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Food Bioscience 2022年第3期47卷 271-278页

作者： Leticia montes maria Santamaria Raquel Garzon cristina m.rosell Ramón moreira Department of Chemical Engineering Universidade de Santiago de Compostelarúa Lope Gómez de Marzoas/n15782Santiago de CompostelaSpain Institute of Agrochemistry and Food Technology (IATA-CSIC).C/Agustin Escardino 746980PaternaSpain

Corn starch gels(1:4 w:w)were made with the addition(up to 2%w/w starch basis)of sodium alginates of different average molecular sizes and *** of the starchy gels were characterized to evaluate their *** were subjected to in vitro digestion to estimate the effect of alginates addition on glycemic *** alginates significantly decreased the value of the elastic modulus of *** coordination number obtained from complex modulus indicated that in general,less compact structures were obtained in the presence of *** results were confirmed by scanning electron micrographs,where significant differences in the structure of alginate-corn starch gels were observed,but molecular size of alginates was not *** rate decreased with the presence of alginates in corn starch gels by interactions of alginates with leached *** high alginate content,slower hydrolysis rates were determined when the most hygroscopic alginates were added.

关键词： Biopolymers In vitro digestion Average molecular weight Rheology Scanning electron microscopy(SEm)

Assays for predicting and monitoring responses to lung cancer immunotherapy

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Cancer Biology & medicine 2015年第2期12卷 87-95页

作者： cristina Teixidó Niki Karachaliou maria González-Cao Daniela morales-Espinosa Rafael rosell Pangaea Biotech Quirón Dexeus University Hospital rosell Oncology Institute Quirón Dexeus University Hospital Cancer Biology and Precision medicine Program Catalan Institute of OncologyHospital Germans Trias i Pujol

Immunotherapy has become a key strategy for cancer treatment, and two immune checkpoints, namely, programmed cell death 1 （PD-1） and its ligand （PD-L1）, have recently emerged as important targets. The interaction blockade of PD-1 and PD-L1 demonstrated promising activity and antitumor efficacy in early phase clinical trials for advanced solid tumors such as non-small cell lung cancer （NSCLC）. many cell types in multiple tissues express PD-L1 as well as several tumor types, thereby suggesting that the ligand may play important roles in inhibiting immune responses throughout the body. Therefore, PD-L1 is a critical immunomodulating component within the lung microenvironment, but the correlation between PD-L1 expression and prognosis is controversial. more evidence is required to support the use of PD-L1 as a potential predictive biomarker. Clinical trials have measured PD-L1 in tumor tissues by immunohistochemistry （IHC） with different antibodies, but the assessment of PD-L1 is not yet standardized. Some commercial antibodies lack specificity and their reproducibility has not been fully evaluated. Further studies are required to clarify the optimal IHC assay as well as to predict and monitor the immune responses of the PD-I/PD-L1 pathway.

关键词： Immunotherapy lung cancer programmed cell death 1(PD-1) PD-1 ligand (PD-L1) antibody

Borderline resectable pancreatic cancer: Definitions and management

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World Journal of Gastroenterology 2014年第31期20卷 10740-10751页

作者： Nicole E Lopez cristina Prendergast Andrew m Lowy Division of Surgical Oncology Department of Surgery Moores Cancer Center University of California San Diego

Pancreatic cancer is the fourth leading cause of cancer death in the United States. While surgical resection remains the only curative option, more than 80% of patients present with unresectable disease. Unfortunately, even among those who undergo resection, the reported median survival is 15-23 mo, with a 5-year survival of approximately 20%. Disappointingly, over the past several decades, despite improvements in diagnostic imaging, surgical technique and chemotherapeutic options, only modest improvements in survival have been realized. Nevertheless, it remains clear that surgical resection is a prerequisite for achieving longterm survival and cure. There is now emerging consensus that a subgroup of patients, previously considered poor candidates for resection because of the relationship of their primary tumor to surrounding vasculature, may benefit from resection, particularly when preceded by neoadjuvant therapy. This stage of disease, termed borderline resectable pancreatic cancer, has become of increasing interest and is now the focus of a multiinstitutional clinical trial. Here we outline the history, progress, current treatment recommendations, and future directions for research in borderline resectable pancreatic cancer.

关键词： Pancreatic cancer Borderline resectable pancreatic cancer Neoadjuvant Vascular resection Pancreaticoduodenectomy Whipple

The ecological performance of metallophyte plants thriving in geochemical islands is explained by the Inclusive Niche Hypothesis

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Journal of Plant Ecology 2015年第1期8卷 41-50页

作者： Helena C.Serrano cristina Antunes manuel J.Pinto cristina máguas maria Amélia martins-Loução cristina Branquinho Centro de Biologia Ambiental Faculdade de CiênciasUniversidade de LisboaCampo Grande1749-016 LisboaPortugal Jardim Botânico do museu Nacional de História Natural e da Ciência Universidade de LisboaR.Escola Politécnica 581250-102 LisboaPortugal

Aims The Inclusive Niche Hypothesis has not been validated for plants using ecophysiological *** few experiments have measured growth and competition but not the physiological response of plants.A metallophyte plant that hyperaccumulates aluminium(Al),Plantago almogravensis,showed a defined spa-tial distribution by occurring mostly on vegetation gaps associ-ated with metalliferous areas(geochemical islands).This case was used to determine,in situ,whether the Inclusive Niche Hypothesis was suitable to explain the extent of the species real-ized *** The vegetation associated with *** geochemical islands in the SW coast of Portugal was *** biotic(neighbouring plants)and abiotic(edaphic)components of the niche were cor-related with parameters of the plant’s ecological and physiological performances(plant density and cover;leaf C and N concentration and isotopic composition;growth).The results were obtained using image analysis,abundance and morphological measures,isotopic signatures and chemical *** Findings The species showed better physiological performance where its ecological performance was lower due to trade-offs with environ-mental *** species’realized niche was mostly limited by shrub competition and soil *** limits contribute to explain the rarity status of the species:the species has a poor capacity to compete but,due to an enhanced Al-tolerance and Al-hyperaccumulator trait,has the ability to find refuge in geochem-ical islands that are too harsh for most other *** work,based on ecophysiological field studies,provides support for the Inclusive Niche Hypothesis relating to plant species.

关键词： competition ecophysiology edaphic endemism hyperaccumulation stable isotopes trade-off

Uncovering the multifaceted roles played by neutrophils in allogeneic hematopoietic stem cell transplantation

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Cellular & molecular Immunology 2021年第4期18卷 905-918页

作者： cristina Tecchio marco Antonio Cassatella Department of medicine Section of Hem atology and Bone Marrow Transplant UnitUniversity of VeronaVeronaItaly Department of medicine Section of General PathologyUniversity of VeronaVeronaItaly

Allogeneic hematopoietic stem cell transplantation(alloHSCT)is a life-saving procedure used for the treatment of selected hematological malignancies,inborn errors of metabolism,and bone marrow *** role of neutrophils in alloHSCT has been traditionally evaluated only in the context of their ability to act as a first line of defense against ***,recent evidence has highlighted neutrophils as key effectors of innate and adaptive immune responses through a wide array of newly discovered ***,neutrophils are emerging as highly versatile cells that are able to acquire different,often opposite,functional capacities depending on the microenvironment and their differentiation ***,we review the current knowledge on the multiple functions that neutrophils exhibit through the different stages of alloHSCT,from the hematopoietic stem cell(HSC)mobilization in the donor to the immunological reconstitution that occurs in the recipient following HSC *** also discuss the influence exerted on neutrophils by the immunosuppressive drugs delivered in the course of alloHSCT as part of graft-versushost disease(GVHD)***,the potential involvement of neutrophils in alloHSCT-related complications,such as transplant-associated thrombotic microangiopathy(TA-TmA),acute and chronic GVHD,and cytomegalovirus(CmV)reactivation,is also *** on the data reviewed herein,the role played by neutrophils in alloHSCT is far greater than a simple antimicrobial ***,much remains to be investigated in terms of the potential functions that neutrophils might exert during a highly complex procedure such as alloHSCT.

关键词： neutrophils allogeneic hematopoietic stem cell transplantation(alloHSCT) alloHSCT-associated complications lowdensity neutrophils(LDNs) normal-density neutrophils(NDNs)

Unveiling sinus venosus atrial septal defect and partial anomalous pulmonary venous return in an elderly patient

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Journal of Geriatric Cardiology 2024年第4期21卷 462-464页

作者： cristina m Font Anamarys Blanco Fernandez Dinesh Kadariya Department of medicine Division of CardiologyUniversity of Florida College of MedicineJacksonvilleFloridaUSA

Sinus venosus defect(SVD) accounts for 4%–11% of all atrial septal defects(ASD) and may present with dyspnea, heart failure(HF), palpitations, or angina.^[1] The malformation typically involves an interatrial communication due to a deficiency in the common wall connecting the right pulmonary veins and the superior vena cava(SVC) and often accompanies anomalous pulmonary venous connection of some or all of the pulmonary veins.

关键词： atrial septal venous

Understanding the function and dysfunction of the immune system in lung cancer: the role of immune checkpoints

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Cancer Biology & medicine 2015年第2期12卷 79-86页

作者： Niki Karachaliou maria Gonzalez Cao cristina Teixidó Santiago Viteri Daniela morales-Espinosa mariacarmela Santarpia Rafael rosell Instituto Oncológico Dr rosell Quiron Dexeus University Hospital Pangaea Biotech medical Oncology Unit Human Pathology Department University of Messina Catalan Institute of Oncology Hospital Germans Trias i Pujol molecular Oncology Research (mORe) Foundation Germans Trias i Pujol Health Sciences Institute and Hospital

Survival rates for metastatic lung cancer, including non-small cell lung cancer （NSCLC） and small cell lung cancer （SCLC）, are poor with S-year survivals of less than 5%. The immune system has an intricate and complex relationship with tumorigenesis; a groundswell of research on the immune system is leading to greater understanding of how cancer progresses and presenting new ways to halt disease progress. Due to the extraordinary power of the immune system-- with its capacity for memory, exquisite specificity and central and universal role in human biology--immunotherapy has the potential to achieve complete, long-lasting remissions and cures, with few side effects for any cancer patient, regardless of cancer type. As a result, a range of cancer therapies are under development that work by turning our own immune cells against tumors. However deeper understanding of the complexity of immunomodulation by tumors is key to the development of effective immunotherapies, especially in lung cancer.

关键词： Lung cancer immunotherapy immune checkpoint program death-ligand 1 (PD -L 1) program death- 1 (PD - i)

Erratum to Assays for predicting and monitoring responses to lung cancer immunotherapy

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Cancer Biology & medicine 2015年第3期12卷 259-259页

作者： cristina Teixidó Niki Karachaliou maria González-Cao Daniela morales-Espinosa Rafael rosell Pangaea Biotech Quirón Dexeus University Hospital Dr. rosell Oncology Institute Quirón Dexeus University Hospital Cancer Biology and Precision medicine Program Catalan Institute of OncologyHospital Germans Trias i Pujol

In the published article1,one error appeared on page *** has not yet received FDA approval for NSCLC *** October 2014 pembrolizumab received FDA breakthrough therapy designation for lung cancer treatment supported by ... 详细信息

关键词： lung Erratum to Assays for predicting and monitoring responses to lung cancer immunotherapy

Recent results from NA48/2

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Chinese Physics C 2010年第6期34卷 749-752页

作者： cristina morales morales Institut für Physik Universitt Mainz

Recent results on radiative K^± decays from the NA48/2 experiment are reported. From the full NA48/2 data set, about a million K^±→π^±π^γ decays were reconstructed. Based on this sample, the first measurement of the interference between direct photon emission and inner bremsstrahlung in K^±→π^±π^γ decays was performed. Stringent limits on CP violation in this decay were also set. In addition, a precise measurement of the branching fraction of K^±→π^±γγ is presented. This measurement was based on a data sample of more than 1000 event candidates. Also the related decay K^±→π^±e^＋e^-γ has first been observed. Results of the measurement of the decay rate and the decay parameter 5 are summarized.

关键词： radiative K^± decays NA48/2 CP violation

Spatial modelling of deforestation in Romanian Carpathian mountains using GIS and Logistic Regression

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Journal of mountain Science 2019年第5期16卷 1005-1022页

作者： Gheorghe KUCSICSA cristina DUmITRICA Institute of Geography Romanian Academy

Deforestation process represents a wide concern mainly in the mountain environments due to its role in global warming, biodiversity loss, land degradation and natural hazards occurrence. Thus, the present study is focused on the largest afforested landform unit of Romania and, consequently, the most affected area by forest losses: Carpathian mountains. The main goal of the paper is to examine and analyze the various explanatory variables associated with deforestation process and to model the probability of deforestation using GIS spatial analysis and logistic regression. The forest cover for 1990 and 2012, derived from CORINE Land Cover(CLC) database, were used to quantify historical forest cover change included in the modelling. To explain the biophysical and anthropogenic effects, this study considered several explanatory factors related to local topography, forest cover pattern, accessibility, urban growth and population density. Using ROC(Receiver Operating Characteristic) and 500 controlling sampling points, the statistical and spatial validations were assessed in order to evaluate the performance of the resulted data. The analysis showed that the area experienced a continuous forest cover change, leading to the loss of over 250,000 ha of forested area during the period 1990–2012. The most significant influence of the explanatory factors of deforestation were noticed in case of distance to forest edge(β=–4.215), forest fragmentation(β=2.231), slope declivity(β=–1.901), elevation(β=1.734) and distance to roads(β=–1.713). The statistical and spatial validation indicates a good accuracy of the model with reasonably AUC(0.736) and Kappa(0.739) values. The model's results suggest an intensification of the deforestation process in the area, designing numerous new clusters with high probability in the Apuseni mountains, northern and central part of the Eastern Carpathians, western part of the Southern Carpathians and northern part of the Banat mountains. The study cou

关键词： Deforestation probability Romanian Carpathians Logistic Regression