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A study on monoterpenoid-based natural deep eutectic solvents

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Green Chemical Engineering 2023年第1期4卷 99-114页

作者： Sara Rozas Lorena Zamora cristina Benito Mert Atilhan Santiago Aparicio Department of Chemistry University of BurgosBurgos09001Spain Department of Chemical and Paper Engineering Western Michigan UniversityKalamazooMI49008-5462USA

Herein,the synthesis and characterization methods of natural deep eutectic solvents based on monoterpenoids have been *** viscous fluids with suitable physicochemical properties are *** materials are non-toxic,biodegradable,and ***,they can be used to develop sustainable solvents for various processes and can find their applications in various fields.A theoretical study based on quantum chemistry and classical molecular dynamics is used for the nanoscopic characterization of structure,dynamics,and hydrogen *** reported results help analyze the properties of this new family of *** required information for developing structure–property relationships for proper solvent design to form a sustainable chemistry framework is obtained.

关键词： Natural deep eutectic solvents Terpenes DFT md COSMO-RS CO_(2)solubility

Understanding plant drought resistance in a Mediterranean coastal sand dune ecosystem:differences between native and exotic invasive species

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Journal of Plant Ecology 2018年第1期11卷 26-38页

作者： cristina Antunes Ana Júlia Pereira Patrícia Fernandes Margarida Ramos Lia Ascensão Otília Correia cristina Máguas Centre for Ecology Evolution and Environmental ChangesFaculdade de CiênciasUniversidade de LisboaCampo Grande1749-016 LisboaPortugal PPG-Ecologia Instituto de BiologiaCP 6109Universidade Estadual de Campinas-UNICAMP13083-970 CampinasSão PauloBrazil SPBotânica-Botanical Society of Portugal Travessa do Jardim 3A-dos-Potes2615-018 Alverca do RibatejoPortugal CESAM-Centre for Environmental and Marine Studies Faculdade de Ciências-CBVUniversidade de Lisboa1749-016 LisboaPortugal

Aims Mediterranean coastal dunes are habitats of great conservation interest,with a distinctive and rich *** the last century,Acacia spp.,native from Australia,have been introduced in Portugal,with the objective of stabilizing sand dunes,and since have become dominant in numerous sand dune *** invasion process led to the reduction of native plant species richness,changed soil characteristics and modified habitat’s microclimatic *** aim of this research was to typify and compare,in Mediterranean sand dune ecosystems,the ecophysiological responses to drought of Helichrysum italicum and Corema album,two native species,and Acacia longifolia,an exotic invasive *** addressed the following specific objectives:(i)to com-pare water relations and water use efficiencies,(ii)to evaluate water stress,(iii)to assess water use strategies and water sources used by plants and(iv)to evaluate the morphological adaptations at leaf and phyllode *** In order to obtain an integrative view of ecophysiological patterns,water relations and performance measuring methods have been applied:predawn(ψPD)and midday(ψmd)water potential,chloro-phyll a fluorescence,oxygen isotopic composition of xylem,rain and groundwater(δ18O)and leaf carbon isotopic discrimination(Δ13C).The leaf characteristics of the three species,as well as the histochemistry of non-glandular trichome cell walls,were also studied to identify morpho-traits related to drought *** Findings The results support our initial hypothesis:although *** clearly possesses a degree of resistance to water stress,such ability is provided by a different water strategy,when compared to native *** relied on morphological adaptations to restrict water loss,whereas the invasive species adjusted the water uptake as a way to balance their limited ability of restricting water *** corroborate that woody native species(i)have a conservative water-saving strategy an

关键词： ecophysiology water use strategy leaf morphology Acacia longifolia Corema album Helichrysum italicum

Gastrointestinal manifestations in myotonic muscular dystrophy

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World Journal of Gastroenterology 2006年第12期12卷 1821-1828页

作者： Massimo Bellini Sonia Biagi cristina Stasi Francesco Costa Maria Gloria Mumolo Angelo Ricchiuti Santino Marchi Gastroenterology Unit Department of Internal MedicineUniversity of PisaItaly

Myotonic dystrophy （md） is characterized by myotonic phenomena and progressive muscular weakness. Involvement of the gastrointestinal tract is frequent and may occur at any level. The clinical manifestations have previously been attributed to motility disorders caused by smooth muscle damage, but histologic evidence of alterations has been scarce and conflicting. A neural factor has also been hypothesized. In the upper digestive tract, dysphagia, heartburn, regurgitation and dyspepsia are the most common complaints, while in the lower tract, abdominal pain, bloating and changes in bowel habits are often reported. Digestive symptoms may be the first sign of dystrophic disease and may precede the rnusculo-skeletal features. The impairment of gastrointestinal function may be sometimes so gradual that the patients adapt to it with little awareness of symptoms. In such cases routine endoscopic and ultrasonographic evaluations are not sufficient and targeted techniques （electrogastrography, manornetry, electromyography, functional ultrasonography, scintigraphy, etc.） are needed. There is a low correlation between the degree of skeletal muscle involvement and the presence and severity of gastrointestinal disturbances whereas a positive correlation with the duration of the skeletal muscle disease has been reported. The drugs recommended for treating the gastrointestinal complaints such as prokinetic, antidyspeptic drugs and laxatives, are mainly aimed at correcting the motility disorders. Gastrointestinal involvement in md remains a complex and intriguing condition since many important problems are still unsolved. Further studies concentrating on genetic aspects, early diagnostic techniques and the development of new therapeutic strategies are needed to improve our management of the gastrointestinal manifestations of md.

关键词： Myotonic dystrophy Digestive disorders Gastrointestinal symptoms

Lymphoepithelioma-like carcinoma of the breast presenting as breast abscess

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World Journal of Clinical Oncology 2014年第5期5卷 1107-1112页

作者： Ikumi Suzuki Pimchandr Chakkabat Lindsay Goicochea cristina Campassi Saranya Chumsri Department of Medicine University of Maryland School of Medicine and the Marlene and Stewart Greenebaum Cancer Center Baltimore MD 21201 United States Department of Medicine Chulalongkorn University Department of Pathology University of Maryland School of Medicine and the Marlene and Stewart Greenebaum Cancer Center Baltimore MD 21201 United States Department of Diagnostic Radiology and Nuclear Medicine University of Maryland School of Medicine and the Marlene and Stewart Greenebaum Cancer Center Baltimore MD 21201 United States

Lymphoepithelioma-like carcinoma(LELC) is a rare type of neoplasm in which only twenty cases have been reported in the breast. This type of tumor can be difficult to distinguish from other breast tumors particularly medullary carcinoma and lymphoma in the breast. We present a case of LELC of the breast presenting as an abscess along with a review of the literature. This is the 21 st reported case of LELC of the breast and the first case to present as an abscess. Her clinical picture could have been mistaken for other infectious or inflammatory diseases. Given the potential for favorable outcome, early detection and general knowledge of this neoplasm are essential to expedite treatment for this rare tumor type.

关键词： Lymphoepithelioma-like carcinoma of the breast Breast cancer Breast abscess

血小板减少时纤维蛋白原水平对血栓弹力测定参数的影响

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麻醉与镇痛 2011年第3期7卷 39-47页

作者： Thomas Lang md Kai Johanning, md Helfried Metzler, md Siegfried Piepenbrock, md cristina Solomon, md NielsRahe-Meyer, md, PhD Kenichi A. Tanaka, md, MSc 杨静(译) Department of Anesthesiology Medical School Hannover Germany Emory University School of Medicine Atlanta GA Werlhof Institut Hannover GermanyEmory University School of Medicine Atlanta GA Department of Anesthesiology University Medical School Graz Austria Emory University School of Medicine Atlanta GA Department of Anesthesiology Emory University School of Medicine Atlanta GA 不详

背景纤维蛋白原及纤维蛋白与血小板的结合，在正常的止血过程中发挥着重要作用。血小板一纤维蛋白相互作用的程度可通过旋转式血栓弹力测定法（ROTEM）测量血凝块粘弹性的强度进行评估。在本试验中，我们研究了纤维蛋白原浓度对ROTEM测... 详细信息

背景纤维蛋白原及纤维蛋白与血小板的结合，在正常的止血过程中发挥着重要作用。血小板一纤维蛋白相互作用的程度可通过旋转式血栓弹力测定法（ROTEM）测量血凝块粘弹性的强度进行评估。在本试验中，我们研究了纤维蛋白原浓度对ROTEM测得整体血凝强度的影响及其发挥的作用。方法采集健康志愿者的血样作为研究样品。通过ROTEM检测一系列用同源血浆调配为含不同血小板数量的富含血小板血浆（PRP）的最大凝固程度（MCE），以此评估血小板数量对血凝强度的影响。经调配后PRPs的血小板数量分别为10×10^3mm^-3、50×10^3mm^-3和100×10^3mm^-3，并各加入浓度为550和780mg／dl的纤维蛋白原浓缩液。纤维蛋白的聚合作用可不依赖于血小板的附着对血凝强度产生影响，细胞松弛素D－修正的血栓弹力测定法（FIBTEM）可对以上影响进行分析。此外，本研究还回顾性分析了两组血小板减少患者的血凝强度（MCE）。结果血小板低于100×10^3mm^-3时血凝强度（MCE）有所降低，而当血小板数量为400×10^3mm^-3时MCE上升达峰值并延伸为一平台。PRP中渐增的纤维蛋白原浓度以浓度依赖的方式逐渐增加血凝强度，即使在血小板数量较低时（10×10^3mm^-3）仍有同样表现。904例血小板减少患者的资料分析也证实血凝强度和血浆纤维蛋白原水平之间存在正相关。结论这些体外研究和临床资料的ROTEM分析结果提示，血凝强度以纤维蛋白原浓度依赖的方式增加，而且不依赖血小板的数量。血小板减少时维持纤维蛋白原的浓度至关重要。外源性激活（EXTEM）和FIBTEM对于指导纤维蛋白原的补充治疗具有一定应用价值。

关键词：纤维蛋白原水平血小板减少血小板数量测定弹力血栓纤维蛋白原浓度富含血小板血浆

Collagen matrix scaffolds:Future perspectives for the management of chronic liver diseases

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World Journal of Clinical Cases 2023年第6期11卷 1224-1235页

作者： Moises Martinez-Castillo Itzel Altamirano-Mendoza Rafal Zielinski Waldemar Priebe cristina Piña-Barba Gabriela Gutierrez-Reyes Liver Pancreas and Motility LaboratoryUnit of Experimental MedicineSchool of MedicineUniversidad Nacional Autonoma de MexicoMexico City 06726Mexico CityMexico Department of Experimental Therapeutics The University of Texas MD Anderson Cancer CenterHoustonTX 77054United States Materials Research Institute Universidad Nacional Autónoma de MéxicoMexico City 06726Mexico CityMexico

Approximately 1.5 billion chronic liver disease(CLD)cases have been estimated worldwide,encompassing a wide range of liver damage ***,liver disease causes approximately 1.75 million deaths per *** is typically characterized by the silent and progressive deterioration of liver parenchyma due to an incessant inflammatory process,cell death,over deposition of extracellular matrix proteins,and dysregulated ***,these processes impair the correct function of this vital *** and liver cancer are the main complications of CLD,which accounts for 3.5%of all deaths *** transplantation is the optimal therapeutic option for advanced liver *** liver is one of the most common organs transplanted;however,only 10%of liver transplants are *** this context,regenerative medicine has made significant progress in the design of biomaterials,such as collagen matrix scaffolds,to address the limitations of organ transplantation(e.g.,low donation rates and biocompatibility).Thus,it remains crucial to continue with experimental and clinical studies to validate the use of collagen matrix scaffolds in liver disease.

关键词： Liver Chronic liver disease Collagen matrix scaffold Transplant Management

冠状动脉旁路移植术前对环氧化酶-1抑制性的评估：血小板聚集率与患者自测的对比研究

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麻醉与镇痛 2011年第3期7卷 32-38页

作者： Niels Rahe-Meyer, md, PhD Michael Winterhalter, M4 Julia Hartmann Albert Pattison Hartmut Hecker Andreas Calatzis, md cristina Solomon, md 曹晖(译) Department of Anesthesiology Hannover Medical School Hannover Germany Hart Biologicals Hartlepool UK University Hospital Munich Munich Germany Institute for Biometry Hannover Medical School Hannover Germany University Hospital Munich Munich Germany Department of Hemostasis and Transfusion Medicine University Hospital Munich Munich Germany 不详

背景抗血小板治疗导致的血小板功能减退可产生围手术期出血，数项对手术前5日内摄入阿司匹林的影响研究结果不一，有的认为摄入阿司匹林会增加围手术期输血量，而有的认为并无显著影响。本项研究的目的在于对比患者自身报告服药情况与... 详细信息

背景抗血小板治疗导致的血小板功能减退可产生围手术期出血，数项对手术前5日内摄入阿司匹林的影响研究结果不一，有的认为摄入阿司匹林会增加围手术期输血量，而有的认为并无显著影响。本项研究的目的在于对比患者自身报告服药情况与血小板功能测定两种方法评估阿司匹林摄入对围手术期输血需求的影响。方法在一项前瞻性研究中，对100例行冠状动脉旁路移植术的患者，术前5日阿司匹林的摄入进行标准化问卷调查。另外，使用Multiplate血小板功能分析仪测定花生四烯酸介导的全血血小板聚集率。结果23例手术前5日内服用阿司匹林的患者中有11例血小板聚集功能异常，77例手术前未服用阿司匹林的患者中有9例血小板功能异常。服用与未服用阿司匹林的患者相比，手术后24小时内胸管引流量及红细胞输注量无显著差别。手术前血小板聚集功能异常的患者（〈51U）所需的血小板输注量（1．1U）显著高于血小板聚集功能正常的患者（0．3U，P=0．001）。结论本研究结果显示全血花生四烯酸诱导血小板聚集率对于血小板相关的凝血功能异常及血小板输注量的预测优于患者自身报告阿司匹林的摄入情况。

关键词：冠状动脉旁路移植术血小板聚集率手术前环氧化酶-1 患者血小板聚集功能异常评估血小板功能分析仪

Gsα^(R201C)and estrogen reveal different subsets of bone marrow adiponectin expressing osteogenic cells

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Bone Research 2022年第4期10卷 784-798页

作者： Biagio Palmisano Rossella Labella Samantha Donsante cristina Remoli Emanuela Spica Ilenia Coletta Giorgia Farinacci Michele Dello Spedale Venti Isabella Saggio Marta Serafini Pamela Gehron Robey Alessandro Corsi Mara Riminucci Department of Molecular Medicine Sapienza University of RomeRome 00161Italy Tettamanti Research Center Department of PediatricsUniversity of Milano Bicocca/Fondazione MBBMMonza 20900Italy Department of Biology and Biotechnology Sapienza University of RomeRome 00185Italy Institute of Structural Biology and School of Biological Sciences Nanyang Technological University 639798 SingaporeSingapore CNR Institute of Molecular Biology and Pathology Piazzale Aldo Moro 5Rome 00185Italy Skeletal Biology Section National Institute of Dental and Craniofacial ResearchNational Institutes of HealthDepartment of Health and Human ServicesBethesdaMD 20892USA

The Gsα/cAMP signaling pathway mediates the effect of a variety of hormones and factors that regulate the homeostasis of the post-natal ***,the dysregulated activity of Gsαdue to gain-of-function mutations (R201C/R201H)results in severe architectural and functional derangements of the entire bone/bone marrow *** the consequences of gain-of-function mutations of Gsαhave been extensively investigated in osteoblasts and in bone marrow osteoprogenitor cells at various differentiation stages,their effect in adipogenically-committed bone marrow stromal cells has remained *** generated a mouse model with expression of Gsα^(R201C) driven by the Adiponectin(Adq)***-Gsα^(R201C) mice developed a complex combination of metaphyseal,diaphyseal and cortical bone *** the metaphysis,Gsα^(R201C) caused an early phase of bone resorption followed by bone *** bone formation was sustained by cells that were traced by Adq-Cre and eventually resulted in a high trabecular bone mass *** the diaphysis,Gsα^(R201C),in combination with estrogen,triggered the osteogenic activity of Adq-Cre-targeted perivascular bone marrow stromal cells leading to intramedullary bone ***,consistent with the previously unnoticed presence of Adq-Cre-marked pericytes in intraosseous blood vessels,Gsα^(R201C) caused the development of a lytic phenotype that affected both cortical(increased porosity)and trabecular(tunneling resorption)*** results provide the first evidence that the Adq-cell network in the skeleton not only regulates bone resorption but also contributes to bone formation,and that the Gsα/cAMP pathway is a major modulator of both functions.

关键词： estrogen sustained skeleton

Differential Requirement of IFN Consensus Sequence Binding Protein for the Production of IL-12 and Induction of Th1-Type Cells in Response to IFN-γ

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Differential Requirement of IFN Consensus Sequence Binding P...