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Chinese Journal of Chemical Engineering 2017年第4期25卷 442-452页

作者： Alice Medeiros Lima Antonio Jose Goncalves cruz Wu Hong Kwong Chemical Engineering Graduate Program Federal University of Sdo CarlosRodovia Washington Luizkm 235-5P310Sao CarlosSP 13565-905Brazil Department of Chemical Engineering Federal University of Sao CarlosRodovia Washington Luizkm 235-SP 310Silo CarlosSP 13565-905Brazil

This paper proposes the use of the flexible tolerance method(FTM) modified with scaling of variables and hybridized with different unconstrained optimization methods to solve real constrained optimization *** benchmark problems used to analyze the performance of the methods were taken from G-Suite *** original method(FTM) and other four proposed methods:(i) FTM with scaling of variables(FTMS),(ii) FTMS hybridized with BFGS(FTMS-BFGS),(iii) FTMS hybridized with modified Powell's method(FTMS-Powell)and(iv) FTMS hybridized with PSO(FTMS-PSO), were implemented. The success rates of the methods were 80%,100%, 75%, 95% and 85%, for FTM, FTMS, FTMS-BFGS, FTMS-Powell and FTMS-PSO, respectively. Numerical experiments including real constrained problems indicated that FTMS gave the best performance, followed by FTMSPowell and FTMS-PSO. Despite the inferior performance compared to FTMS and FTMS-Powell, the FTMS-PSO method presented some advantages since good different initial points could be obtained, which allow exploring different routes through the solution space and to escape from local optima. The proposed methods proved to be an effective way of improving the performance of the original FTM.

关键词： Flexible tolerance method Modified Powell’s method BFGS PSO Scaling Hybridization

An improved flexible tolerance method for solving nonlinear constrained optimization problems:Application in mass integration

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Chinese Journal of Chemical Engineering 2017年第5期25卷 617-631页

作者： Alice Medeiros Lima Wu Hong Kwong Antonio José Goncalves cruz Chemical Engineering Graduate Program Federal University of Sao Carlos Department of Chemical Engineering Department of Chemical Engineering Federal University of Sao Carlos

This paper proposes the use of the flexible tolerance method(FTM) modified with adaptive Nelder–Mead parameters and barrier to solve constrained optimization problems. The problems used to analyze the performance of the methods were taken from G-Suite functions, and the methods with the best performance were applied in mass integration problems. Four methods were proposed:(1) flexible tolerance method(FTM) using adaptive parameters(FTMA),(2) flexible tolerance method with scaling(FTMS) and with adaptive parameters(FTMAS),(3) FTMS including the barrier modification(MFTMS) and(4) MFTMS hybridized with PSO(MFTMS-PSO). The success rates of these methods were 100%(MFTMS), 85%(MFTMS-PSO), 40%(FTMAS) and 30%(FTMA).Numerical experiments indicated that the MFTMS could efficiently and reliably improve the accuracy of global optima. in mass integration, the method was able, from current process situation, to reach the optimum process configuration that includes integration issues, which was not possible using FTM in its standard formulation. The hybridization of FTMS with PSO(without barrier), FTMS-PSO, was also able to solve mass integration problems efficiently.

关键词： Flexible tolerance method Adaptive parameters Scaling constrained optimization Barrier PSO Mass integration

Output Second-order Sliding-mode control for a Gecko Biomimetic Climbing Robot

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Journal of Bionic Engineering 2019年第4期16卷 633-646页

作者： David cruz-Ortiz Mariana Ballesteros-Escamilla isaac Chairez Alberto Luviano SEPl UPIITAInstitute Politecnico NationalAv.Institute Politecnico National 258007340Mexico Bioprocesses Department UPIBIInstitute Politecnico NationalAv.Acueducto 55007340Mexico

The aim of this study is to propose the output controller to solve the execution of the gait sequence for Gecko Bio-inspired Robotic Devices (GBRDs).The Twisting controller (TC) serves as basis of the tracking trajectory designed *** TC uses both the tracking error and its estimated derivative,which is calculated by a set of distributed Super-Twisting Algorithms (STAs).Each STA is implemented as a robust and exact *** output-based controller structure corresponds to a sort of decentralized form for robotic ***,each articulation is controlled by an independent TC.A set of proposed references trajectories reproduce the gait cycle of a Real Gecko-Lizard (RG-L).The reference trajectories are proposed as the superposition of sigmoid functions ful-filling the conditions of the Bezzier *** simulations evaluate the GBRD movement enforced by the suggested controller in the horizontal as well as the vertical *** own 3D printed GBRD is the experimental platform aimed to test the distributed *** controlled vacuum pumps are used to adhere the GBRD to the wall surfaces.A set of experimental validations confirm the robustness and the reliability of the proposed controller when its performance is compared with classical output feedback controllers.

关键词： gecko robot biomimetic output-based controller twisting controller Super-Twisting Algorithm(STA)

internal mammary artery harvesting with its distal end occluded

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Chinese Medical Journal 2019年第11期132卷 1385-1386页

作者： Yoandy Lopez-de la cruz Yolepsis Quintero-Fleites Department of Cardiovascular Surgery Santa Clara Cardiac Center Santa Clara Villa Clara 50200 Cuba

To the Editor:We have read with great interest the comment of Chen et al"What can we learn from cases of internal mammary artery damage in coronary artery bypass graft ", The advice that the authors propose in relation to the internal mammary artery (iMA) harvesting is very useful because they are based on a 20-year experience in more than 10,000 patients.

关键词： coronary artery mammary Lesion of internal mammary artery

Sepsis-induced mitochondrial dysfunction:A narrative review

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World Journal of Critical Care Medicine 2023年第3期12卷 139-152页

作者： Wagner Nedel Caroline Deutschendorf Luis Valmor cruz Portela intensive Care Unit Grupo Hospitalar ConceiçãoPorto Alegre 91350200Brazil Laboratory of Neurotrauma and Biomarkers Departamento de BioquímicaICBSUniversidade Federal do Rio Grande do SulPorto Alegre 90035-003Brazil Brazilian Research in intensive Care Network-BRiCNet São Paulo 04039-002Brazil infection control committee Hospital de Clínicas de Porto AlegrePorto Alegre 90410-000Brazil

Sepsis represents a deranged and exaggerated systemic inflammatory response to infection and is associated with vascular and metabolic abnormalities that trigger systemic organic *** function has been shown to be severely impaired during the early phase of critical illness,with a reduction in biogenesis,increased generation of reactive oxygen species and a decrease in adenosine triphosphate synthesis of up to 50%.Mitochondrial dysfunction can be assessed using mitochondrial DNA concentration and respirometry assays,particularly in peripheral mononuclear *** of monocytes and lymphocytes seems to be the most promising strategy for measuring mitochondrial activity in clinical settings because of the ease of collection,sample processing,and clinical relevance of the association between metabolic alterations and deficient immune responses in mononuclear *** have reported alterations in these variables in patients with sepsis compared with healthy controls and non-septic ***,few studies have explored the association between mitochondrial dysfunction in immune mononuclear cells and unfavorable clinical *** improvement in mitochondrial parameters in sepsis could theoretically serve as a biomarker of clinical recovery and response to oxygen and vasopressor therapies as well as reveal unexplored pathophysiological mechanistic *** features highlight the need for further studies on mitochondrial metabolism in immune cells as a feasible tool to evaluate patients in intensive care *** evaluation of mitochondrial metabolism is a promising tool for the evaluation and management of critically ill patients,especially those with *** this article,we explore the pathophysiological aspects,main methods of measurement,and the main studies in this field.

关键词： Sepsis Mitochondria Mitochondrial dysfunction Oxidative phosphorylation inflammation Respirometry

Data-Driven Approaches to integrated Disaster Risk Management Special issue of the 9th conference of the international Society for integrated Disaster Risk Management

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international Journal of Disaster Risk Science 2020年第6期11卷 693-695页

作者： Vincent Lemiale Mahesh Prakash Ana Maria cruz CSiRO Data61 Clayton SouthVIC 3169Australia Disaster Prevention Research institute Kyoto UniversityKyoto 611-0011Japan

The 9 th conference of the international Society for integrated Disaster Risk Management(iDRiM)was held in Sydney on 2–4 October *** event was hosted by Data61,the data innovation hub of Australia’s National Science Agency *** iDRiM annual conference series traditionally brings together researchers and practitioners across all disciplines of disaster risk management(DRM)and the Australian instalment was no exception.

关键词： disaster traditionally Sydney

insulin:A connection between pancreaticβcells and the hypothalamus

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World Journal of Diabetes 2023年第2期14卷 76-91页

作者： Brenda De la cruz concepción Yaccil Adilene Flores cortez Martha isela Barragán Bonilla Juan Miguel Mendoza Bello Monica Espinoza Rojo Molecular and Genomic Biology Laboratory Faculty of Chemical-Biological SciencesAutonomous University of GuerreroChilpancingo 39070GuerreroMexico

insulin is a hormone secreted by pancreaticβ*** concentration of glucose in circulation is proportional to the secretion of insulin by these *** target cells,insulin binds to its receptors and activates phosphatidylinositol-3-kinase/protein kinase B,inducing different mechanisms depending on the cell *** the liver it activates the synthesis of glycogen,in adipose tissue and muscle it allows the capture of glucose,and in the hypothalamus,it regulates thermogenesis and *** in insulin function[insulin resistance(iR)]are related to the development of neurodegenerative diseases in obese ***,in obesity and diabetes,its role as an anorexigenic hormone in the hypothalamus is diminished during ***,hyperphagia prevails,which aggravates hyperglycemia and iR further,becoming a vicious circle in which the patient cannot regulate their need to *** calorie intake induces an increase in reactive oxygen species,overcoming cellular antioxidant defenses(oxidative stress).Reactive oxygen species activate stress-sensitive kinases,such as c-Jun Nterminal kinase and p38 mitogen-activated protein kinase,that induce phosphorylation in serine residues in the insulin receptor,which blocks the insulin signaling pathway,continuing the mechanism of *** brain and pancreas are organs mainly affected by oxidative *** use of drugs that regulate food intake and improve glucose metabolism is the conventional therapy to improve the quality of life of these ***,the use of antioxidants that regulate oxidative stress has given good results because they reduce oxidative stress and inflammatory processes,and they also have fewer side effects than synthetic drugs.

关键词： insulin Pancreas Hypothalamus Hyperphagia Hyperglycemia Stress

Effect of piperine on the epididymis of adult male rats

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Asian Journal of Andrology 2005年第4期7卷 363-368,页

作者： S.C.D'cruz P.P.Mathur School of Life Sciences Pondicherry UniversityPondicherry 605014India

Aim： To study the effect of piperine on the epididymal antioxidant system of adult male rats. Methods： Adult male rats were orally administered piperine at doses of 1 mg/kg, 10 mg/kg and 100 mg/kg body weight each day for 30 consecutive days. Twenty-four hours after the last treatment, the rats were weighed and killed with ether and the epididymis was dissected from the bodies. Sperm collected from the cauda region of the epididymis was used for the assessment of its count, motility and viability. Caput, corpus and cauda regions of the epididymis were separated and homogenized separately to obtain 10 % homogenates. The supernatants were used for the assays of sialic acid, superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, lipid peroxidation and hydrogen peroxide generation. Results： Body weight of the piperine-treated rats remained unchanged. The weights of the caput, corpus and cauda regions of the epididymis significantly decreased at dose of 100 mg/kg. Epididymal sperm count and motility decreased at 10 mg/kg and 100 mg/kg, and sperm viability decreased significantly at 100 mg/kg. Sialic acid levels in the epididymis decreased significantly at 100 mg/kg while significant decrease in the cauda region alone was observed at 10 mg/kg. A significant decline in the activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase, along with an increase in hydrogen peroxide generation and lipid peroxidation were observed at 10 mg/kg and 100 mg/kg. conclusion： Piperine caused a decrease in the activity of antioxidant enzymes and sialic acid levels in the epididymis and thereby increased reactive oxygen species levels that could damage the epididymal environment and sperm function.

关键词： piperine epididymis reactive oxygen species antioxidant enzymes sialic acid

Effect of Eugenia winzerlingii Extracts on Bemisia tabaci and Evaluation of its Nursery Propagation

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Phyton-international Journal of Experimental Botany 2019年第2期88卷 161-170页

作者： A.cruz-Estrada E.Ruiz-Sánchez i.L.Medina Baizabal E.Balam-Uc M.Gamboa-Angulo Unidad de Biotecnología Centro de Investigación Científica de YucatánCalle 43 No.130Chuburna de HidalgoMérida CP 97205YucatánMéxico Tecnológico Nacional de México.instituto Tecnológico de conkal.Avenida Tecnológico s/n C.P.97345.ConkalYucatánMéxico

The development of plant-derived products to control Bemisia tabaci Genn.(Hemiptera:Aleyrodidae)is an urgent need for production of horticultural *** extracts and essential oils of several species of the genus Eugenia(Myrtaceae)have shown insecticidal *** southern Mexico,leaf extracts from Eugenia winzerlingii showed nematicidal effect but its insecticidal properties have not been ***,the objective of this study was to evaluate the insecticidal effect of aqueous and organic extracts from *** leaves on *** egg,nymph and adult stages,and else to explore its nursery ***,extracts of this species were obtained by maceration with different polarity *** were carried out on Capsicum chinense *** assays showed that aqueous and total crude ethanol(TCE)extracts necrosed the eggs(LC50=0.21%w/v and 4.68 mg/mL,respectively),whereas hexane,ethyl acetate(ETA),residual ethanol and TCE extracts affected the nymphs(LC50=0.25-4.85 mg/mL).in adults,oviposition inhibition by free choice assay indicated that TCE and ETA extracts had major activity(EC50=14.62 and 27.86μg/cm2,respectively).On other hand,the sexual and vegetative propagation of *** showed that this species can be easily cultivated by *** conclusion,extracts of *** leaves are highly effective in controlling *** extract,in particular,was toxic to three stages of *** plant could be a potential alternative to develop a novel botanical insecticide to manage this destructive pest.

关键词： Bemisia tabaci bioassays eugenia winzerlingii oviposition inhibition plant propagation

combination of photodynamic therapy and stimulator of interferon genes(STiNG)agonist inhibits colorectal tumor growth and recurrence

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Cancer communications 2023年第4期43卷 513-518页

作者： Yang Hao Sen Ma Zili Gu Alireza Haghparast Timo Schomann Zhenfeng Yu Yuanyuan He Xiaoxv Dong Luis J cruz Peter ten Dijke Translational Nanobiomaterials and imaging(TNi)Group Department of RadiologyLeiden University Medical CenterZA Leidenthe Netherlands Department of Laboratory Animals College of Animal SciencesJilin UniversityChangchunChina Department of Ophthalmology Leiden University Medical Center(LUMC)ZA Leidenthe Netherlands Percuros B.V. CL Leidenthe Netherlands immunology Section Department of PathobiologyFaculty of Veterinary MedicineFerdowsi University of Mashhad.MashhadIran School of Chinese Material Medica Beijing University of Chinese MedicineBeijingP.R.China Department of Cell and Chemical Biology and Oncode institute Leiden University Medical CenterRC Leidenthe Netherlands

Dear Editor,Great progress has been made in the clinical use of photodynamic therapy(PDT)for the treatment of patients with superficial tumors[1].However,cancer recurrence and metastasis have limited the application of PDT in the treatment of solid tumors and advanced *** this context,combining PDT with other complementary immunotherapy regimens may overcome these limitations of PDT[2].

关键词： stimulator superficial clinical