检索结果-南通市图书馆

Serum biomarkers for the differentiation of autoimmune pancreatitis from pancreatic ductal adenocarcinoma

World Journal of Gastrointestinal Oncology 2023年第2期15卷 268-275页

作者： Octavio Caba Carmelo Diéguez-Castillo Joaquina Martínez-Galán Irene González-Cebrián cristina Jiménez-Luna Institute of Biopathology and Regenerative Medicine(IBIMER) University of GranadaGranada 18016Spain Biosanitary Institute of Granada(ibs.GRANADA) 18014 GranadaSpain Department of Gastroenterology San Cecilio University HospitalGranada 18016Spain Department of Medical Oncology Virgen de las Nieves University HospitalGranada 18014Spain.Biosanitary Institute of Granada(ibs.GRANADA)18014 GranadaSpain Department of Digestive Cancer San Cecilio University HospitalGranada 18016Spain

Autoimmune pancreatitis(AIP),a chronic inflammation caused by the immune system attacking the pancreas,usually presents imaging and clinical features that overlap with those of pancreatic ductal adenocarcinoma(PDAC).Serum biomarkers,substances that quantitatively change in sera during disease development,are a promising non-invasive tool with high utility for differentiating between these *** this way,the presence of AIP is currently suspected when serum concentrations of immunoglobulin G4(IgG4)antibody are ***,this approach has some ***,IgG4 antibody concentrations are also elevated in sera from some patients with *** review focuses on the most recent and relevant serum biomarkers proposed to differentiate between AIP and PDAC,evaluating the usefulness of immunoglobulins,autoantibodies,chemokines,and *** proposed serum biomarkers have proven useful,although most studies had a small sample size,did not examine their presence in patients with PDAC,or did not test them in *** addition,current evidence suggests that a single serum biomarker is unlikely to accurately differentiate these diseases and that a set of biomarkers will be needed to achieve adequate specificity and sensitivity,either alone or in combination with clinical data and/or radiological images.

关键词： Autoimmune pancreatitis Pancreatic ductal adenocarcinoma Serum Biomarkers Differentiation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Adding vortexing to the Maki technique provides no benefit for the diagnosis of catheter colonization or catheter-related bacteremia

引用

World Journal of Critical Care Medicine 2024年第1期13卷 58-64页

作者： Leonardo Lorente Maria Lecuona Fernandez Adriana González-Mesa Judith Oliveras-Roura cristina Rosado Pablo Cabrera Emma Casal Alejandro Jiménez María Luisa Mora Ana Madueño Intensive Care Unit Hospital Universitario de CanariasLa Laguna 38320Spain Microbiology and Infection Control Service Hospital Universitario de CanariasLa Laguna 38320Spain Research Unit Hospital Universitario de CanariasLa Laguna 38320Spain

BACKGROUND A previous study compared vortexing and Maki techniques for the diagnosis of catheter-related bloodstream infection(CRBSI),and concluded that vortexing was not superior to Maki *** To determine whether the combined use of vortexing and Maki techniques provides profitability versus the Maki technique for the diagnosis of catheter tip colonization(CTC)and *** Observational and prospective study carried out in an Intensive Care *** with suspected catheter-related infection(CRI)and with one central venous catheter for at least 7 days were *** area under the curve(AUC)of the Maki technique,the vortexing technique and the combination of both techniques for the diagnosis of CTC and CRBSI were *** We included 136 episodes of suspected *** found 21 cases of CTC of which 10 were also CRBSI *** the 21 CTC episodes,18(85.7%)were diagnosed by Maki technique and vortexing technique,3(14.3%)only by the technique of Maki,and none only by technique of *** the 10 CRBSI episodes,9(90.0%)were diagnosed by the techniques of Maki and vortexing,1(10.0%)was diagnosed only by the technique of Maki,and none only by the technique of *** no found differences in the comparison of AUC between the technique of Maki and the combination of Maki and vortexing techniques for the diagnosis of CTC(P=0.99)and CRBSI(P=0.99).CONCLUSION The novel finding of our study was that the combined use of vortexing and Maki techniques did not provide profitability to the technique of Maki alone to CRBSI diagnosis of.

关键词： Vortexing Maki Bloodstream infection Colonization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

用Lewis酸或Brnsted酸催化剂和N_2汽提法使木糖脱水为糠醛(英文)

引用

催化学报 2013年第7期34卷 1402-1406页

作者： Iker AGIRREZABAL-TELLERIA cristina garcíA-SANCHO Pedro MAIRELES-TORRES Pedro Luis ARIAS Department of Chemical and Environmental Engineering Engineering School University of the Basque Country (EHU/UPV) Alameda Urquijo s/n48013 Bilbao Spain Department of Inorganic Chemistry Cristallography and Mineralogy (Unit Associated to ICP-CSIC) Science Faculty University of Mdlaga Campus Teatinos s/n 29071 M61aga Spain

The activity of Lewis (Nb2O5) and Br nsted (Amberlyst 70) acid catalysts for the cyclodehydration of xylose to furfural was studied. The nature of the acidity resulted in significant changes in the reaction mechanism. Lewis acid sites promote the formation of xylulose, while Br nsted acid sites are required to further dehydrate the sugar to furfural. Amberlyst 70 in water/toluene at 175 ℃ showed lower activity but gave a higher furfural yield. Using N2 as the stripping agent considerably improved the furfural yield and product purity in the stripped stream. Catalyst stability was also studied.

关键词：环化脱水酸催化剂刘易斯糠醛木糖 Br 氮气大孔树脂

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

New perspectives in the management of small cell lung cancer

引用

World Journal of Clinical Oncology 2022年第6期13卷 429-447页

作者： cristina Pangua Jacobo Rogado Gloria Serrano-Montero JoséBelda-Sanchís BeatrizÁlvarez rodríguez Laura Torrado Nuria rodríguez De Dios Xabier Mielgo-Rubio Juan Carlos Trujillo Felipe Couñago Department of Medical Oncology Hospital Universitario Infanta LeonorMadrid 28031Spain Department of Thoracic Surgery Hospital de la Santa Creu i Sant Pau&Hospital de MarUniversitat Autònoma de BarcelonaBarcelona 08041CataloniaSpain Department of Radiation Oncology Hospital Universitario HM SanchinarroHM HospitalesHM CIOCC Centro Integral Oncológico Clara CampalMadrid 28050Spain Department of Radiation Oncology Hospital Universitario Lucus Augusti&Instituto de Investigación Sanitaria Santiago de Compostela(IDIS)Lugo 27003Spain Department of Radiation Oncology Hospital Del Mar&Hospital Del Mar Medical Research Institute(IMIM)&Pompeu Fabra UniversityBarcelona 08003CataloniaSpain Department of Medical Oncology Alcorcón Foundation University HospitalAlcorcón 28922MadridSpain Department of Thoracic Surgery Hospital de la Santa Creu i Sant PauBarcelona 08029Spain Department of Radiation Oncology Hospital Universitario Quirónsalud MadridHospital La LuzUniversidad Europea de MadridMadrid 28223Spain

The treatment of small cell lung cancer(SCLC)is a challenge for all specialists *** treatments have been added to the therapeutic armamentarium in recent months,but efforts must continue to improve both survival and quality of *** in surgery and radiotherapy have resulted in prolonged survival times and fewer complications,while more careful patient selection has led to increased staging *** in the field of systemic therapy have resulted in changes to clinical guidelines and the management of patients with advanced disease,mainly with the introduction of *** this article,we describe recent improvements in the management of patients with SCLC,review current treatments,and discuss future lines of research.

关键词： Small cell lung cancer Whole-brain radiotherapy Prophylactic cranial irradiation Stereotactic body radiotherapy Immunotherapy Atezolizumab Durvalumab

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mechanical characterization and induced crystallization in nanocomposites of thermoplastics and carbon nanotubes

引用

npj Computational Materials 2020年第1期6卷 413-423页

作者： Eduardo R.Cruz-Chú Gonzalo J.Villegas-rodríguez Tobias Jäger Luca Valentini Nicola M.Pugno Konstantinos Gkagkas Frauke Gräter Laboratorios de Investigación y Desarrollo Facultad de Ciencias y FilosofíaUniversidad Peruana Cayetano HerediaLimaPeru Molecular Biomechanics Group Heidelberg Institute for Theoretical StudiesHeidelbergGermany Civil and Environmental Engineering Department University of Perugia and INSTM Research UnitTerniItaly Laboratory of Bio-inspired BionicNanoMeta Materials MechanicsUniversity of TrentoTrentoItaly School of Engineering and Materials Science Queen Mary University of LondonLondonUK Advanced Technology Group Toyota Motor EuropeZaventemBelgium Interdisciplinary Center for Scientific Computing(IWR) Heidelberg UniversityHeidelbergGermany

Nanocomposites built from polymers and carbon nanotubes(CNTs)are a promising class of *** modeling can provide nanoscale views of the polymer–CNT interface,which are much needed to foster the manufacturing and development of such ***,setting up periodic nanocomposite models is a challenging *** we propose a computational workflow based on Molecular Dynamics simulations.

关键词： materials composites crystallization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The role of radiotherapy in the treatment of oral cavity cancer

引用

Plastic and Aesthetic Research 2016年第1期3卷 158-166页

作者： Joaquín J.Cabrera-rodríguez Department of Radiation Oncology University Hospital Infanta Cristina06080 BadajozSpain

Radiotherapy plays a critical role in the treatment of oral cavity squamous cell carcinoma as monotherapy in early stage cancer or combined with surgery and/or chemotherapy in advances *** developments in the imaging of cancer and radiation technology have allowed developing more precise delivery of treatment with recent data demonstrating improvement in survival and lessening of adverse toxics effects of *** review will focus in the recent advances and current state-of-the-art in radiation oncology both external beam radiotherapy and *** complexity of cancer treatments increases a close coordination between head-neck surgeons and radiation oncologist is needed due to a significant proportion of patients will be treated with combined modality therapy.

关键词： Radiotherapy intensity modulated radiation therapy high dose rate low dose rate head neck cancer brachytherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Conservation and variability of hepatitis B core at different chronic hepatitis stages

引用

World Journal of Gastroenterology 2020年第20期26卷 2584-2598页

作者： Marcal Yll Maria Francesca Cortese Mercedes Guerrero-Murillo Gerard Orriols Josep Gregori Rosario Casillas Carolina González Sara Sopena cristina Godoy Marta Vila David Tabernero Josep Quer Ariadna Rando Rosa Lopez-Martinez Rafael Esteban Mar Riveiro-Barciela Maria Buti Francisco rodríguez-Frías Liver Pathology Unit Departments of Biochemistry and MicrobiologyHospital Universitari Vall d'HebronUniversitat Autònoma de BarcelonaBarcelona 08035Spain Liver Unit Liver Disease Laboratory-Viral HepatitisVall d'Hebron Institut Recerca-Hospital Universitari Vall d'HebronUniversitat Autònoma de BarcelonaBarcelona 08035Spain Department of Microbiology Hospital Universitari Vall d'HebronUniversitat Autònoma de BarcelonaBarcelona 08035Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas Instituto de Salud Carlos ⅢMadrid 28029Spain Liver Unit Department of Internal MedicineHospital Universitari Vall d'HebronUniversitat Autónoma de BarcelonaBarcelona 08035Spain

BACKGROUND Since it is currently not possible to eradicate hepatitis B virus(HBV)infection with existing treatments,research continues to uncover new therapeutic *** core protein,encoded by the HBV core gene(HBC),intervenes in both structural and functional processes,and is a key protein in the HBV life *** this reason,both the protein and the gene could be valuable targets for new therapeutic and diagnostic ***,alterations in the protein sequence could serve as potential markers of disease *** To detect,by next-generation sequencing,HBC hyper-conserved regions that could potentially be prognostic factors and targets for new *** Thirty-eight of 45 patients with chronic HBV initially selected were included and grouped according to liver disease stage[chronic hepatitis B infection without liver damage(CHB,n=16),liver cirrhosis(LC,n=5),and hepatocellular carcinoma(HCC,n=17)].HBV DNA was extracted from patients’plasma.A region between nucleotide(nt)1863 and 2483,which includes HBC,was amplified and analyzed by next-generation sequencing(Illumina Mi Seq platform).Sequences were genotyped by distance-based discriminant *** and intergroup nt and amino acid(aa)conservation was determined by sliding window *** presence of nt insertion and deletions and/or aa substitutions in the different groups was determined by aligning the sequences with genotype-specific consensus *** Three nt(nt 1900-1929,2249-2284,2364-2398)and 2 aa(aa 117-120,159-167)hyper-conserved regions were shared by all the clinical *** groups showed a similar pattern of conservation,except for five nt regions(nt 1946-1992,2060-2095,2145-2175,2230-2250,2270-2293)and one aa region(aa 140-160),where CHB and LC,respectively,were less conserved(P<0.05).Some group-specific conserved regions were also observed at both nt(2306-2334 in CHB and 1935-1976 and 2402-2435 in LC)and aa(between aa 98-103 in CHB and 28-30 and 5

关键词： Hepatitis B virus Hepatitis B core gene Next-generation sequencing Genetic conservation Amino acid substitution Gene therapy Small interfering RNA

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Safety and visual outcomes following posterior chamber phakic intraocular lens bilensectomy

引用

Eye and Vision 2020年第1期7卷 328-335页

作者： Veronica Vargas Jorge L.Alió Rafael I.Barraquer Justin Christopher D’Antin cristina garcía Francisco Duch Joan Balgos Jorge LAliódel Barrio Vissum Instituto Oftalmológico de Alicante AlicanteSpain Division of Ophthalmology Universidad Miguel HernándezAlicanteSpain Institut Universitari Barraquer Universitat Autònoma de BarcelonaBarcelonaSpain Centro de Oftalmología Barraquer BarcelonaSpain Universitat Internacional de Catalunya BarcelonaSpain Clínica Real Vision MadridSpain Instituto Catalán de Retina(ICR)unidad de Cirugía Refractiva BarcelonaSpain

Background:To evaluate the safety,efficacy,refractive outcomes and causes for bilensectomy(phakic intraocular lens–pIOL–explantation with cataract surgery and pseudophakic intraocular lens implantation)in patients previously implanted with posterior chamber ***:This multi-center retrospective study included 87 eyes of 55 patients who underwent bilensectomy for posterior chamber pIOL with a follow up time of 12 *** uncorrected and best corrected distance visual acuities(UDVA,CDVA),endothelial cell density before and after bilensectomy were assessed,as well as the cause of bilensectomy and intra or postoperative ***:There was a statistically significant improvement in uncorrected and best corrected visual acuities after bilensectomy(p=0.00).The main reason for bilensectomy was cataract development(93.1%of the cases),followed by miscalculation of lens size,and corneal *** endothelial cell count remained stable without a statistically significant change after surgery(p=0.67).The refractive efficacy index was 0.8,none of the patients lost lines of CDVA after surgery,73%of the patients were within±1 D(spherical equivalent)of the target *** complications were one posterior capsule rupture with the intraocular lens(IOL)implanted in the sulcus,and 3 eyes required the use of pupil expanders for adequate pupil ***,one eye developed retinal *** three pIOLs models explanted were the Implantable Collamer Lens(ICL),Implantable Phakic Contact Lens(IPCL)and the Phakic Refractive Lens(PRL).Conclusions:Good safety and visual outcomes were observed 1 year after bilensectomy for posterior chamber phakic intraocular lenses(PC pIOLs).There were few intra and postoperative complications and there was no significant endothelial cell loss after the bilensectomy procedure.

关键词： Bilensectomy Posterior chamber phakic intraocular lenses Cataract Endothelial cell count Visual outcomes Postoperative complications Intraoperative complications

来源：

维普期刊数据库

维普期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Characterization of hepatitis B virus X gene quasispecies complexity in mono-infection and hepatitis delta virus superinfection

引用

World Journal of Gastroenterology 2019年第13期25卷 1566-1579页

作者： cristina Godoy David Tabernero Sara Sopena Josep Gregori Maria Francesca Cortese Carolina González Rosario Casillas Mar?al Yll Ariadna Rando Rosa López-Martínez Josep Quer Gloria González-Aseguinolaza Rafael Esteban Mar Riveiro-Barciela Maria Buti Francisco rodríguez-Frías Liver Pathology Unit Departments of Biochemistry and Microbiology Hospital Universitari Vall d’Hebron Universitat Autònoma de Barcelona Liver Unit Liver Disease Laboratory-Viral Hepatitis Vall d’Hebron Institut Recerca-Hospital Universitari Vall d'Hebron Universitat Autònoma de Barcelona Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd) Instituto de Salud Carlos Ⅲ Roche Diagnostics SL Centro de Investigación Médica Aplicada (CIMA) Universidad de Navarra Liver Unit Department of Internal MedicineHospital Universitari Vall d’Hebron Universitat Autònoma de Barcelona (UAB)

Hepatitis delta virus(HDV) seems to strongly suppress hepatitis B virus(HBV)replication, although little is known about the mechanism of this interaction. Both these viruses show a dynamic distribution of mutants, resulting in viral quasispecies. Next-generation sequencing is a viable approach for analyzing the composition of these mutant spectra. As the regulatory hepatitis B X protein(HBx) is essential for HBV replication, determination of HBV X gene(HBX)quasispecies complexity in HBV/HDV infection compared to HBV monoinfection may provide information on the interactions between these two *** To compare HBV quasispecies complexity in the HBX 5' region between chronic hepatitis delta(CHD) and chronic HBV mono-infected *** Twenty-four untreated patients were included: 7/24(29.2%) with HBeAgnegative chronic HBV infection(CI, previously termed inactive carriers), 8/24(33.3%) with HBeAg-negative chronic hepatitis B(CHB) and 9/24(37.5%) with CHD. A serum sample from each patient was first tested for HBV DNA *** HBX 5' region [nucleotides(nt) 1255-1611] was then PCR-amplified for subsequent next-generation sequencing(MiSeq, Illumina, United States). HBV quasispecies complexity in the region analyzed was evaluated using incidencebased indices(number of haplotypes and number of mutations), abundancebased indices(Hill numbers of order 1 and 2), and functional indices(mutation frequency and nucleotide diversity). We also evaluated the pattern of nucleotide changes to investigate which of them could be the cause of the quasispecies *** CHB patients showed higher median HBV-DNA levels [5.4 logIU/mL,interquartile range(IQR) 3.5-7.9] than CHD(3.4 logIU/mL, IQR 3-7.6)(P = n.s.)or CI(3.2 logIU/mL, IQR 2.3-3.5)(P < 0.01) patients. The incidence and abundance indices indicated that HBV quasispecies complexity was significantly greater in CI than CHB. A similar trend was observed in CHD patients, although only Hill numbers of order 2 showed

关键词： Hepatitis B virus Hepatitis delta virus Hepatitis B X gene Next-generation sequencing Viral quasispecies Hepatitis B virus-hepatitis delta virus interaction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Uncovering the multifaceted roles played by neutrophils in allogeneic hematopoietic stem cell transplantation

引用

Cellular & Molecular Immunology 2021年第4期18卷 905-918页

作者： cristina Tecchio Marco Antonio Cassatella Department of Medicine Section of Hem atology and Bone Marrow Transplant UnitUniversity of VeronaVeronaItaly Department of Medicine Section of General PathologyUniversity of VeronaVeronaItaly

Allogeneic hematopoietic stem cell transplantation(alloHSCT)is a life-saving procedure used for the treatment of selected hematological malignancies,inborn errors of metabolism,and bone marrow *** role of neutrophils in alloHSCT has been traditionally evaluated only in the context of their ability to act as a first line of defense against ***,recent evidence has highlighted neutrophils as key effectors of innate and adaptive immune responses through a wide array of newly discovered ***,neutrophils are emerging as highly versatile cells that are able to acquire different,often opposite,functional capacities depending on the microenvironment and their differentiation ***,we review the current knowledge on the multiple functions that neutrophils exhibit through the different stages of alloHSCT,from the hematopoietic stem cell(HSC)mobilization in the donor to the immunological reconstitution that occurs in the recipient following HSC *** also discuss the influence exerted on neutrophils by the immunosuppressive drugs delivered in the course of alloHSCT as part of graft-versushost disease(GVHD)***,the potential involvement of neutrophils in alloHSCT-related complications,such as transplant-associated thrombotic microangiopathy(TA-TMA),acute and chronic GVHD,and cytomegalovirus(CMV)reactivation,is also *** on the data reviewed herein,the role played by neutrophils in alloHSCT is far greater than a simple antimicrobial ***,much remains to be investigated in terms of the potential functions that neutrophils might exert during a highly complex procedure such as alloHSCT.

关键词： neutrophils allogeneic hematopoietic stem cell transplantation(alloHSCT) alloHSCT-associated complications lowdensity neutrophils(LDNs) normal-density neutrophils(NDNs)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：