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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： Danko Jeremic Lydia Jiménez-Díaz Juan D.navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(AD)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in AD,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Validation of a Marker Model for Gait Analysis with Wearable Exoskeletons

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Journal of Mechanics Engineering and Automation 2015年第7期5卷 407-410页

作者： Maria gomez cristina Lopez de Subijana Eloy Urendes Enrique navarro Faculty of Physical Activity and Sport Technical University of Madrid Madrid 28040 Spain Bioengineering Group of the Spanish National Research Council Madrid 28500 Spain

The aim of the present study was to develop and validate a new marker model for optoelectronic systems adapted to wearable devices, in order to have an analysis tool for kinematic gait evaluation of reproduced patterns by exoskeletons. The marker model has a total of 36 retro-reflective markers attached bilaterally to anatomical landmarks during the static measures （without exoskeleton） and 28 markers at the dynamics measures （with exoskeleton）. The main difference between others kinematic models and the described adapted model was the placement of the three markers in the back thigh and the other three in the back calf, what allowed removing the hip, thigh, knee, tibia and ankle markers. The proposed adapted marker model could be an effective tool to validate the joint movement and velocities of those wearable exoskeletons that at present have been developing.

关键词： Optoelectronic system adapted model gait analysis

A prospective analysis of factors that influence weight loss in patients undergoing radiotherapy

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Chinese Journal of Cancer 2014年第4期33卷 204-210页

作者： Jon Cacicedo Francisco Casquero Lorea Martinez-Indart Olga del Hoyo Alfonso gomez de Iturriaga Arturo navarro Pedro Bilbao Department of Radiation Oncology Cruces University Hospital Department of Statistics and Epidemiology Cruces University Hospital Department of Radiation Oncology Catalan Institute of OncologyL'Hospitalet de Llobregat

Malnutrition occurs frequently in patients with ***,a variety of nutritional and tumorrelated factors must be taken into account in these *** this relationship,we aimed to prospectively evaluate the risk factors that influence weight loss in patients undergoing radiotherapy with oral nutritional supplementation and dietetic *** loss of 74 patients during radiotherapy and 1 month after treatment was *** such as age,gender,tumor location,tumor stage,Eastern Cooperative Oncology Group performance status(ECOG PS)score,and the use of chemotherapy were analyzed to evaluate their influence on weight *** patients underwent oral nutritional supplementation and dietetic ***-six(65.7%)patients lost weight,with a mean weight loss of(4.73±3.91)kg,during *** 1 month after treatment,45(66.2%)patients lost weight,presenting a mean weight loss of(4.96±4.04)kg,corresponding to a(6.84±5.24)%net reduction from their baseline *** and neck cancer patients had a mean weight loss of(3.25±5.30)kg,whereas the remaining patients had a mean weight loss of(0.64±2.39)kg(P=0.028)during *** the multivariate analysis,the head and neck tumor location(P=0.005),use of chemotherapy(P=0.011),and ECOG PS score of 2-3(P=0.026)were considered independent risk *** status and parameters,such as tumor location(especially the head and neck),the use of chemotherapy,and the ECOG PS score,should be evaluated before radiotherapy because these factors can influence weight loss during radiotherapy and 1 month after treatment.

关键词：癌症患者放疗减肥头颈部肿瘤平均体重营养不良危险因素营养补充

Nutritional quality and physiological effects of halal meat:A pilot study in non-Muslim consumers

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Food Bioscience 2022年第5期49卷 738-745页

作者： cristina Carrasco Trinidad Perez-Palacios Luis Miguel Luengo Sergio gomez Miguel Fajardo María de los Angeles gomez Ana Beatriz Rodríguez Neuroimmunophysiology and Chrononutrition Research Group Department of Physiology(Faculty of Sciences)University of Extremadura06006BadajozSpain Research Institute of Meat and Meat Products(IProCar) University of Extremadura10003C´aceresSpain Service of Endocrinology and Nutrition University Hospital of Badajoz06006BadajozSpain Service of Clinical Analysis University Hospital of Badajoz06006BadajozSpain Service of Microbiology University Hospital of Badajoz06006BadajozSpain

Despite the current controversy,red meat remains essential to the proper functioning of our *** the trend meat products available for consumers,halal meat is becoming an interesting choice,independently of their religious ***,little is known about its nutritional content and possible health *** this reason,a comparative analysis of the physical-chemical and nutritional properties between halal and non-halal meats(beef and lamb)was ***,a pilot study was performed by University of Extremadura analysing the impact of its consumption on body composition,gut microbiota,biomarkers,and antioxidant *** healthier lipid profile founded in halal meat may have had a positive impact on the weight,muscle mass,body fat and antioxidant status of the participants,without altering the gut microbiota and levels of biomarkers such as glucose,insulin,or *** research can help meat consumers to choose healthier and more eco-friendly products.

关键词： Halal meat Lipid profile Body composition gut microbiota Antioxidant status Biomarkers

Sexual behavior and male volatile compounds in wild and mass-reared strains of the Mexican fruit fly Anastrepha ludens （Diptera： Tephritidae） held under different colony management regimes

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Insect Science 2016年第1期23卷 105-116页

作者： Carlos Felipe Bosa Leopoldo Cruz-Lopez cristina Silvia Zepeda-Cisneros Javier Valle-Mora Karina Guillen-navarro Pablo Liedo El Colegio de la Frontera Sur Carretera Antiguo Aeropuerto km 2.5 Chiapas 30700 Mexico Campana Nacional Moscas de laFruta Programa Moscafrut SAGARPA-IICA Metapa de Dominguez Chiapas Mexico

We compared the calling and mating behavior and volatile release of wild males Anastrepha ludens （Loew） with males from 4 mass-reared strains：（i） a stan- dard mass-reared colony （control）, （ii） a genetic sexing strain （Tap-7）, （iii） a colony started from males selected on their survival and mating competitiveness abilities （selected）, and （iv） a hybrid colony started by crossing wild males with control females. Selected and wild males were more competitive, achieving more matings under field cage conditions. Mass-reared strains showed higher percentages of pheromone calling males under field conditions except for Tap-7 males, which showed the highest percentages of pheromone calling males under laboratory cage conditions. For mature males of all strains, field-cage calling behavior increased during the last hour before sunset, with almost a 2 fold increase exhibited by wild males during the last half hour. The highest peak mating activity of the 4 mass-reared strains occurred 30 rain earlier than for wild males. By means of solid phase microextraction （SPME） plus gas chromatography-mass spectrometry （GC- MS）, the composition of volatiles released by males was analyzed and quantified, Wild males emitted significantly less amounts of （E,E）-α-farnesene but emitted significantly more amounts of （E,E）-suspensolide as they aged than mass-reared males. Within the 4 mass-reared strains, Tap-7 released significantly more amounts of （E,E）-α-farnesene and hybrid more of （E,E）-suspensolide. Differences in chemical composition could be ex- plained by the intrinsic characteristics of the strains and the colony management regimes. Characterization of calling behavior and age changes of volatile composition between wild and mass-reared strains could explain the differences in mating competitiveness and may be useful for optimizing the sterile insect technique in A. ludens.

关键词： age-dependent changes fruit fly mating pheromone

Review of laser diagnostics at the Vulcan laser facility

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High Power Laser Science and Engineering 2015年第3期3卷 3-12页

作者： Ian Musgrave Marco Galimberti Alexis Boyle cristina Hernandez-gomez Andrew Kidd Bryn Parry Dave Pepler Trevor Winstone John Collier Central Laser Facility Science and Technology Facilities CouncilRAL

In this paper we review the provision of the laser diagnostics that are installed on the Vulcan laser facility. We will present strategies for dealing with the energy of high energy systems and with ways of handling the beam sizes of the lasers. We present data captured during typical experimental campaigns to demonstrate their reliability and variation in shot to shot values.

关键词： calorimeter high power laser laser diagnostics pulse energy

Postural control quantification in minimally and moderately impaired persons with multiple sclerosis:The reliability of a posturographic test and its relationships with functional ability

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Journal of Sport and Health Science 2020年第6期9卷 677-684页

作者： David Barbado Ramon gomez-Illan Pedro Moreno-navarro Gregori Valero-Conesa Raul Reina Francisco J.Vera-Garcia Department of Sport Sciences Sports Research CentreMiguel Hern_andez University of ElcheElche(Alicante)03202Spain

Background:Postural control has been associated with the functional impairment in persons with multiple sclerosis(pwMS).However,there is a need for reliable methods to assess postural control in early stages of the disease,when subtle changes can be difficult to *** aims of this study were to assess the absolute and relative reliability of a standing and a sitting posturographic protocol in minimally(Expanded Disability Status Scale≤2)and moderately(2.5≤Expanded Disability Status Scale≤4)impaired pwMS,and to analyze relationships among postural control and functional mobility and gait ***:To assess postural control in an upright stance,14 minimally and 16 moderately impaired pwMS performed six 70 s trials in tandem stance,3 with their weaker leg behind(TSWL)and 3 with their stronger leg behind(TSSL).Additionally,participants completed five 70 s trials using an unstable sitting protocol(US)to assess trunk *** mean radial errors of TSWL,TSSL,and US trials were calculated as postural control ***,participants performed the Timed Up and Go test(TUG)and the Timed 25-foot Walk test(T25FW)to measure their functional mobility and gait speed,*** was evaluated using the intraclass correlation coefficient(ICC3,1)and the standard error of measurement(SEM).Analyses of variances were carried out to assess between-group ***’g index(dg)was used to estimate the effect size of *** correlation analyses(r)were performed to examine the relationships among the postural control and the functional ***:Posturographic tests showed a high reliability in both minimally(0.87≤ICC≤0.92;9.32%≤SEM≤11.76%)and moderately(0.80≤ICC≤0.92;10.33%≤SEM≤15.33%)impaired ***,T25FW and TUG displayed a high consistency in minimally(0.89≤ICC≤0.94;3.43%≤SEM≤5.17%)and moderately(0.85≤ICC≤0.93;5.57%≤SEM≤6.56%)impaired *** impaired pwMS showed a better performance on the TUG,T25FW

关键词： Balance Consistency of the assessment Core stability Functional mobility

Transanal endoscopic surgery in rectal cancer

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World Journal of Gastroenterology 2014年第33期20卷 11538-11545页

作者： Xavier Serra-Aracil Laura Mora-Lopez Manel Alcantara-Moral Aleidis Caro-Tarrago Carlos Javier gomez-Diaz Salvador navarro-Soto Coloproctology Unit General and Digestive Surgery Service Parc Tauli University Hospital Universitat Autònoma de Barcelona 08208 Sabadell (Barcelona) Spain

Total mesorectal excision(TME) is the standard treatment for rectal cancer, but complications are frequent and rates of morbidity, mortality and genitourinary alterations are high. Transanal endoscopic microsurgery(TEM) allows preservation of the anal sphincters and, via its vision system through a rectoscope, allows access to rectal tumors located as far as 20 cm from the anal verge. The capacity of local surgery to cure rectal cancer depends on the risk of lymph node invasion. This means that correct preoperative staging of the rectal tumor is necessary. Currently, local surgery is indicated for rectal adenomas and adenocarcinomas invading the submucosa, but not beyond(T1). Here we describe the standard technique for TEM, the different types of equipment used, and the technical limitations of this approach. TEM to remove rectal adenoma should be performed in the same way as if the lesion were an adenocarcinoma, due to the high percentageof infiltrating adenocarcinomas in these lesions. In spite of the generally good results with T1, some authors have published surprisingly high recurrence rates; this is due to the existence of two types of lesions, tumors with good and poor prognosis, divided according to histological and surgical factors. The standard treatment for rectal adenocarcinoma T2N0M0 is TME without adjuvant therapy. In this type of adenocarcinoma, local surgery obtains the best results when complete pathological response has been achieved with previous chemoradiotherapy. The results with chemoradiotherapy and TEM are encouraging, but the scientific evidence remains limited at present.

关键词： Rectal cancer Rectal adenocarcinoma Transanal endoscopic microsurgery Transanal endo-scopic surgery Colorectal cancer

Potential strategies offered by animals to implement in buildings' energy performance: Theory and practice

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Frontiers of Architectural Research 2019年第1期8卷 17-31页

作者： Cesar Martin-gomez Amaia Zuazua-Ros Javier Bermejo-Busto Enrique Baquero Rafael Miranda cristina Sanz Department of Building Construction Building Services and Structures Universidad de Navarra Pamplona 31009 Spain School of Sciences Department of Environmental Biology Universidad de Navarra Pamplona 31080 Spain

The strategies for thermal regulation and envir on mental control found in nature are countless. In this article, a parallelism between animals and building energy systems is defined in order to identJfy and emphasize the immediate opportunities that biomimicry offers for future research. The motivation was the need to find alternative solutions to tackle problems mainly in the efficiency of heating, ventilation and cooling systems. Due to the wide range of possibilities offered by animals, this study is largely limited to the strategies that cold-blooded animals have developed through evolutionary adaptation to the environment. The method used for the an a lysis is based on a soluti on-based approach. Firstly, differe nt animal thermoregulation strategies are defined (biological domain). Then the strategy is an a lyzed and classified into three categories. This classification is esse ntial in order to formulate the parallelism with building systems (transfer phase). The final step is to identify the potential implementation (technological domain).This approach has been seen to be useful in creating new research opportunities based on biomimicry. In addition, suitable solutions arising from multidisciplinary team research are presented as promising answers to the challenges that building energy systems face no wadays.

关键词： Biomimicry Building services Energy systems Passive design Multidisciplinary