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Resilience in action: The bottom up! architecture festival in Turin (Italy)

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Journal of Safety Science and Resilience 2023年第2期4卷 174-187页

作者： cristina Coscia Angioletta Voghera Department of Architecture and Design(DAD) Politecnico di Torinoviale Mattioli39Torino 10125Italy Responsble Riskresilience InteruniverstyDepartmentof Rgional and Urban Studies and Planing(DIST) Politecnico diTorinoviale Mattioli39Torino12 Italy

This article describes the practice of co-evolutionary and transformative resilience through a case study con-ducted in Turin(Italy).According to a broad definition,resilience includes performing actions of urban design and planning,innovating community-based project procedures,and creating positive financial outcomes that are assessable because of the monitoring process of short-and long-term outcomes and *** the Turin-based case of the Bottom Up!Architecture Festival,this article observes processes in which resilience is in action in metropolitan areas,feeding urban projects and practices of self-organization of the social and financial actors *** applying the definition of community projects,the festival manages to take territorial problems and crises(the pandemic,inequality,etc.)and view them as an opportunity to change the system,recommending in-tegrated action on the natural,cultural,financial,and social capital,innovating practices and holding society and institutions more *** transformation of spaces relies on collaborations between social and institu-tional actors,operating spatially concentrated transformations in the city of Turin,and using flexible governance tools based on co-planning and crowdfunding for project design and financing.

关键词： Resilience Bottom-up Co-evolution Crowdfunding AdaptiveGovernance Turin(Italy)

Can dietary flavonoids be useful in the personalized treatment of colorectal cancer?

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World Journal of Gastrointestinal Oncology 2022年第6期14卷 1115-1123页

作者： cristina Pereira-Wilson Department of Biology Centre of Biological EngineeringLABBELS Associate LaboratoryUniversity of MinhoBraga 4710-057Portugal

Activating mutations in the oncogenes KRAS,BRAF and PI3K define molecular colorectal cancer(CRC)subtypes because they play key roles in promoting CRC development and in determining the efficacy of chemotherapeutic agents such as 5-fluorouracil and anti-epidermal growth factor receptor monoclonal *** of patients with cancers displaying these molecular profiles is *** the limited efficacy of therapeutic strategies for CRC presenting mutational activations in mitogen-activated protein kinase and/or PI3K pathways,developing combination therapies with natural flavonoids or other phytochemicals with demonstrated effects on these pathways(and little or no toxic effects)may constitute a valuable path *** has been published on the anticancer effects of dietary ***,even an exhaustive characterization of potential beneficial effects produced by in vitro studies cannot be extrapolated to effects in *** far,the available data constitute a good starting *** results show quercetin and curcumin as possibly the best candidates to be further explored in the context of adjuvant CRC therapy either as part of dietary prescriptions or as purified compounds in combination regimens with the drugs currently used in CRC *** trial data is still largely missing and is urgently needed to verify relevant effects and for the development of more personalized treatment approaches.

关键词： Colorectal cancer Personalized treatment Quercetin Curcumin KRAS BRAF

Overview of dyslipidemia and metabolic syndrome in myeloproliferative neoplasms

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World Journal of Clinical Oncology 2024年第6期15卷 717-729页

作者： Mihnea-Alexandru Găman Bahadar Singh Srichawla Yong-Feng Chen Poulami Roy Arkadeep Dhali Ahmed Nahian Muhammad Romail Manan Vincent Kipkorir Richard Christian Suteja Lakshmi Venkata Simhachalam Kutikuppala Amelia Maria Găman Camelia cristina Diaconu Faculty of Medicine “Carol Davila”University of Medicine and PharmacyBucharest 050474Romania Department of Hematology Center of Hematolog Department of Cellular and Molecular Pathology Stefan S Nicolau Institute of VirologyRomanian AcademyBucharest 030304Romania Department of Neurology University of Massachusetts Chan Medical SchoolWorcesterMA 01655United States Department of Basic Medical Sciences School of Medicine of Taizhou UniversityTaizhou UniversityTaizhou 318000Zhejiang ProvinceChina Department of Medicine North Bengal Medical College and HospitalWest Bengal 734012India Academic Department of Gastroenterology Sheffield Teaching Hospitals NHS Foundation TrustSheffield S57AUUnited Kingdom Lecom at Seton Hill GreensburgPA 15601United States Faculty of Medicine Services HospitalLahore 54000Pakistan Department of Human Anatomy and Physiology University of NairobiNairobi 00100Kenya Faculty of Medicine Udayana UniversityDenpasarBali 80361Indonesia Department of General Surgery Dr.NTR University of Health SciencesVijayawada 520008Andhra PradeshIndia Department of Pathophysiology University of Medicine and Pharmacy of CraiovaCraiova 200349Romania Clinic of Hematology Filantropia City HospitalCraiova 200143Romania Department of Internal Medicine Faculty of Medicine“Carol Davila”University of Medicine and PharmacyBucharest 050474Romania Internal Medicine Clinic Clinical Emergency Hospital of BucharestBucharest 105402Romania

Myeloproliferative neoplasms(MPNs)occur due to the abnormal proliferation of one or more terminal myeloid cell lines in peripheral *** suffering from MPNs display a high burden of cardiovascular risk factors,and thrombotic events are often the cause of death in this population of ***,we provide a brief overview of dyslipidemia and metabolic syndrome and their epidemiology in MPNs and examine the common molecular mechanisms between dyslipidemia,metabolic syndrome,and MPNs,with a special focus on cardio-vascular risk,atherosclerosis,and thrombotic ***,we investigate the impact of dyslipidemia and metabolic syndrome on the occurrence and survival of thrombosis in MPN patients,as well as the management of dyslipidemia in MPNs,and the impact of MPN treatment on serum lipid concentrations,particularly as side/adverse effects reported in the context of clinical trials.

关键词： Polycythemia vera Essential thrombocythemia Myelofibrosis Cardiovascular disease Hypercholesterolemia Hypertriglyceridemia Obesity Diabetes Inflammation Oxidative stress

α-Synuclein oligomers and fibrils:partners in crime in synucleinopathies

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Neural Regeneration Research 2023年第11期18卷 2332-2342页

作者： Alessandra Bigi Roberta Cascella cristina Cecchi Department of Experimental and Clinical Biomedical Sciences Section of BiochemistryUniversity of FlorenceFlorenceItaly

The misfolding and aggregation of a-synuclein is the general hallmark of a group of devastating neurodegenerative pathologies referred to as synucleinopathies,such as Parkinson’s disease,dementia with Lewy bodies,and multiple system *** such conditions,a range of different misfolded aggregates,including oligomers,protofibrils,and fibrils,are present both in neurons and glial *** expe rimental evidence supports the proposition that solu ble oligomeric assemblies,formed during the early phases of the aggregation process,are the major culprits of neuronal toxicity;at the same time,fibrillar confo rmers appear to be the most efficient at propagating among interconnected neurons,thus contributing to the spreading ofα-synuclein ***,α-synuclein fibrils have been recently repo rted to release soluble and highly toxic oligomeric species,responsible for an immediate dysfunction in the recipient *** this review,we discuss the current knowledge about the plethora of mechanisms of cellular dysfunction caused byα-synuclein oligome rs and fibrils,both contributing to neurodegeneration in synucleinopathies.

关键词： amyloid aggregation neurodegeneration Parkinson’s disease protein aggregation protein misfolding

Visual rating and the use of image analysis for assessing canopy density in a pecan provenance collection during leaf fall

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林业研究:英文版 2023年第6期34卷 1843-1854页

作者： cristina Pisani Clive H.Bock Jennifer Randall United States Department of Agriculture−Agricultural Research Service (USDA-ARS)Southeastern Fruit and Tree Nut Research Station(SEFTNRS)ByronGA 31008USA Department of Entomology Plant Pathology and Weed ScienceNew Mexico State UniversityLas CrucesNM 88003USA

A collection representing the native range of pecan was planted at the US DA-ARS Southeastern Fruit and Tree Nut Research Station,Byron,*** collection(867 trees)is a valuable genetic resource for characterizing important horticultural *** density during leaf fall is important as the seasonal canopy dynamics provides insights to environmental cues and breeding potential of *** ability of visual raters to estimate canopy density on a subset of the provenance collection(76 trees)as an indicator of leaf shed during autumn along with image analysis values was *** canopy density using the image analysis software was less compared to visual estimates(11.9%vs 18.4%,respectively).At higher canopy densities,the raters overestimated foliage density,but overall agreement between raters and measured values was good(ρc=0.849 to 0.915),and inter-rater reliability was high(R^(2)=0.910 to 0.953).The provenance from Missouri(MOL),the northernmost provenance,had the lowest canopy density in November,and results show that the higher the latitude of the provenance,the lower the canopy *** on regression,the source provenance latitude explained 0.609 of the variation using image analysis,and0.551 to 0.640 when based on the rater estimates of canopy *** assessment of pecan canopy density due to late season leaf fall for comparing pecan genotypes provides accurate and reliable estimates and could be used in future studies of the whole provenance collection.

关键词： Carya illinoinensis Accuracy Reliability Canopy Foliage density Leaf area density Leaf area index

Model Identification and Control of Electromagnetic Actuation in Continuous Casting Process With Improved Quality

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IEEE/CAA Journal of Automatica Sinica 2023年第1期10卷 203-215页

作者： Isabela Birs cristina Muresan Dana Copot Clara Ionescu Research Group of Dynamical Systems and Control Faculty of Engineering and ArchitectureGhent University and with EEDT Decision&ControlFlanders Make ConsortiumTech Lane Science Park 125 and 131B-9052 GhentBelgium.I.Birs the Automation Department Faculty of Automation and Applied InformaticsTechnical University of Cluj-NapocaRomania IEEE

This paper presents an original theoretical framework to model steel material properties in continuous casting line process. Specific properties arising from non-Newtonian dynamics are herein used to indicate the natural convergence of distributed parameter systems to fractional order transfer function models. Data driven identification from a real continuous casting line is used to identify model of the electromagnetic actuator device to control flow velocity of liquid steel. To ensure product specifications, a fractional order control is designed and validated on the system. A projection of the closed loop performance onto the quality assessment at end production line is also given in this paper.

关键词： Electromagnetic actuator fractional order control fractional order system model non-Newtonian material

Implication of salivary lactoferrin and periodontal-mediated infections in Alzheimer's disease

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Neural Regeneration Research 2023年第12期18卷 2691-2692页

作者： cristina Municio Eva Carro Group of Neurodegenerative Diseases Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpainNetwork Center for Biomedical Research in Neurodegenerative Diseases(CIBERNED)Instituto de Salud Carlos IIIMadridSpain Neurobiology of Alzheimer’s disease Unit Functional Unit for Research into Chronic DiseasesInstituto de Salud Carlos IIIMadridSpainNetwork Centre for Biomedical Research in Neurodegenerative Diseases(CIBERNED)Instituto de Salud Carlos IIIMadridSpain

Lactoferrin is an antimicrobial prote in characterized by the exertion of many protective functions,including antibacterial,antifungal,antiviral,and antiparasitic properties,as well as anti-inflammatory and immunomodulatory activities(Kruzel et al.,2017).Lactoferrin is one of the major proteins present in exocrine secretions,including saliva,and is therefore associated with host defense against oral pathogens and control of the oral *** recent years,it has become clear that alterations in the oral microbiome may contribute to opportunistic pathogen infections in the brains of Alzheimer’s disease(AD)patients and thus participate in or contribute to the development of this neurodegenerative disease(Sureda et al.,2020).Pathogenic oral microbes can affect neurological processes by entering brain tissue through various pathways and directly damaging the central nervous *** the central nervous system,oral microbes may trigger an immune response that increases amyloidβ(Aβ)production and may even trigger the Aβcascade to promote the onset of AD,as we discuss in our previous study supporting the“infectious hypothesis”in AD(González-Sánchez et al.,2020).

关键词： Alzheimer infections protective

Induced pluripotent stem cells for defining Parkinsonian patient subtypes:a further step toward precision medicine

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Neural Regeneration Research 2022年第4期17卷 767-769页

作者： Federica Bono cristina Missale Chiara Fiorentini Division of Pharmacology Department of Molecular and Translational MedicineUniversity of BresciaBresciaItaly

Introduction:Parkinson's disease PD is a common neurodegenerative disorder mainly characterized by the progressive decline of motor function with a prevalence that is greatly increasing since the pathology is principally driven by *** currently available treatments only mitigate motor symptoms;therefore,a great deal of studies are aimed at finding novel drugs that are able to arrest the evolution of the *** progressive death of nigrostriatal dopaminergic(DA)neurons and the formation of the typical Lewy bodies neuronal inclusions containing misfolded alpha-synuclein are two key histopathological features of the ***,it is now evident that PD has to be considered as a heterogeneous disorder that includes subtypes with distinctive clinical and biological characteristics(Ryden and Lewis,2019).

关键词： drugs progressive finding

Erratum to: Born to sing! Song development in a singing primate

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Current Zoology 2024年第2期70卷 276-276页

作者： Chiara De Gregorio Filippo Carugati Vittoria Estienne Daria Valente Teresa Raimondi Valeria Torti Longondraza Miaretsoa Jonah Ratsimbazafy Marco Gamba cristina Giacoma Department of Lifte Sciences and Systems Biology University of Torinovia Accademia Alberina 13Torino 10125Italy Groupe d'Etude et de Recherche sur les Primates de Madagascar(GERP) BP 779-Antananarivo 101Madagascar

The pagination of this article online has been updated to pages 597-608 to match the print *** Publisher sincerely apologizes for introducing this error online.

关键词： introducing sincerely match