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α-Synuclein oligomers and fibrils:partners in crime in synucleinopathies

Neural Regeneration Research 2023年第11期18卷 2332-2342页

作者： Alessandra Bigi Roberta Cascella cristina cecchi Department of Experimental and Clinical Biomedical Sciences Section of BiochemistryUniversity of FlorenceFlorenceItaly

The misfolding and aggregation of a-synuclein is the general hallmark of a group of devastating neurodegenerative pathologies referred to as synucleinopathies,such as Parkinson’s disease,dementia with Lewy bodies,and multiple system atrophy.In such conditions,a range of different misfolded aggregates,including oligomers,protofibrils,and fibrils,are present both in neurons and glial cells.Growing expe rimental evidence supports the proposition that solu ble oligomeric assemblies,formed during the early phases of the aggregation process,are the major culprits of neuronal toxicity;at the same time,fibrillar confo rmers appear to be the most efficient at propagating among interconnected neurons,thus contributing to the spreading ofα-synuclein pathology.Moreover,α-synuclein fibrils have been recently repo rted to release soluble and highly toxic oligomeric species,responsible for an immediate dysfunction in the recipient neurons.In this review,we discuss the current knowledge about the plethora of mechanisms of cellular dysfunction caused byα-synuclein oligome rs and fibrils,both contributing to neurodegeneration in synucleinopathies.

关键词： amyloid aggregation neurodegeneration Parkinson’s disease protein aggregation protein misfolding

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Hemodynamic changes acutely determined by primary PCI in STEMI patients evaluated with a minimally invasive method

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World Journal of Cardiovascular Diseases 2013年第4期3卷 69-72页

作者： cristina Giglioli Omar Tujjar Emanuele cecchi Daniele Landi Marco Chiostri Serafina Valente Giorgio Jacopo Baldereschi Francesco Meucci Gian Franco Gensini Salvatore Mario Romano Department of Critical Care and Surgery Unit of Internal Medicine and Cardiology University of Florence Italy Department of Heart and Vessels Azienda Ospedaliero-Universitaria Careggi Florence Italy

Objective: Few studies are available on the hemodynamic changes acutely determined by Primary Percutaneous Coronary Intervention (PCI) in ST-Elevation Myocardial Infarction (STEMI) patients, probably for the difficult evaluation of hemodynamic variables in this acute setting. Therefore, the paper is to evaluate the variations of several hemodynamic parameters determined by PCI using PRAM (Pressure Recording Analytical Method), minimally invasive hemodynamic monitoring. Methods: We analyzed in 20 STEMI patients submitted to PCI several hemodynamic variables, assessed with PRAM from radial/ femoral artery, 3-minute before PCI and at endprocedure. Variables measures were: systolic, diastolic, dicrotic and mean arterial pressures;heart rate (HR);stroke volume (SV);systemic vascular resistance (SVR);dP/dtmax;cardiac cycle efficiency (CCE). Results: In our patients HR, SVR and dP/dtmax decreased significantly (85 ± 6.3 to 77 ± 4.5, p = 0.002;1738 ± 241 to 1450 ± 253, p = 0.022;1.22 ± 0.11 to 1.11 ± 0.12, p = 0.007, respectively) while CCE and SV increased significantly (?0.25 ± 0.23 to ?0.01 ± 0.12,

关键词： STEMI Primary PCI Hemodynamic Monitoring Cardiac Output

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