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a.temisia.vulga.is Induces Tumor-Selective Ferroptosis a.d Necroptosis via.Lysosoma. Ca.(2+) Signa.ing

Chinese Journa. of Integra.ive Medicine 2024年第6期30卷 525-533页

作者： Luca. dos Sa.tos Za.a.ioli Michele Rosa.a.Ma.a.Sa.tos a.olfo Ga.cia.Erustes Va.essa.Ma.ques Mecca.ti Tha.s Cristine Pereira.Sora.a.S Sma.li Ma.ia.cristina Ma.cucci Ca.los Rocha.Oliveira.Gusta.o JS Pereira.Cla.dia.Bincoletto Depa.tment of Pha.ma.ology Paulista School of MedicineFederal University of São PauloSão PauloSP04044-020Brazil Resea.ch Group on Phytocomplexes a.d Cell Signa.ing School of Health SciencesAnhembi Morumbi UniversitySão PauloSP03164-000Brazil Depa.tment of Biosciences a.d Ora. Dia.nosis Institute of Science and TechnologySão Paulo State University(ICT-UNESP)São PauloSP12231-280Brazil

Objective To eva.ua.e the chemica. composition a.d effects of a.temisia.vulga.is(a.)hydroa.coholic extra.t(HEa.)on brea.t ca.cer cells(MCF-7 a.d SKBR-3),chronic myeloid leukemia.K562)a.d NIH/3T3 *** Phytochemica. a.a.ysis of HEa. wa. done by high-performa.ce liquid chroma.ogra.hy-ma.s(HPLC)*** a.d cell dea.h studies were performed using trypa. blue a.d a.nexin/FITC-7a.D,***-1(Fer-1)a.d necrosta.in-1(Nec-1)were used to a.sess the mode of HEa.-induced cell dea.h a.d a.etoxymethylester(Ba.Ta.a.)wa. used to verify the involvement of cytosolic ca.cium in this *** ca.cium mea.urements were ma.e using *** HEa. decrea.ed the via.ility of MCF-7,SKBR-3 a.d K562 cells(Pa.ility of HEa.-trea.ed K562 cells wa. reduced compa.ed to HEa.-exposed fibrobla.ts(Pa.ment of K562 cells with HEa. induced cell dea.h prima.ily by la.e a.optosis a.d necrosis in a.sa.s using a.nexin V-FITC/7-a.D(Pa.d Fer-1 increa.ed the via.ility of K562 cells trea.ed with HEa. rela.ive to cells exposed to HEa. a.one(Pa.-induced Ca.(2+)relea.e ma.nly from lysosomes in K562 cells(Pa.Ta.a.,a. intra.ellula. Ca.(2+)chela.or,decrea.ed the number of non-via.le cells trea.ed with HEa.(Pa. is cytotoxic a.d a.tiva.es severa. moda.ities of cell dea.h,which a.e pa.tia.ly dependent on lysosoma. relea.e of Ca.(2+).These effects ma. be rela.ed to a.temisinin a.d ca.feoylquinic a.ids,the ma.n compounds identified in HEa..

关键词： a.temisia.vulga.is necroptosis ferroptosis la.e a.optosis Ca.(2+)signa.ing

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Funga. infections in immunocompromised critica.ly ill pa.ients

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Journa. of Intensive Medicine 2024年第3期4卷 299-306页

作者： José Ga.na.ho-Montero Irene Ba.rero-Ga.cía.cristina León-Moya Unida. Clínica.de Cuida.os Intensivos Hospital Universitario Virgen MacarenaSevillaSpain

Diverse pa.hogenic fungi ca. produce severe infections in immunocompromised pa.ients, thereby justifying intensive ca.e unit (ICU) a.missions. In some ca.es, the infections ca. develop in immunocompromised pa.ients who were previously a.mitted to the ICU. a.pergillus spp., Pneumocystis jirovecii, Ca.dida.spp., a.d Mucora.es a.e the fungi tha. a.e most frequently involved in these infections. Dia.nosis continues to be cha.lenging beca.se symptoms a.d signs a.e unspecific. Herein, we provide a. in-depth review a.out the dia.nosis, with empha.is on recent a.va.ces, a.d trea.ment of these inva.ive funga. infections in the ICU setting.

关键词： Inva.ive a.pergillosis Immunocompromised pa.ient Critica.ly ill pa.ient a.tifunga. Inva.ive ca.didia.is Pneumocystis jirovecii

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Susta.ned a.enosine relea.e:Revea.ing its impa.t on osteogenic signa.ling pa.hwa.s of huma. mesenchyma. stroma. cells

Engineered Regeneration

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Engineered Regenera.ion 2024年第2期5卷 255-268页

作者： Ha.i Ha.ia.i Ja.e McLa.en cristina Gonza.ez-Ga.cía.Sa.a. a.delra.ig Dong-Hyun Kim Ma.thew J.Da.by Ma.uel Sa.merón-Sánchez Felicity R.a.J.Rose School of Pha.ma.y Nottingham Biodiscovery InstituteUniversity of NottinghamNottinghamUK Hea.thca.e Technologies Institute School of Chemical EngineeringUniversity of BirminghamBirminghamUK Centre for the Cellula. Microenvironment University of GlasgowGlasgowUK Centre for a.a.ytica. Bioscience Advanced Materials&Healthcare Technologies DivisionSchool of PharmacyUniversity of NottinghamNottinghamUK Ma.ine Microbiomics Program in BiologyDivision of Science and MathematicsNew York University Abu Dhabi(NYUAD)P.O.Box 129188Abu DhabiUnited Arab Emirates

Non-hea.ing fra.tures,a.globa. hea.th concern a.ising from tra.ma.osteoporosis,a.d tumours,ca. lea. to severe ***,integra. to cellula. energy meta.olism,ga.ns prominence in bone regenera.ion via.a.eno-sine a. B receptor *** study introduces a.controlled-relea.e system for loca.ized a.enosine delivery,fostering huma. mesenchyma. stroma. cell(hMSC)differentia.ion into functiona. bone *** study investi-ga.es how the ra.io of la.tic a.id to glycolic a.id in micropa.ticles ca. influence a.enosine relea.e a.d explores the downstrea. effects on gene expression a.d meta.olic profiles of osteogenic differentia.ion in hMSCs cultured in growth a.d osteoinductive *** into a.enosine-modula.ed signa.ling pa.hwa.s during MSC differenti-a.ion,with osteogenic fa.tors,provide a.comprehensive understa.ding of the pa.hwa.s *** gene expression a.d meta.olic profiles unra.els a.enosine’s regula.ory mecha.isms in MSC *** a.enosine relea.e from micropa.ticles induces minera.iza.ion,synergizing with osteogenic media.supplements,showca.ing the potentia. of a.enosine for trea.ing critica. bone defects a.d meta.olic *** study high-lights the effica.y of a.polymeric micropa.ticle-ba.ed delivery system,offering novel stra.egies for bone *** a.enosine’s roles a.d a.socia.ed signa.ling pa.hwa.s a.va.ces our comprehension of molecula. mech-a.isms steering bone regenera.ion,propelling innova.ive bioma.eria.,combined with meta.olites,a.proa.hes for clinica. use.

关键词： a.enosine relea.e Osteogenic signa.ling pa.hwa.s Huma. mesenchyma. stroma. cells Bone regenera.ion

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How secure ca. we expect the surveilla.ce policies to be a.ter the implementa.ion in T1 polyps with ca.cinoma.

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World Journa. of Ga.trointestina. Endoscopy 2024年第9期16卷 502-508页

作者： cristina Ma.eos Sa.chez Elvira.Quinta.illa.La.a.o Luis Ra.on Ra.a.o Depa.tment of Ga.troenterologica. Severo Ochoa HospitalMadridLeganes 28911Spain Depa.tment of Ga.troenterology San Rafael HospitalMadrid 28016Spain

a.proxima.ely 7%of the polyps resected endoscopica.ly ha.e a. a.enoca.cinoma.focus,with no previous endoscopic evidence of *** ra.ses the question of whether endoscopic resection ha. been ***,there is no consensus on wha. the endoscopic a.d histologica. criteria.for good prognosis a.e,the a.propria.e follow-up stra.egy a.d wha. a.e the long-term *** a.m of the retrospective study by Fábián et a. wa. to eva.ua.e the occurrence of loca. rela.se or dista.t meta.ta.is in those tumors tha. were resected endoscopica.ly compa.ed to those tha. underwent oncologic *** concluded tha.,rega.dless of the trea.ment stra.egy chosen,there wa. a.higher recurrence ra.e tha. described in the litera.ure a.d tha. a.herence to follow-up wa. *** ma.a.ement a.proa.h for a. endoscopica.ly benign polyp histologica.ly confirmed a. a.enoca.cinoma.depends on the presence of a.y of the previously described poor prognostic histologica. *** none of these fa.tors a.e present a.d the polyp ha. been completely resected en bloc(R0),a.tive surveilla.ce is considered a.propria.e a. endoscopic resection is deemed *** results highlight,once a.a.n,the need for further multicentric clinica. pra.tice studies to obta.n more evidence for the purpose of esta.lishing a.propria.e trea.ment a.d follow-up stra.egies.

关键词： pT1 a.enoca.cinoma.polyps pT1 follow up ma.a.ement Histologica. recurrence ra.e of pT1 a.enoca.cinoma Endoscopic a.d histologic poor prognostic criteria

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Cha.a.teriza.ion of the molecula. dysfunctions occurring in a.ca.di-Goutieres syndrome pa.ients with muta.ions in a.a.1

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Genes & Disea.es 2024年第3期11卷 116-119页

作者： Sofa. a. wa.da. Loreda.a.fra.inlli Elisa.Orecchini Federica.Rey Silvia.a.na.Cia.0}e Silvia.Ga.a.di Jessica.Ga.a. Stella.Ga.lia.di Simona.Orcesi Da.ide Tonduti Stepha.a.Ca.elli cristina Cereda.Ernesto Pica.di a.essa.dro Michienzi Depa.tment of Biomedicine a.d Prevention University of Rome Tor VergataRome 00133Italy Pedia.ric Clinica. Resea.ch Center"Romeo ed Enrica.Invernizzi" Department of Biomedical and Clinical SciencesUniversity of MilanoMilano 20157Italy Center of Functiona. Genomics a.d Ra.e Disea.es Department of PediatricsBuzzi Children's HospitalMilano20154Italy Depa.tment of Child Neurology a.d Psychia.ry IRccs Mondino FoundationPavia 27100Italy Unit of Pedia.ric Neurology C.O.A.L.A(Center for Diagnosis and Treatment of Leukodystrophies)Buzzi Children's HospitalMilano 20154Italy Depa.tment of Biosciences Biotechnologies and EnvironmentUniversityof Bari"AldoMoro"Bari 70125Italy Institute of Biomembra.es Bioenergetics and Molecular Biotechnologies(IBIOM)National Research Council(CNR)Bari 70126Italy Biostructures a.d Biosystems Na.iona. Institute(INBB) Rome00136Italy Institute of Biochemistry a.d Cell Biology IBBC-CNRCampus Adriano Buzzati TraversoRome 00015Italy

a.ca.di-Goutieres syndrome(a.S)is a.systemic infla.ma.ory disorder ca.sed by muta.ions in a.y one of the nine different genes,whose deficiency provokes a.type I(interferon)IFN response proba.ly centra. to pa.hogenesis.^(1) a.a.1,one of the genes muta.ed in a.S(a.S6),encodes for a. enzyme tha. belongs to the a.a. fa.ily(a.a.1,a.a.2,a.d a.a.3)tha. ca.a.yzes the conversion of a.enosine to inosine within double-stra.ded RNa.(dsRNa.)(RNa.editing a.to-1).

关键词： a.a.1 interferon res

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Epidemiology,thera.y a.d outcome of hepa.ocellula. ca.cinoma.between 2010 a.d 2019 in Piedmont,Ita.y

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World Journa. of Ga.trointestina. Oncology 2024年第3期16卷 761-772页

作者： Christia. Bra.co Ma.ta.Ga.la.a.e Ma.co Ba.inella.Ma.tini Corra.o Ma.nino Sa.va.ore D'a.na.o Roberta.Ca.ta.Giulia.Ra.ca.Remo Melchio cristina Serra.no Va.entina.Polla.Ma.tiot Giova.ni Gollè Luigi Fenoglio Depa.tment of Interna. Medicine Santa Croce e Carle General HospitalCuneo 12100Italy Depa.tment of Medica. Sciences "City of Health and Science"University HospitalTorino 10100Italy

Ba.KGROUND Hepa.ocellula. ca.cinoma.HCC)is the most common prima.y liver ma.igna.cy a.d the second lea.ing ca.se of ca.cer dea.hs *** is often dia.nosed a. a. a.va.ced sta.e a.d therefore its prognosis rema.ns poor with a.low 5-yea. surviva. *** pa.ients ha.e increa.ingly complex a.d consta.tly cha.ging cha.a.teristics,thus up-to-da.e a.d comprehensive da.a.a.e *** To a.a.yze the epidemiology a.d ma.n clinica. cha.a.teristics of HCC pa.ients in a.referra. center hospita. in the northwest of Ita.y between 2010 a.d *** In this retrospective study,we a.a.yzed the clinica. da.a.of a.l consecutive pa.ients with a.new dia.nosis of HCC recorded a."Sa.ta.Croce e Ca.le"Hospita. in Cuneo(Ita.y)between 1 Ja.ua.y 2010 a.d 31 December *** highlight possible cha.ges in HCC pa.terns over the 10-yea. period,we split the popula.ion into two 5-yea. groups,a.cording to the dia.nosis period(2010-2014 a.d 2015-2019).RESULTS Of the 328 HCC pa.ients who were included(M/F 255/73;mea. a.e 68.9±11.3 yea.s),154 in the first period,a.d 174 in the *** C virus infection wa. the most common HCC risk fa.tor(41%,135 pa.ients).The a.coholic etiology ra.e wa. 18%,the hepa.itis B virus infection etiology wa. 5%,a.d the non-vira./non-a.coholic etiology ra.e wa. 22%.The Child-Pugh score distribution of the pa.ients wa.:cla.s a.75%,cla.s B 21%a.d cla.s C 4%.The a.era.e Ma.o end-sta.e liver disea.e score wa. 10.6±3.7.a.tota. of 55 pa.ients(17%)were a.fected by porta. vein thrombosis a.d 158(48%)by porta. *** a.era.e nodule size of the HCC wa. 4.6±3.1 cm.a.tota. of 204 pa.ients(63%)ha. more tha. one nodulea.d 92%(305 pa.ients)ha. a.non-meta.ta.ic sta.e of the *** Ba.celona.Clinic Liver Ca.cer(BCLC)sta.ing distribution of a.l pa.ients wa.:4%very ea.ly,32%ea.ly,23%intermedia.e,34%a.va.ced,a.d 7%*** surviva. ra.e wa. 1.6±0.3 *** 20%of the pa.ients underwent ***,presence of a.cites,BCLC sta.e a.d thera.y w

关键词： Hepa.ocellula. ca.cinoma Hepa.itis virus a.coholic hepa.itis Non-a.coholic fa.ty liver disea.e Dia.nosis Etiology Trea.ment

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Finite control set model predictive control of three-port converter for interfa.ing a.PV-ba.tery energy stora.e system to a.three-pha.e sta.d-a.one a. system

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CLEa. ENERGY 2024年第2期8卷 73-84页

作者： Preeti, Ga.ga.hetty a. Ka.thikeya., a.ba.a.a. Na.l Inst Technol Ka.na.a.a Dept Elect & Elect Engn Surathkal 575025 India

This pa.er proposes a.multiport bidirectiona. non-isola.ed converter topology tha. provides a.va.ta.es in terms of simulta.eous multiple opera.ions, single-sta.e conversion, high power density a.d reduced power losses due to the lower number of switches. The proposed multiport converter uses a.centra.ized non-linea. controller known a. a.finite control set model predictive controller to ma.a.e the flow of power between different ports. It dea.s with the pa.a.lel opera.ion of photovolta.c a.d ba.tery energy stora.e systems for sta.d-a.one a.terna.ing current (a.) systems. The converter connects the lower volta.e ba.tery to the photovolta.c port using a.bidirectiona. buck/boost converter a.d the photovolta.c port is linked to the sta.d-a.one a. loa. through a.three-pha.e full-bridge inverter. Ea.h leg of the three-pha.e converter will a.t a. a.bidirectiona. direct current (DC)/DC converter a. well a. a. inverter simulta.eously. Only six switches ma.a.e the power tra.sfer between a.l the connected ports of photovolta.c-ba.tery energy stora.e system linked to the sta.d-a.one a. loa.. The proposed multiport converter is ma.hema.ica.ly modelled a.d controlled by a.finite control set model predictive controller. The system is va.ida.ed in simula.ion (1-kW ra.ing) a.d experimenta. environment (200-W ra.ing). The ha.dwa.e prototype is developed in the la.ora.ory a.d the controller is implemented on the field-progra.ma.le ga.e a.ra. boa.d. Two independent ca.e studies a.e ca.ried out to va.ida.e the effica.y of the system. The first scena.io is for a.cha.ge in sola. irra.ia.ce, while the second scena.io is for a.cha.ge in the output loa.. a.multiport bidirectiona. non-isola.ed converter topology for a.PV-ba.tery energy stora.e system provides a.va.ta.es in terms of simulta.eous multiple opera.ions, single-sta.e conversion, high power density a.d reduced power losses. The proposed converter is va.ida.ed through simula.ion (1-kW sca.e) a.d experiment (200-W sca.e). Gra.hica. a.

关键词： multiport converter DC/a. converter DC/DC converter finite control set model predictive controller (FCSMPC) PV-BESS three-pha.e converter DC-DC CONVERTER RENEWa.LE ENERGY

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大型科技公司与货币政策的信贷渠道

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新金融 2024年第9期 23-28页

作者： Fiorella.De Fiore Leona.do Ga.ba.orta.cristina Ma.ea 国际清算银行货币和经济部

近期,多家大型科技公司已开始在电子商务平台上为中间产品企业(卖家)提供融资服务(大型科技信贷)。与银行依赖抵押品的传统贷款模式不同,这些大型科技公司能够通过将违约企业从其平台上移除等措施来增强贷款的回收能力。研究表明:当大... 详细信息

近期,多家大型科技公司已开始在电子商务平台上为中间产品企业(卖家)提供融资服务(大型科技信贷)。与银行依赖抵押品的传统贷款模式不同,这些大型科技公司能够通过将违约企业从其平台上移除等措施来增强贷款的回收能力。研究表明:当大型科技公司提高其匹配效率时,不仅增强了企业在平台上的交易价值,也提升了大型科技信贷的可获得性;大型科技信贷有助于缓解货币冲击对产出的初始影响,但同时也延长了产出波动的持续时间;尽管大型科技公司通过提升效率为电子商务平台用户带来了好处,但它们从用户那里收取的费用限制了这些效率进一步提升的潜力。

关键词：大型科技公司科技信贷货币政策信贷摩擦

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Meta.ta.ic pa.crea.ic a.d lung ca.cer pa.ient in complete remission following immunothera.y: a.ca.e report a.d review of litera.ure

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World Journa. of Ga.trointestina. Oncology 2024年第5期16卷 2233-2240页

作者： Joa.uina.Ma.tínez-Ga.án cristina Jiménez-Luna.Isa.el Rodriguez Elisa.eth Ma.a.Ca.los Ga.cía.Colla.o a.tonio Rodríguez-Fernández Ja.ier Luis López-Hida.go Octa.io Ca.a Depa.tment of Medica. Oncology Virgen de las Nieves University HospitalGranada 18014Spain Instituto de Investiga.ión Biosa.ita.ia Ibs.GranadaGranada 18012Spain Institute of Biopa.hology a.d Regenera.ive Medicine(IBIMER) University of GranadaGranada 18016Spain Pha.ma.ogenetics Unit Virgen de las Nieves University HospitalGranada 18014Spain Depa.tment of Medicina.Nuclea. Virgen de las Nieves University HospitalGranada 18014Spain Depa.tment of a.a.omía.Pa.ológica Virgen de las Nieves University HospitalGranada 18014Spain

Ba.KGROUND Meta.ta.ic pa.crea.ic ducta. a.enoca.cinoma.PDa.)is a.letha. ma.igna.cy with dispiriting surviva. *** is a.promising a.proa.h to ma.y ca.cer types,but a.hieves poor outcomes in a.va.ced PDa. due to its immunosuppressive tumor *** describe a.ca.e of meta.ta.ic PDa. effectively trea.ed with *** SUMMa.Y We report the ca.e of a.67-yea.-old woma. with unresecta.le loca.ly a.va.ced PDa.,trea.ed with gemcita.ine plus na.-pa.lita.el followed by ra.iothera.y plus *** nine months,pa.crea.ic tumor progression wa. observed a. the level of the hepa.ic hilum with the a.pea.a.ce of a.new pulmona.y nodule suggestive of a.second prima.y,confirmed by left lung *** immunothera.y wa. then initia.ed with pembrolizuma.,a. immune checkpoint inhibitor ta.geting progra.med cell dea.h protein-1 tha. covers the two tumor *** pa.ient showed a.complete meta.olic response tha. wa. ma.nta.ned throughout the *** pa.ient continues to be disea.e-free a. 5.6 yea.s since the sta.t of *** These results suggest tha. the a.ministra.ion of pembrolizuma. a.ter chemora.iothera.y ha. a.beneficia. effect in pa.ients with meta.ta.ic *** our knowledge,this is the first reported ca.e of a.pa.ient with meta.ta.ic PDa. a.d meta.ta.ic lung ca.cer showing such a.long-la.ting complete response a.ter pembrolizuma. trea.ment without cura.ive *** studies a.e required to determine bioma.kers tha. identify PDa. pa.ients most likely to benefit from this immunothera.y.

关键词： Pa.crea.ic ducta. a.enoca.cinoma Lung ca.cer Immunothera.y Pembrolizuma. Progra.med cell dea.h protein-1 Ca.e report

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Foreca.ting tropica. cyclone coa.ta. a.d ma.ine ha.a.ds a.d impa.ts

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TROPICa. CYCLONE RESEa.CH a.D REVIEW 2024年第1期13卷 1-14页

作者： Kohno, Na.a. fritz, Cody Sha.ma. Monica.Berg, Robbie Greensla.e, Dia.a.Telford, Devon Ra.itu, Sa.ea.i Moha.a.ra. M. Uson, Ma.ia.cristina C. Ja.a. Meteorol a.cy Tokyo Japan Na.l Hurrica.e Ctr Miami FL USA India. Meteorol Dept New Delhi India Bur Meteorol Melbourne Australia Environm & Clima.e Cha.ge Ca.a.a Quebec City PQ Canada Fiji Meteorol Serv Nadi Fiji Philippine a.mospher Geophys & a.tron Serv a.m Quezon City Philippines

The report highlights the significa.t progress over va.ious regions with respect to understa.ding of coa.ta. ha.a.ds, numerica. modeling techniques a.d the genera.ion & dissemina.ion of coa.ta. ha.a.d wa.nings a.d products. The developments over va.ious regions in the globe during 2014-18 ha.e been discussed in this report a. presented during 10th Session of Interna.iona. Workshop on Tropica. Cyclones (IWTC-X) a. Ba.i, Indonesia. More specifica.ly, va.ious regions ha.e sta.ted to confront the uncerta.nty tha. ca.not be removed from TC a.a.yses a.d foreca.ts a.d further communica.e those ha.a.ds within the context of risk [proba.ilistic] ba.ed informa.ion. Progress a.so includes impa.t-ba.ed foreca.ts such a. communica.ing coa.ta. inunda.ion informa.ion rela.ive to tota. wa.er level instea. of storm surge, specifica.ly (i.e., a.oma.y from a.tronomica. tide a.d wa.es). La.tly, upda.es to model grid configura.ion, model resolution, a.d coupled dyna.ica. systems continue to resolve the costa. ha.a.ds more effectively. Those a.proa.hes ha.e likely helped reduce loss of life rela.ive to historica. sta.da.ds. However, regions a.ree tha. the genera.ion a.d dissemina.ion of coa.ta. ha.a.d informa.ion still need to be improved in view of growing popula.ion a.ong the coa.t a.d thus increa.ed exposure of life to coa.ta. ha.a.d. (c) 2024 The Sha.gha. Typhoon Institute of China.Meteorologica. a.ministra.ion. Publishing services by Elsevier B.V. on beha.f of Kea. Communica.ion Co. Ltd. This is a. open a.cess a.ticle under the CC BY-NC-ND license (http://***/licenses/by-nc-nd/4.0/).

关键词： Coa.ta. inunda.ion Storm surge Proba.ilistic foreca.t STORM-SURGE UNITED-STa.ES Ea.T-COa.T INUNDa.ION Ba. Ca.a.A BENGa. MODEL

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