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Giardia infection:Protein-losing enteropathy in an adult with immunodeficiency

World Journal of Gastroenterology 2012年第19期18卷 2430-2433页

作者： Alexandre Khodr Furtado Virginia Lucia Ribeiro Cabral Thiago Nunes Santos Eli Mansour cristiane kibune nagasako Sonia Leticia Lorena Rogerio Antunes Pereira-Filho Faculdade de Ciências Médicas Universidade de Campinas-UnicampRua Tessália Vieira de Camargo126Cidade Universitária "Zeferino Vaz"13083-887 CampinasBrazil

The case of a 52-year-old woman with a past history of thymoma resection who presented with chronic diarrhea and generalized edema is the focal point of this article.A diagnosis of Giardia lamblia infection was established,which was complicated by protein-losing enteropathy and severely low serum protein level in a patient with no urinary protein loss and normal liver *** anti-helmintic treatment,there was recovery from hypoalbuminemia,though immunoglobulins persisted at low serum levels leading to the hypothesis of an immune system ***'s syndrome is a rare cause of immunodeficiency characterized by the association of hypogammaglobulinemia and *** primary immune disorder may be complicated by severe infectious diarrhea secondary to disabled humoral and cellular immune *** is the first description in the literature of an adult patient with an immunodeficiency syndrome who presented with protein-losing enteropathy secondary to giardiasis.

关键词： Chronic diarrhea Giardiasis Protein-losingenteropathy Immunodeficiency

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Assessment of disease activity in inflammatory bowel diseases:Non-invasive biomarkers and endoscopic scores

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World Journal of Gastrointestinal Endoscopy 2020年第12期12卷 504-520页

作者： Bruno Lima Rodrigues Marcia Carolina Mazzaro cristiane kibune nagasako Maria de Lourdes SetsukoAyrizono Joao Jose Fagundes Raquel Franco Leal Inflammatory Bowel Disease Research Laboratory GastrocenterColorectal Surgery UnitDepartment of SurgerySchool of Medical SciencesUniversity of Campinas(UNICAMP)Campinas 13083-878São PauloBrazil Department of Gastroenterology GastrocenterSchool of Medical SciencesUniversity of Campinas(UNICAMP)Campinas 13083-878Sao PauloBrazil

Inflammatory bowel diseases(IBD)comprise two major forms:Crohn’s disease and ulcerative *** diagnosis of IBD is based on clinical symptoms combined with results found in endoscopic and radiological *** addition,the discovery of biomarkers has significantly improved the diagnosis and management of *** potential genetic,serological,fecal,microbial,histological and immunological biomarkers have been proposed for IBD,and they have been evaluated for clinical routine and clinical ***,especially with biopsy collection,has been considered the standard method to diagnose IBD and to assess clinical activity of the disease,but it is limited to the colon and terminal ileum and is considered *** this reason,non-invasive biomarkers are necessary for this type of chronic inflammatory disease,which affects mostly young individuals,as they are expected to have a long follow-up.

关键词： Inflammatory bowel diseases Biomarkers Endoscopic scores Crohn's disease Ulcerative colitis Inflammation

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