检索结果-南通市图书馆

Hemodynamic management in brain dead donors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Transplantation 2021年第10期11卷 410-420页

作者： Chiara Lazzeri Manuela Bonizzoli cristiana guetti Giorgio Enzo Fulceri Adriano Peris Intensive Care Unit and Regional ECMO Referral Centre Azienda Ospedaliero Universitaria CareggiFlorence 50134Italy

Donor management is the key in the complex donation process,since up to 20%of organs of brain death donors(DBD)are lost due to hemodynamic *** challenge is made more difficult due to the lack of strong recommendations on therapies for hemodynamic management in DBDs and more importantly to the epidemiologic changes in these donors who are becoming older and with more comorbidities(marginal donors).In the present manuscript we aimed at summarizing the available evidence on therapeutic strategies for hemodynamic management(focusing on vasoactive drugs)and monitoring(therapeutic goals).Evidence on management in elderly DBDs is also *** management continues critical care but with different and specific therapeutic goals since the number of donor goals met is related to the number of organs retrieved and *** monitoring of selected parameters(possibly including serial echocardiography)is the clinical tool able to guarantee the achievement and maintaining of therapeutic *** worldwide differences,norepinephrine is the vasoactive of choice in most countries but,whenever higher doses(>0.2 mcg/kg/min)are needed,a second vasoactive drug(vasopressin)is *** therapy(desmopressin,corticosteroid and thyroid hormone)are suggested in all DBDs independently of hemodynamic *** the single patient,therapeutic regimen(imprimis vasoactive drugs)should be chosen also according to the potential organs retrievable(*** vs liver and kidneys).

关键词： Brain-dead donors Hemodynamic Management Vasoactive drugs Hormanal therapy Echocardiography

Circular and Adaptive Transformation of the Housing Stock towards a Regenerative Future

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Civil Engineering and Architecture 2024年第4期18卷 155-164页

作者： cristiana Cellucci Department of Architecture and Arts IuavUniversity of VeniceVenice 2196Italy

The transition from a linear economy to a CE(circular economy)has the potential to reduce resource use,environmental impacts,and waste in the built *** a CE in the built environment is therefore of fundamental importance to achieve a sustainable *** the application of a systemic approach that considers the building as a set of technological subsystems(*** closures,roof,furniture,etc.),components(*** panels),and materials,this paper-starting from a review of the literature on the topic of the CE applied to construction-establishes a framework of circular design strategies and definitions that link the VRPs(value retention processes)framework,based on the R-imperatives,to the Design-for-X *** first research objective is to develop a design tool for circular building components and technological subsystems.

关键词： Adaptability sustainability circular transition regeneration remanufacturing

Integration of Environmental and Social Values in Cultural Spaces:Sustainable and Inclusive Wayfinding Materials for Museums

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Civil Engineering and Architecture 2024年第5期18卷 207-217页

作者： cristiana Cellucci Teresa Villani Department of Architecture and Arts IUAV University of VeniceVenice 219630123Italy Department of Planning Designand TechnologyFaculty of ArchitectureSapienza University of RomeRome 00185Italy

In the context of use of large museum centers,numerous national and international methodological experiments show that the wayfinding project must consider the needs of both habitual users(user-centered design)and local communities(design for communities)and the importance of environmental protection(eco-design)as a priority interest of the ***“double target”,“user-centered”and“environment-centered”can be applied during the selection process of materials to be used in the *** respect to these possibilities,this contribution intends to present the results of research focused on material characterization of the reception and distribution spaces of large museum *** characterization is based on use of sensory materials and aims to evaluate their impact on the usability and sustainability of wayfinding *** paper directed towards a proposal for organization of integrated information on new generation so-called smart materials;within the design of a wayfinding system,these can balance the aesthetic-perceptual and performance and environmental impact,in order to allow designers to make informed decisions oriented towards inclusion and *** study was addressed by conducting two phases of systematic literature and library review of *** investigations conducted led to achievement of a first research result which consists in the identification of a“standard sheet”for the mapping and cataloging of the materials used for ***“standard sheet”allows organizing the information on smart,sensorial,and eco-friendly materials,balancing the aesthetic-perceptive component with the performance on the environmental impact along the entire life cycle in a circular *** tool could guide designers towards an environmental communication project oriented towards sustainability and is effective for usability and wayfinding.

关键词： Wayfinding eco-friendly materials sensory materials user-centered design eco-design innovative museum

Botulinum Toxin for the Treatment of Nystagmus Associated with Exotropia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Ophthalmology 2022年第4期12卷 392-396页

作者： Lelio Sabetti Francesca guetti Valeria Pomanti Gianluca Murano Department of Biotechnological and Applied Clinical Sciences L’Aquila University L’Aquila Italy

Purpose: Nystagmus can severely impact the visual function, lifestyle and quality of life of patients. Patient with Nystagmus may assume an abnormal compensatory head position and it can result in posture disorders. Botulinum toxin is an important treatment for much pathology of the eye, in particular for blepharospasm, strabismus and nystagmus. The mechanism of action is to prevent lease of acetylcholine in the neuromuscular junction getting the neuromuscular blockade and transient flaccid paralysis. The objective of this work is to evaluate the efficacy of botulinum toxin injection in patients with Nystagmus. Methods: n. 6 patients, (3 females and 3 males) aged 17 - 35 years, exhibiting exotropia (XT) associated with Nystagmus received an injection of Botulinum Toxin A Dysport (Ipsen) in the Lateral Muscles of each eye with a 27-gauge retrobulbar needle. Patients underwent an orthoptic and ophthalmic eye exam before and after surgery. Results: A significant reduction of the nystagmus in primary position was reported in all patients;the abnormal position of the head was noticeably reduced. Side-effects were limited and well tolerated by the patients. Conclusion: Botulinum toxin injection is a valuable treatment of Nystagmus associated with exotropia.

关键词： Nystagmus Botulinum Toxin Exotropia Strabismus

Modelling Strategy and Parametric Study of Metal Gaskets for Automotive Applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2020年第10期125卷 51-64页

作者： Fabio Bruzzone cristiana Delprete Carlo Rosso Politecnico di Torino Corso Duca degli Abruzzi 24Torino10129Italy

This paper is focused on finite element simulation of cylinder head *** element codes support several methodologies,each of which has its own strengths and *** of the key points lies in the influence of the gasket geometry on its final *** a contribution can come from the detailed modelling of the gasket or by defining a global non-linear behaviour in which material and geometry non-linearities are *** approaches were used to simulate the gasket *** first one consists in using a 2D approach,which allows to model through-thickness non-linear behaviour of *** second one consists in using conventional 3D finite element *** numerical methods have been discussed and compared in relation to the accordance with experimental data,amount of information supplied and computational time ***,a parametric study shows how some geometric parameters influence the compressive load and the elastic recovery of a single-layer steel gasket.

关键词： Gaskets finite elements parametric study

Simplified Wave Models Applicability to Shallow Mud Flows Modeled as Power-Law Fluids

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mountain Science 2014年第6期11卷 1454-1465页

作者： cristiana DI CRISTO Michele IERVOLINO Andrea VACCA DICeM Università di Cassino e del Lazio Meridionale DICDEA Seconda Università di Napoli

Simplified wave models- such as kinematic,diffusion and quasi-steady- are widely employed as a convenient replacement of the full dynamic one in the analysis of unsteady open-channel flows,and especially for flood *** their use may guarantee a significant reduction of the computational effort,it is mandatory to define the conditions in which they may be confidently *** present paper investigates the applicability conditions of the kinematic,diffusion and quasisteady dynamic shallow wave models for mud flows of power-law *** power-law model describes in an adequate and convenient way fluids that at low shear rates fluids do not posses yield stress,such as clay or kaolin suspensions,which are frequently encountered in Chinese *** the framework of a linear analysis,the propagation characteristics of a periodic perturbation of an initial steady uniform flow predicted by the simplified models are compared with those of the full dynamic *** on this comparison,applicability criteria for the different wave approximations for mud flood of power-law fluids are *** presented results provide guidelines for selecting the appropriate approximation for a given flow problem,and therefore they may represent a useful tool for engineering predictions.

关键词：幂律流体模型描述适用性泥流建模高岭土悬浮液洪水演进周期性扰动

Engineering nanoparticles for targeting rheumatoid arthritis： Past, present, and future trends

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nano Research 2018年第9期11卷 4489-4506页

作者： Isabel Matos Oliveira cristiana Goncalves Rui Lufs Reis Joaquim Miguel Oliveira B's Research Group - Biomatefials Biodegradables and Biomimetics Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine AvePark 4805-017 Barco Guimaraes Portugal ICVS/3B's-PTGovernment Associate Laboratory University of Minho Campus de Gualtar 4710-057 Braga Portugal The Discoveries Centre for Regenerative and Precision Medicine Headquarters at University of Minho Avepark 4805-017 Barco Guimaraes Portugal

Rheumatoid arthritis （RA） is a chronic inflammatory disease characterized by synovial joint inflammation and cartilage and bone tissue destruction. Although there exist some treatment strategies for RA, they are not completely safe and effective. Therefore, it is important to develop and test new drugs for RA that specifically target inflamed/swollen joints and simultaneously attenuate other possible damages to healthy tissues. Nanotechnology can be a good alternative to consider when envisioning predse medication for treating RA. Through the use of nanopartides, it is possible to increase bioavailability and bioactivity of therapeutics and enable selective targeting to damaged joints. Herein, recent studies using nanoparticles for the treatment of RA, namely with liposomes, polymeric nanoparticles, dendrimers, and metallic nanoparticles, have been reviewed. These therapeutic strategies have shown great promise in improving the treatment over that by traditional drugs. The results of these studies confirm that feasibility of the use of nanopartides is mainly due to their biocompatibility, low toxicity, controlled release, and selective drug delivery to inflamed tissues in animal RA models. Therefore, it is possible to claim that nanotechnology will, in the near future, play a crucial role in advanced treatments and patient-specific therapies for human diseases such as RA.

关键词： nanoparticles liposomes dendrimers rheumatoid arthritis

Transference of the“Albergo Diffuso”Model to Spain:Regeneration of Uninhabited Rural Areas

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Civil Engineering and Architecture 2022年第4期16卷 173-182页

作者： Teresa Villani cristiana Cellucci MRosario Chaza Fernando Rico Department of Planning Designand Technology of Architecture(PDTA)“Sapienza”University of RomeItaly Department of Architecture and Arts IuavUniversity of VeniceItaly Department of Graphic Expression and Building Engineering University of SevilleSpain

In recent years,human health and user wellbeing have become more important in contemporary society and urban *** has been highlighted by the outbreak of the COVID-19 pandemic in the *** open-air urban spaces constitutes an opportunity to design walkable areas and paths that can produce direct positive effects on environmental health and indirect consequences on“lifestyles”.This design vision can be implemented within small localities where there are still important continuities and long-term relationships between the human scale of public spaces and the sense of place related to historic/traditional infrastructural *** interest of various international research and of the WHO(World Health Organization)itself extends the subject of public health to the relationship of the individual with the environment,and with the rest of the social interactions,considering the latter a factor that can affect the reduction of *** order to act in the direction of improving people’s health,to determine the conditions for a life free of diseases and disabilities,and to generate cities and common spaces of use capable of encouraging the adoption of healthy and active lifestyles by people of all ages,the research makes a comparison between possible interventions in Italy and Spain.

关键词： Health COVID-19 pandemic public spaces infastructure lifestyle albergo diffuso BIM(building information modelling).

Numerical simulation of mud-flows impacting structures

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mountain Science 2019年第2期16卷 364-382页

作者： GRECO Massimo DI CRISTO cristiana IERVOLINO Michele VACCA Andrea DICEA Università di Napoli Federico II DI Università della Campania Luigi Vanvitelli

The study of the interaction of mud-flows with obstacles is important to define inundation zones in urban areas and to design the possible structural countermeasures. The paper numerically investigates the impact of a mud-flow on rigid obstacles to evaluate the force acting on them using two different depth-integrated theoretical models, Single-Phase Model(SPM) and Two-Phase Model(TPM), to compare their performance and limits. In the first one the water-sediment mixture is represented as a homogeneous continuum described by a shearthinning power-law rheology. Alternatively, the twophase model proposed by Di Cristo et al in 2016 is used, which separately accounts for the liquid and solid phases. The considered test cases are represented by a 1D landslide flowing on a steep slope impacting on a rigid wall and a 2D mud dam-break flowing on a horizontal bottom in presence of single and multiple rigid obstacles. In the 1D test case, characterized by a very steep slope, the Two-Phase Model predicts the separation between the two phases with a significant longitudinal variation of the solid concentration. In this case the results indicate appreciable differences between the two models in the estimation of both the wave celerity and the magnitude of the impact, with an overestimation of the peak force when using the Single-Phase Model. In the 2D test-cases, where the liquid and solid phases remain mixed, even if the flow fields predicted by the two models present some differences, the essential features of the interaction with the obstacles, along with the maximum impact force, are comparable.

关键词： Mud-Flow Impact force Two-phase model Power-law