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Arsenite provides a selective signal that coordinates arsenate uptake and detoxification through the regulation of PHR1 stability in Arabidopsis

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Molecular Plant 2021年第9期14卷 1489-1507页

作者： cristina navarro Cristian Mateo-Elizalde Thotegowdanapalya C.Mohan Eduardo Sanchez-Bermejo Oscar Urrutia Maria Nieves Fernandez-Muniz Jose M.Garcia-Mina Riansares Munoz Javier Paz-Ares Gabriel Castrillo Antonio Leyva Department of Plant Molecular Genetics Centro Nacional de Biotecnología-Consejo Superior de Investigaciones CientíficasMadrid 28049Spain Department of Environmental Biology Sciences SchoolUniversity of NavarraPamplona 31008Spain Department of Analytical Chemistry School of Chemical SciencesUniversidad Complutense de MadridMadrid 28040Spain Present address:Department of Biotechnology and Bioinformatics Faculty of Life SciencesJSS Academy of Higher Education and ResearchMysuruKarnataka 570015India Present address:S&A Fresh Produce.Brook Farm MardenHereford HR13ETUK Future Food Beacon of Excellence&School of Biosciences University of NottinghamNottingham LE125RDUK

In nature,plants acquire nutrients from soils to sustain growth,and at the same time,they need to avoid the uptake of toxic compounds and/or possess tolerance systems to cope with them.This is particularly challenging when the toxic compound and the nutrient are chemically similar,as in the case of phosphate and arsenate.In this study,we demonstrated that regulatory elements of the phosphate starvation response(PSR)coordinate the arsenate detoxification machinery in the cell.We showed that arsenate repression of the phosphate transporter PHT1;1 is associated with the degradation of the PSR master regulator PHR1.Once arsenic is sequestered into the vacuole,PHR1 stability is restored and PHT1;1 expression is recovered.Furthermore,we identified an arsenite responsive SKP1-like protein and a PHR1 interactor F-box(PHIF1)as constituents of the SCF complex responsible for PHR1 degradation.We found that arsenite,the form to which arsenate is reduced for compartmentalization in vacuoles,represses PHT1;1 expression,providing a highly selective signal versus phosphate to control PHT1;1 expression in response to arsenate.Collectively,our results provide molecular insights into a sensing mechanism that regulates arsenate/phosphate uptake depending on the plant’s detoxification capacity.

关键词： arsenic signaling F-box protein arsenate uptake arsenic detoxification phosphate starvation phytoremediation

Arsenite provides a selective signal that coordinates arsenate uptake and detoxification through the regulation of PHR1 stability in Arabidopsis

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Molecular Plant 2022年第11期15卷 1826-1826页

作者： cristina navarro Cristian Mateo-Elizalde Thotegowdanapalya CMohan Eduardo Sánchez-Bermejo Oscar Urrutia María Nieves Fernández-Muñiz JoséMGarcía-Mina Riansares Muñoz Javier Paz-Ares Gabriel Castrillo Antonio Leyva 不详

(Molecular Plant 14,1489-1507;September 6,2021)In the“Accession numbers”section in the originally published version of our manuscript,we mistakenly listed At5g44570 as the Arabidopsis Genome Initiative locus identif... 详细信息

关键词： Arabidopsis identifier stability

Impact of HIV on the health-related quality of life in youth with perinatally acquired HIV

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World Journal of Pediatrics 2019年第5期15卷 492-498页

作者： Isabel Cuéllar-Flores Talís Saínz Carlos Velo María Isabel González-Tomé cristina García-navarro Caroclina Fernández-Mcphee Sara Guillén JoséTomás Ramos Pilar Miralles Rafae Rubio JoséIgnacio Bernardino Luis Prieto Pablo Rojo Santiago Jiménez de Ory Maria Luisa navarro CoRiSpe(FARO and NeuroCoRISpeS projects,RITIP-Traslational Research Network in Pediatric Infectious Diseases) Pediatric Department Hospital Clínico San CarlosMadridSpain Infectious Diseases Service Paed DepartmentHospital La PazMadridSpain La Paz Research Institute(IdiPAZ) MadridSpain Infectious Diseases Service Paed DepartmentHospital 12 de OctubreMadridSpain Infectious Diseases Service Paed DepartmentH.Gregorio MaranónMadridSpain Paed Department Hospital de GetafeMadridSpain Infectious Diseases Service H.Gregorio MaranónMadridSpain HIV Service Hospital 12 de OctubreMadridSpain Infectious Diseases Service Hospital La PazMadridSpain Instituto de Investigación Sanitaria Hospital Gregorio Maranón(IiSGM) MadridSpain Universidad Complutense de Madrid MadridSpain Translational Research Network in Pediatric Infectious Diseases(RITIP) MadridSpain 不详

Background Studies investigating health-related quality of life(HRQoL)in youth with perinatally acquired HIV(PHIV+)are scarce.This study aimed to compare HRQoL of PHIV+to sociodemographic-matched youth not living with HIV(HIV-),Spanish general youth population,and to explore associations between sociodemographic variables,drug consumption,and HRQoL.Methods PHIV+youth were randomly selected from CoRISpe database(Cohort of the Spanish Pediatric HIV Network).HRQoL was evaluated by SF-12v2.Results Thirty-nine PHIV+youth(mean age:23.36 years,SD=3.83)and thirty-nine HIV-youth(mean age:22.97 years,SD=3.80)participated in this study.PHIV+obtained lower scores in SF-12 physical health subscale(PCS)than HIV-(P=0.001)and Spanish general youth population(P=0.006).PHIV+had lower scores on the mental health subscale(MCS)than the Spanish general youth population(P<0.001).PHIV+who were at school obtained better scores than those were not at school.PHIV+youth who had used cocaine and cannabis had lower scores in MCS(P=0.002).Conclusions There is a need for HRQoL management in the associated medical follow-up.

关键词： Drug consumption Health-related quality of life Mental health Perinatally acquired HIV youth

Proposed Occupational Vulnerability Index COVID-19

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Occupational Diseases and Environmental Medicine 2020年第4期8卷 175-187页

作者： Mª Teófila Vicente-Herrero Mª Victoria Ramírez Iñiguez de la Torre Mª Teresa del Campo Balsa Luis Reinoso Barbero Juan Carlos Rueda Garrido cristina Santamaría navarro Asociación Españ ola de Especialistas en Medicina del Trabajo Madrid Spain Occupational Health and Safety Services of SPP Correos Valencia Spain Occupational Health and Safety Services of SPP Correos Albacete Spain Occupational Health and Safety Services of SPA ITEM-Prevención Albacete Spain Department of Occupational and Prevention at University Hospital Fundación Jiménez Díaz Universidad Autónoma de Madrid Madrid Spain Occupational Medicine Service Grupo Banco Santander Madrid Spain Faculty of Health Sciences Universidad Internacional de la Rioja La Rioja Spain Occupational Medicine SABIC Medical Services Cartagena Spain University-PDI. Instituto de Matemática Multidisciplinar. Universitat Politècnica de València Valencia Spain

Introduction: Vulnerable is someone who can be hurt or receive injury, physically or morally. The work environment appears as one of the dimensions in which social vulnerability develops and social and occupational vulnerability is defined. The literature does not include an assessment of quantified occupational vulnerability as it already exists in the case of social vulnerability. The aim of this paper is to identify and quantify the variables included in the Protocol for the Assessment of Vulnerability to COVID-19 in such a way that the result can be quantified and allows for a predictive effect on the degree of vulnerability. Methodology: The starting point is the design of a protocol proposal that includes 29 variables. Data is collected from a sample of 420 workers, quantifying the results according to each variable, the overall scores for each group of aspects assessed and, finally, the total score that estimates the degree of vulnerability according to established ranges. Results: Variables that have the highest coefficient and, therefore, the greatest weight in the probability of reaching a group of high or medium vulnerability are cardiovascular disease, cancer, and coagulation alteration. The weight of the labour aspects due to inadequate working conditions stands out. Conclusions: The results obtained with this protocol allow us to make a quantified assessment of labour vulnerability to COVID-19 by integrating individual variables of the worker, his working conditions and the preventive actions of his company against COVID-19, and can be useful as an Occupational Vulnerability Index (OVI).

关键词： COVID-19 Index Occupational Vulnerability Occupational Health Occupational Medicine

Chemotherapy induces cell plasticity;controlling plasticity increases therapeutic response

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Signal Transduction and Targeted Therapy 2023年第8期8卷 3563-3566页

作者： Francisco J.Iborra cristina Martí Virtu Calabuig-navarro Petros Papadopoulos Salvador Meseguer Pedro M.Iborra Francisco García Antonio Martínez-Lorente Fernando Almazán Juana Calabuig Centro de Investigación Príncipe Felípe(Associated Unit to Instituto de Biomedicína de Valencia) ValenciaSpain Pathology and Molecular Therapy Department Instituto de Biomedicína de Valencia(IBV)CSICValenciaSpain Molecular and Cellular Biology Department Centro Nacional de Biotecnología(CNB)CSICMadridSpain Hematology Department Hospital Clínico San CarlosMadridSpain Medical Systems Biology Faculty of MedicineUniversity of HelsinkiHelsinkiFinland IC Biomed AlicanteSpain VinalopóHospitals Elcheand Biotechnology DepartmentUniversidad de AlicanteAlicanteSpain

Dear Editor,One of the most serious issues in modern oncology is the ineffectiveness of treatments in destroying tumours,which leads to tumour recurrence and,ultimately,patient death.This phenomenon is caused by conventional therapies’fractional killing of tumour cells,which can also cause resistant cells to spread.1 We analysed chemotherapy-resistant cells and discovered that they are smaller than untreated cells(Fig.1a).The fact that this phenomenon occurs in all tested cell types(Hela,A549,Huh7,and MCF7)and regardless of the chemotherapy regimen(TRAIL,Camptothecin,Doxorubicin)suggests that it is a widespread phenomenon(Fig.1a,Supplementary Fig.S1).

关键词： chemotherapy tumour plasticity

Sexual behavior and male volatile compounds in wild and mass-reared strains of the Mexican fruit fly Anastrepha ludens （Diptera： Tephritidae） held under different colony management regimes

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Insect Science 2016年第1期23卷 105-116页

作者： Carlos Felipe Bosa Leopoldo Cruz-Lopez cristina Silvia Zepeda-Cisneros Javier Valle-Mora Karina Guillen-navarro Pablo Liedo El Colegio de la Frontera Sur Carretera Antiguo Aeropuerto km 2.5 Chiapas 30700 Mexico Campana Nacional Moscas de laFruta Programa Moscafrut SAGARPA-IICA Metapa de Dominguez Chiapas Mexico

We compared the calling and mating behavior and volatile release of wild males Anastrepha ludens （Loew） with males from 4 mass-reared strains：（i） a stan- dard mass-reared colony （control）, （ii） a genetic sexing strain （Tap-7）, （iii） a colony started from males selected on their survival and mating competitiveness abilities （selected）, and （iv） a hybrid colony started by crossing wild males with control females. Selected and wild males were more competitive, achieving more matings under field cage conditions. Mass-reared strains showed higher percentages of pheromone calling males under field conditions except for Tap-7 males, which showed the highest percentages of pheromone calling males under laboratory cage conditions. For mature males of all strains, field-cage calling behavior increased during the last hour before sunset, with almost a 2 fold increase exhibited by wild males during the last half hour. The highest peak mating activity of the 4 mass-reared strains occurred 30 rain earlier than for wild males. By means of solid phase microextraction （SPME） plus gas chromatography-mass spectrometry （GC- MS）, the composition of volatiles released by males was analyzed and quantified, Wild males emitted significantly less amounts of （E,E）-α-farnesene but emitted significantly more amounts of （E,E）-suspensolide as they aged than mass-reared males. Within the 4 mass-reared strains, Tap-7 released significantly more amounts of （E,E）-α-farnesene and hybrid more of （E,E）-suspensolide. Differences in chemical composition could be ex- plained by the intrinsic characteristics of the strains and the colony management regimes. Characterization of calling behavior and age changes of volatile composition between wild and mass-reared strains could explain the differences in mating competitiveness and may be useful for optimizing the sterile insect technique in A. ludens.

关键词： age-dependent changes fruit fly mating pheromone

GOECP/SEOR radiotheraphy guidelines for non-small-cell lung cancer

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World Journal of Clinical Oncology 2022年第4期13卷 237-266页

作者： Nuria Rodriguez De Dios Arturo navarro-Martin cristina Cigarral Rodolfo Chicas-Sett Rafael Garcia Virginia Garcia Jose Antonio Gonzalez Susana Gonzalo Mauricio Murcia-Mejia Rogelio Robaina Amalia Sotoca Carmen Vallejo German Valtuena Felipe Counago Department of Radiation Oncology Hospital del MarBarcelona 08003Spain Radiation Oncology Research Group Hospital Del Mar Medical Research InstitutionBarcelona 08003Spain Department of Experimental and Health Sciences Pompeu Fabra UniversityBarcelona 08003Spain Department of Radiation Oncology Thoracic Malignancies UnitHospital Duran i Reynals.ICOL´Hospitalet de LLobregat 08908Spain Department of Radiation Oncology Hospital Clinico de SalamancaSalamanca 37007Spain Department of Radiation Oncology ASCIRES Grupo BiomedicoValencia 46004Spain Department of Radiation Oncology Hospital Ruber InternacionalMadrid 28034Spain Department of Radiation Oncology Hospital Universitario Arnau de VilanovaLleida 25198Spain Department of Radiation Oncology Genesis Care-SpainSevilla 41092Spain Department of Radiation Oncology Hospital Universitario La PrincesaMadrid 28006Spain Department of Radiation Oncology Hospital Universitario Sant Joan de ReusReus 43204TarragonaSpain Department of Radiation Oncology Hospital Universitario Ramon y CajalMadrid 28034Spain Department of Radiation Oncology Hospital Clinico Universitario Lozano BlesaZaragoza 50009Spain Department of Radiation Oncology Hospital Universitario QuirónsaludMadrid 28223Spain Department of Radiation Oncology Hospital La LuzMadrid 28003Spain Department of Clinical Universidad EuropeaMadrid 28670Spain

Non-small cell lung cancer(NSCLC) is a heterogeneous disease accounting for approximately 85% of all lung cancers. Only 17% of patients are diagnosed at an early stage. Treatment is multidisciplinary and radiotherapy plays a key role in all stages of the disease. More than 50% of patients with NSCLC are treated with radiotherapy(curative-intent or palliative). Technological advancesincluding highly conformal radiotherapy techniques, new immobilization and respiratory control systems, and precision image verification systems-allow clinicians to individualize treatment to maximize tumor control while minimizing treatment-related toxicity. Novel therapeutic regimens such as moderate hypofractionation and advanced techniques such as stereotactic body radiotherapy(SBRT) have reduced the number of radiotherapy sessions. The integration of SBRT into routine clinical practice has radically altered treatment of early-stage disease. SBRT also plays an increasingly important role in oligometastatic disease. The aim of the present guidelines is to review the role of radiotherapy in the treatment of localized, locally-advanced, and metastatic NSCLC. We review the main radiotherapy techniques and clarify the role of radiotherapy in routine clinical practice. These guidelines are based on the best available evidence. The level and grade of evidence supporting each recommendation is provided.

关键词： Radiotherapy Non-small cell lung cancer Guidelines Stereotactic radiation therapy Hypofractionated radiation Oligometastasis

Gastrotomy closure with a new tissue anchoring device:A porcine survival study

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World Journal of Gastroenterology 2011年第13期17卷 1732-1738页

作者： Carlos Guarner-Argente Henry Córdova Graciela Martínez-Pallí Ricard navarro-Ripoll Antonio Rodríguez-d’Jesús cristina Rodríguez de Miguel Mireia Beltrán Gloria Fernández-Esparrach Endoscopy Unit Hospital Clínic CIBERehd Barcelona 08026 Spain Anesthesiology Department Hospital Clínic CIBERehd Barcelona 08026 Spain

AIM: To evaluate the feasibility, reproducibility and efficacy of a new tissue anchoring device in a porcine survival model. METHODS: Gastrotomies were performed using a needle-knife and balloon dilator in 10 female Yorkshire pigs weighing 30-35 kg. Gastric closure was attempted using a new tissue anchoring device. The tightness of the closure was confirmed by means of air insufflation and the ability to maintain gastric distension with stability in peritoneal pressure measured with a Veress needle. All animals were monitored daily for signs of peritonitis and sepsis over 14 d. During necropsy, the peritoneal cavity and the gastric access site were examined.RESULTS: Transgastric access, closure and 14 d survival was achieved in all pigs. The mean closure time was 18.1 ± 19.2 min and a mean of 2.1 ± 1 devices were used. Supplementary clips were necessary in 2 cases. The closure time was progressively reduced (24.8 ± 13.9 min in the first 5 pigs vs 11.4 ± 5.9 min in the last 5, P = NS). At necropsy, the gastric access site was correctly closed in all cases with all brace-bars present. One device was misplaced in the mesocolon. Minimal adhesions were observed in 3 pigs and signs of mild peritonitis and adhesions in one. CONCLUSIONS: The use of this new tissue anchoring device in porcine stomachs is feasible, reproducible and effective and requires a short learning curve.

关键词：锚固装置组织封闭猪闭合时间设备使用胃扩张锚定装置

Validation of a Marker Model for Gait Analysis with Wearable Exoskeletons

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Journal of Mechanics Engineering and Automation 2015年第7期5卷 407-410页

作者： Maria Gomez cristina Lopez de Subijana Eloy Urendes Enrique navarro Faculty of Physical Activity and Sport Technical University of Madrid Madrid 28040 Spain Bioengineering Group of the Spanish National Research Council Madrid 28500 Spain

The aim of the present study was to develop and validate a new marker model for optoelectronic systems adapted to wearable devices, in order to have an analysis tool for kinematic gait evaluation of reproduced patterns by exoskeletons. The marker model has a total of 36 retro-reflective markers attached bilaterally to anatomical landmarks during the static measures (without exoskeleton) and 28 markers at the dynamics measures (with exoskeleton). The main difference between others kinematic models and the described adapted model was the placement of the three markers in the back thigh and the other three in the back calf, what allowed removing the hip, thigh, knee, tibia and ankle markers. The proposed adapted marker model could be an effective tool to validate the joint movement and velocities of those wearable exoskeletons that at present have been developing.

关键词：运动模型步态分析外骨骼标记验证光电系统分析工具关节运动