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Cell-free therapy:a neuroregenerative approach to sensory neuropathy?

Neural Regeneration Research 2019年第8期14卷 1383-1384页

作者： Afranio Ferreira Evangelista Milena Botelho Pereira Soares cristiane flora villarreal Instituto Gongalo Moniz Fundacao Oswaldo Cruz Salvador BA Brazil Faculdade de Farmacia Universidade Federal da Bahia Salvador BA Brazil

Stem cells are considered as key therapeutic tools in the field of regenerative medicine. In the last decade, based on a growing body of knowledge about their mechanisms of action, a new way of exploring the therapeutic potential of stem cells without the need for cell transplantation has been evidenced. This approach, called cell-free therapy, uses stem cells as a source of therapeutic molecules rather than the therapeutic agent per se, and several studies have shown relevant therapeutic effects under a variety of experimental conditions, including nervous system disorders.

关键词： Cell-free therapy neuroregenerative approach sensory neuropathy

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Multi-resistant bacteria in spontaneous bacterial peritonitis: A new step in management?

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World Journal of Gastroenterology 2014年第39期20卷 14079-14086页

作者： Angelo Alves de Mattos Ane Micheli Costabeber Livia Caprara Lion?o cristiane Valle Tovo Department of Gastroenterology Universidade Federal de Ciências da Saúde de Porto Alegre Porto Alegre 90430-080 Brasil

Spontaneous bacterial peritonitis(SBP) is the most typical infection observed in cirrhosis patients. SBP is responsible for an in-hospital mortality rate of approximately 32%. Recently, pattern changes in the bacterial flora of cirrhosis patients have been observed, and an increase in the prevalence of infections caused by multi-resistant bacteria has been noted. The wide-scale use of quinolones in the prophylaxis of SBP has promoted flora modifications and resulted in the development of bacterial resistance. The efficacy of traditionally recommended therapy has been low in nosocomial infections(up to 40%), and multi-resistance has been observed in up to 22% of isolated germs in nosocomial SBP. For this reason, the use of a broad empirical spectrum antibiotic has been suggested in these situations. The distinction between community-acquired infectious episodes, healthcare-associated infections, or nosocomial infections, and the identification of risk factors for multi-resistant germs can aid in the decision-making process regarding the empirical choice of antibiotic therapy. Broad-spectrum antimicrobial agents, such as carbapenems with or without glycopeptides or piperacillin-tazobactam, should be considered for the initial treatment not only of nosocomial infections but also of healthcare-associated infections when the risk factors or severity signs for multi-resistant bacteria are apparent. The use of cephalosporins should be restricted to community-acquired infections.

关键词： Spontaneous peritonitis Multi-resistant bacteria Cirrhosis Infection Ascites

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