检索结果-南通市图书馆

多囊卵巢综合征妇女的血清可溶性瘦素受体水平和游离瘦素指数:与胰岛素抵抗和雄激素的关系

世界核心医学期刊文摘（妇产科学分册） 2006年第11期2卷 22-23页

作者： Sepilian V.P. crochet j.r. NagamaniM. 朱磊 Division of reproductive Endocrinology Department of Obstetrics and Gynecology University of Texas Medical Branch Galveston TX United States Dr.

Objective: To evaluate levels of soluble receptor (sOB-r) and free leptin inwomen with polycystic ovarian syndrome (PCOS)- and note any relationships with insulin resistance,adiposity, and androgens. Leptin is an adipokine that circulates in a free form and bound to an sOB- r. Only free leptin is biologically active. Design: Prospective, case-control study. Setting: University-based reproductive endocrinology practice. Patient(s): Forty women with PCOS and severe insulin resistance and 15 body mass index (BMI)-matched ovulatory controls. Intervention(s): Measurements of serum insulin, leptin, sOB-r at fasting and during a standard oral glucose tolerance test (OGTT), and measurements before and after treatment with rosiglitazone. Main Outcome Measure(s): Fasting glucose, insulin, leptin, sOB-r, T, and DHEAS levels in women with PCOS and controls were measured to investigate the relationship of sOB-r and the free leptin index (FLI) to insulin, adipocity, and androgens and to investigate the effect of acute hyperinsulinemia during OGTT and the effect of improvement of insulin resistance with rosiglitazone on the leptin system. FLI was calculated by dividing leptin levels by sOB-r. result(s): Total leptin and FLI correlated significantly with BMI in both patients with PCOS and in controls. There was a significant negative correlation between DHEAS and sOB-r in PCOS. Leptin, sOB-r, and FLI were not significantly different in the two groups, and neither sOB-r nor FLI correlated with insulin or glucose levels. The sOB-r levels increased significantly 3 hours after oral glucose ingestion, resulting in a significant decline in FLI. Conclusion(s): [1] Adiposity rather than insulin resistance appears to be the main determinant of leptin levels and FLI. [2] Acute increase in insulin levels during OGTT is associated with an increase in levels of sOB-r. [3] DHEAS may play a role in leptin bioavailability by modulating sOB-r levels.

关键词：多囊卵巢综合征胰岛素抵抗可溶性瘦素受体脂肪细胞因子高胰岛素血症硫酸脱氢表雄酮正常排卵口

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Automation of Ultrafast Pump Probe Spectroscopy of(6,5)Single-Walled Carbon Nanotubes

Automation of Ultrafast Pump Probe Spectroscopy of(6,5)Singl...

引用

第三十五届国际光谱会议

作者： j.crochet M.S.Arnold M.C.Hersam T.Hertel Department of Physics and Astronomy Vanderbilt University NashvilleTNUSA Department of Materials Science and Engineering Northwestern University EvanstonIllinoisUSA Vanderbilt Institute of Nanoscale Science and Engineering Vanderbilt UniversityNashvilleTNUSA

Optical pump probe spectroscopy with ultrashort laser pulses is a powerful tool to study excited state dynamics,which helps to understand the electronic structure,the relaxation channels,the quantum yield,the interaction between electrons and phonons,etc,of a *** is a necessary technique of characterization of new materials for optical- electronic application.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：