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Trihalomethane concentrations in tap water as determinant of bottled water use in the city of Barcelona

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Journal of Environmental sciences 2017年第8期29卷 77-92页

作者： Laia Font-Ribera Jordi Colomer Cotta Anna Gómez-gutiérrez cristina M.Villanueva IsGlobal Centre for Research in Environmental Epidemiology (CREAL) 08003 Barcelona Spain IMIM (Hospital del Mar Medical Research Institute) 08003 Barcelona Spain Uniuersitat Pompeu Fabra (UPF) 08003 Barcelona Spain CIBER Epidemiologfa y salud Publica (CIBEREsP) 28029 Madrid Spain Public Health Agency of Barcelona (AsPB) 08023 Barcelona Spain

Bottled water consumption is increasing worldwide, despite its huge economic and environmental cost. We aim to describe personal and tap water quality determinants of bottled water use in the city of Barcelona. This cross-sectional study used data from the Health survey of Barcelona in 2006（N = 5417 adults）. The use of bottled water to drink and to cook was evaluated in relation to age, gender, educational level, district and levels of trihalomethanes（THMs）, free chlorine, conductivity, chloride, sodium, p H, nitrate and aluminium in municipal tap water using Robust Poisson Regression. The prevalence of bottled water use to drink and cook was 53.9% and 6.7%, respectively. Chemical parameters in water had a large variability（interquartile range of THMs concentrations： 83.2–200.8 μg/L）and were correlated between them, except aluminium. Drinking bottled water increased with educational level, while cooking with bottled water was higher among men than among women and decreased with age. After adjusting by these personal determinants, a dose–response relationship was found between concentrations of all chemicals except aluminium in tap water and bottled water use. The highest association was found for THMs,with a Prevalence Ratio of 2.00（95%CI = 1.86, 2.15） for drinking bottled water and 2.80（95%CI = 1.72, 4.58） for cooking with bottled water, among those with 〉 150 μg/L vs. 〈 100 μg/L THMs in tap water. Conclusion： More than half of Barcelona residents regularly drank bottled water, and the main determinant was the chemical composition of tap water,particularly THM level.

关键词： Tap water Drinking water Trihalomethanes Organoleptics Determinants Prevalence

Resource economics and coordination among above- and below-ground functional traits of three dominant shrubs from the Chilean coastal desert

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Journal of Plant Ecology 2015年第1期8卷 70-78页

作者： Joaquín Morales Francisco A.squeo Yann Tracol cristina Armas Julio R.gutiérrez Facultad de Ciencias Universidad de La SerenaCasilla 554La SerenaChile Institute of Ecology and Biodiversity(IEB) Casilla 653SantiagoChile Center of Advanced studies in Arid Zones Casilla 554La SerenaChile

Aims Plant functional traits determine how plants respond to environmen-tal factors and influence ecosystem *** them,root traits and analyses of relations between above and below-ground traits in natural communities are *** we characterized a set of above-and below-ground traits of three dominant shrub species in a semiarid shrub-steppe that had contrasting leaf pheno-logical habits(deciduous,semideciduous and evergreen).We ana-lysed if there was coordination among above-and below-ground resource economics patterns:*** of biomass allocation,construction costs and *** Findings Above-and below-ground traits and their resource economics relations pointed to species-specific functional strategies to cope with drought and poor soils and to a species ranking of fast to slow whole-plant strategies in terms of resource uptake,biomass con-struction costs and *** deciduous shrub,Proustia cunei-folia,had relatively deep and even distribution of roots,and high proportion of short-lived tissues of low C construction costs:it had high fine to coarse root and high leaf-to-stem biomass ratios,high specific leaf area(sLA),and stems of low wood *** strat-egy allows Proustia to maximize and coordinate above-and below-ground resources uptake as long as the most limiting factor(water)is available,but at the cost of having relative high plant biomass *** evergreen Porlieria chilensis,instead,displayed a more conservative and slow strategy in terms of resource *** had~80%of the roots in the 40 cm topsoil profile,low pro-portion of fine compared with coarse roots and low leaf-to-stem ratios,low sLA and stems of high wood density,*** invested in C costly tissues that,overall,persist longer but probably at the cost of having lower plant resource uptake *** in the semide-ciduous Adesmia bedwellii were in between these two functional *** results revealed high functional diversity and above-

关键词： drought functional diversity mass fractions root distribution specific leaf area

New data sources for social indicators: the case study of contacting politicians by Twitter

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International Journal of Digital Earth 2017年第8期10卷 829-845页

作者： cristina Rosales sánchez Massimo Craglia Arnold K.Bregt European Commission–DG Joint Research Centre Digital Economy UnitIspraItaly Wageningen University and Research Centre Laboratory of Geo-information Science and Remote SensingWageningenThe Netherlands

Data availability is a persistent constraint in social policy *** 2.0 technologies could provide valuable new data sources,but first,their potentials and limitations need to be *** paper reports on a method using Twitter data for deriving indications of active citizenship,taken as an example of social *** citizenship is a dimension of social capital,empowering communities and reducing possibilities of social ***,classical measurements of active citizenship are generally costly and *** paper looks at one of such classic indicators,namely,responses to the survey question‘contacts to politicians’.It compares official survey results in spain with findings from an analysis of Twitter *** method presents its own strengths and weakness,thus best results may be achieved by the combination of *** surveys have the clear advantage of being statistically robust and representative of a total ***,Twitter data offer more timely and less costly information,with higher spatial and temporal *** paper presents our full methodological workflow for analysing and comparing these two data *** research results advance the debate on how social media data could be mined for policy analysis.

关键词： Twitter active citizenship social media indicators data mining

serrated polyposis syndrome:Molecular,pathological and clinical aspects

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World Journal of Gastroenterology 2012年第20期18卷 2452-2461页

作者： Carla Guarinos cristina sánchez-Fortún María Rodríguez-soler cristina Alenda Artemio Payá Rodrigo Jover Research Unit Hospital General Universitario de Alicante03010 AlicanteSpain Unidad de Gastroenterología Hospital General Universitario de Alicante03010 AlicanteSpain Department of Pathology Hospital General Universitario de Alicante03010 AlicanteSpain

Hyperplastic polyps have traditionally been considered not to have malignant *** pathological classification of serrated polyps and recent discoveries about the serrated pathway of carcinogenesis have revolutionized the concepts and revitalized the research in this *** recently,it has been thought that most colorectal cancers arise from conventional adenomas via the traditional tumor suppressor pathway initiated by a mutation of the APC gene,but it has been found thatthis pathway accounts for only approximately 70%-80% of colorectal cancer(CRC)*** majority of the remaining colorectal cancer cases follow an alternative pathway leading to CpG island methylator phenotype carcinoma with BRAF mutation and with or without microsatellite *** mechanism of carcinomas arising from this alternative pathway seems to begin with an activating mutation of the BRAF *** polyposis syndrome is a relatively rare condition characterized by multiple and/or large serrated polyps of the *** characteristics,etiology and relationship of serrated polyposis syndrome to CRC have not been clarified *** with this syndrome show a high risk of CRC and both sporadic and hereditary cases have been *** criteria have been used for diagnosis and frequent colonoscopy surveillance should be performed in order to prevent colorectal *** this review,we try to gather new insights into the molecular pathogenesis of serrated polyps in order to understand their possible clinical implications and to make an approach to the management of this syndrome.

关键词： Colorectal cancer Hyperplastic polyps CpG island methylator phenotype serrated polyposis serrated pathway

Is physical performance(in mice)increased by Veillonella atypica or decreased by Lactobacillus bulgaricus?

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Journal of sport and Health science 2020年第3期9卷 197-200页

作者： Manuel Fernández-sanjurjo Javier Fernández cristina Tomás-Zapico Benjamín Fernández-García Claudio J.Villar Felipe Lombó Eduardo Iglesias-gutiérrez Department of Functional Biology PhysiologyUniversity of OviedoAsturias 33006Spain Health Research Institute of the Principality of Asturias(IsPA) Asturias 33011Spain Department of Functional Biology MicrobiologyUniversity of OviedoOviedo 33006Spain Department of Morphology and Cell Biology AnatomyUniversity of OviedoOviedo 33006Spain

*** Regular exercise induces changes in the overall diversity and in the relative abundance of certain gut microbiota phyla and families in humans1,2 and in animal models.3,4 This relationship has attracted a great deal of interest because it is one of the mechanisms involved in the health benefits of regular exercise3 that could also influence performance.5 A recent publication by scheiman et al.

关键词： al. performance Regular

C3G contributes to platelet activation and aggregation by regulating major signaling pathways

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signal Transduction and Targeted Therapy 2020年第1期5卷 2103-2117页

作者： sara gutiérrez-Herrero cristina Fernández-Infante Luis Hernández-Cano sara Ortiz-Rivero Carlos Guijas Víctor Martín-Granado JoséRamón González-Porras Jesús Balsinde Almudena Porras Carmen Guerrero Instituto de Biología Molecular y Celular del Cáncer(IMBCC) University of Salamanca-CSICSalamancaSpain Instituto de Investigación Biomédica de salamanca(IBsAL) SalamancaSpain Instituto de Biología y Genética Molecular(IBGM) Consejo Superior de Investigaciones Científicas(CSIC)University of ValladolidValladolidSpain Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas(CIBERDEM) MadridSpain Departamento de Hematologiá Hospital Universitario de Salamanca(HUS)SalamancaSpain Departamento de Bioquímica y Biología Molecular Facultad de FarmaciaComplutense University of Madrid.Instituto de Investigación Sanitaria del Hospital Clínico San Carlos(IdISSC)MadridSpain Departamento de Medicina University of SalamancaSalamancaSpain

C3G is a GEF(guanine nucleotide exchange factor)for Rap GTPases,among which the isoform Rap1b is an essential protein in platelet *** transgenic mouse models with platelet-specific overexpression of C3G or mutant C3GΔCat,we have unveiled a new function of C3G in regulating the hemostatic function of platelets through its participation in the thrombin-PKCRap1b pathway.C3G also plays important roles in angiogenesis,tumor growth,and metastasis through its regulation of the platelet *** addition,C3G contributes to megakaryopoiesis and ***,we used a platelet-specific C3G-KO mouse model to further support the role of C3G in hemostasis.C3G-KO platelets showed a significant delay in platelet activation and aggregation as a consequence of the defective activation of Rap1,which resulted in decreased thrombus formation in ***,we explored the contribution of C3G-Rap1b to platelet signaling pathways triggered by thrombin,PMA or ADP,in the referenced transgenic mouse model,through the use of a battery of specific *** found that platelet C3G is phosphorylated at Tyr504 by a mechanism involving *** phosphorylation was shown to be positively regulated by ERKs through their inhibition of the tyrosine phosphatase ***,C3G participates in the ADP-P2Y12-PI3K-Rap1b pathway and is a mediator of thrombin-TXA2 ***,it inhibits the synthesis of TXA2 through cPLA2 *** together,our data reveal the critical role of C3G in the main pathways leading to platelet activation and aggregation through the regulation of Rap1b.

关键词： C3G platelet activation

stem cells and tissue engineering: an alternative treatment for craniofacial congenital malformations and articular degenerative diseases

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Plastic and Aesthetic Research 2020年第6期7卷 24-37页

作者： cristina Velasquillo Antonio Madrazo-Ibarra Claudia gutiérrez-Gómez Marcia Rosario Pérez-Dosal Yaaziel Melgarejo-Ramírez Clemente Ibarra Biotecnología Instituto Nacional de Rehabilitación LGIICiudad de México 14389México Hospital General Manuel Gea González and Instituto Nacional de Rehabilitación LGII Ciudad de México 14080México Médico Adscrito al servicio de Cirugía Plástica Instituto Nacional de PediatríaCiudad de México 04530México Dirección General Instituto Nacional de Rehabilitación LGIICiudad de México 14389México

The life quality of patients with craniofacial malformations is severely affected by the physical disabilities caused by the malformation itself,but also by being subjected to bullying,which leads to a series of relevant psychological and societal effects that have an economic impact on the health *** clefts,notably cleft lip(CL),cleft palate,and microtia,are the most common craniofacial birth defects in humans and represent a substantial burden,both personal and *** the other hand,osteoarthritis is a widespread degenerative disease that is becoming more common due to the extension of the human lifespan and to an increase in injuries in young people as a result of their *** in tissue engineering as a part of regenerative medicine offer new hope to patients that can benefit from new tissue engineering therapies based on the supportive action of tailored 3D biomaterials and the synergic action of stem cells that can be driven to the process of bone and cartilage *** review provides an update on recent considerations for stem cells and studies on the use of advanced biomaterials and cell therapies for the regeneration of craniofacial congenital malformations and articular degenerative diseases.

关键词： Mesenchymal stromal cells microtia cartilage cleft lip cleft palate

structural and biological engineering of 3D hydrogels for wound healing

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Bioactive Materials 2023年第6期24卷 197-235页

作者： Mohammad Hadi Norahan sara cristina Pedroza-González Mónica Gabriela sánchez-salazar Mario Moisés Álvarez Grissel Trujillo de santiago Escuela de Ingeniería y Ciencias Tecnológico de MonterreyMonterreyNL64849Mexico Centro de Biotecnología-FEMsA Tecnológico de MonterreyMonterreyNuevo LeónCP64849Mexico Departamento de Bioingeniería Tecnológico de MonterreyMonterreyNuevo LeónCP64849Mexico

Chronic wounds have become one of the most important issues for healthcare systems and are a leading cause of death *** dressings are necessary to facilitate wound *** wound dressings may substantially reduce healing time,reduce the risk of recurrent infections,and reduce the disability and costs *** the path of engineering of an ideal wound dressing,hydrogels have played a leading *** are 3D hydrophilic polymeric structures that can provide a protective barrier,mimic the native extracellular matrix(ECM),and provide a humid *** to their advantages,hydrogels(with different architectural,physical,mechanical,and biological properties)have been extensively explored as wound dressing *** we describe recent studies on hydrogels for wound healing applications with a strong focus on the interplay between the fabrication method used and the architectural,mechanical,and biological performance ***,we review different categories of additives which can enhance wound regeneration using 3D hydrogel *** engineering for wound healing applications promises the generation of smart solutions to solve this pressing problem,enabling key functionalities such as bacterial growth inhibition,enhanced re-epithelialization,vascularization,improved recovery of the tissue functionality,and overall,accelerated and effective wound healing.

关键词： Wound healing Wound dressing Hydrogel Tissue engineering 3D culture

Improving skin Aging, skin Hydration and sensitive skin with Four specific skin Care Products: Results from a single-Centre, Observational, Prospective study

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Journal of Cosmetics, Dermatological sciences and Applications 2017年第1期7卷 48-56页

作者： Antonella Piccioni Carlota gutiérrez García-Rodrigo cristina Pellegrini Giampiero Mazzocchetti Maria Concetta Fargnoli Department of Dermatology University of L’Aquila L’Aquila Italy UOsDDermatology Hospital “Santo Spirito” Pescara Italy

In this study, we assessed the efficacy and safety of four skin care products indicated for skin hydration (Aqua Therapy? and Perfecta? ), skin aging (Unica Resurfacing Therapy? ) and sensitive skin (Comfort Therapy? ), in four groups of 7 volunteers with different skin types. These products belong to four skin care ranges (Aqua? , Perfecta? , Unica? and Comfort? ) and are formulated with a specific combination of active compounds (Dermo28? ). Evaluation of sebum secretion, hydration and pH of the skin (all groups), wrinkle severity (Unica Resurfacing Therapy? ) and erythema (Comfort Therapy? ) was performed at baseline and after 4 weeks of treatment. A significant increase in hydration was recorded in subjects with dry skin receiving Aqua Therapy? for facial hydration and Perfecta? for body hydration, respectively (p ? group. In subjects with sensitive skin (Comfort Therapy? ), a decrease in erythema (p = 0.012), an increase in sebum secretion (p = 0.001) and hydration (p se event. This specific combination of active ingredients was clinically effective and safe, and contributed to skin surface hydrolipidic film regeneration, improvement of wrinkle depth and reduction of redness.

关键词： skin Hydration skin Aging sensitive skin