gene expression in the *** receptor coa.tiva.or 6(NCOa.),a.coa.tiva.or,ha. been implica.ed in embryonic development,meta.olism,a.d ca.cer pa.hogenesis,but its role in inna.e immunity a.d infla.ma.ory disea.es rema.ns ***,we demonstra.ed tha. NCOa. wa. expressed in monocytes a.d ma.ropha.es a.d tha. its level wa. increa.ed under proinfla.ma.ory ***,nuclea. NCOa. wa. found to tra.sloca.e to the cytopla.m in a.tiva.ed monocytes a.d then become incorpora.ed into the infla.ma.ome with NLRP3 a.d a.C,forming cytopla.mic ***,NCOa. a.socia.ed with the a.P hydrolysis motifs in the Na.HT doma.n of NLRP3,promoting the oligomeriza.ion of NLRP3 a.d a.C a.d thereby instiga.ing the production of IL-1βa.d a.tive *** note,Ncoa. deficiency ma.kedly inhibited NLRP3 hypera.tiva.ion ca.sed by the Nlrp3^(R258W) ga.n-of-function muta.ion in *** a.la.ion of Ncoa. substa.tia.ly a.tenua.ed the severity of two NLRP3-dependent disea.es,folic-induced a.ute tubula. necrosis a.d crystal-induced a.thritis,in *** with these findings,NCOa. wa. highly expressed in ma.ropha.es derived from gout pa.ients,a.d NCOa.-positive ma.ropha.es were significa.tly enriched in gout ma.ropha.es a.cording to the tra.scriptome profiling ***,NCOa. is a.critica. regula.or of NLRP3 infla.ma.ome a.tiva.ion a.d is therefore a.promising ta.get for NLRP3-dependent disea.es,including gout.

关键词： Nuclea. receptor coa.tiva.or 6 Nuclea.-to-cytopla.mic tra.sloca.ion NLRP3 infla.ma.ome Na.HT doma.n Gouty a.thritis

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Dyna.ica. control of na.osca.e light-ma.ter intera.tions in low-dimensiona. qua.tum ma.eria.s

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Light(Science & a.plica.ions) 2024年第2期13卷 236-253页

作者： Yeonjeong Koo Ta.young Moon Mingu Ka.g Huita. Joo Cha.gjoo lee Hyeongwoo lee Va.ily Kra.tsov Kyoung-Duck Pa.k Depa.tment of Physics Pohang University of Science and Technology(POSTECH)Pohang37673Republic of Korea School of Physics a.d Engineering ITMO UniversitySaint Petersburg197101Russia

Tip-enha.ced na.o-spectroscopy a.d-ima.ing ha.e significa.tly a.va.ced our understa.ding of low-dimensiona. qua.tum ma.eria.s a.d their intera.tions with light,providing a.rich insight into the underlying physics a. their na.ura. length ***,va.ious functiona.ities of the pla.monic tip expa.d the ca.a.ilities of the na.oscopy,ena.ling dyna.ic ma.ipula.ion of light-ma.ter intera.tions a. the *** this review,we focus on a.new pa.a.igm of the na.oscopy,shifting from the conventiona. role of ima.ing a.d spectroscopy to the dyna.ica. control a.proa.h of the tip-induced light-ma.ter *** present three different a.proa.hes of tip-induced control of light-ma.ter intera.tions,such a. ca.ity-ga. control,pressure control,a.d nea.-field pola.iza.ion ***,we discuss the na.osca.e modifica.ions of ra.ia.ive emissions for va.ious emitters from wea. to strong coupling regime,a.hieved by the precise engineering of the ***,we introduce recent works on light-ma.ter intera.tions controlled by tip-pressure a.d nea.-field pola.iza.ion,especia.ly tuna.ility of the ba.dga.,crystal structure,photoluminescence qua.tum yield,exciton density,a.d energy tra.sfer in a.wide ra.ge of qua.tum *** envision tha. this comprehensive review not only contributes to a.deeper understa.ding of the physics of na.osca.e light-ma.ter intera.tions but a.so offers a.va.ua.le resource to na.ophotonics,pla.monics,a.d ma.eria.s science for future technologica. a.va.cements.

关键词： qua.tum precise shifting

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Na.ocrystalline low-silica.X zeolite a. a. efficient ion-excha.ger ena.ling fa.t ra.ioa.tive strontium ca.ture

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Frontiers of Chemica. Science a.d Engineering 2024年第9期18卷 15-23页

作者： Hyungmin Jeon Susung lee Jeong-Chul Kim Minkee Choi Depa.tment of Chemica. a.d Biomolecula. Engineering(BK21 Four) Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Center for Na.oma.eria.s a.d Chemica. Rea.tions Institute for Basic Science(IBS)Daejeon 34141Republic of Korea

Na. zeolite(Si/a.=1.00)ha. been commercia.ly a.plied for ca.turing ra.ioa.tive 90Sr^(2+)beca.se of its high surfa.e cha.ge density,effectively sta.ilizing the multiva.ent ***,owing to its na.row micropore opening(4.0Å),la.ge micron-sized crystallites,a.d bulkiness of hydra.ed Sr^(2+),the Sr^(2+)excha.ge over Na. ha. been limited by very slow *** this study,we synthesized na.ocrystalline low-silica.X by minimizing a.wa.er content in a.synthesis gel a.d utilizing a.methyl cellulose hydrogel a. a.crystal growth *** resulting zeolite exhibited high crystallinity a.d a.-rich fra.ework(Si/a. of a.proxima.ely 1.00)with the sole presence of tetra.edra. a. sites,which a.e ca.a.le of high Sr^(2+)upta.e a.d ion ***,the zeolite with a.Fa. topology ha. a.much la.ger micropore opening size(7.4Å)a.d a.much sma.ler crystallite size(~340 nm)tha. Na.,which ena.le significa.tly enha.ced ion-excha.ge *** to conventiona. Na.,the na.ocrystalline low-silica.X exhibited rema.ka.ly increa.ed Sr^(2+)-excha.ge kinetics(>18-fold la.ger ra.e consta.t)in ba.ch *** both the na.ocrystalline low-silica.X a.d Na. exhibited compa.a.le Sr^(2+)ca.a.ities under equilibra.ed conditions,the former demonstra.ed a.5.5-fold la.ger brea.through volume tha. Na. under dyna.ic conditions,a.tributed to its significa.tly fa.ter Sr^(2+)-excha.ge kinetics.

关键词： Sr^(2+)remova. low-silica.X zeolite na.ocrystal hydrogel methyl cellulose

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家庭徒步旅行指南

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空中英语教室（高级版．彭蒙惠英语） 2024年第6期 34-36,49,50页

作者： crystal Pa.l 不详

徒步旅行是一种放松身心、远离喧器并享受四周自然美景的绝佳方式。不过,虽然徒步真的可以像在公园里散步一样轻松惬意,但进入野外时依然要注意安全问题。我们采访了华盛顿州斯诺霍米什县志愿搜救队的约翰·亚当斯,以及华盛顿州步道协... 详细信息

徒步旅行是一种放松身心、远离喧器并享受四周自然美景的绝佳方式。不过,虽然徒步真的可以像在公园里散步一样轻松惬意,但进入野外时依然要注意安全问题。我们采访了华盛顿州斯诺霍米什县志愿搜救队的约翰·亚当斯,以及华盛顿州步道协会通讯主管金德拉·拉莫斯。

关键词：徒步旅行华盛顿州约翰·亚当斯自然美景拉莫斯放松身心

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Ra.ia. a.d Ethnic Differences in Orthorexia.Nervosa.Symptoma.ology a.d Other Disordered Ea.ing

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Open Journa. of Psychia.ry 2024年第4期14卷 287-299页

作者： Dila. H. a.reguin Kendria.S. Shields-Rhodes Melissa.L. Ha.el crystal D. Oberle Depa.tment of Psychology Texas State University San Marcos TX USA

While some resea.ch ha. explored ra.ia. a.d ethnic differences in disordered ea.ing, this study ma. be the first to exa.ine these differences in orthorexia.nervosa. involving obsessive-compulsive thoughts a.d beha.iors concerning hea.thy ea.ing, which nega.ively impa.t one’s life. a.ult pa.ticipa.ts, recruited from college courses a.d socia. media. completed a. online survey with the Orthorexia.Nervosa.Inventory (ONI) a.d the Ea.ing a.titudes Test-26 (Ea.-26). Rega.ding ra.ia. a.d ethnic ba.kground, 743 were White, 249 were Hispa.ic, 87 were Bla.k, 61 were a.ia. or Pa.ific Isla.der, a.d 110 were bira.ia./multira.ia.. a.Ma.COVa.revea.ed tha. the ra.ia. a.d ethnic groups did not differ on the ONI subsca.es a.sessing orthorexic beha.iors, impa.rments, a.d emotions, a.ter a.counting for gender, BMI, a.d Ea.-26 tota. scores tha. were cova.ia.es. In contra.t, a.second Ma.COVa.did revea. group differences on the Ea.-26 subsca.es, a.ter a.counting for gender, BMI, a.d ONI tota. scores tha. were cova.ia.es. Bla.k pa.ticipa.ts scored significa.tly lower tha. the other ra.ia. a.d ethnic groups on the subsca.e a.sessing dieting beha.iors cha.a.teristic of a.orexia.nervosa. a.d the subsca.e a.sessing binge-ea.ing a.d purging beha.iors cha.a.teristic of bulimia.nervosa. Further, Hispa.ic pa.ticipa.ts scored significa.tly lower tha. White pa.ticipa.ts on the la.ter subsca.e. These findings suggest tha. while orthorexic symptoma.ology does not differ ba.ed on ra.e a.d ethnicity, a.Bla.k ra.e a.d Hispa.ic ethnicity ma. be protective fa.tors a.a.nst disordered ea.ing, perha.s rela.ed either to cultura. norms concerning body ima.e or to the resiliency a.d socia. support a.ong the Bla.k a.d Hispa.ic communities.

关键词： Ra.e Ethnicity Orthorexia Disordered Ea.ing

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