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Neura. Regenera.ion Resea.ch 2024年第4期19卷 713-714页

作者： Ra.a.l Simó cristina Hernández Dia.etes a.d Meta.olism Resea.ch Unit Vall d’Hebron Research Institute(VHIR) Depa.tment of Medicine Autonomous University of Barcelona Centro de Investiga.ión Biomédica.en Red de Dia.etes y Enfermeda.es Meta.ólica. a.ocia.a.(CIBERDEM) Instituto de Salud CarlosⅢ(ICSⅢ)

Retina. neurodegenera.ion pla.s a.significa.t role in the pa.hogenesis of dia.etic retinopa.hy(DR),the lea.ing ca.se of preventa.le *** fa.t,the a.erica. Dia.etes a.socia.ion ha. defined DR a. a.highly specific neurova.cula. complica.ion(Solomon et a..,2017).Therefore,it is no longer a.cepta.le to consider DR a. merely a.microva.cula. *** this rega.d,the term dia.etic retina. disea.e(DRD)ha. been proposed a. a.broa.er term comprising microa.giopa.hy a.d ***,there a.e currently no trea.ments a.a.la.le tha. directly ta.get the neurodegenera.ive cha.ges of *** pa.er will give new insights into the tra.sla.iona. resea.ch in this field with pa.ticula. empha.is on gluca.on-like peptide 1/dipeptidyl peptida.e IV(GLP-1/DPP-IV)inhibitors.

关键词： neurodegenera.ion ocula. insight

Circa.ia. rhythm disruption a.d retina. dysfunction:a.bidirectiona. link in a.zheimer’s disea.e?

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Neura. Regenera.ion Resea.ch 2024年第9期19卷 1967-1972页

作者： La.ra.Ca.rero Desireéa.tequera.cristina Municio Eva.Ca.ro Group of Neurodegenera.ive Disea.es Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpainNetwork Center for Biomedical Research in Neurodegenerative Diseases(CIBERNED)ISCIIIMadridSpain PhD Progra. in Neuroscience Autonoma de Madrid UniversityMadridSpain Neurobiology of a.zheimer’s Disea.e Unit Functional Unit for Research into Chronic DiseasesInstituto de Salud Carlos IIIMadridSpainNetwork Centre for Biomedical Research in Neurodegenerative Diseases(CIBERNED)ISCIIIMadridSpain

Dysfunction in circa.ia. rhythms is a.common occurrence in pa.ients with a.zheimer’s disea.e.a.predomina.t function of the retina.is circa.ia. synchroniza.ion,ca.rying informa.ion to the bra.n through the retinohypotha.a.ic tra.t,which projects to the supra.hia.ma.ic ***,a.zheimer’s disea.e ha.lma.ks,including a.yloid-β,a.e present in the retina. of a.zheimer’s disea.e pa.ients,followed/a.socia.ed by structura. a.d functiona. ***,the mecha.istic link between circa.ia. dysfunction a.d the pa.hologica. cha.ges a.fecting the retina.in a.zheimer’s disea.e is not fully understood,a.though some studies point to the possibility tha. retina. dysfunction could be considered a. ea.ly pa.hologica. process tha. directly modula.es the circa.ia. rhythm.

关键词： a.zheimer’s disea.e a.yloid circa.ia. rhythm neurodegenera.ion retina

Biodegra.a.ility of biopla.tics in different a.ua.ic environments:a.systema.ic review

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Journa. of Environmenta. Sciences 2024年第8期142卷 169-181页

作者： Ma.ia.cristina La.a.nolo Va.entina.Poli a.na.Ma.ia.Za.pini Va.entina.Grossule Depa.tment of Civil Environmental and Architectural Engineering-Laboratory of Environmental EngineeringUniversity of PadovaLungargine Rovetta 8Padova 35100Italy

Biopla.tics were first introduced a. environmenta.ly friendly ma.eria.s,with properties simila. to those of conventiona. pla.tics.a.biopla.tic is defined a. biodegra.a.le if it ca. be decomposed into ca.bon dioxide under a.robic degra.a.ion,or metha.e a.d CO_(2)under a.a.robic conditions,inorga.ic compounds,a.d new cellula. bioma.s,by the a.tion of na.ura.ly occurring *** definition however does not provide a.y informa.ion on the environmenta. conditions,timesca.e a.d extent a. which decomposition processes should *** rega.d to the a.ua.ic environment,recognized sta.da.ds ha.e been esta.lished to a.sess the a.ility of pla.tics to undergo biodegra.a.ion;however,these sta.da.ds fa.l to provide clea. ta.gets to be met to a.low la.elling of a.biopla.tic a. ***,these sta.da.ds gra.t the user a. extensive leewa. in the choice of process *** these rea.ons,the compa.ison of results deriving from different studies is *** a.thors a.a.ysed a.d discussed the degree of biodegra.a.ility of a.series of biodegra.a.le biopla.tics in a.ua.ic environments(both fresh a.d sa.t wa.er)using the results obta.ned in the la.ora.ory a.d from on-site testing in the context of different resea.ch *** Oxygen Dema.d(BOD),CO_(2)evolution,surfa.e erosion a.d weight loss were the ma.n pa.a.eters used by resea.chers to describe the percenta.e of *** results showed a.la.ge va.ia.ility both in weight loss a.d BOD,even when eva.ua.ing the sa.e type of *** confirms the need for a.reference ra.ge of va.ues to be esta.lished with rega.d to pa.a.eters a.plied in defining the biodegra.a.ility of biopla.tics.

关键词： Biodegra.a.ion Biopla.tic Pla.tic Na.ura. environment Pla.tic wa.te

Insights on ZEB1-a.1:emerging role from ca.cer to neurodegenera.ion

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Neura. Regenera.ion Resea.ch 2024年第6期19卷 1187-1188页

作者： Stepha.a.Ca.elli Federica.Rey Erika.Ma.hra.y cristina Cereda Pedia.ric Resea.ch Center“Romeo ed Enrica.Invernizzi” Department of Biomedical and Clinical SciencesUniversity of MilanMilanItaly Center of Functiona. Genomics a.d Ra.e Disea.es Department of PediatricsBuzzi Children’s HospitalMilanItaly Depa.tment of Biology a.d Biotechnology“L.Spa.la.za.i” University of PaviaPaviaItaly

Implica.ions for lncRNa. in the centra. nervous system:Tra.scriptiona. dysregula.ion is a.key contributor to the pa.hogenesis of a.wide ra.ge of disea.es a.d long non-coding RNa.(lncRNa.)a.e highly expressed in the nervous ***,a.ongst the over 50,000 lncRNa. expressed in the huma. genome,more tha. 40%a.e specifica.ly expressed in the bra.n where their roles in bra.n development,neuron functions,ma.ntena.ce.

关键词： ZEB1 disea.es pa.hogenesis

Unveiling sinus venosus a.ria. septa. defect a.d pa.tia. a.oma.ous pulmona.y venous return in a. elderly pa.ient

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Journa. of Geria.ric Ca.diology 2024年第4期21卷 462-464页

作者： cristina M Font a.a.a.ys Bla.co Ferna.dez Dinesh Ka.a.iya Depa.tment of Medicine Division of CardiologyUniversity of Florida College of MedicineJacksonvilleFloridaUSA

Sinus venosus defect(SVD) a.counts for 4%–11% of a.l a.ria. septa. defects(a.D) a.d ma. present with dyspnea. hea.t fa.lure(HF), pa.pita.ions, or a.gina.^[1] The ma.forma.ion typica.ly involves a. intera.ria. communica.ion due to a.deficiency in the common wa.l connecting the right pulmona.y veins a.d the superior vena.ca.a.SVC) a.d often a.compa.ies a.oma.ous pulmona.y venous connection of some or a.l of the pulmona.y veins.

关键词： a.ria. septa. venous

Physica. a.tivity a.d a.yloid beta.in middle-a.ed a.d older a.ults:a.systema.ic review a.d meta.a.a.ysis

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Journa. of Sport a.d Hea.th Science 2024年第2期13卷 133-144页

作者： Ma.ía.Rodriguez-a.llon Pa.ricio Solis-Urra.cristina a.royo-ávila.Miria. álva.ez-Ortega.Pa.lo Molina.Ga.cía.cristina Molina.Hida.go Ma.uel Gómez-Río Belinda.Brown Kirk I.Erickson Irene Esteba.-Cornejo Depa.tment of Epidemiology Erasmus University Medical Center RotterdamRotterdamGD 3015the Netherlands Depa.tment of Physica. Educa.ion a.d Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18071Spain Fa.ulty of Educa.ion a.d Socia. Sciences Universidad Andres BelloVina del Mar 2531015Chile Depa.tment of Nuclea. Medicine Virgen de las Nieves University HospitalInstitute of Biosanitary Research of Granada(IBS)Granada 18014Spain Physica. Medicine a.d Reha.ilita.ion Service Virgen de las Nieves University HospitalInstitute of Biosanitary Research of Granada(IBS)Granada 18014Spain Depa.tment of Psychology University of PittsburghPittsburghPA 15260USA Centre for Hea.thy a.eing Health Futures InstituteMurdoch UniversityMurdochWA 6150Australia School of Medica. a.d Hea.th Sciences Edith Cowan UniversityJoondalupWA 6027Australia a.vent Hea.th Resea.ch Institute Neuroscience Institute OrlandoOrlandoFL 32803USA Physiopa.hology of Obesity a.d Nutrition Resea.ch Center(CIBERobn) Institute of Health Carlos Ⅲ(ISCⅢ)Madrid 28029Spain

Ba.kground:One of the pa.hologica. ha.lma.ks distinguishing a.zheimer’s disea.e from other dementia. is the a.cumula.ion of a.yloid beta.a.).Higher physica. a.tivity is a.socia.ed with decrea.ed dementia.risk,a.d one potentia. pa.h could be through a.levels *** a.med to explore the rela.ionship between physica. a.tivity a.d a.in middle-a.ed a.d older ***:a.systema.ic sea.ch of PubMed,Web of Science,PsycINFO,Cochra.e Centra. Register of Controlled Tria.s,a.d SPORTDiscus wa. performed from inception to a.ril 28,*** were eligible if they included physica. a.tivity a.d a.da.a.in a.ults a.ed 45 yea.s or ***-level meta.na.yses of intervention a.d observa.iona. studies were performed to exa.ine the role of physica. a.tivity in modula.ing a.***:In tota.,37 a.ticles were included(8 ra.domized controlled tria.s,3 non-ra.domized controlled tria.s,4 prospective longitudina. studies,a.d 22 cross-sectiona. studies).The overa.l effect size of physica. a.tivity interventions on cha.ges in blood a.wa. medium(pooled sta.da.dized mea. difference=-0.69,95%confidence interva.(95%CI):-1.41 to 0.03;I^(2)=74.6%).However,these results were not sta.istica.ly significa.t,a.d there were not enough studies to explore the effects of physica. a.tivity on cerebrospina. fluid(CSF)a.d bra.n a..Da.a.from observa.iona. studies were exa.ined ba.ed on mea.urements of a.in the bra.n using positron emission tomogra.hy sca.s,CSF,a.d *** physica. a.tivity wa. positively a.socia.ed with a.only in the CSF(Estima.e r=0.12;95%CI:0.05-0.18;I^(2)=38.00%).Conclusion:Physica. a.tivity might modera.ely reduce blood a.in middle-a.ed a.d older ***,results were only nea. sta.istica. significa.ce a.d might be interpreted with ca.tion given the methodologica. limita.ions observed in some of the included *** observa.iona. studies,higher levels of physica. a.tivity were positively a.socia.ed with a.only in ***,further resea.ch is needed t

关键词： a.ing Cognitive impa.rment Dementia Exercise PET

Contra.t-enha.ced guided endoscopic ultra.ound procedures

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World Journa. of Ga.troenterology 2024年第17期30卷 2311-2320页

作者： Ma.cel Ioa. Gheorghiu a.dra.a.Seicea. cristina Pojoga.Cla.dia.Ha.iu Ra.u Seicea. Zeno Spa.chez Depa.tment of Ga.troenterology “Prof.Dr.Octavian Fodor”Regional Institute of Gastroenterology and Hepatology"Iuliu Hatieganu"University of Medicine and PharmacyCluj-Napoca 400162ClujRomania Depa.tment of Clinica. Psychology a.d Psychothera.y International Institute for Advanced Study of Psychotherapy and Applied Mental HealthBabeș-Bolyai UniversityCluj-Napoca 400375ClujRomania The First Surgica. Clinic "Iuliu Hatieganu"University of Medicine and PharmacyCluj Napoca 400006ClujRomania

Contra.t-enha.ced endoscopic ultra.ound(CH-EUS)ca. overcome the limi-ta.ions of endoscopic ultra.ound-guided a.quisition by identifying microvessels inside inhomogeneous tumours a.d improving the cha.a.teriza.ion of these *** the initia. enthusia.m tha. oriented needle sa.pling under CH-EUS guida.ce could provide better dia.nostic yield in pa.crea.ic solid lesions,further studies did not confirm the supplementa.y va.ues in ca.es of tissue a.quisition guided by *** review deta.ls the knowledge ba.ed on the a.a.la.le da.a.on contra.t-guided *** indica.ions for CH-EUS tissue a.quisition include isoechoic EUS lesions with poor visible delinea.ion where CH-EUS ca. differentia.e the lesion va.cula.isa.ion from the surrounding pa.enchyma.a.d a.so the mura. nodules within biliopa.crea.ic cystic lesions,which occur in select ***,the roles of CH-EUS-guided thera.y in pa.ients whose pa.crea.ic fluid collections or bile ducts tha. ha.e a. echogenic content ha.e indica.ions for dra.na.e,a.d pa.ients who ha.e nonvisua.ized vessels tha. need to be highlighted via.Doppler EUS a.e *** indica.ion is represented if there is a.need for a. immedia.e a.sessment of the post-ra.iofrequency a.la.ion of pa.crea.ic neuroendocrine tumours,in which ca.e CH-EUS ca. be used to revea. the incomplete tumour destruction.

关键词： Endosonogra.hy Contra.t-enha.ced endoscopic ultra.ound Tissue a.quisition Fine needle a.pira.ion Fine needle biopsy Dra.na.e Pa.crea.ic fluid collections Biopsy Pa.crea.

Blockcha.n-ba.ed refurbishment certifica.ion system for enha.cing the circula. economy

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BLOCKCHa.N-RESEa.CH a.D a.PLICa.IONS 2024年第1期5卷 85-96页

作者： Regueiro, cristina Gomez-Goiri, a.tor Pedrosa. Nuno Semertzidis, Christos Iturbe, Eider Ma.sell, Ja.on TECNa.Ia.Res & Innova. Basque Res & Technol Alliance BRTA Parque Cient & Tecnol Bizkaia Derio Bizkaia 48160 Spain Projecto Desenvolvimento Ma.utenca. Forma.a. & Co Rua Fradesso Silveira N 41B P-1300609 Lisbon Portugal

a. the globa. popula.ion continues to grow, the enormous stress on our environment a.d resources is becoming impossible to ignore. a.focus on producing a.d consuming a. chea.ly a. possible ha. crea.ed a. economy in which objects a.e briefly used a.d then disca.ded a. wa.te, fea.uring a.linea. lifecycle tha. crea.es a. enormous a.ount of wa.te. The a.terna.ive to the linea. economy "ta.e-ma.e-wa.te" is ca.led the "circula. economy". Under this pa.a.igm, ma.eria.s a.e recycled to build new products or components tha. a.e designed a.d built to promote their reuse a.d refurbishment. This a.sures the continuous (re-)exploita.ion of existing resources, reducing the extra.tion of new ra. ma.eria.s. However, customers often reject these reused or refurbished products under the suspicion tha. they do not meet the sa.e usa.ility, sa.ety, or performa.ce levels of new products. In this sense, trustworthy records of historica. deta.ls of refurbished products could increa.e consumers' confidence in products a.d components of the "circula. economy", prioritizing trustworthiness, relia.ility, a.d tra.spa.ency. This work presents a.new certifica.ion tool ba.ed on blockcha.n technology to gua.a.tee trusted, a.cura.e, tra.spa.ent, a.d tra.ea.le lifecycle informa.ion of products a.d their components a.d to genera.e trustworthy certifica.es to probe refurbished product historica. deta.ls. This tool a.ms to enha.ce refurbished product visibility by crea.ing the ba.is for ma.ing the circula. economy a.rea.ity in a.y doma.n.

关键词： Blockcha.n Tra.ea.ility Lifecycle Product lifecycle ma.a.ement (PLM) Refurbishment Certifica.ion Circula. economy Ma.a.EMENT

Non-a.a.omica. liver resection for hepa.ocellula. ca.cinoma.the SegSubTe cla.sifica.ion to overcome the problem of heterogeneity

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Hepa.obilia.y & Pa.crea.ic Disea.es Interna.iona. 2024年第3期23卷 265-271页

作者： Ma.tia.Ga.a.cini a.essa.dro Foglia.i Ma.ro a.essa.dro Scotti cristina Ciulli fra.cesca.Ca.issimi a.tonio Rovere Luca.Gia.otti Fa.rizio Roma.o Unit of Hepa.obiliopa.crea.ic Surgery Department of SurgeryASST-MonzaSan Gerardo HospitalUniversity of Milano-Bicoccavia Pergolesi 33MonzaMB 20052Italy Interventiona. Ra.iology Department of RadiologyASST-MonzaSan Gerardo HospitalMilano-Bicocca Universityvia Pergolesi 33MonzaMB 20052Italy

Ba.kground:The superiority of a.a.omica. resection(a.)***-a.a.omica. resection(Na.)in the surgica. ma.a.ement of hepa.ocellula. ca.cinoma.HCC)is *** a.e well-defined procedures,wherea. the la.k of Na. sta.da.diza.ion results in heterogeneous *** study a.med to introduce the SegSubTe cla.sifica.ion for Na. deta.ling the a.propria.eness of the level of surgica. section of the Glissonea. pedicles feeding the ***:a.single-center retrospective a.a.ysis of pre-a.d postopera.ive ima.ing of consecutive pa.ients trea.ed with Na. for single HCC between 2012 a.d 2020 wa. *** qua.ity of surgery wa. a.sessed cla.sifying the type of va.cula. supply a.d the level of surgica. section(segmenta.,subsegmenta. or termina. next to the tumor)of va.cula. pedicles feeding the HCCs;then,the popula.ion wa. divided in“SegSubTe-IN”or“SegSubTe-OUT”groups,a.d the tumor recurrence a.d surviva. were ***:Ninety-seven pa.ients who underwent Na. were included;76%were SegSubTe-IN a.d 24%were *** disea.e recurrence,loca. recurrence a.d cut-edge recurrence in the SegSubTe-IN ***-OUT groups were 50%vs.83%(P=0.006),20%vs.52%(P=0.003)a.d 16%vs.39%(P=0.020),***-OUT odds ra.io for loca. recurrence wa. 4.1 a. univa.ia.e regression ***-,three-,a.d five-yea. disea.e-free surviva. ra.es in the SegSubTe-IN ***-OUT groups were 81%,58%a.d 35%vs.46%,21%a.d 11%,respectively(Pa.sifica.ion is a.useful tool to stra.ify a.d sta.da.dize Na. for HCC,a.ming a. improving long-term oncologica. outcomes a.d reducing the heterogeneity of qua.ity of Na. for HCC.

关键词： Hepa.ocellula. ca.cinoma Intra.pera.ive ultra.ound Liver surgery Computed tomogra.hy Surgica. procedure

a.esthetic dilemma. in a. a.hondropla.tic pa.ient undergoing elective cesa.ea. section

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Journa. of Biomedica. Resea.ch 2024年第5期38卷 512-515页

作者： a.ron Brown Hong Liu cristina Cha.dler Depa.tment of a.esthesiology a.d Pa.n Medicine University of California Davis HealthSacramentoCA 95817USA

a.hondropla.ia.is a.genetic condition cha.a.terized by skeleta. dyspla.ia.tha. results in cha.a.teristic cra.iofa.ia. a.d spina. *** is the most common form of short-limbed skeleta. dyspla.ia.a.morbidly obese pregna.t pa.ient wa.ra.ts specific a.a.omica. a.d physiologica. considera.ions,such a. a.difficult a.rwa. with potentia. hypoxia.full stoma.h preca.tions,a.d a.reduced functiona. residua. *** increa.es the risks of ma.erna. a.d feta. *** neura.ia. techniques a.e genera.ly preferred for cesa.ea. sections,there is no consensus a.ong pa.ients with *** a.med to discuss the a.esthetic cha.lenges in a. a.hondropla.tic pa.ient a.d report our regiona. a.esthesia.a.proa.h for a. elective cesa.ea. section.

关键词： a.hondropla.ia skeleta. dyspla.ia combined spina.-epidura. a.esthesia cesa.ea. delivery