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Cancer and age related colonic crypt deficiencies in cytochrome c oxidase Ⅰ

World Journal of Gastrointestinal Oncology 2010年第12期2卷 429-442页

作者： Carol Bernstein Alexander Facista Huy Nguyen Beryl Zaitlin Nadia Hassounah cristy loustaunau Claire Margaret Payne Bhaskar Banerjee Steve Goldschmid V Liana Tsikitis Robert Krouse Harris Bernstein Department of Cell Biology and Anatomy College of MedicineUniversity of ArizonaTucsonAZ 85724United State Schulich School of Civil Engineering University of CalgaryCalgary Alberta T2L 1M3Canada Department of Cell Biology and Anatomy College of MedicineUniversity of ArizonaTucsonAZ 85724United States Biomedical Diagnostics and Research Inc TucsonAZ 85719United States Department of Medicine College of MedicineUniversity of ArizonaTucsonAZ 85724United States Department of Surgery College of MedicineUniversity of ArizonaTucsonAZ 85724United States Southern Arizona Veterans Affairs Health Care System TucsonAZ 85723United States

AIM: To investigate whether defi ciency of expressionof cytochrome c oxidase I (CcOI) in colonic crypts is associated with colon ***: The pattern and level of expression of CcOI in non-neoplastic colonic crypts,and in dysplastic tissues,was assessed using standard immunohis-tochemical *** were obtained from individuals undergoing colonoscopies for screening purposes or for a medically indicated *** samples were also obtained from surgical colonic *** from resections were taken from colonic mucosa 1 and 10 cm from tumors and from the tumors *** were evaluated for frequency of crypts with reduced or absent expression of *** most crypts the loss was apparent throughout the entire crypt,while in a small minority the loss was *** strong immunoreactivity using this monoclonal antibody makes the scoring *** percent of crypts with reduced or absent expression of CcOI or (infrequent) segmented loss of expression was then *** analyses were performed using SPSS statistical package ***: The average frequency of CcOI deficient crypts (CcOI-DC) is low in individuals between 20 and 39 years of age,with 0.48% ± 0.40% CcOI-DC for women and 1.80% ± 0.35% for ***-DC increases after age 40 years,so that between the ages of 40 and 44 years the average frequency of CcOI- DC goes up to 5.89% ± 0.84% in women and 2.15% ± 1.27% in *** 80-84 years of age,the average frequency of CcOI-DC goes up in women to 15.77% ± 0.97% and in men to 22.6% ± 0.65%.The increases in CcOI-DC from ages 40-44 years compared to 80-84 years in women and men are significantly different with P < *** women over age 60 years,deficiency of CcOI expression is greater in those women who have had a cancer in their *** frequency of CcOI-DC,measured in men,increased in tissues adjacent to colon cancer,being 4.03% ± 0.27% in individuals free of neoplasia in the age range 55-64 yearsand 14.13% ± 0.

关键词： Cytochrome c oxidase Aging Colon crypts Colorectal cancer Focal lesions

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