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In‑depth proteome characterization of endometrium and extraembryonic membranes during implantation in pig

Journal of Animal Science and Biotechnology 2024年第3期15卷 1027-1055页

作者： maria A.Gil Josep M.Cambra Heriberto Rodriguez‑Martinez cristina Cuello Inmaculada Parrilla Emilio A.Martinez department of Medicine and Animal Surgery International Excellence Campus for Higher Education and Research“Campus Mare Nostrum”University of MurciaMurciaSpain Institute for Biomedical Research of Murcia(IMIB-Pascual Parrilla) MurciaSpain Technical University of Munich MunichGermany department of Biomedical&Clinical Sciences(BKV) BKH/Obstetrics&GynaecologyLinkoping UniversityLinkopingSweden

Background Proteome characterization of the porcine endometrium and extraembryonic membranes is important to understand mother-embryo *** this study,the proteome of the endometrium and cho-rioallantoic membrane was characterized in pregnant sows(PS)during early gestation(d 18 and 24 of gestation)and in the endometrium of non-pregnant sows(NPS)during the same days using LC-MS/MS *** UniProtKB database and ClueGO were used to obtain functional Gene Ontology annotations and biological and functional networks,*** Our analysis yielded 3,254 and 3,457 proteins identified in the endometrium of PS and NPS,respectively;of these,1,753 being common while 1,501 and 1,704 were exclusive to PS and NPS,*** addition,we iden-tified 3,968 proteins in the extraembryonic membranes of *** analyses of function revealed some proteins had relevance for the immune system process and biological adhesion in endometrium while the embryonic chorion displayed abundance of proteins related to cell adhesion and cytoskeletal organization,suggesting they dominated the moment of endometrial remodeling,implantation and adhesion of the lining *** are available via Pro-teomeXchange with identifier *** This is the first in-depth proteomic characterization of the endometrium and extraembryonic mem-branes during weeks 3 to 4 of gestation;data that contribute to the molecular understanding of the dynamic environ-ment during this critical period,associated with the majority of pregnancy losses.

关键词： Endometrium Extraembryonic membranes Implantation Pig Proteome

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Topical ocular administration of dPP-Ⅳ inhibitors:a new approach for treating diabetes-induced retinal neurodegeneration

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Neural Regeneration Research 2024年第4期19卷 713-714页

作者： Rafael Simó cristina Hernández diabetes and Metabolism Research Unit Vall d’Hebron Research Institute(VHIR) department of Medicine Autonomous University of Barcelona Centro de Investigación Biomédica en Red de diabetes y Enfermedades Metabólicas Asociadas(CIBERdEM) Instituto de Salud CarlosⅢ(ICSⅢ)

Retinal neurodegeneration plays a significant role in the pathogenesis of diabetic retinopathy(dR),the leading cause of preventable *** fact,the American diabetes Association has defined dR as a highly specific neurovascular complication(Solomon et al.,2017).Therefore,it is no longer acceptable to consider dR as merely a microvascular *** this regard,the term diabetic retinal disease(dRd)has been proposed as a broader term comprising microangiopathy and ***,there are currently no treatments available that directly target the neurodegenerative changes of *** paper will give new insights into the translational research in this field with particular emphasis on glucagon-like peptide 1/dipeptidyl peptidase IV(GLP-1/dPP-IV)inhibitors.

关键词： neurodegeneration ocular insight

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Liquid biopsy for gastric cancer:Techniques,applications,and future directions

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World Journal of Gastroenterology 2024年第12期30卷 1680-1705页

作者： cristina díaz del Arco M Jesús Fernández Aceñero Luis Ortega Medina department of Surgical Pathology Health Research Institute of the Hospital Clínico San CarlosHospital Clínico San CarlosMadrid 28040Spain department of Legal Medicine Psychiatry and PathologyUniversidad Complutense de MadridMadrid 28040Spain

After the study of circulating tumor cells in blood through liquid biopsy(LB),this technique has evolved to encompass the analysis of multiple materials originating from the tumor,such as nucleic acids,extracellular vesicles,tumor-educated platelets,and other ***,research has extended to include the examination of samples other than blood or plasma,such as saliva,gastric juice,urine,or *** techniques are diverse,intricate,and *** must be highly sensitive,and pre-analytical,patient,and tumor-related factors significantly influence the detection threshold,diagnostic method selection,and potential ***,the implementation of LB in clinical practice still faces several *** potential applications of LB range from early cancer detection to guiding targeted therapy or immunotherapy in both early and advanced cancer cases,monitoring treatment response,early identification of relapses,or assessing patient *** the other hand,gastric cancer(GC)is a disease often diagnosed at advanced *** recent advances in molecular understanding,the currently available treatment options have not substantially improved the prognosis for many of these *** application of LB in GC could be highly valuable as a non-invasive method for early diagnosis and for enhancing the management and outcomes of these *** this comprehensive review,from a pathologist’s perspective,we provide an overview of the main options available in LB,delve into the fundamental principles of the most studied techniques,explore the potential utility of LB application in the context of GC,and address the obstacles that need to be overcome in the future to make this innovative technique a game-changer in cancer diagnosis and treatment within clinical practice.

关键词： Liquid biopsy Gastric cancer Circulating tumor cells Cell-free dNA Circulating tumor dNA Molecular

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Epidemiology,therapy and outcome of hepatocellular carcinoma between 2010 and 2019 in Piedmont,Italy

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 761-772页

作者： Christian Bracco Marta Gallarate Marco Badinella Martini Corrado Magnino Salvatore d'Agnano Roberta Canta Giulia Racca Remo Melchio cristina Serraino Valentina Polla Mattiot Giovanni Gollè Luigi Fenoglio department of Internal Medicine Santa Croce e Carle General HospitalCuneo 12100Italy department of Medical Sciences "City of Health and Science"University HospitalTorino 10100Italy

BACKGROUNd Hepatocellular carcinoma(HCC)is the most common primary liver malignancy and the second leading cause of cancer deaths *** is often diagnosed at an advanced stage and therefore its prognosis remains poor with a low 5-year survival *** patients have increasingly complex and constantly changing characteristics,thus up-to-date and comprehensive data are *** To analyze the epidemiology and main clinical characteristics of HCC patients in a referral center hospital in the northwest of Italy between 2010 and *** In this retrospective study,we analyzed the clinical data of all consecutive patients with a new diagnosis of HCC recorded at"Santa Croce e Carle"Hospital in Cuneo(Italy)between 1 January 2010 and 31 december *** highlight possible changes in HCC patterns over the 10-year period,we split the population into two 5-year groups,according to the diagnosis period(2010-2014 and 2015-2019).RESULTS Of the 328 HCC patients who were included(M/F 255/73;mean age 68.9±11.3 years),154 in the first period,and 174 in the *** C virus infection was the most common HCC risk factor(41%,135 patients).The alcoholic etiology rate was 18%,the hepatitis B virus infection etiology was 5%,and the non-viral/non-alcoholic etiology rate was 22%.The Child-Pugh score distribution of the patients was:class A 75%,class B 21%and class C 4%.The average Mayo end-stage liver disease score was 10.6±3.7.A total of 55 patients(17%)were affected by portal vein thrombosis and 158(48%)by portal *** average nodule size of the HCC was 4.6±3.1 cm.A total of 204 patients(63%)had more than one noduled 92%(305 patients)had a non-metastatic stage of the *** Barcelona Clinic Liver Cancer(BCLC)staging distribution of all patients was:4%very early,32%early,23%intermediate,34%advanced,and 7%*** survival rate was 1.6±0.3 *** 20%of the patients underwent ***,presence of ascites,BCLC stage and therapy w

关键词： Hepatocellular carcinoma Hepatitis virus Alcoholic hepatitis Non-alcoholic fatty liver disease diagnosis Etiology Treatment

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Synthesis and applications of lanthanoid complexes of pentadentate and hexadentate N_(5) and N_(6) macrocycles:A review

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Journal of Rare Earths 2024年第1期42卷 1-15,I0001页

作者： Julio Corredoira-Vázquez cristina González-Barreira Paula Oreiro-Martínez Ana M.García-deibe Jesús Sanmartín-Matalobos Matilde Fondo departamento de Química Inorganica Facultade de QuímicaUniversidade de Santiago de CompostelaCampus Vida15782Santiago de CompostelaSpain Phantom-g CICECO-Aveiro Institute of MaterialsDepartment of PhysicsUniversity of Aveiro3810-193AveiroPortugal Institute of Materials(iMATUS) Universidade de Santiago de Compostela15782Santiago de CompostelaSpain

In this paper,the lanthanoid complexes of N_(5) and N_(6) macrocycle ligands,without pendant arms or additional heteroatoms,are *** review covers the period from 2015 to the current date,since in 2014 Schiff base macrocyclic ligands incorporating the pyridine moiety,and their complexes,were revised,and in 2015 the chemistry of pentaaza macrocycle ligands with rare earth metals was also *** and phthalocyanine ligands are not included in this review,which primarily focuses on complexes with Schiff bases and amines without pendant arms or any additional donor other than *** synthetic methods,structural characterization,based on single X-ray crystal data,and properties of the lanthanoid complexes,with special attention to magneto-structural correlations,are presented herein.

关键词： Lanthanoid N_(5),N_(6)macrocycle Coordination chemistry Chirality Biological activity Molecule magnet

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Neuropsychological alterations in hepatitis C infection:The role of inflammation

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World Journal of Gastroenterology 2011年第29期17卷 3369-3374页

作者： Marco Senzolo Sami Schiff cristina maria d.aloiso Chiara Crivellin Evangelos Cholongitas Patrizia Burra Sara Montagnese Multivisceral Transplant Unit Department of Surgical and Gastroenterological SciencesUniversity Hospital of Padua35128 PaduaItaly department of Clinical and Experimental Medicine University Hospital of Padua35128 PaduaItaly The Royal Free Sheila Sherlock Liver Centre and department of Surgery UCL and Royal Free HospitalPond StreetLondon NW3 2QGUnited Kindom

About 50% of patients with hepatitis C virus(HCV)infection complain of neuropsychiatric symptoms,"brain fog",weakness,fatigue,and exhibit some degree of quality of life impairment,irrespective of the severity of liver *** the first observation of HCV-related cognitive deficits,10 studies have been published that have evaluated neuropsychiatric performance in patients with HCV infection and different degrees of hepatic ***,these have often included patients with cirrhosis,patients who had acquired the infection through previous intravenous drug misuse,who had a history of relatively recent treatment with interferon,or were on psychoactive *** addition,different neuropsychological batteries and tests that explored different cognitive domains were used,which makes the results of the studies difficult to ***,limited information is available on the pathogenesis of HCV-related cognitive *** and/or systemic inflammation may be important players but their potential role has not been substantiated by experimental *** present review outlines the available evidence of the presence of cognitive impairment in patients with HCV infection,with a focus on the potential relationship with cerebral and/or systemic inflammation.

关键词： Cognitive alterations Hepatitis C virus Inflammation

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Human leukocyte antigen compatibility and incidence of donorspecific antibodies in pediatric liver transplant recipients

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World Journal of Gastroenterology 2024年第33期30卷 3837-3845页

作者： Melina U Melere Flavia H Feier Jorge Neumann Antônio N Kalil Juliana de M Montagner Luiza S Nader Carolina S da Silva Marco Aurélio F Junior Gabriela P Coral Guilherme P Bobsin cristina T Ferreira department of Hepatology and Liver Transplantation Santa Casa de Porto AlegrePorto Alegre 90050170Rio Grande do SulBrazil department of Hepato-biliary-pancreatic Surgery and Liver Transplantation Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Rio Grande do SulBrazil Postgraduation Program in Medicine:Hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Rio Grande do SulBrazil Laboratory of Transplantation Immunology Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Rio Grande do SulBrazil

BACKGROUNd Antibody-mediated rejection following liver transplantation(LT)has been increasingly recognized,particularly with respect to the emergence of de novo donor-specific antibodies(dSAs)and their impact on graft *** substantial evidence for adult populations exists,research focusing on pediatric LT outcomes remains *** To investigate the prevalence of human leukocyte antigen(HLA)mismatches and dSA and evaluate their association with rejection episodes after pediatric *** A cohort of pediatric LT recipients underwent HLA testing at Santa Casa de Porto Alegre,Brazil,between december 2013 and december *** patients who survived for>30 days after LT with at least one dSA analysis were *** classes I and II and cross-matches were *** presence of de novo dSA(dndSA)was evaluated at least 3 months after LT using the Luminex®single antigen bead method,with a positive reaction threshold set at 1000 *** episodes were confirmed by liver *** Overall,67 transplanted children were analyzed;61 received grafts from living donors,85%of whom were related to ***-transplant dSA(class I or II)was detected in 28.3%of patients,and dndSA was detected in 48.4%.The median time to dSA detection after LT was 19.7[interquartile range(IQR):4.3-35.6]*** rejection occurred in 13 patients at follow-up,with C4d positivity observed in 5/13 Liver *** median time to rejection was 7.8(IQR:5.7-12.8)*** presence of dndSA was significantly associated with rejection(36%vs 3%,Pd 24 months were 76%vs 100%and 58%vs 95%for patients with dndSA anti-dQ vs those without,*** Our findings highlight the importance of incorporating dSA assessment into pre-and post-transplantation protocols for pediatric LT *** implications may include immunosuppression minimization strategies based on this analysis in pediatric LT recip

关键词： Human leukocyte antigens donor-specific antibodies Liver transplantation Pediatric Rejection

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Prospective study of hepatitis B and d epidemiology and risk factors in Romania:A 10-year update

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World Journal of Hepatology 2024年第4期16卷 640-649页

作者： Speranta Iacob Liana Gheorghe Mirela Onica Laura Huiban Corina Silvia Pop Ciprian Brisc Roxana Sirli Carmen Ester cristina Mihaela Brisc Sorina diaconu Ion Rogoveanu Larisa Sandulescu deiana Vuletici Anca Trifan department of Gastroenterology Carol Davila University of Medicine and PharmacyBucharest 050474Romania department of Gastroenterology and Hepatology Fundeni Clinical InstituteBucharest 022328Romania department of Gastroenterology Grigore T Popa University of Medicine and PharmacyIasi 700115Romania Institute of Gastroenterology and Hepatology Saint Spiridon County HospitalIasi 700111Romania department of Gastroenterology and Medical Oncology University Emergency Clinical HospitalBucharest 050098Romania Faculty of Medicine and Pharmacy University of OradeaOradea 410087Romania department of Gastroenterology Emergency County HospitalOradea 410169Romania Center for Advanced Research in Gastroenterology and Hepatology Department of Gastroenterology and Hepatology“Victor Babeş”University of Medicine and PharmacyTimisoara 300041Romania department of Gastroenterology and Hepatology TimişCounty Emergency Clinical Hospital"Pius Branzeu"Timisoara 300723Romania department of Internal Medicine II and Gastroenterology University Emergency Clinical HospitalBucharest 050098Romania department of Gastroenterology University of Medicine and PharmacyCraiova 200349Romania department of Cardiology Emergency County HospitalCraiova 200642Romania department of Gastroenterology Research Center of Gastroenterology and HepatologyUniversity of Medicine and PharmacyCraiova 200349Romania department of Gastroenterology Emergency County HospitalCraiova 200642Romania department of Gastroenterology Faculty of MedicineGrigore T Popa University of Medicine and PharmacyIasi 700115Romania

BACKGROUNd The global burden of hepatitis d virus(HdV)infection represents a major medical challenge and a public health crisis ***,there is a lack of accurate data on the epidemiology and risk factors for *** B virus(HBV)and HdV coinfection causes the most severe form of viral hepatitis,leading to a higher cumulative incidence of liver-related events compared with HBV monoinfection,including the need for liver transplantation and *** To investigate the epidemiology,natural history,risk factors and clinical management of HBV and HdV coinfection in Romanian *** This prospective study was conducted between January and July 2022 in six tertiary gastroenterology and hepatology referral centres in *** consecutive adults admitted for any gastroenterology diagnosis who were HBV-positive were *** with acute hepatitis or incomplete data were *** the 25390 individuals who presented with any type of gastroenterology diagnosis during the study period,963 met the inclusion *** for anti-HdV antibodies and HdV RNA was performed for all *** and risk factor data were collected by investigators using medical charts and patient *** data were stored in an anonymized online database during the *** The prevalence of HBV was 3.8%;among these patients,the prevalence of HBV/HdV coinfection was 33.1%.The median age of the study population was 54.0 years,and it consisted of 55.1%men.A higher prevalence of HBV/HdV coinfection was observed in patients 50–69 years *** with HBV/HdV coinfection were significantly older than those with HBV monoinfection(P=0.03).Multivariate multiple regression analysis identified female gender(P=0.0006),imprisonment(Pder age at diagnosis(P=0.01)and sexual contact with persons with known viral hepatitis(P=0.0003)as significant risk factors for *** This study shows that HdV infection among those with HBV re

关键词： Epidemiology Hepatitis B Hepatitis d Natural history Risk factors Romania

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Acoustic Scattering Cross Sections of Smart Obstacles: A Case Study

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Communications in Computational Physics 2011年第8期10卷 672-694页

作者： Lorella Fatone maria cristina Recchioni Francesco Zirilli dipartimento di Matematica e Informatica Universitadi CamerinoVia Madonna delle Carceri 962032 Camerino(MC)Italy dipartimento di Scienze Sociali"d.Serrani" Universit`a Politecnica delle MarchePiazza Martelli 860121 AnconaItaly CERI-Centro di Ricerca"Previsione Prevenzione e Controllo dei Rischi Geologici" Universit`a di Roma"La Sapienza"Piazza Umberto Pilozzi 900038 Valmontone(RM)Italy

Acoustic scattering cross sections of smart furtive obstacles are studied and discussed.A smart furtive obstacle is an obstacle that,when hit by an incoming field,avoids detection through the use of a pressure current acting on its boundary.A highly parallelizable algorithm for computing the acoustic scattering cross section of smart obstacles is *** a case study,this algorithm is applied to the(acoustic)scattering cross section of a"smart"(furtive)simplified version of the NASA space shuttle when hit by incoming time-harmonic plane waves,the wavelengths of which are small compared to the characteristic dimensions of the *** solution to this numerically challenging scattering problem requires the solution of systems of linear equations with many unknowns and *** to the sparsity of these systems of equations,they can be stored and solved using affordable computing resources.A cross section analysis of the simplified NASA space shuttle highlights three findings:i)the smart furtive obstacle reduces the magnitude of its cross section compared to the cross section of a corresponding"passive"obstacle;ii)several wave propagation directions fail to satisfactorily respond to the smart strategy of the obstacle;iii)satisfactory furtive effects along all directions may only be obtained by using a pressure current of considerable *** experiments and virtual reality applications can be found at the website:http://***/ceri/zirilli/w7.

关键词： Acoustic obstacle scattering smart obstacles acoustic cross section open loop control operator expansion method wavelet expansion

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Electrochemical Study and Electrodeposition of Copper（I） in Ionic Liquid-reline

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Chemical Research in Chinese Universities 2013年第5期29卷 991-997页

作者： POPESCU Ana-maria COJOCARU Anca dONATH cristina CONSTANTIN Virgil Laboratory of Molten Salts "Hie Murgulescu" Institute of Physical Chemistry of Romanian Academy Bucharest 060021 Romania department of Applied Physical Chemistry and Electrochemistry University Politehnica of Bucharest Bucharest 010737 Romania

The authors made the electrochemical studies on the electrode processes during copper electrodeposition with ionic liquids-reline as an electrolytic medium. Reline is a commercial name for a eutectic mixture of choline chloride and urea（1：2, molar ratio）. This new proposed method of copper deposition is an ecological one because the ionic liquids are recyclable, non-volatile and non-toxic. Cyclic voltammetry investigations were conducted at 343 and 353 K in choline chloride-urea（Reline） deep eutectic solvent with single salt CuCl（generally in 0.05--0.38 mol/L concentration range）. Electrochemical impedance spectroscopy investigations were conducted in choline chloride- urea ionic liquid with CuCI（0.05 mol/L）. We investigated both cathodic and anodic processes of Cu＋ ions at different sweep rates in this new electrolytic system based on choline chloride. We have proposed by this an alternative to the classical copper electrodeposition. Coefficient of diffusion, do, for the system Reline-CuCl is presented and the value of d0 is 1.22× 10^-8 cm2/s.

关键词： Ionic liquid Reline Electrodeposition Cu(I) Coefficient of diffusion

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