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International Journal of Clinical Medicine 2014年第9期5卷 507-513页

作者： Natania Florentino Diniz1] Evelim Leal de Freitas Dantas Gomes1] cristiane aparecida moran1] Silvana Alves Pereira1] Livia Maria de Andrade Martins1] Luciana Carnevalli Pereira1] Universidade Nove de Julho(UNINOVE) Sao PauloBrazil 2Universidade Federal do Rio Grande do Norte(UFRN/FACISA)Santa CruzBrazil

Objectives: To evaluate the effect of manual chest compression (MCC) in the variables of oxygenation, hemodynamic and respiratory effeteness in infants suffering from respiratory diseases with atelectasis. Methods: Controlled clinical trial, in which 38 infants were evaluated,19 ineach study group (group A: atelectasis and group B: control). Data were measured before, immediately after and 10 minutes after the end of the technique’s application. Results: The average age was of 5.05 months. There was an increase of RR in group A immediately after the application of the technique and signs of respiratory distress with a decrease in the oxygen saturation. Conclusion: There was a reduction in SpO2, an increase of RR and a worsening of clinical signs of respiratory distress. Given this, one may consider that there is a controversy about the benefits, mechanism of action, physiological and therapeutic effects of MCC when applied to infants.

关键词： Pulmonary Atelectasis Physiotherapy Modality Respiratory Therapy Infant Infant Care Clinical Trials

Orientation Program on the Care of Children Tracheostomized in the Home Environment

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World Journal of Neuroscience 2014年第5期4卷 421-426页

作者： cristiane aparecida moran Natalia Henrique de Almeida Silvana Alves Pereira Nove de Julho University Sao Paulo Brazil Ana Bezerra Hospital Federal University of Rio Grande do Norte and EBSERH Rio Grande do Norte Brazil

Objective: The aim of the study was to make a literature review on counseling and family education about the care with tracheostomy and develop a guidance booklet for parents about the cautions in handling tracheostomy tubes at home. Methods: This research is based on literature review from 1992 to 2012, realized from October of 2011 to August 2012, through the following databases: medline, lilacs, scielo and sibinet USP, with the elaboration of a guidance booklet for parents, about home care of tracheostomized children. Results: We elaborated a guidance booklet for parents, about the care of tracheostomized children and all were described according to literature review. Conclusion: According to the literature review family education in the care of tracheostomized children is essential so that caregivers have full autonomy to safely and effectively conduct the necessary techniques in their homes.

关键词： Tracheostomy Newborn Child Care Home Care Services

Incidence of hepatocellular carcinoma in outpatients with cirrhosis in Brazil: A 10-year retrospective cohort study

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World Journal of Gastroenterology 2016年第46期22卷 10219-10225页

作者： Marcelo Campos Appel-da-Silva Suelen aparecida da Silva Miozzo Isabella de Azevedo Dossin cristiane Valle Tovo Fernanda Branco Angelo Alves de Mattos Graduate Program:Hepatology Universidade Federal de Ciências da Saúde de Porto Alegre(UFCSPA)Porto AlegreRS 900150-170Brazil Ultrasound Imaging Servince Hospital Santa Casa de Porto AlegrePorto AlegreRS 90050-170Brazil

AIM To determine the incidence of hepatocellular carcinoma(HCC) and the impact of HCC surveillance on early diagnosis and survival of cirrhotic outpatients. METHODS In this retrospective cohort study, cirrhotic outpatients undergoing HCC surveillance between March 2005 and March 2014 were analyzed. Exclusion criteria were HIV coinfection; previous organ transplantation; diagnosis of HCC at first consultation; missing data in the medical chart; and less than 1 year of follow-up. Surveillance was carried out every six months using ultrasound and serum alpha-fetoprotein determination. Ten-year cumulative incidence and survival were estimated through Kaplan-Meier analysis. RESULTS Four hundred and fifty-three patients were enrolled, of which 57.6% were male. Mean age was 55 years. Hepatitis C virus and heavy use of alcohol were the main etiologic agents of cirrhosis. HCC was diagnosed in 75 patients(16.6%), with an estimated cumulative incidence of 2.6% in the 1st year, 15.4% in the 5th year, and 28.8% in the 10 th year. Median survival was estimated at 17.6 mo in HCC patients compared to 234 mo in non-HCC patients(P 1). Early-stage HCC was more often detected in patients who underwent surveillance every 6 mo or less(P = 0.05). However, survival was not different between patients with early stage vs non-early stage tumors [HR = 0.54(0.15-1.89), P = 0.33].CONCLUSION HCC is a frequent complication in patients with cirrhosis and adherence to surveillance programs favors early diagnosis.

关键词： Liver cirrhosis Hepatocellular carcinoma Epidemiology Surveillance Survival

Income Diversification through a Crop-Livestock-Forest Integration System in the Midwest Brazilian Region

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Journal of Agricultural Science and Technology(B) 2017年第6期7卷 374-385页

作者： Clarisse Maia Lana Nicoli Abilio Rodrigues Pacheco cristiane aparecida Fioravante Reis FabioVenturoli Embrapa Produtos e Mercado Rodovia BR-153 Km 4 Caixa Postal 714 Goidnia 74001-970 Goias Brazil Embrapa Florestas Estrada da Ribeira Km 111 Caixa Postal 319 Colombo 83411-000 Parana Brazil Universidade Federal de Goids Avenida Esperanga s/n Campus Samambaia Goidnia 74690-900 Goias Brazil

Sustainability on farms is a challenge to competitiveness in the globalized market. In this scenario, due to the strong environmental, economic and social appeal, crop-livestock-forest integration systems have been considered as the future of agriculture. Regarding the economic approach, this system is based on the diversification of income generating activities, with revenue entry at different times, rationalization of resource use and reduction of risk of financial losses. Thus, the purpose of this work was to carry out the economic analysis of a crop-livestock-forest integration system, located at Boa Vereda＇s farm, in the municipality of Cachoeira Dourada in the state of Goi^is in the central-west region of Brazil. The system was composed of the following traditional crops of the region： soybean, corn, pasture, beef cattle and eucalyptus. The technical coefficients and the prices used for economic evaluation were obtained from the experimental unit and from the local market when crops were harvested in 2016/2017. The economic indicators used to assess economic viability were the net present value （NPV） and the equivalent annual uniform value （EAUV）. The results showed a return greater than the opportunity cost of the land, showing the attractiveness of the crop-livestock-forest integration system. Thus, this system represents an economically viable alternative that, among other benefits, allows the diversification of its sources of income, with a reduction of risk.

关键词： Agroforestry system economic analysis soybean corn beef cattle eucalyptus.

Clinical implications of single cell sequencing for bladder cancer

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Oncology Research 2024年第4期32卷 597-605页

作者： REZA YADOLLAHVANDMIANDOAB MEHRSA JALALIZADEH FRANCIELE aparecida VECHIA DIONATO KEINI BUOSI PATRÍCIA A.F.LEME LUCIANA S.B.DAL COL cristiane F.GIACOMELLI ALEX DIAS ASSIS NASIM BASHIRICHELKASARI LEONARDO OLIVEIRA REIS UroScience School of Medical SciencesUniversity of CampinasUNICAMPCampinasSao Paulo13083-872Brazil ImmunOncology Pontifical Catholic University of CampinasPUC-CampinasCampinasSao Paulo13087-571Brazil

Bladder cancer(BC)is the 10th most common cancer worldwide,with about 0.5 million reported new cases and about 0.2 million deaths per *** this scoping review,we summarize the current evidence regarding the clinical implications of single-cell sequencing for bladder cancer based on PRISMA *** searched PubMed,CENTRAL,Embase,and supplemented with manual searches through the Scopus,and Web of Science for published studies until February *** included original studies that used at least one single-cell technology to study bladder ***-one publications were included in the ***-nine studies showed that this technology can identify cell subtypes in the tumor microenvironment that may predict prognosis or response to immune checkpoint inhibition *** studies were able to diagnose BC by identifying neoplastic cells through single-cell sequencing urine *** remaining studies were mainly a preclinical exploration of tumor microenvironment at single cell ***-cell sequencing technology can discriminate heterogeneity in bladder tumor cells and determine the key molecular properties that can lead to the discovery of novel perspectives on cancer *** nascent tool can advance the early diagnosis,prognosis judgment,and targeted therapy of bladder cancer.

关键词： Bladder cancer Urothelial carcinoma Transitional cell carcinoma Single-cell sequencing Tumor heterogeneity Immunotherapy Scoping review Tumor microenvironment

The in Vitro Antioxidant Capacities of Hydroalcoholic Extracts from Roots and Leaves of Smallanthus sonchifolius (Yacon) Do Not Correlate with Their in Vivo Antioxidant Action in Diabetic Rats

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Journal of Biosciences and Medicines 2016年第2期4卷 15-27页

作者： Ana Carla Broetto Biazon Mariana Marques Nogueira Wendt Júlia Rosa Moreira cristiane Vizioli Castro Ghizoni Andreia Assunção Soares Sandra da Silva Silveira Anacharis Babeto de Sá-Nakanishi Ciomar aparecida Bersani Amado Rosane Marina Peralta Adelar Bracht Jurandir Fernando Comar Pharmacy Department Faculdades Integrado Campo Mourao Brazil Biochemistry Department University of Maringá Maringá Brazil Pharmacology and Therapeutics Department University of Maringá Maringá Brazil

Leaf and root extracts of Smallanthus sonchifolius (yacon), have antihyper-glycemic activity and antioxidant properties. The present study aims to compare the in vivo hepatic antioxidant activity of hydroalcoholic extracts of yacon leaves and roots in rats with streptozotocin-induced diabetes in terms of their in vitro antioxidant capacity. Rats were treated during 14 days with 1060 mg·Kg-1 root extract or 400 mg·Kg-1 leaf extract. The latter was richer in phenolics and possessed a much higher in vitro antioxidant activity. Both extracts prevented hyperglycemia in diabetic rats. The liver of diabetic rats presented increased levels of protein carbonyls and ROS and decreased activities of antioxidant enzymes. Treatment with both root and leaf extracts restored the protein carbonyl levels to normality. The root extract also restored the ROS levels to normality, but the leaf extract was not effective. The root extract was also more effective in restoring the activity of at least two important antioxidant enzymes (glucose 6-phosphate dehydrogenase and glutathione peroxidase). In terms of the antioxidant load (which was 17 times lower in the root extract treatment), the in vivo action of the root extract was more effective than the leaf extract in reducing the hepatic oxidative stress that accompanies diabetes.

关键词： Smallanthus sonchifolius Yacon Streptozotocin-Induced Diabetes Liver Oxidative Status